Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation

Current Opinion in Genetics and Development

Volumn 6, Issue 2, 1996, Pages 176-184

  Brownell, James E ^a   Allis, C David ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; HISTONE ACETYLTRANSFERASE;

ACETYLATION; AMINO TERMINAL SEQUENCE; CHROMATIN; CHROMATIN STRUCTURE; CONTROLLED STUDY; DRUG ACETYLATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC TRANSCRIPTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029925512     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80048-7     Document Type: Article

References (83)

1. Wolffe AP (Ed): Chromatin structure and function. London: Academic Press; 1992.
2. Bradbury EM: Reversible histone modifications and the chromosome cell cycle. Bioessays 1992, 14:9-16.
3. Csordas A: On the biological role of histone acetylation. Biochem J 1990, 265:23-38.
4. Loidl P: Histone acetylation: facts and questions. Chromosoma 1994, 103:441-449.
5. Turner BM, O'Neill LP: Histone acetylation in chromatin and chromosomes. Semin Cell Biol 1995, 6:229-236.
6. Allfrey VG, Faulkner R, Mirsky AE: Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci USA 1964, 51:786-794.
7. Wolffe AP: Transcription: in tune with the histones. Cell 1994, 77:13-16.
8. Hebbes TR, Thorne AW, Crane-Robinson C: A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J 1988, 7:1395-1403.
9. •].
10. ••] an anti-acetyllysine antibody was used to directly demonstrate enrichment of acetylated H4 in transcriptionally 'poised' chromatin versus bulk chromatin in a region that coincided with a region of increased DNase I sensitivity (the chicken β-globin locus), thus fitting with the idea that acetylation is related to gene activation. In this paper, immunoprecipitation experiments using antibodies directed against H4 acetylated at specific sites failed to show enrichment of acetylated histone in active versus bulk chromatin, although H4 associated with pericentric heterochromatin was underacetylated. In similar studies ([14]; M Braunstein, CD Allis, BM Turner, JR Broach, unpublished data) using both antibodies directed towards acetylated and unacetylated forms of H3 and H4 demonstrate that inactive loci are enriched in hypoacetylated histones, although some specific acetylated sites may predominate (i.e. H4.Ac12).
11. Kayne PS, Kim UJ, Han M, Mullen JR, Yoshizaki F, Grunstein M: Extremely conserved histone H4 N-terminus is dispensible for growth but essential for repressing the silent mating loci in yeast. Cell 1988, 55:27-39.
12. Durrin LK, Mann RK, Kayne PS, Grunstein M: Yeast histone H4 N-terminal sequence is required for promoter activation in vivo. Cell 1991, 65:1023-1031.
13. ••].
14. Braunstein M, Rose AB, Holmes SG, Allis CD, Broach JR: Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 1993, 7:592-604.
15. Bauer WR, Hayes JJ, White JH, Wolffe AP: Nucleosome structural changes due to acetylation. J Mol Biol 1994, 236:685-690.
16. Juan L-J, Utley RT, Adams CC, Vettesse-Dadey M, Workman JL: Differential repression of transcription factor binding by histone H1 is regulated by the core histone amino termini. EMBO J 1994, 13:6031-6040.
17. Ura K, Wolffe AP, Hayes JJ: Core histone acetylation does not block linker histone binding to a nucleosome including a Xenopus borealis 5 S rRNA gene. J Biol Chem 1994, 269:27171-27174.
18. Dimitrov S, Almouzni G, Dasso M, Wolffe AP: Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type. Dev Biol 1993, 160:214-227.
19. Ura K, Hayes JJ, Wolffe AP: A positive role for nucleosome mobility in the transcriptional activity of chromatin templates: restriction by linker histones. EMBO J 1995, 14:3752-3765.
20. Lee DY, Hayes JJ, Pruss D, Wolffe AP: A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 1993, 72:73-84.
21. Vettesse-Dadey M, Walter P, Chen H, Juan L-J, Workman JL: Role of the histone amino termini in faciliated binding of a transcription factor, GAL4-AH, to nucleosome cores. Mol Cell Biol 1994, 14:970-981.
22. Fisher-Adams G, Grunstein M: Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter. EMBO J 1995, 14:1468-1477.
23. Roth SY: Chromatin-mediated transcriptional repression in yeast. Curr Opin Genet Dev 1995, 5:168-173.
24. Johnson LM, Fisher-Adams G, Grunstein M: Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci. EMBO J 1992, 11:2201-2209.
25. •], biochemical and genetic evidence for the interaction of Sir3 and Sir4 with the amino termini of H3 and H4 is shown to be dependent on specific histone silencing domains. Combined with data from genetic analyses and immunofluorescence studies with anti-RAP1 and Sir3 antibodies, a model is presented for the formation of heterochromatin-mediated transcriptional silencing in yeast.
26. Kaufman PD, Botchan MR: Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms? Curr Opin Genet Dev 1995, 4:229-235.
27. Dimitrov S, Wolffe AP: Chromatin and nuclear assembly: experimental approaches towards the reconstitution of transcriptionally active and silent states. Biochim Biophys Acta 1995, 1260:1-13.
28. Krude T: Nucleosome assembly during DNA replication. Curr Biol 1995, 5:1232-1234.
29. Annunziato AT: Histone acetylation during chromatin replication and nucleosome assembly. The Nucleus 1995, 1:31-56.
30. Allis CD, Chicoine LG, Richman R, Schulman IG: Deposition-related histone acetylation in micronuclei of conjugating Tetrahymena. Proc Natl Acad Sci USA 1985, 82:8048-8052.
31. Ruiz-Carrilo A, Wangh LJ, Allfrey VG: Assembly of newly replicated chromatin. Science 1975, 190:117-128.
32. Chicoine LG, Schulman IG, Richman R, Cook RG, Allis CD: Nonrandom utilization of acetylation sites in histones isolated from Tetrahymena. J Biol Chem 1986, 261:1071-1076.
33. Sobel RE, Cook RG, Allis CD: Non-random acetylation of histone H4 by a cytoplasmic histone acetyltransferase as determined by novel methodology. J Biol Chem 1994, 269:18576-18582. This paper describes the first application of a protein deblocking procedure that allows the identification of acetyllysine residues in otherwise amino-terminally blocked H4s.
34. Sobel RE, Cook RG, Perry CA, Annunziato AT, Allis CD: Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4. Proc Natl Acad Sci USA 1995, 92:1237-1241.
35. Weingand RC, Brutlag DL: Histone acetylase from Drosophila melanogaster specific for H4. J Biol Chem 1981, 256:4578-4583.
36. Richman R, Chicoine LG, Collini MP, Cook RG, Allis CD: Micronuclei and the cytoplasm of growing Tetrahymena contain a histone acetylase activity which Is highly specific for free histone H4. J Cell Biol 1988, 106:1017-1026.
37. Mingarro I, Sendra R, Salvador ML, Franco L: Site specificity of pea histone acetyltransferase B in vitro. J Biol Chem 1993, 268:13248-13252.
38. ••] binds specifically to acetylated cytoplamic H4 implies a functional relationship between Hat1p and chromatin assembly.
39. Smith S, Stillman B: Purification and characterization of CAF1, a human cell factor required for chromatin assembly during DNA replication in vitro. Cell 1989, 58:15-25.
40. ••].
41. ••].
42. Belikoff E, Wong L-J, Alberts BM: Extensive purification of histone acetylase A, the major histone N-acetyl transferase activity detected in mammalian cell nuclei. J Biol Chem 1980, 255:11448-11453.
43. Wiktorowicz JE, Bonner J: Studies on histone acetyltransferase; partial purification and basic properties. J Biol Chem 1982, 257:12893-12900.
44. Travis GH, Colavito-Shepanski M, Grunstein M: Extensive purification and characterization of chromatin-bound histone acetyltransferase from Saccharomyces cerevisiae. J Biol Chem 1984, 259:14406-14412.
45. Kelner DN, McCarty KS: Porcine liver nuclear histone acetyltransferase; partial purification and basic properties. J Biol Chem 1984, 259:3413-3418.
46. Yukioka M, Sasaki S, Qi S-L, Inoue A: Two species of histone acetyltransferase in rat liver nuclei. J Biol Chem 1984, 259:8372-8377.
47. López-Rodas G, Tordera V, Sánchez del Pino MM, Franco L: Yeast contains multiple forms of histone acetyltransferase. J Biol Chem 1989, 264:19028-19033.
48. Attisano L, Lewis PN: Purification and characterization of two porcine liver nuclear histone acetyltransferases. J Biol Chem 1990, 265:3949-3955.
49. López-Rodas G, Tordera V, Sánchez del Pino MM, Franco L: Subcellular localization and nucleosome specificity of yeast histone acetyltransferases. Biochemistry 1991, 30:3728-3732.
50. •] describe the identification and subsequent cloning of the gene that encodes p55: a catalytically active HAT from Tetrahymena macronuclei, Analysis of the derived sequence of p55 revealed extensive homology to Gcn5p, a yeast transcription co-adaptor, thus establishing a direct link between acetyltransferases and gene activation.
51. Georgakopoulos T, Thireos G: Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J 1992, 11:4145-4152.
52. •].
53. ••], provides an immediate mechanism for targeting HAT A to chromatin for transcriptional activation.
54. 53••].
55. ••].
56. ••].
57. Guarente L: Transcriptional coactivators in yeast and beyond. Trends Biochem Sci 1995, 20:516-521.
58. Candau R, Moore PA, Wand L, Barlev N, Ying CY, Rosen CA, Berger SL: Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol 1996, 16:593-602.
59. Shaw WV, Leslie AGW: Chloramphenical acetyltransferase. Annu Rev Biophys Chem 1991, 20:363-386.
60. Husain SS, Lowe G: Evidence for histidine in the active site of papain. Biochem J 1968, 108:855-859.
61. Kurihara T, Ueda M, Kanayama N, Kondo J, Ternishi Y, Tanaka A: Peroxisomal acetoacetyl-CoA thiolase of an n-alkane-utilizing yeast, Canadida tropicalis. Eur J Biochem 1992, 210:999-1005.
62. Hruz PW, Narasimhan C, Miziorko HM: 3-Hydroxy-3-methylglutaryl coenzyme A lyase: affinity labeling of the Pseudomonas mevalonii enzyme and assignment of cysteine-237 to the active site. Biochemistry 1992, 31:6842-6847.
63. Hendzel MJ, Sun J-M, Chen HY, Rattner JB, Davie JR: Histone acetyltransferase is associated with the nuclear matrix. J Biol Chem 1994, 269:22894-22901.
64. Grabher A, Brosch G, Sendra R, Lechner T, Eberharter A, Georgieva EI, López-Rodas G, Franco L, Dietrich H, Loidl P: Subcellular location of enzymes involved in core histone acetylation. Biochemistry 1994, 33:14887-14895.
65. Davie JR: Histone modifications, chromatin structure and the nuclear matrix. J Cell Biochem 1996, in press.
66. Haynes SR, Dollard C, Winston F, Beck S, Trowsdale J, Dawid IB: The bromodomain, a conserved sequence found in human, Drosophila, and yeast proteins. Nucleic Acids Res 1992, 80:2603.
67. Hope IA, Struhl K: Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast Cell 1986, 46:885-894.
68. Eissenberg JC, James TC, Foster-Hartnett DM, Hartnett T, Ngan V, Elgin SCR: Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc Natl Acad Sci USA 1990, 87:9923-9927.
69. Paro R: Imprinting a determined state into the chromatin of Drosophila. Trends Genet 1990, 6:416-421.
70. Messmer S, Franke A, Paro R: Analysis of the functional role of the Polycomb chromodomain in Drosophila melanogaster, Genes Dev 1992, 6:1241-1254.
71. Powers J, Eissenberg JC: Overlapping domains of the heterochromatin associated protein HP1 mediate nuclear localization and heterochromatin binding. J Cell Biol 1993, 120:291-299.
72. Platero JS, Hartnett T, Eissenberg JC: Functional analysis of the chromodomain of HP1, EMBO J 1995, 14:3977-3986.
73. Hirschorn JN, Bortvin AL, Ricupero-Hovasse SL, Winston F: A new class of histone H2A mutations in Saccharomyces cerevisiae causes specific transcriptional defects. Mol Cell Biol 1992, 15:1999-2009.
74. Laurent BC, Treich I, Carlson M: The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation. Genes Dev 1993, 7:583-591.
75. Winston F, Carlson M: Yeast SNF/SWI transcriptional activators and SPT/SIN chromatin connection. Trends Genet 1992, 8:387-391.
76. Carlson M, Laurent BC: The SNF/SWI family of global transcriptional activators. Curr Opin Cell Biol 1994, 6:396-402.
77. ••].
78. •] support the notion that the SWI/SNF complex functions to alleviate repressive chromatin structure.
79. Peterson CL, Tamkun JW: The SWI-SNF complex: a chromatin remodeling machine? Trends Biochem Sci 1995, 20:143-146.
80. ••].
81. Koleske AJ, Young RA: The RNA polymerase II holoenzyme and its implications for gene regulation. Trends Biochem Sci 1995, 20:113-116.
82. ••] suggest a global role for the SWI/SNF complex in antagonizing chromatin structure and promoting the activities of both positive and negative regulators of transcription.
83. Yoshida M, Horinouchi S, Beppu T: Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 1995, 17:423-430.