Free radicals in Alzheimer's disease

Journal of Neural Transmission, Supplement

Volumn , Issue 54, 1998, Pages 221-236

  Retz, W ^a   Gsell, W ^a   Munch G ^a   Rosler M ^a   Riederer, P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; FREE RADICAL;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; GLUCOSE METABOLISM; HUMAN; IRON METABOLISM; LIPID MEMBRANE; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ANIMAL; BRAIN; METABOLISM; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; ANIMALS; ANTIOXIDANTS; BRAIN; FREE RADICALS; HUMANS; NERVE DEGENERATION; OXIDATIVE STRESS;

EID: 0031593602     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-7508-8_22     Document Type: Review

References (108)

1. Adams IM (1991) Structural plasticity of synapses in Alzheimer's disease. Mol Neurobiol 5: 411-419
2. Adams JD, Klaidman LK, Odunze IN, Shen HC, Miller CA (1991) Alzheimer's disease and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol 14: 213-226
3. Adolfsson R, Gottfries C-G, Oreland L, Wiberg A, Winblad B (1980) Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci 27: 1029-1034
4. Ahlskog JE, Uitti RJ, Low PA, Tyce GM, Nickander KK, Petersen RC, Kokmen E (1995) No evidence for systemic oxidant stress in Parkinson's or Alzheimer's disease. Mov Disord 10: 566-573
5. Alzheimer A (1907) Über eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat 64: 146-148
6. Andorn AC, Britton RS, Bacon BR (1990) Evidence that lipid peroxidation and total iron are increased in Alzheimer's brain [abstract]. Neurobiol Aging 11: 316
7. Anneren G, Gardner A, Lundin T (1986) Increased glutathion peroxidase activity in erythrocytes in patients with Alzheimer's disease/senile dementia of Alzheimer's type. Acta Neurol Scand 73: 586-589
8. Aruoma OI, Halliwell B, Laughton MJ, Quinlan GJ, Gutteridge JMC (1989) The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex. Biochem J 258: 617-620
9. Bachman DL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, White LR, D'Agostino RB (1993) Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study. Neurology 43: 515-519
10. Balazs L, Leon M (1994) Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res 19: 1131-1137
11. Bartzokis G, Sultzer D, Mintz J, Holt LE, Marx P, Phelan CK, Marder SR (1994) In vivo evaluation of brain iron in Alzheimer's disease and normal subjects using MRI. Biol Psychiatry 35: 480-487
12. Bauer J (1994) Die Alzheimer Krankheit. Neurobiologie, Psychosomatik, Diagnostik und Therapie. Schattauer, Stuttgart
13. Bauer J, Berger M (1993) Neuropathologie, Immunologie und psychobiologische Aspekte der Alzheimer Krankheit. Fortschr Neurol Psychiatr 61: 225-240
14. Banyes JW (1991) Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412
15. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38: 357-366
16. Beal MF (1996) Mitochondria, free radicals, and neurodegeneration. Curr Opin Neurobiol 6: 661-666
17. Benzi G, Moretti A (1995) Are reactive oxygen species involved in Alzheimer's disease? Neurobiol Aging 16: 661-674
18. Benzi G, Marzatico F, Pastoris O, Villa RF (1989) Influence of oxidative stress on the age-linked alterations of the cerebral glutathione system. J Neurosci Res 26: 120-128
19. Blass JP, Baker AC, Ko L, Black RS (1990) Induction of Alzheimer antigen an uncoupler of oxidative phosphorylation. Arch Neurol 47: 864-869
20. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82: 239-259
21. Busciglio J, Yankner BA (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378: 776-779
22. Ceballos-Picot I, Merad-Boudia M, Nicole A, Thevenin M, Hellier G, Legrain S, Berr C (1996) Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type - place of the extracellular glutathion peroxidase. Free Radic Biol Med 20: 579-587
23. Chen L, Richardson JS, Caldwell JE, Ang LC (1994) Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls. Int J Neurosci 75: 83-90
24. Colton CA, Gilbert DL (1987) Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 223: 284-288
25. Connor JR, Snyder BS, Beard JL, Fine RE, Mufson EJ (1992a) Regional distribution of iron and iron-regulatory proteins in the brain in aging and Alzheimer's disease. J Neurosci Res 31: 327-335
26. Connor JR, Menzies SL, St. Martin SM, Mufson EJ (1992b) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. Neurosci Res 31: 75-83
27. Connor JR, Tucker P, Johnson M, Snyder B (1993) Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease. Neurosci Lett 159: 88-90
28. Danielczyk W, Streifler M, Konradi C, Riederer P, Moll G (1988) Platelet MAO-B activity and the psychopathology of Parkinson's disease, senile dementia and multiinfarct dementia. Acta Psychiatr Scand 78: 730-736
29. Delamarche C (1989) A homologous domain between the amyloid protein of Alzheimer's disease and the neuriofilament subunits. Biochimie 71: 853-856
30. Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther KE (1992) Amyloidogenicity of β A4 and β A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J Biol Chem 267: 18210-18217
31. Ebrahim S, Schupf S, Silverman W, Zigman WB, Moretz RC, Wisniewski HM, Taylor E, Devakumar M, Lindegard B, Lindesay J, Grant DJ, McMurdo MET, Corrigan FM, Reynolds GP, Ward NI, Farrar G, Blair JA, Curran S, Hindmarch I, Steer C (1989) Aluminium and Alzheimer's disease. Lancet ii: 267-269
32. Ehmann WD, Markesbery WR, Alauddin M, Hossain TIM, Brubaker EH (1986) Brain trace elements in Alzheimer's disease. Neurotoxicology 7: 195-206
33. Fischer P, Götz ME, Ellinger B, Streifler M, Riederer P, Danielczyk W (1994) Platelet monoamine oxidase B activity and vitamin B12 in dementia. Biol Psychiat 35: 772-774
34. Fleming J, Joshi JG (1987) Ferritin: isolation of aluminium-ferritin complex from brain. Proc Natl Acad Sci 84: 7866-7870
35. Frölich L, Riederer P (1995) Free radical mechanisms in dementia of Alzheimer type and the potential for antioxidative treatment. Arzneimittelforschung 43: 443-446
36. Gautrin D, Gauthier S (1989) Alzheimer's disaese: environmental factors and etiologic hypothesis. Can J Neurol Sci 16: 375-387
37. Gerlach M, Ben Shachar D, Riederer P, Youdim MB (1994) Altered metabolism of iron as a cause of neurodegenerative diseases? J Neurochem 63: 793-807
38. Götz ME, Freyberger A, Hauer E, Burger R, Sofic E, Gsell W, Heckers S, Jellinger K, Hebenstreit G, Frölich L, Beckmann H, Riederer P (1992) Susceptibility of brains from patients with Alzheimer's disease to oxygen-stimulated lipid peroxidation and differential scanning calorimetry. Dementia 3: 213-222
39. Götz ME, Dirr A, Freyberger A, Burger R, Riederer P (1993) The thiobarbituric acid assay reflects susceptibility to oxygen-induced lipid peroxidation in vitro rather than levels of lipid hydroperoxides in vivo: a methodological approach. Neurochem Int 22: 255-262
40. Götz ME, Künig G, Riederer P, Youdim MBH (1994) Oxidative stress: free radical production in neuronal degeneration. Pharmac Ther 63: 37-122
41. Götz ME, Fischer P, Gsell W, Riederer P, Streifler M, Simanyi M, Müller F, Danielczyk W (1998) Platelet monoamine oxidase B activity in dementia: a 4 year follow up. Dementia 9: 74-77
42. Good PF, Perl DP, Bierer LM, Schmeidler J (1992) Selective accumulation of aluminium and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Ann Neurol 31: 286-292
43. Greenamyre JT, Maragos WF (1993) Neurotransmitter receptors in Alzheimer disease. Cerebrovasc Brain Metab Rev 5: 61-94
44. Greenlund LJ, Deckwerth TL, Johnson EM Jr (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 147: 303-315
45. Grootveld M, Halliwell B (1986) Aromatic hydroxylation as a potential measure of hydroxyl radical formation in vivo. Biochem J 237: 499-504
46. Grundke-Iqbal I, Fleming J, Tung YC, Lassmann H, Iqbal K, Joshi JG (1990) Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol (Berl) 81: 105-110
47. Gsell W, Conrad R, Hickethier M, Sofic E, Frölich L, Wichart I, Jellinger K, Moll G, Ransmayr G, Beckmann H, Riederer P (1995) Decreased catalase activity but unchanged superoxide dismutase activity in brain of patients with dementia of Alzheimer type. J Neurochem 64: 1216-1223
48. Gutteridge JM, Quinlan GJ, Clark I, Halliwell B (1985) Aluminium salts accelerate peroxidation of membrane lipids stimulated by iron salts. Biochim Biophys Acta 835: 441-447
49. Halliwell B, Gutteridge JM (1984) Oxygen toxicity, transition metals and disease. Biochem J 219: 1-14
50. Hajimohammadreza I, Brammer M (1990) Brain membrane fluidity and lipid peroxidation in Alzheimer's disease. Neurosci Lett 112: 333-337
51. Harman D (1956) Ageing: a theory based on free radical and rediation chemistry. J Gerontol 11: 298-300
52. Hoyer S (1996) Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease. Acta Neuropathol Scand [Suppl] 165: 18-24
53. Jeandel C, Nicolas MB, Dubois F, Nabet-Belleville F, Penin F, Cuny G (1989) Lipid peroxidation and free radical scavengers in Alzheimer's disease. Gerontology 35: 275-282
54. Jellinger K, Paulus W, Grundke-Iqbal I, Riederer P, Youdim MB 1990) Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J Neural Transm [PD-Sect] 2: 327-340
55. Kala SV, Hasinoff BB, Richardson JS (1996) Brain samples from Alzheimer's patients have elevated levels of loosely bound iron. Int J Neurosci 86: 263-269
56. Kawai M, Kalaria RN, Cras P, Siedlak SL, Velasco ME, Shelton ER, Chan HW, Greenberg BD, Perry G (1993) Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer's disease. Brain Res 623: 142-146
57. Kawamata T, Tooyama I, Yamada T, Walker DG, McGeer PL (1993) Lactotransferrin immunocytochemistry in Alzheimer and normal human brain. Am J Pathol 142: 1574-1585
58. Kish SJ, Morito CL, Hornykiewicz O (1986) Brain glutathione peroxidase in neuro-degenerative disorders. Neurochem Pathol 4: 23-28
59. Lovell MA, Ehmann WD, Butler SM, Markesbery WR (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain of Alzheimer's disease. Neurology 45: 1594-1601
60. Maggio JE, Stimson ER, Ghilardi JR, Allen CJ, Dahl CE, Whitcomb DC, Vigna SR, Vinters HV, Labenski ME, Mantyh PW (1992) Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci USA 89: 5462-5466
61. Makar TK, Cooper AJ, Tofel-Grehl B, Thaler HAT, Blass JP (1995) Carnitine, carnitine acetyltransferase, and glutathione in Alzheimer brain. Neurochem Res 20: 705-711
62. Margaglione M, Garofano R, Cirillo F, Ruocco A, Grandone E, Vecchione G, Milan G, di Minno G, de Blasi A, Postiglione A (1995) Cu/Zn superoxide dismutase in patients with non-familial Alzheimer's disease. Aging Milano 7: 49-54
63. Markesberry W, Ehmann WD (1994) In: Terry RD, Katzman R, Bick L (eds) Alzheimer's disease. Raven Press, New York, pp 353-367
64. Marklund SL, Adolffson R, Gottfries CG, Winblad B (1985) Superoxide isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type. J Neurol Sci 67: 319-325
65. Marttila RJ, Röyttä M, Lorentz H, Rinne UK (1988) Oxygen toxicity protecting enzymes in the human brain. J Neural Transm 74: 87-95
66. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12: 379-389
67. McCord J, Fridovich I (1988) Superoxide dismutase: the first twenty years (1968-1988). Free Radic Biol Med 5: 363-369
68. McMillian M, Kong LY, Sawin SM, Wilson B, Das K, Hudson P, Hong JS, Bing G (1995) Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures. Biochem Biophys Res Commun 215: 572-577
69. Metcalfe T, Bowen DM, Müller DP (1989) Vitamin E concentrations in human brain from patients with Alzheimer's disease, fetuses with Down's syndrome, cetenarians, and controls. Neurochem Res 14: 1209-1212
70. Meccoci P, MacGarvey MS, Beal MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36: 747-751
71. Morris CM, Candy JM, Kerwin JM, Edwardson JA (1994) Transferrin receptors in the normal human hippocampus and in Alzheimer's disease. Neuropathol Appl Neurobiol 20: 473-477
72. Mullarkey CJ, Edelstein D, Brownlee M (1990) Free radical generation by early glycation products: a mechanism of accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 173: 923-929
73. Nitsch RM, Pittas AG, Blusztajin JK, Slack BE, Growdon HJ (1991) Alterations of phospholipid metabolites in postmortem brain from patients with Alzheimer's disease. Ann NY Acad Sci 640: 110-113
74. Nitsch RM, Blusztajin JK, Pittas AG, Slack BE, Growdon JH, Wurtman RD (1992) Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci 89: 1671-1675
75. Oreland L, Gottfries CG (1986) Brain monoamine oxidase in aging and in dementia of Alzheimer type. Prog Neuropsychopharmacol Biol Psychiatry 10: 533-540
76. Palmer AM, Burns MA (1994) Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease. Brain Res 645: 338-342
77. Perl DP, Good PF (1992) Aluminium and the neurofibrillary tangle: results of tissue microprobe studies. Ciba Found Symp 169: 217-227
78. Perrin R, Briancon S, Jaendel C, Artur Y, Min A, Penin F, Siest G (1990) Blood activity of Cu/Zn superoxide dismutase, glutathione peroxidase and catalase in Alzheimer's disease: a case-control study. Gerontology 36: 306-313
79. Quinlan GJ, Halliwell B, Moorhouse CP, Gutteridge JMC (1988) Action of lead(II) and aluminium(III) ions on iron-stimulated lipid peroxidation in liposomes, erythrocytes and rat liver microsomal fractions. Biochim Biophys Acta 962: 196-200
80. Richardson JS (1993) Free radicals in the genesis of Alzheimer's disease. Ann NY Acad Sci 695: 73-76
81. Riederer P, Youdim MBH (1993) The therapeutic place and value of present and future MAO-B inhibitors - L-deprenyl as the gold standard. In: Szeleny I (ed) Inhibitors of monoamine oxidase B. Pharmacology and clinical use in neurodegenerative disorders. Birkhäuser, Basel, pp 327-338
82. Selkoe DJ, Ihara Y, Salazar F (1982) Alzheimer disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science 215: 1243-1245
83. Shaw PJ (1992) Excitatory amino acid neurotransmission, excitotoxicity and excitotoxins. Curr Opin Neurol Neurosurg 5: 383-390
84. Smith CD, Corney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR (1991) Excess brain protein peroxidation and enzyme dysfunction in normal aging and Alzheimer's disease. Am J Pathol 145: 42-47
85. Smith MA, Taneda S, Richey PL, Yan S-D, Sayre LM, Monnier VM, Perry G (1994) Advanced Mallard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci USA 91: 5710-5714
86. Smith MA, Sayre L, Perry G (1995a) Is Alzheimer's a disease of oxidative stress? Alz Dis Rev 1: 63-67
87. Smith MA, Sayre ML, Monnier VM, Perry G (1995b) Radical AGEing in Alzheimer's disease. Trends Neurosci 18: 172-176
88. Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N (1996a) Oxidative damage in Alzheimer's. Nature 382:120-121
89. Smith MA, Sayre ML, Monnier VM, Perry G (1996b) Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenetic role in the formation of senile plaques and neurofibrillary tangles. Mol Chem Neuropathol 28: 41-48
90. Sofic E, Frölich L, Riederer P, Jellinger K, Heckers S, Beckmann H, Deinzer E, Pantucek F, Hebenstreit G, Ransmayr (1991) Biochemical membrane constituents and activities of alkaline and acid phosphatase and cathepsin in cortical and subcortical brain areas in dementia of the Alzheimer type. Dementia 2: 39-44
91. St George-Hyslop PH, Haines JL, Farrer, Polinsky R, van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni HC (1990) Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. FAD Collaborative Study Group. Nature 347: 194-197
92. Subbarao KV, Richardson JS, Ang LC (1990) Autopsy samples of Alzheimer's cortex show increased lipid peroxidation in vitro. J Neurochem 55: 342-345
93. Sulkava R, Nordberg UR, Erkinjuntti T, Westermarck T (1986) Erythrocyte glutathione peroxidase and superoxide dismutase in Alzheimer's disease and other dementias. Acta Neurol Scand 73: 487-489
94. Thome J, Kornhuber J, Münch G, Schinzel R, Taneli Y, Zielke B, Rösler M, Riederer P (1996) Neue Hypothese zur Äthiopathogenese des Alzheimer-Syndroms - Advanced glycation end products (AGEs). Nervenarzt 67: 924-929
95. Thome J, Zhang J, Davids E, Foley P, Weijers H-G, Wiesbeck GA, Boning J, Riederer P, Gerlach M (1997a) Evidence for increased oxidative stress in alcohol-dependent patients provided by quantification of in vivo salicylate hydroxylation products. Alcohol Clin Exp Res 21: 82-85
96. Thome J, Gsell W, Rösler M, Kornhuber J, Frölich L, Hashimoto E, Zielke B, Wiesbeck GA, Riederer P (1997b) Oxidative-stress associated parameters (lactoferrin, superoxide dismutase) in serum of patients with Alzheimer's disease. Life Sci 60: 13-19
97. Thompson CM, Markesbery WR, Ehmann WD, Mao YX, Vance DE (1988) Regional brain trace-element studies in Alzheimer's disease. Neurotoxicology 9: 1-7
98. Troncoso JC, Costello A, Watson AL, Johnson GVW (1993) In vitro polymerization of oxidized tau into filaments. Brain Res 613: 313-316
99. Urakami K, Sato K, Okada A, Mura T, Shimomura T, Takenaka T, Wakutani Y, Oshima T, Adachi Y, Takahashi K et al. (1995) Cu, Zn superoxide dismutase in patients with dementia of the Alzheimer type. Acta Neurol Scand 91: 165-168
100. van Rensburg SJ, Carstens ME, Potocnik FC, van der Spuy G, van der Walt BJ, Taljaard JJ (1995) Transferrin C2 and Alzheimer's disease: another piece of the puzzle found? Med Hypotheses 44: 268-272
101. Vitek MP, Bhattacharya K, Glendening JM, Stopa E, Vlassara H, Bucala R, Manogue K, Cerami A (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proc Natl Acad Sci USA 91: 4766-4770
102. Vlassara H, Li YM, Imani F, Wojciechowicz D, Yang Z, Liu FT, Cerami A (1995) Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Mol Med 1:634-646
103. Wallace DC (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256: 628-632
104. Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM (1996) RAGE and amyloid-b peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691
105. Zaman Z, Roche S, Fielden P, Frost PG, Niriella DC, Cayley AC (1992) Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age Ageing 21: 91-94
106. Zemlan FP, Thienhaus OJ, Bosmann HB (1989) Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation. Brain Res 476: 160-162
107. Zhou Y, Richardson JS, Mombourquette MJ, Weil JA (1995) Free radical formation in autopsy samples of Alzheimer and control cortex. Neurosci Lett 195: 89-92
108. Zoccarato F, Cavallini L, Deana R, Alexandre A (1988) Pathways of hydrogen peroxide generation in guinea pig cerebral cortex mitochondria. Biochem Biophy Res Commun 154: 727-734