Oxidative damage and breakage of DNA in rat brain after transient MCA occlusion

Brain Research

Volumn 832, Issue 1-2, 1999, Pages 159-163

  Hayashi, Takeshi ^a   Sakurai, Masahiro ^b   Itoyama, Yasuto ^b   Abe, Koji ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

8 Hydroxy 2' deoxyguanosine; Cerebral ischemia; Oxidative stress; Rat; Terminal deoxynucleotidyl transferase mediated dUTP biotin in situ nick end labeling (TUNEL)

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MIDDLE CEREBRAL ARTERY; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RAT; REPERFUSION INJURY; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; DNA DAMAGE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; ISCHEMIC ATTACK, TRANSIENT; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 0033583920     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01409-2     Document Type: Article

References (21)

1. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G to T and A to C substitutions. J. Biol. Chem. 267:1992;166-172.
2. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
3. Dawson T.M., Dawson V.L., Snyder S.H. A novel neuronal messenger in brain: the free radical, nitric oxide. Ann. Neurol. 32:1992;297-311.
4. Devasagayam T.P.A., Steeken S., Obendorf M.S.W., Schultz W.A., Sies H. Formation of 8-hydroxy(deoxy)-guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen. Biochemistry. 30:1991;6283-6289.
5. Dizdaroglu M. Oxidative damage to DNA in mammalian chromatin. Mutat. Res. 275:1992;331-342.
6. Floyd R.A., West M.S., Eneff K.L., Schneider J.E. Methylene blue plus light mediates 8-hydroxyguanine formation in DNA. Arch. Biochem. Biophys. 273:1989;106-111.
7. Hayashi T., Abe K., Suzuki H., Itoyama Y. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke. 28:1997;2039-2044.
8. Hayashi T., Sakurai M., Abe K., Sadahiro M., Tabayashi K., Itoyama Y. Apoptosis of motor neurons with induction of caspases in the spinal cord after ischemia. Stroke. 29:1998;1007-1013.
9. Heintz N. Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biol. Sci. 18:1993;157-159.
10. Hiramoto M., Yoshimizu N., Satoh K., Takamatsu S. Intra-arterial urokinase therapy in thromboembolic stroke. Stroke. 25:1994;268.
11. Kasai H., Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucl. Acids Res. 12:1984;2137-2145.
12. Kondo T., Sharp F.R., Honkaniemi J., Mikawa S., Epstein C.J., Chan P.H. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn superoxide dismutase. J. Cereb. Blood Flow Metab. 17:1997;241-256.
13. Li Y., Chopp M., Powers C., Jiang N. Apoptosis and protein expression after focal cerebral ischemia in rat. Brain Res. 765:1997;301-312.
14. Mayevsky A., Weiss H.R. Cerebral blood flow and oxygen consumption in cortical spreading depression. J. Cereb. Blood Flow Metab. 11:1991;829-836.
15. Mecocci P., Polidori M.C., Ingegni T., Cherubini A., Chionne F., Cecchetti R., Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology. 51:1998;1014-1017.
16. Morgan J.I., Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:1991;421-451.
17. Tanaka T., Nishiyama Y., Okada K., Hirota K., Matsui M., Yodoi J., Hiai H., Toyokuni S. Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfohydryl depletion. Lab. Invest. 77:1997;145-155.
18. Toyokuni S., Tanaka T., Hattori Y., Nishiyama Y., Yoshida A., Uchida K., Hiai H., Ochi H., Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest. 76:1997;365-374.
19. Wei E.P., Kontos H.A. Oxygen radicals in cerebral ischemia. Physiologist. 30:1987;122-128.
20. Yang G., Chan P.H., Chen J., Carlson E., Chen S.F., Weinstein P., Epstein C.J., Kamii H. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke. 25:1994;165-170.
21. Zeumer H., Freitag J.J., Zanella F., Thie A., Arning C. Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus recombinant tissue plasminogen activator (r-tPA). Neuroradiology. 35:1993;159-162.