Chaperone Suppression of Cellular Toxicity of Huntingtin Is Independent of Polyglutamine Aggregation

Journal of Biological Chemistry

Volumn 276, Issue 51, 2001, Pages 48417-48424

  Zhou, Hui ^b   Li, Shi Hua ^b   Li, Xiao Jiang ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MUTAGENESIS; NEUROLOGY; PROTEINS; TOXICITY;

CELLULAR TOXICITY;

CELLS;

CASPASE; CASPASE 3; CASPASE 9; CHAPERONE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HUNTINGTIN; N ETHYLMALEIMIDE; POLYGLUTAMINE; CARRIER PROTEIN; DNAS PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEINS; HEAT SHOCK PROTEINS 70; HUNTINGTIN PROTEIN, HUMAN; N ETHYLMALEIMIDE SENSITIVE PROTEIN; N-ETHYLMALEIMIDE-SENSITIVE PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PRIMER DNA;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICITY; AMINO ACID SEQUENCE; CELL LINE; GENETIC TRANSFECTION; GENETICS; METABOLISM; NERVE CELL; NUCLEOTIDE SEQUENCE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; DNA PRIMERS; HEAT-SHOCK PROTEINS; HEAT-SHOCK PROTEINS 70; HUMAN; MOLECULAR CHAPERONES; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION;

EID: 0035930598     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104140200     Document Type: Article

References (52)

1. Perutz, M. F. (1999) Trends Biochem. Sci. 24, 58-63
2. HD Collaborative Research Group (1993) Cell 72, 971-983
3. Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., and Bates, G. P. (1997) Cell 90, 537-548
4. DiFiglia, M., Sapp, E., Chase, K. O., Davies, S. W., Bates, G. P., Vonsattel, J. P., and Aronin, N. (1997) Science 277, 1990-1993
5. Gutekunst, C. A., Li, S. H., Yi, H., Mulroy, J. S., Kuemmerle, S., Jones, R., Rye, D., Ferrante, R. J., Hersch, S. M., and Li, X. J. (1999) J. Neurosci. 19, 2522-2534
6. Li, H., Li, S. H., Johnston, H., Shelbourne, P. F., and Li, X. J. (2000) Nat. Genet. 25, 385-389
7. Yamamoto, A., Lucas, J. J., and Hen, R. (2000) Cell 101, 57-66
8. Scherzinger, E., Sittler, A., Schweiger, K., Heiser, V., Lurz, R., Hasenbank, R., Bates, G. P., Lehrach, H., and Wanker, E. E. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 4604-4609
9. Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H., and Wanker, E. E. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6739-6744
10. Carmiehael, J., Chatellier, J., Woolfson, A., Milstein, C., Fersht, A. R., and Rubinsztein, D. C. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9701-9705
11. Wyttenbach, A., Carmichael, J., Swartz, J., Furlong, R. A., Narain, Y., Rankin, J., and Rubinsztein, D. C. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2898-2903
12. Krobitsch, S., and Lindquist, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1589-1594
13. Cummings, C. J., Mancini, M. A., Antalffy, B., DeFranco, D. B., Orr, H. T., and Zoghbi, H. Y. (1998) Nat. Genet. 19, 148-154
14. Cummings, C. J., Reinstein, E., Sun, Y., Antalffy, B., Jiang, Y., Ciechanover, A., Orr, H. T., Beaudet, A. L., and Zoghbi, H. Y. (1999) Neuron 24, 879-892
15. Chai, Y., Koppenhafer, S. L., Bonini, N. M., and Paulson, H. L. (1999) J. Neurosci. 19, 10338-10347
16. Stenoien, D. L., Cummings, C. J., Adams, H. P., Mancini, M. G., Patel, K., DeMartino, G. N., Marcelli, M., Weigel, N. L., and Mancini, M. A. (1999) Hum. Mol. Genet. 8, 731-741
17. Kobayashi, Y., Kume, A., Li, M., Doyu, M., Hata, M., Ohtsuka, K., and Sobue, G. (2000) J. Biol. Chem. 275, 8772-8778
18. Muchowski, P. J., Schaffar, G., Sittler, A., Wanker, E. E., Hayer-Hartl, M. K., and Hartl, F. U. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7841-7846
19. Jana, N. R., Tanaka, M., Wang, G., and Nukina, N. (2000) Hum. Mol. Genet. 9, 2009-2018
20. Hartl, F. U. (1996) Nature 381, 571-579
21. Silver, P. A., and Way, J. C. (1993) Cell 74, 5-6
22. Kelley, W. L. (1999) Curr. Biol. 9, R305-R308
23. Fink, A. L. (1999) Physiol. Rev. 79, 425-449
24. Mosser, D. D., Caron, A. W., Bourget, L., Meriin, A. B., Sherman, M. Y., Morimoto, R. I., and Massie, B. (2000) Mol. Cell. Biol. 20, 7146-7159
25. Pandey, P., Saleh, A., Nakazawa, A., Kumar, S., Srinivasula, S. M., Kumar, V., Weichselbaum, R., Nalin, C., Alnemri, E. S., Kufe, D., and Kharbanda, S. (2000) EMBO J. 19, 4310-4322
26. Saleh, A., Srinivasula, S. M., Balkir, L., Robbins, P. D., and Alnemri, E. S. (2000) Nat. Cell Biol. 2, 476-483
27. Beere, H. M., Wolf, B. B., Cain, K., Mosser, D. D., Mahboubi, A., Kuwana, T., Tailor, P., Morimoto, R. I., Cohen, G. M., and Green, D. R. (2000) Nat. Cell Biol. 2, 469-475
28. Li, C. Y., Lee, J. S., Ko, Y. G., Kim, J. I., and Seo, J. S. (2000) J. Biol. Chem. 275, 25665-25671
29. Warrick, J. M., Chan, H. Y., Gray-Board, G. L., Chai, Y., Paulson, H. L., and Bonini, N. M. (1999) Nat. Genet. 23, 425-428
30. Kazemi-Esfarjani, P., and Benzer, S. (2000) Science 287, 1837-1840
31. Hay, J. C., and Scheller, R. H. (1997) Curr. Opin. Cell Biol. 9, 505-512
32. Haas, A. (1998) Trends Cell Biol. 8, 471-473
33. Li, S. H., Lam, S., Cheng, A. L., and Li, X. J. (2000) Hum. Mol. Genet. 9, 2859-2867
34. Rigamonti, D., Sipione, S., Goffredo, D., Zuccato, C., Fossale, E., and Cattaneo, E. (2001) J. Biol. Chem. 5, 14545-14548
35. Zou, H., Li, Y., Liu, X., and Wang, X. (1999) J. Biol. Chem. 274, 11549-11556
36. Jana, N. R., Zemskov, E. A., Wang, G., and Nukina, N. (2001) Hum. Mol. Genet. 1049-1059
37. Samali, A., and Orrenius, S. (1998) Cell Stress Chaperones 3, 228-236
38. Jaattela, M., Wissing, D., Kokholm, K, Kallunki, T., and Egeblad, M. (1998) EMBO J. 17, 6124-6134
39. Cooper, J. K., Schilling, G., Peters, M. F., Herring, W. J., Sharp, A. H., Kaminsky, Z., Masone, J., Khan, F. A., Delanoy, M., Borclhelt, D. R., Dawson, V. L., Dawson, T. M., and Ross, C. A. (1998) Hum. Mol. Genet. 7, 783-790
40. Rigamonti, D., Bauer, J. H., De-Fraja, C., Conti, L., Sipione, S., Sciorati, C., Clementi, E., Hackam, A., Hayden, M. R., Li, Y., Cooper, J. K., Ross, C. A., Govoni, S., Vincenz, C., and Cattaneo, E. (2000) J. Neurosci. 20, 3705-3713
41. Sawa, A., Wiegand, G. W., Cooper, J., Margolis, R. L., Sharp, A. H., Lawler, J. F., Jr., Greenamyre, J. T., Snyder, S. H., and Ross, C. A. (1999) Nat. Med. 5, 1194-1198
42. Garrido, C., Bruey, J. M., Fromentin, A., Hammann, A., Arrigo, A. P., and Solary, E. (1999) FASEB J. 13, 2061-2070
43. Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y., and Orr, H. T. (1998) Cell 95, 41-53
44. Saudou, F., Finkbeiner, S., Devys, D., and Greenberg, M. E. (1998) Cell 95, 55-66
45. Osten, P., Srivastava, S., Inman, G. J., Vilim, F. S., Khatri, L., Lee, L. M., States, B. A., Einheber, S., Milner, T. A., Hanson, P. I., and Ziff, E. B. (1998) Neuron 21, 99-110
46. Han, S. Y., Park, D. Y., Park, S. D., and Hong, S. H. (2000) Biochem. J. 352, 165-173
47. McBride, H. M., Rybin, V., Murphy, C., Giner, A., Teasdale, R., and Zerial, M. (1999) Cell 98, 377-386
48. McDonald, P. H., Cote, N. L., Lin, F. T., Premont, R. T., Pitcher, J. A., and Lefkowitz, R. J. (1999) J. Biol. Chem. 274, 10677-10680
49. Song, I., Kamboj, S., Xia, J., Dong, H., Liao, D., and Huganir, R. L. (1998) Neuron 21, 393-400
50. Chan, H. Y., Warrick, J. M., Gray-Board, G. L., Paulson, H. L., and Bonini, N. M. (2000) Hum. Mol. Genet. 9, 2811-2820
51. Moulder, K. L., Onodera, O., Burke, J. R., Strittmatter, W. J., and Johnson, E. M., Jr. (1999) J. Neurosci. 19, 705-715
52. Turmaine, M., Raza, A., Mahal, A., Mangiarini, L., Bates, G. P., and Davies, S. W. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8093-8097