-
1
-
-
0036468432
-
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
-
Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM (2002) Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science 295:865-868.
-
(2002)
Science
, vol.295
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.2
Trojanowski, J.Q.3
Lee, V.M.4
Bonini, N.M.5
-
2
-
-
0037059040
-
Chaperoning brain degeneration
-
Bonini NM (2002) Chaperoning brain degeneration. Proc Natl Acad Sci USA 99 [Suppl 4]:16407-16411.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.SUPPL. 4
, pp. 16407-16411
-
-
Bonini, N.M.1
-
3
-
-
0037186074
-
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome
-
Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA (2002) Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33:677-688.
-
(2002)
Neuron
, vol.33
, pp. 677-688
-
-
Busciglio, J.1
Pelsman, A.2
Wong, C.3
Pigino, G.4
Yuan, M.5
Mori, H.6
Yankner, B.A.7
-
4
-
-
0033499931
-
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease
-
Chai Y, Koppenhafer SL, Bonini NM, Paulson HL (1999) Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease. J Neurosci 19:10338-10347.
-
(1999)
J Neurosci
, vol.19
, pp. 10338-10347
-
-
Chai, Y.1
Koppenhafer, S.L.2
Bonini, N.M.3
Paulson, H.L.4
-
5
-
-
0034703863
-
Mechanisms of chaperone suppression of polyglutamine disease: Selectivity, synergy and modulation of protein solubility in Drosophila
-
Chan HY, Warrick JM, Gray-Board GL, Paulson HL, Bonini NM (2000) Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila. Hum Mol Genet 9:2811-2820.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2811-2820
-
-
Chan, H.Y.1
Warrick, J.M.2
Gray-Board, G.L.3
Paulson, H.L.4
Bonini, N.M.5
-
6
-
-
0036850456
-
Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila
-
Chan HY, Warrick JM, Andriola I, Merry D, Bonini NM (2002) Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila. Hum Mol Genet 11:2895-2904.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2895-2904
-
-
Chan, H.Y.1
Warrick, J.M.2
Andriola, I.3
Merry, D.4
Bonini, N.M.5
-
7
-
-
0031958152
-
Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease
-
Cotman CW (1998) Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol Aging 19:S29-32.
-
(1998)
Neurobiol Aging
, vol.19
-
-
Cotman, C.W.1
-
8
-
-
0033391428
-
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
-
Cummings CJ, Reinstein E, Sun Y, Antalffy B, Jiang Y, Ciechanover A, Orr HT, Beaudet A, Zoghbi HY (1999) Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 24:879-892.
-
(1999)
Neuron
, vol.24
, pp. 879-892
-
-
Cummings, C.J.1
Reinstein, E.2
Sun, Y.3
Antalffy, B.4
Jiang, Y.5
Ciechanover, A.6
Orr, H.T.7
Beaudet, A.8
Zoghbi, H.Y.9
-
9
-
-
0035394668
-
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
-
Cummings CJ, Sun Y, Opal P, Antalffy B, Mestril R, Orr HT, Dillmann WH, Zoghbi HY (2001) Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet 10:1511-1518.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1511-1518
-
-
Cummings, C.J.1
Sun, Y.2
Opal, P.3
Antalffy, B.4
Mestril, R.5
Orr, H.T.6
Dillmann, W.H.7
Zoghbi, H.Y.8
-
10
-
-
0035120525
-
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
-
D'Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38:120-134.
-
(2001)
Histopathology
, vol.38
, pp. 120-134
-
-
D'Andrea, M.R.1
Nagele, R.G.2
Wang, H.Y.3
Peterson, P.A.4
Lee, D.H.5
-
11
-
-
0028798626
-
Prion protein transgenes and the neuropathology in prion diseases
-
DeArmond SJ, Prusiner SB (1995) Prion protein transgenes and the neuropathology in prion diseases. Brain Pathol 5:77-89.
-
(1995)
Brain Pathol
, vol.5
, pp. 77-89
-
-
DeArmond, S.J.1
Prusiner, S.B.2
-
12
-
-
0037457966
-
Chaperones increase association of tau protein with microtubules
-
Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H (2003) Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100:721-726.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 721-726
-
-
Dou, F.1
Netzer, W.J.2
Tanemura, K.3
Li, F.4
Hartl, F.U.5
Takashima, A.6
Gouras, G.K.7
Greengard, P.8
Xu, H.9
-
13
-
-
0035911163
-
Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains
-
Dul JL, Davis DP, Williamson EK, Stevens FJ, Argon Y (2001) Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains. J Cell Biol 152:705-716.
-
(2001)
J Cell Biol
, vol.152
, pp. 705-716
-
-
Dul, J.L.1
Davis, D.P.2
Williamson, E.K.3
Stevens, F.J.4
Argon, Y.5
-
14
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, She WC, Luchak JM, Martinez P, Turiegano E, Benito J, Capovilla M, Skinner PJ, McCall A, Canal I, Orr HT, Zoghbi HY, Botas J (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408:101-106.
-
(2000)
Nature
, vol.408
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
De Gouyon, B.3
She, W.C.4
Luchak, J.M.5
Martinez, P.6
Turiegano, E.7
Benito, J.8
Capovilla, M.9
Skinner, P.J.10
McCall, A.11
Canal, I.12
Orr, H.T.13
Zoghbi, H.Y.14
Botas, J.15
-
15
-
-
0037047163
-
Interaction of intracellular beta amyloid peptide with chaperone proteins
-
Fonte V, Kapulkin V, Taft A, Fluet A, Friedman D, Link CD (2002) Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc Natl Acad Sci USA 99:9439-9444.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 9439-9444
-
-
Fonte, V.1
Kapulkin, V.2
Taft, A.3
Fluet, A.4
Friedman, D.5
Link, C.D.6
-
16
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H (1995) Transcriptional activation by tetracyclines in mammalian cells. Science 268:1766-1769.
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
17
-
-
0033622324
-
Intraneuronal Abeta42 accumulation in human brain
-
Gouras GK, Tsai J, Naslund J, Vincent B, Edgar M, Checler F, Greenfield JP, Haroutunian V, Buxbaum JD, Xu H, Greengard P, Relkin NR (2000) Intraneuronal Abeta42 accumulation in human brain. Am J Pathol 156:15-20.
-
(2000)
Am J Pathol
, vol.156
, pp. 15-20
-
-
Gouras, G.K.1
Tsai, J.2
Naslund, J.3
Vincent, B.4
Edgar, M.5
Checler, F.6
Greenfield, J.P.7
Haroutunian, V.8
Buxbaum, J.D.9
Xu, H.10
Greengard, P.11
Relkin, N.R.12
-
18
-
-
0029315806
-
Methods for construction of adenovirus vectors
-
Graham FL, Prevec L (1995) Methods for construction of adenovirus vectors. Mol Biotechnol 3:207-220.
-
(1995)
Mol Biotechnol
, vol.3
, pp. 207-220
-
-
Graham, F.L.1
Prevec, L.2
-
20
-
-
0034745017
-
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome
-
Gyure KA, Durham R, Stewart WF, Smialek JE, Troncoso JC (2001) Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med 125:489-492.
-
(2001)
Arch Pathol Lab Med
, vol.125
, pp. 489-492
-
-
Gyure, K.A.1
Durham, R.2
Stewart, W.F.3
Smialek, J.E.4
Troncoso, J.C.5
-
21
-
-
0025736490
-
Expression of heat shock proteins in Alzheimer's disease
-
Hamos JE, Oblas B, Pulaski-Salo D, Welch WJ, Bole DG, Drachman DA (1991) Expression of heat shock proteins in Alzheimer's disease. Neurology 41:345-350.
-
(1991)
Neurology
, vol.41
, pp. 345-350
-
-
Hamos, J.E.1
Oblas, B.2
Pulaski-Salo, D.3
Welch, W.J.4
Bole, D.G.5
Drachman, D.A.6
-
22
-
-
0030724414
-
Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors
-
Harding TC, Geddes BJ, Noel JD, Murphy D, Uney JB (1997) Tetracycline-regulated transgene expression in hippocampal neurones following transfection with adenoviral vectors. J Neurochem 69:2620-2623.
-
(1997)
J Neurochem
, vol.69
, pp. 2620-2623
-
-
Harding, T.C.1
Geddes, B.J.2
Noel, J.D.3
Murphy, D.4
Uney, J.B.5
-
23
-
-
0030769091
-
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides
-
Hartmann T, Bieger SC, Bruhl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (1997) Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med 3:1016-1020.
-
(1997)
Nat Med
, vol.3
, pp. 1016-1020
-
-
Hartmann, T.1
Bieger, S.C.2
Bruhl, B.3
Tienari, P.J.4
Ida, N.5
Allsop, D.6
Roberts, G.W.7
Masters, C.L.8
Dotti, C.G.9
Unsicker, K.10
Beyreuther, K.11
-
24
-
-
0034641589
-
Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: Their role in suppression of aggregation and cellular toxicity
-
Jana NR, Tanaka M, Wang G, Nukina N (2000) Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet 9:2009-2018.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2009-2018
-
-
Jana, N.R.1
Tanaka, M.2
Wang, G.3
Nukina, N.4
-
25
-
-
0030014286
-
Nuclear and cytoplasmic localization of the beta-amyloid peptide (1-43) in transfected 293 cells
-
Johnstone EM, Babbey LE, Stephenson D, Paul DC, Santerre RF, Clemens JA, Williams DC, Little SP (1996) Nuclear and cytoplasmic localization of the beta-amyloid peptide (1-43) in transfected 293 cells. Biochem Biophys Res Commun 220:710-718.
-
(1996)
Biochem Biophys Res Commun
, vol.220
, pp. 710-718
-
-
Johnstone, E.M.1
Babbey, L.E.2
Stephenson, D.3
Paul, D.C.4
Santerre, R.F.5
Clemens, J.A.6
Williams, D.C.7
Little, S.P.8
-
26
-
-
0034629073
-
Genetic suppression of polyglutamine toxicity in Drosophila
-
Kazemi-Esfarjani P, Benzer S (2000) Genetic suppression of polyglutamine toxicity in Drosophila. Science 287:1837-1840.
-
(2000)
Science
, vol.287
, pp. 1837-1840
-
-
Kazemi-Esfarjani, P.1
Benzer, S.2
-
27
-
-
0037013327
-
Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis
-
Kienlen-Campard P, Miolet S, Tasiaux B, Octave JN (2002) Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. J Biol Chem 277:15666-15670.
-
(2002)
J Biol Chem
, vol.277
, pp. 15666-15670
-
-
Kienlen-Campard, P.1
Miolet, S.2
Tasiaux, B.3
Octave, J.N.4
-
28
-
-
0028981717
-
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
-
LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G (1995) The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9:21-30.
-
(1995)
Nat Genet
, vol.9
, pp. 21-30
-
-
LaFerla, F.M.1
Tinkle, B.T.2
Bieberich, C.J.3
Haudenschild, C.C.4
Jay, G.5
-
29
-
-
0029823454
-
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice
-
LaFerla FM, Hall CK, Ngo L, Jay G (1996) Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest 98:1626-1632.
-
(1996)
J Clin Invest
, vol.98
, pp. 1626-1632
-
-
LaFerla, F.M.1
Hall, C.K.2
Ngo, L.3
Jay, G.4
-
30
-
-
0028981288
-
Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
-
Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci USA 92:9368-9372.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9368-9372
-
-
Link, C.D.1
-
31
-
-
0037195617
-
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol
-
Ma J, Lindquist S (2002) Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science 298:1785-1788.
-
(2002)
Science
, vol.298
, pp. 1785-1788
-
-
Ma, J.1
Lindquist, S.2
-
32
-
-
0032909677
-
The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell
-
Magrane J, Casaroli-Marano RP, Reina M, Gafvels M, Vilaro S (1999) The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS Lett 451:56-62.
-
(1999)
FEBS Lett
, vol.451
, pp. 56-62
-
-
Magrane, J.1
Casaroli-Marano, R.P.2
Reina, M.3
Gafvels, M.4
Vilaro, S.5
-
33
-
-
0038334899
-
Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration
-
Manning-Bog AB, McCormack AL, Purisai MG, Bolin LM, Di Monte DA (2003) Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration. J Neurosci 23:3095-3099.
-
(2003)
J Neurosci
, vol.23
, pp. 3095-3099
-
-
Manning-Bog, A.B.1
McCormack, A.L.2
Purisai, M.G.3
Bolin, L.M.4
Di Monte, D.A.5
-
34
-
-
0034632431
-
Expression of wild-type and noncleavable Fas ligand by tetracycline-regulated adenoviral vectors to limit intimal hyperplasia in vascular lesions
-
Mano T, Luo Z, Suhara T, Smith RC, Esser S, Walsh K (2000) Expression of wild-type and noncleavable Fas ligand by tetracycline-regulated adenoviral vectors to limit intimal hyperplasia in vascular lesions. Hum Gene Ther 11:1625-1635.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 1625-1635
-
-
Mano, T.1
Luo, Z.2
Suhara, T.3
Smith, R.C.4
Esser, S.5
Walsh, K.6
-
35
-
-
0028972233
-
Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein
-
Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA (1995) Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem 270:26727-26730.
-
(1995)
J Biol Chem
, vol.270
, pp. 26727-26730
-
-
Martin, B.L.1
Schrader-Fischer, G.2
Busciglio, J.3
Duke, M.4
Paganetti, P.5
Yankner, B.A.6
-
36
-
-
0042318739
-
Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD)
-
McCracken AA, Brodsky JL (2003) Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD). Bioessays 25:868-877.
-
(2003)
Bioessays
, vol.25
, pp. 868-877
-
-
McCracken, A.A.1
Brodsky, J.L.2
-
37
-
-
0033621540
-
Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease
-
Mochizuki A, Tamaoka A, Shimohata A, Komatsuzaki Y, Shoji S (2000) Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease. Lancet 355:42-43.
-
(2000)
Lancet
, vol.355
, pp. 42-43
-
-
Mochizuki, A.1
Tamaoka, A.2
Shimohata, A.3
Komatsuzaki, Y.4
Shoji, S.5
-
38
-
-
0034608868
-
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
-
Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, Hartl FU (2000) Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc Natl Acad Sci USA 97:7841-7846.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7841-7846
-
-
Muchowski, P.J.1
Schaffar, G.2
Sittler, A.3
Wanker, E.E.4
Hayer-Hartl, M.K.5
Hartl, F.U.6
-
39
-
-
0032053984
-
Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
-
Nishimura I, Uetsuki T, Dani SU, Ohsawa Y, Saito I, Okamura H, Uchiyama Y, Yoshikawa K (1998) Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer. J Neurosci 18:2387-2398.
-
(1998)
J Neurosci
, vol.18
, pp. 2387-2398
-
-
Nishimura, I.1
Uetsuki, T.2
Dani, S.U.3
Ohsawa, Y.4
Saito, I.5
Okamura, H.6
Uchiyama, Y.7
Yoshikawa, K.8
-
40
-
-
0025917624
-
Comparison of the heat shock response in cultured cortical neurons and astrocytes
-
Nishimura RN, Dwyer BE, Clegg K, Cole R, de Vellis J (1991) Comparison of the heat shock response in cultured cortical neurons and astrocytes. Brain Res Mol Brain Res 9:39-45.
-
(1991)
Brain Res Mol Brain Res
, vol.9
, pp. 39-45
-
-
Nishimura, R.N.1
Dwyer, B.E.2
Clegg, K.3
Cole, R.4
De Vellis, J.5
-
41
-
-
0042697305
-
Triple transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
Oddo S, Caccamo A, Shepherd J, Murphy MP, Golde T, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM (2003) Triple transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 39:409-421.
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.3
Murphy, M.P.4
Golde, T.5
Kayed, R.6
Metherate, R.7
Mattson, M.P.8
Akbari, Y.9
LaFerla, F.M.10
-
42
-
-
0026091893
-
Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease
-
Perez N, Sugar J, Charya S, Johnson G, Merril C, Bierer L, Perl D, Haroutunian V, Wallace W (1991) Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease. Brain Res Mol Brain Res 11:249-254.
-
(1991)
Brain Res Mol Brain Res
, vol.11
, pp. 249-254
-
-
Perez, N.1
Sugar, J.2
Charya, S.3
Johnson, G.4
Merril, C.5
Bierer, L.6
Perl, D.7
Haroutunian, V.8
Wallace, W.9
-
43
-
-
0034991310
-
Beta-amyloid peptide expression is sufficient for myotube death: Implications for human inclusion body myopathy
-
Querfurth HW, Suhara T, Rosen KM, McPhie DL, Fujio Y, Tejada G, Neve RL, Adelman LS, Walsh K (2001) Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy. Mol Cell Neurosci 17:793-810.
-
(2001)
Mol Cell Neurosci
, vol.17
, pp. 793-810
-
-
Querfurth, H.W.1
Suhara, T.2
Rosen, K.M.3
McPhie, D.L.4
Fujio, Y.5
Tejada, G.6
Neve, R.L.7
Adelman, L.S.8
Walsh, K.9
-
44
-
-
0037059042
-
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
-
Sakahira H, Breuer P, Hayer-Hartl MK, Hartl FU (2002) Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity. Proc Natl Acad Sci USA 99 Suppl 4:16412-16418.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.SUPPL. 4
, pp. 16412-16418
-
-
Sakahira, H.1
Breuer, P.2
Hayer-Hartl, M.K.3
Hartl, F.U.4
-
45
-
-
0028093119
-
HSP72 induction by heat stress in human neurons and glial cells in culture
-
Satoh J, Kim SU (1994) HSP72 induction by heat stress in human neurons and glial cells in culture. Brain Res 653:243-250.
-
(1994)
Brain Res
, vol.653
, pp. 243-250
-
-
Satoh, J.1
Kim, S.U.2
-
46
-
-
0035854437
-
Ubiquitination of a novel form of α-synuclein by parkin from human brain: Implications for Parkinson's disease
-
Shimura H, Schlossmacher M, Hattori N, Frosch M, Trockenbacher A, Schneider R, Mizuno Y, Kosik K, Selkoe DJ (2001) Ubiquitination of a novel form of α-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293:263-269.
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H.1
Schlossmacher, M.2
Hattori, N.3
Frosch, M.4
Trockenbacher, A.5
Schneider, R.6
Mizuno, Y.7
Kosik, K.8
Selkoe, D.J.9
-
47
-
-
0034727889
-
JNK activation is associated with intracellular beta-amyloid accumulation
-
Shoji M, Iwakami N, Takeuchi S, Waragai M, Suzuki M, Kanazawa I, Lippa CF, Ono S, Okazawa H (2000) JNK activation is associated with intracellular beta-amyloid accumulation. Brain Res Mol Brain Res 85:221-233.
-
(2000)
Brain Res Mol Brain Res
, vol.85
, pp. 221-233
-
-
Shoji, M.1
Iwakami, N.2
Takeuchi, S.3
Waragai, M.4
Suzuki, M.5
Kanazawa, I.6
Lippa, C.F.7
Ono, S.8
Okazawa, H.9
-
48
-
-
0031781642
-
Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture
-
Skovronsky DM, Doms RW, Lee VM (1998) Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. J Cell Biol 141:1031-1039.
-
(1998)
J Cell Biol
, vol.141
, pp. 1031-1039
-
-
Skovronsky, D.M.1
Doms, R.W.2
Lee, V.M.3
-
49
-
-
0037404666
-
Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism
-
Suhara T, Magrane J, Rosen K, Christensen R, Kim HS, Zheng B, McPhie DL, Walsh K, Querfurth H (2003) Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism. Neurobiol Aging 24:437-451.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 437-451
-
-
Suhara, T.1
Magrane, J.2
Rosen, K.3
Christensen, R.4
Kim, H.S.5
Zheng, B.6
McPhie, D.L.7
Walsh, K.8
Querfurth, H.9
-
50
-
-
0028198309
-
Familial juvenile parkinsonism: Clinical and pathologic study in a family
-
Takahashi H, Ohama E, Suzuki S, Horikawa Y, Ishikawa A, Morita T, Tsuji S, Ikuta F (1994) Familial juvenile parkinsonism: clinical and pathologic study in a family. Neurology 44:437-441.
-
(1994)
Neurology
, vol.44
, pp. 437-441
-
-
Takahashi, H.1
Ohama, E.2
Suzuki, S.3
Horikawa, Y.4
Ishikawa, A.5
Morita, T.6
Tsuji, S.7
Ikuta, F.8
-
52
-
-
0036827031
-
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology
-
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK (2002b) Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161:1869-1879.
-
(2002)
Am J Pathol
, vol.161
, pp. 1869-1879
-
-
Takahashi, R.H.1
Milner, T.A.2
Li, F.3
Nam, E.E.4
Edgar, M.A.5
Yamaguchi, H.6
Beal, M.F.7
Xu, H.8
Greengard, P.9
Gouras, G.K.10
-
53
-
-
0034609516
-
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain
-
Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ (2000) The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry 39:10831-10839.
-
(2000)
Biochemistry
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
Podlisny, M.B.4
Selkoe, D.J.5
-
54
-
-
0032727617
-
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70
-
Warrick JM, Chan HY, Gray-Board GL, Chai Y, Paulson HL, Bonini NM (1999) Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70. Nat Genet 23:425-428.
-
(1999)
Nat Genet
, vol.23
, pp. 425-428
-
-
Warrick, J.M.1
Chan, H.Y.2
Gray-Board, G.L.3
Chai, Y.4
Paulson, H.L.5
Bonini, N.M.6
-
55
-
-
0032526652
-
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abetal-42 pathogenesis
-
Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG (1998) Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abetal-42 pathogenesis. J Neurosci Res 52:691-698.
-
(1998)
J Neurosci Res
, vol.52
, pp. 691-698
-
-
Yang, A.J.1
Chandswangbhuvana, D.2
Margol, L.3
Glabe, C.G.4
-
56
-
-
0037017399
-
Selective cytotoxicity of intracellular amyloid beta peptidel-42 through p53 and Bax in cultured primary human neurons
-
Zhang Y, McLaughlin R, Goodyer C, LeBlanc A (2002) Selective cytotoxicity of intracellular amyloid beta peptidel-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156:519-529.
-
(2002)
J Cell Biol
, vol.156
, pp. 519-529
-
-
Zhang, Y.1
McLaughlin, R.2
Goodyer, C.3
LeBlanc, A.4
|