-
1
-
-
0029808748
-
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
-
of special interest. This is a comprehensive review that summarizes our knowledge of the structure and function of the JNK signaling pathway prior to 1996. Papers published in 1996 and 1997 are listed below.
-
Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. of special interest J Mol Med. 74:1996;589-607 This is a comprehensive review that summarizes our knowledge of the structure and function of the JNK signaling pathway prior to 1996. Papers published in 1996 and 1997 are listed below.
-
(1996)
J Mol Med
, vol.74
, pp. 589-607
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
2
-
-
0029834756
-
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
-
of outstanding interest. See annotation [3].
-
Riesgo-Escovar JR, Jenni M, Fritz A, Hafen E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. of outstanding interest Genes Dev. 10:1996;2759-2768 See annotation [3].
-
(1996)
Genes Dev
, vol.10
, pp. 2759-2768
-
-
Riesgo-Escovar, J.R.1
Jenni, M.2
Fritz, A.3
Hafen, E.4
-
3
-
-
0029824847
-
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
-
of outstanding interest. These two papers [2,3] describe the molecular genetic analysis of Drosophila JNK (DJNK) and provide the foundation for subsequent studies of the DJNK signaling pathway. DJNK is required for the morphogenetic process of dorsal closure, but not for photoreceptor cell determination. A role for DJNK in the insect immune response is established by the observation that DJNK is activated by bacterial lipopolysaccharide.
-
Sluss HK, Han Z, Barrett T, Goberdhan DCI, Wilson C, Davis RJ, Ip YT. A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. of outstanding interest Genes Dev. 10:1996;2745-2758 These two papers [2,3] describe the molecular genetic analysis of Drosophila JNK (DJNK) and provide the foundation for subsequent studies of the DJNK signaling pathway. DJNK is required for the morphogenetic process of dorsal closure, but not for photoreceptor cell determination. A role for DJNK in the insect immune response is established by the observation that DJNK is activated by bacterial lipopolysaccharide.
-
(1996)
Genes Dev
, vol.10
, pp. 2745-2758
-
-
Sluss, H.K.1
Han, Z.2
Barrett, T.3
Goberdhan, D.C.I.4
Wilson, C.5
Davis, R.J.6
Ip, Y.T.7
-
4
-
-
0031029214
-
Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
-
-/- blastocyts. Loss of MKK4 caused increased thymocyte apoptosis in vitro.
-
-/- blastocyts. Loss of MKK4 caused increased thymocyte apoptosis in vitro.
-
(1997)
Nature
, vol.385
, pp. 350-353
-
-
Nishina, H.1
Fischer, K.D.2
Radvanyl, L.3
Shahinian, A.4
Hakem, R.5
Ruble, E.A.6
Bernstein, A.7
Mak, T.W.8
Woodgett, J.R.9
Penninger, J.M.10
-
5
-
-
0030908341
-
2-terminal kinase activation and defects in AP-1 transcriptional activity
-
of outstanding interest. Disruption of the MKK4 gene causes a selective defect in AP-1 transcriptional activity. This is the first study to provide direct evidence that the JNK signaling pathway regulates AP-1 transcriptional activity in vivo.
-
2-terminal kinase activation and defects in AP-1 transcriptional activity. of outstanding interest Proc Natl Acad Sci USA. 94:1997;3004-3009 Disruption of the MKK4 gene causes a selective defect in AP-1 transcriptional activity. This is the first study to provide direct evidence that the JNK signaling pathway regulates AP-1 transcriptional activity in vivo.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3004-3009
-
-
Yang, D.1
Tournier, C.2
Wysk, M.3
Lu H-T4
Xu, J.5
Davis, R.J.6
Flavell, R.A.7
-
6
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene
-
-/- mice demonstrates that the JNK signaling pathway is required in vivo for AP-1 transcriptional activity and apoptosis of hippocampal neurons in response to exposure to an excitotoxin.
-
-/- mice demonstrates that the JNK signaling pathway is required in vivo for AP-1 transcriptional activity and apoptosis of hippocampal neurons in response to exposure to an excitotoxin.
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.1
Kuan C-Y2
Whitmarsh, A.J.3
Rincon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
7
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
of outstanding interest. This study describes the molecular cloning and characterization of ten human JNK protein kinases that are derived by alternative splicing from the JNK1, JNK2 and JNK3 genes. Each spliced JNK isoform binds preferentially to different substrates, suggesting that these JNK isoforms may target different substrates in vivo.
-
Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ. Selective interaction of JNK protein kinase isoforms with transcription factors. of outstanding interest EMBO J. 15:1996;2760-2770 This study describes the molecular cloning and characterization of ten human JNK protein kinases that are derived by alternative splicing from the JNK1, JNK2 and JNK3 genes. Each spliced JNK isoform binds preferentially to different substrates, suggesting that these JNK isoforms may target different substrates in vivo.
-
(1996)
EMBO J
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
Derijard, B.6
Davis, R.J.7
-
8
-
-
0030931380
-
Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homolog decapentaplegic
-
of special interest. See annotation to [128].
-
Sluss HK, Davis RJ. Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-β homolog decapentaplegic. of special interest J Cell Biochem. 67:1997;1-12 See annotation to [128].
-
(1997)
J Cell Biochem
, vol.67
, pp. 1-12
-
-
Sluss, H.K.1
Davis, R.J.2
-
9
-
-
0030953448
-
Protein tyrosine phosphatases in signal transduction
-
Neel BG, Tonks NK. Protein tyrosine phosphatases in signal transduction. Curr Opin Cell Biol. 9:1997;193-204.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 193-204
-
-
Neel, B.G.1
Tonks, N.K.2
-
10
-
-
0029918680
-
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
-
Chu Y, Solski PA, Khosravi-Far R, Der CJ, Kelly K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J Biol Chem. 271:1996;6497-6501.
-
(1996)
J Biol Chem
, vol.271
, pp. 6497-6501
-
-
Chu, Y.1
Solski, P.A.2
Khosravi-Far, R.3
Der, C.J.4
Kelly, K.5
-
11
-
-
0029905354
-
Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase
-
Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15:1996;3621-3632.
-
(1996)
EMBO J
, vol.15
, pp. 3621-3632
-
-
Groom, L.A.1
Sneddon, A.A.2
Alessi, D.R.3
Dowd, S.4
Keyse, S.M.5
-
12
-
-
0030028222
-
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
-
Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J Biol Chem. 271:1996;4319-4326.
-
(1996)
J Biol Chem
, vol.271
, pp. 4319-4326
-
-
Muda, M.1
Boschert, U.2
Dickinson, R.3
Martinou, J.C.4
Martinou, I.5
Camps, M.6
Schlegel, W.7
Arkinstall, S.8
-
13
-
-
0029910140
-
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases
-
Muda M, Theodosiou A, Rodrigues N, Boschert U, Camps M, Gillieron C, Davies K, Ashworth A, Arkinstall S. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J Biol Chem. 271:1996;27205-27208.
-
(1996)
J Biol Chem
, vol.271
, pp. 27205-27208
-
-
Muda, M.1
Theodosiou, A.2
Rodrigues, N.3
Boschert, U.4
Camps, M.5
Gillieron, C.6
Davies, K.7
Ashworth, A.8
Arkinstall, S.9
-
14
-
-
0030794511
-
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress- activated protein kinase in U937 cells
-
Franklin CC, Kraft AS. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress- activated protein kinase in U937 cells. J Biol Chem. 272:1997;16917-16923.
-
(1997)
J Biol Chem
, vol.272
, pp. 16917-16923
-
-
Franklin, C.C.1
Kraft, A.S.2
-
15
-
-
0031058730
-
Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo
-
Hirsch DD, Stork PJ. Mitogen-activated protein kinase phosphatases inactivate stress-activated protein kinase pathways in vivo. J Biol Chem. 272:1997;4568-4575.
-
(1997)
J Biol Chem
, vol.272
, pp. 4568-4575
-
-
Hirsch, D.D.1
Stork, P.J.2
-
16
-
-
15144352589
-
Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4
-
Muda M, Boschert U, Smith A, Antonsson B, Gillieron C, Chabert C, Camps M, Martinou I, Ashworth A, Arkinstall S. Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4. J Biol Chem. 272:1997;5141-5151.
-
(1997)
J Biol Chem
, vol.272
, pp. 5141-5151
-
-
Muda, M.1
Boschert, U.2
Smith, A.3
Antonsson, B.4
Gillieron, C.5
Chabert, C.6
Camps, M.7
Martinou, I.8
Ashworth, A.9
Arkinstall, S.10
-
17
-
-
0030046479
-
Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts
-
Bokemeyer D, Sorokin A, Yan M, Ahn NG, Templeton DJ, Dunn MJ. Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts. J Biol Chem. 271:1996;639-642.
-
(1996)
J Biol Chem
, vol.271
, pp. 639-642
-
-
Bokemeyer, D.1
Sorokin, A.2
Yan, M.3
Ahn, N.G.4
Templeton, D.J.5
Dunn, M.J.6
-
18
-
-
0030793160
-
Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis
-
of special interest. See annotation to [128].
-
Glise B, Noselli S. Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. of special interest Genes Dev. 11:1997;1738-1747 See annotation to [128].
-
(1997)
Genes Dev
, vol.11
, pp. 1738-1747
-
-
Glise, B.1
Noselli, S.2
-
19
-
-
0029757347
-
Disruption of the erp/mkp-1 gene does not affect mouse development: Normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts
-
Dorfman K, Carrasco D, Gruda M, Ryan C, Lira SA, Bravo R. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene. 13:1996;925-931.
-
(1996)
Oncogene
, vol.13
, pp. 925-931
-
-
Dorfman, K.1
Carrasco, D.2
Gruda, M.3
Ryan, C.4
Lira, S.A.5
Bravo, R.6
-
20
-
-
0030826412
-
A cytoplasmic inhibitor of the JNK signal transduction pathway
-
of special interest. This paper describes the molecular cloning and characterization of JIP-1, a cytoplasmic inhibitor of JNK. Overexpression of JIP-1 inhibits both nerve growth factor withdrawal-induced apoptosis of PC12 cells and pre-B cell transformation by BCR-ABL. This study provides direct evidence for a role for the JNK signaling pathway in both apoptosis and transformation.
-
Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ. A cytoplasmic inhibitor of the JNK signal transduction pathway. of special interest Science. 277:1997;693-696 This paper describes the molecular cloning and characterization of JIP-1, a cytoplasmic inhibitor of JNK. Overexpression of JIP-1 inhibits both nerve growth factor withdrawal-induced apoptosis of PC12 cells and pre-B cell transformation by BCR-ABL. This study provides direct evidence for a role for the JNK signaling pathway in both apoptosis and transformation.
-
(1997)
Science
, vol.277
, pp. 693-696
-
-
Dickens, M.1
Rogers, J.S.2
Cavanagh, J.3
Raitano, A.4
Xia, Z.5
Halpern, J.R.6
Greenberg, M.E.7
Sawyers, C.L.8
Davis, R.J.9
-
21
-
-
0030754827
-
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor α
-
Jun D-Y, Teramoto H, Giam C-Z, Chun RF, Gutkind JS, Jeang K-T. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor α J Biol Chem. 272:1997;25816-25823.
-
(1997)
J Biol Chem
, vol.272
, pp. 25816-25823
-
-
Jun D-Y1
Teramoto, H.2
Giam C-Z3
Chun, R.F.4
Gutkind, J.S.5
Jeang K-T6
-
22
-
-
0030614745
-
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells
-
Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 272:1997;2620-2628.
-
(1997)
J Biol Chem
, vol.272
, pp. 2620-2628
-
-
Marti, A.1
Luo, Z.2
Cunningham, C.3
Ohta, Y.4
Hartwig, J.5
Stossel, T.P.6
Kyriakis, J.M.7
Avruch, J.8
-
23
-
-
0030825190
-
MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous
-
of special interest. See annotation to [26].
-
Holland PM, Suzanne M, Campbell JS, Noselli S, Cooper JA. MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. of special interest J Biol Chem. 272:1997;24994-24998 See annotation to [26].
-
(1997)
J Biol Chem
, vol.272
, pp. 24994-24998
-
-
Holland, P.M.1
Suzanne, M.2
Campbell, J.S.3
Noselli, S.4
Cooper, J.A.5
-
24
-
-
0030770419
-
2-terminal protein kinase (JNK)-activating kinase 2 as an indicator of JNK but not p38
-
of special interest. See annotation to [26].
-
2-terminal protein kinase (JNK)-activating kinase 2 as an indicator of JNK but not p38. of special interest J Biol Chem. 272:1997;24751-24754 See annotation to [26].
-
(1997)
J Biol Chem
, vol.272
, pp. 24751-24754
-
-
Lu, X.1
Nemoto, S.2
Lin, A.3
-
25
-
-
0030702895
-
A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses
-
of special interest. See annotation to [26].
-
Moriguchi T, Toyoshima F, Masuyama N, Hanafusa H, Gotoh Y, Nishida E. A novel SAPK/JNK kinase, MKK7, stimulated by TNFα and cellular stresses. of special interest EMBO J. 16:1997;7045-7053 See annotation to [26].
-
(1997)
EMBO J
, vol.16
, pp. 7045-7053
-
-
Moriguchi, T.1
Toyoshima, F.2
Masuyama, N.3
Hanafusa, H.4
Gotoh, Y.5
Nishida, E.6
-
26
-
-
0030786344
-
2-terminal kinase
-
of special interest. These four papers [23,24,25,26] describe the molecular cloning and characterization of MKK7, which functions as a specific activator of JNK. MKK7 is the mammalian homolog of the Drosophila MAP kinase kinase Hep. MKK7 is activated by exposure of cells to TNFα and environmental stress. Unlike MKK4, which activates both JNK and p38 MAP kinase, MKK7 activates only JNK.
-
2-terminal kinase. of special interest Proc Natl Acad Sci USA. 94:1997;7337-7342 These four papers [23,24,25,26] describe the molecular cloning and characterization of MKK7, which functions as a specific activator of JNK. MKK7 is the mammalian homolog of the Drosophila MAP kinase kinase Hep. MKK7 is activated by exposure of cells to TNFα and environmental stress. Unlike MKK4, which activates both JNK and p38 MAP kinase, MKK7 activates only JNK.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7337-7342
-
-
Tournier, C.1
Whitmarsh, A.J.2
Cavanagh, J.3
Barrett, T.4
Davis, R.J.5
-
27
-
-
0028875388
-
Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
-
Glise B, Bourbon H, Noselli S. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell. 83:1995;451-461.
-
(1995)
Cell
, vol.83
, pp. 451-461
-
-
Glise, B.1
Bourbon, H.2
Noselli, S.3
-
28
-
-
0031044561
-
MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: Upstream regulators of the c-Jun amino-terminal kinases
-
Fanger GR, Gerwins P, Widmann C, Jarpe MB, Johnson GL. MEKKs, GCKs, MLKs, PAKs, TAKs, and Tpls: upstream regulators of the c-Jun amino-terminal kinases. Curr Opin Genet Dev. 7:1997;67-74.
-
(1997)
Curr Opin Genet Dev
, vol.7
, pp. 67-74
-
-
Fanger, G.R.1
Gerwins, P.2
Widmann, C.3
Jarpe, M.B.4
Johnson, G.L.5
-
29
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
of special interest. The MAP kinase kinase kinase ASK1 is shown to induce apoptosis through activation of stress-activated MAP kinases. ASK1 is activated by TNFα. Unlike other MAPKKK isoforms, ASK1 activates both JNK and p38 MAP kinases.
-
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. of special interest Science. 275:1997;90-94 The MAP kinase kinase kinase ASK1 is shown to induce apoptosis through activation of stress-activated MAP kinases. ASK1 is activated by TNFα. Unlike other MAPKKK isoforms, ASK1 activates both JNK and p38 MAP kinases.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
30
-
-
0029913457
-
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
-
Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 271:1996;5361-5368.
-
(1996)
J Biol Chem
, vol.271
, pp. 5361-5368
-
-
Blank, J.L.1
Gerwins, P.2
Elliott, E.M.3
Sather, S.4
Johnson, G.L.5
-
31
-
-
0030952084
-
Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3.
-
Deacon K, Blank JL. Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. J Biol Chem. 272:1997;14489-14496.
-
(1997)
J Biol Chem
, vol.272
, pp. 14489-14496
-
-
Deacon, K.1
Blank, J.L.2
-
32
-
-
0031036629
-
Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative
-
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 272:1997;2668-2674.
-
(1997)
J Biol Chem
, vol.272
, pp. 2668-2674
-
-
Ellinger-Ziegelbauer, H.1
Brown, K.2
Kelly, K.3
Siebenlist, U.4
-
33
-
-
0030934694
-
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
-
Gerwins P, Blank JL, Johnson GL. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem. 272:1997;8288-8295.
-
(1997)
J Biol Chem
, vol.272
, pp. 8288-8295
-
-
Gerwins, P.1
Blank, J.L.2
Johnson, G.L.3
-
34
-
-
0030851904
-
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
-
Takekawa M, Posas F, Saito H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 16:1997;4973-4982.
-
(1997)
EMBO J
, vol.16
, pp. 4973-4982
-
-
Takekawa, M.1
Posas, F.2
Saito, H.3
-
35
-
-
0029954102
-
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
-
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J Biol Chem. 271:1996;31607-31611.
-
(1996)
J Biol Chem
, vol.271
, pp. 31607-31611
-
-
Wang, X.S.1
Diener, K.2
Jannuzzi, D.3
Trollinger, D.4
Tan, T.H.5
Lichenstein, H.6
Zukowski, M.7
Yao, Z.8
-
36
-
-
0030918591
-
MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
-
Hirai S, Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S. MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 272:1997;15167-15173.
-
(1997)
J Biol Chem
, vol.272
, pp. 15167-15173
-
-
Hirai, S.1
Katoh, M.2
Terada, M.3
Kyriakis, J.M.4
Zon, L.I.5
Rana, A.6
Avruch, J.7
Ohno, S.8
-
37
-
-
0030907935
-
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
-
Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J. 16:1997;1279-1290.
-
(1997)
EMBO J
, vol.16
, pp. 1279-1290
-
-
Su, Y.C.1
Han, J.2
Xu, S.3
Cobb, M.4
Skolnik, E.Y.5
-
38
-
-
0031059833
-
A novel human SPS1/STE20 homolog, KHS, activates Jun N-terminal kinase
-
Tung RM, Blenis J. A novel human SPS1/STE20 homolog, KHS, activates Jun N-terminal kinase. Oncogene. 14:1997;653-659.
-
(1997)
Oncogene
, vol.14
, pp. 653-659
-
-
Tung, R.M.1
Blenis, J.2
-
39
-
-
12644257580
-
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
-
Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci USA. 94:1997;9687-9692.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9687-9692
-
-
Diener, K.1
Wang, X.S.2
Chen, C.3
Meyer, C.F.4
Keesler, G.5
Zukowski, M.6
Tan, T.H.7
Yao, Z.8
-
40
-
-
0030481580
-
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
-
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 15:1996;7013-7025.
-
(1996)
EMBO J
, vol.15
, pp. 7013-7025
-
-
Kiefer, F.1
Tibbles, L.A.2
Anafi, M.3
Janssen, A.4
Zanke, B.W.5
Lassam, N.6
Pawson, T.7
Woodgett, J.R.8
Iscove, N.N.9
-
41
-
-
0001447092
-
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
-
of special interest. See annotation to [43].
-
Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. of special interest Nature. 383:1996;716-719 See annotation to [43].
-
(1996)
Nature
, vol.383
, pp. 716-719
-
-
Liu, Z.G.1
Hsu, H.2
Goeddel, D.V.3
Karin, M.4
-
42
-
-
0031013545
-
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway
-
of special interest. See annotation to [43].
-
Natoli G, Costanzo A, Ianni A, Templeton DJ, Woodgett JR, Balsano C, Levrero M. Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2- dependent pathway. of special interest Science. 275:1997;200-203 See annotation to [43].
-
(1997)
Science
, vol.275
, pp. 200-203
-
-
Natoli, G.1
Costanzo, A.2
Ianni, A.3
Templeton, D.J.4
Woodgett, J.R.5
Balsano, C.6
Levrero, M.7
-
43
-
-
0031048067
-
Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2
-
of special interest. These three papers [41-43] identify TRAF2 as a mediator of signals from the TNF receptor that lead to JNK activation. The signaling intermediates downstream of TRAF2 remain to be described.
-
Reinhard C, Shamoon B, Shyamala V, Williams LT. Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2. of special interest EMBO J. 16:1997;1080-1092 These three papers [41-43] identify TRAF2 as a mediator of signals from the TNF receptor that lead to JNK activation. The signaling intermediates downstream of TRAF2 remain to be described.
-
(1997)
EMBO J
, vol.16
, pp. 1080-1092
-
-
Reinhard, C.1
Shamoon, B.2
Shyamala, V.3
Williams, L.T.4
-
44
-
-
0031587883
-
Daxx, a novel Fas-binding protein that activates JNK and apoptosis
-
of special interest. This study identifies Daxx as a mediator of JNK activation by Fas. Interestingly, Daxx activates JNK and apoptosis. Daxx is, therefore, a common mediator of these events.
-
Yang X, Khosravi-Far R, Chang HY, Baltimore D. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. of special interest Cell. 89:1997;1067-1076 This study identifies Daxx as a mediator of JNK activation by Fas. Interestingly, Daxx activates JNK and apoptosis. Daxx is, therefore, a common mediator of these events.
-
(1997)
Cell
, vol.89
, pp. 1067-1076
-
-
Yang, X.1
Khosravi-Far, R.2
Chang, H.Y.3
Baltimore, D.4
-
45
-
-
0030047481
-
Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway
-
Coso OA, Teramoto H, Simonds WF, Gutkind JS. Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem. 271:1996;3963-3966.
-
(1996)
J Biol Chem
, vol.271
, pp. 3963-3966
-
-
Coso, O.A.1
Teramoto, H.2
Simonds, W.F.3
Gutkind, J.S.4
-
46
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
-
of special interest. See annotation to [49].
-
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. of special interest Science. 275:1997;394-397 See annotation to [49].
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
47
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
of special interest. See annotation to [49].
-
Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. of special interest Mol Cell Biol. 16:1996;4117-4127 See annotation to [49].
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
48
-
-
0030840413
-
Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
-
of special interest. See annotation to [49].
-
Logan SK, Falasca M, Hu P, Schlessinger J. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. of special interest Mol Cell Biol. 17:1997;5784-5790 See annotation to [49].
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5784-5790
-
-
Logan, S.K.1
Falasca, M.2
Hu, P.3
Schlessinger, J.4
-
49
-
-
0031575749
-
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF
-
of special interest. These four papers [46-49] identify PI-3 kinase isoforms as mediators of signals from serpentine and tyrosine kinase receptors to the JNK signaling pathway.
-
Lopez-Ilasaca M, Li W, Uren A, Yu JC, Kazlauskas A, Gutkind JS, Heidaran MA. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. of special interest Biochem Biophys Res Commun. 232:1997;273-277 These four papers [46-49] identify PI-3 kinase isoforms as mediators of signals from serpentine and tyrosine kinase receptors to the JNK signaling pathway.
-
(1997)
Biochem Biophys Res Commun
, vol.232
, pp. 273-277
-
-
Lopez-Ilasaca, M.1
Li, W.2
Uren, A.3
Yu, J.C.4
Kazlauskas, A.5
Gutkind, J.S.6
Heidaran, M.A.7
-
50
-
-
0029770721
-
Activation of PYK2 by stress signals and coupling with JNK signaling pathway
-
of special interest. See annotation to [51].
-
Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of PYK2 by stress signals and coupling with JNK signaling pathway. of special interest Science. 273:1996;792-794 See annotation to [51].
-
(1996)
Science
, vol.273
, pp. 792-794
-
-
Tokiwa, G.1
Dikic, I.2
Lev, S.3
Schlessinger, J.4
-
51
-
-
0010233279
-
Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation
-
2+ and stress nor the mechanism of signal transmission by PYK2 are understood.
-
2+ and stress nor the mechanism of signal transmission by PYK2 are understood.
-
(1996)
J Biol Chem
, vol.271
, pp. 29993-29998
-
-
Yu, H.1
Li, X.2
Marchetto, G.S.3
Dy, R.4
Hunter, D.5
Calvo, B.6
Dawson, T.L.7
Wilm, M.8
Anderegg, R.J.9
Graves, L.M.10
Earp, H.S.11
-
52
-
-
0029768088
-
Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
-
2+ via a CAM kinase cascade. The mechanism by which CAM kinase 4 activates MAP kinases is not established.
-
2+ via a CAM kinase cascade. The mechanism by which CAM kinase 4 activates MAP kinases is not established.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 10803-10808
-
-
Enslen, H.1
Tokumitsu, H.2
Stork, P.J.3
Davis, R.J.4
Soderling, T.R.5
-
53
-
-
0029860936
-
Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
-
of special interest. See annotation to [54].
-
Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. of special interest Science. 274:1996;1194-1197 See annotation to [54].
-
(1996)
Science
, vol.274
, pp. 1194-1197
-
-
Rosette, C.1
Karin, M.2
-
54
-
-
0030868999
-
Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
-
of special interest. These two papers [53,54] demonstrate that induced receptor aggregation may contribute to the activation of JNK in response to UV radiation.
-
Rehemtulla A, Hamilton CA, Chinnaiyan AM, Dixit VM. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). of special interest J Biol Chem. 272:1997;25783-25786 These two papers [53,54] demonstrate that induced receptor aggregation may contribute to the activation of JNK in response to UV radiation.
-
(1997)
J Biol Chem
, vol.272
, pp. 25783-25786
-
-
Rehemtulla, A.1
Hamilton, C.A.2
Chinnaiyan, A.M.3
Dixit, V.M.4
-
55
-
-
0029796368
-
Activation of p38 MAP kinase by c-ABL-dependent and independent mechanisms
-
of special interest. This study established that the c-Abl tyrosine kinase contributes to the effect of the DNA damaging agent 1-β-D-arabinofuranosylcytosine. The effects of other DNA damaging agents known to activate JNK are not mediated by ABL.
-
Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 MAP kinase by c-ABL-dependent and independent mechanisms. of special interest J Biol Chem. 271:1996;23775-23779 This study established that the c-Abl tyrosine kinase contributes to the effect of the DNA damaging agent 1-β-D-arabinofuranosylcytosine. The effects of other DNA damaging agents known to activate JNK are not mediated by ABL.
-
(1996)
J Biol Chem
, vol.271
, pp. 23775-23779
-
-
Pandey, P.1
Raingeaud, J.2
Kaneki, M.3
Weichselbaum, R.4
Davis, R.J.5
Kufe, D.6
Kharbanda, S.7
-
56
-
-
0030789179
-
The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
-
of special interest. This study provides evidence that alkylating agents activate JNK through changes in the redox potential of intracellular glutathione. The relevant redox sensor that mediates JNK activation has not been defined.
-
Wilhelm D, Bender K, Knebel A, Angel P. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. of special interest Mol Cell Biol. 17:1997;4792-4800 This study provides evidence that alkylating agents activate JNK through changes in the redox potential of intracellular glutathione. The relevant redox sensor that mediates JNK activation has not been defined.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4792-4800
-
-
Wilhelm, D.1
Bender, K.2
Knebel, A.3
Angel, P.4
-
57
-
-
0030973162
-
Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA
-
of special interest. This is an interesting study which examines the mechanism of JNK activation by translational inhibitors. The authors propose that JNK activation is mediated by specific damage to the 28S ribosomal RNA.
-
Iordanov MS, Pribnow D, Magun JL, Dinh TH, Pearson JA, Chen SL, Magun BE. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA. of special interest Mol Cell Biol. 17:1997;3373-3381 This is an interesting study which examines the mechanism of JNK activation by translational inhibitors. The authors propose that JNK activation is mediated by specific damage to the 28S ribosomal RNA.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 3373-3381
-
-
Iordanov, M.S.1
Pribnow, D.2
Magun, J.L.3
Dinh, T.H.4
Pearson, J.A.5
Chen, S.L.6
Magun, B.E.7
-
58
-
-
0029802561
-
RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase
-
of special interest. See annotation to [59].
-
Joneson T, McDonough M, Bar-Sagi D, Van Aelst L. RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase. of special interest Science. 274:1996;1374-1376 See annotation to [59].
-
(1996)
Science
, vol.274
, pp. 1374-1376
-
-
Joneson, T.1
McDonough, M.2
Bar-Sagi, D.3
Van Aelst, L.4
-
59
-
-
0030298138
-
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
-
of special interest. These two papers [58,59] describe the use of mutant Rac and Cdc42 proteins to distinguish signaling pathways that are initiated by these small GTPases. The JNK pathway is shown to be independent of the effects of Rac and Cdc42 on actin cytoskeleton re-organization.
-
Lamarche N, Tapon N, Stowers L, Burbelo PD, Aspenstrom P, Bridges T, Chant J, Hall A. Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. of special interest Cell. 87:1996;519-529 These two papers [58,59] describe the use of mutant Rac and Cdc42 proteins to distinguish signaling pathways that are initiated by these small GTPases. The JNK pathway is shown to be independent of the effects of Rac and Cdc42 on actin cytoskeleton re-organization.
-
(1996)
Cell
, vol.87
, pp. 519-529
-
-
Lamarche, N.1
Tapon, N.2
Stowers, L.3
Burbelo, P.D.4
Aspenstrom, P.5
Bridges, T.6
Chant, J.7
Hall, A.8
-
60
-
-
0029913510
-
Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway
-
Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind JS. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. J Biol Chem. 271:1996;27225-27228.
-
(1996)
J Biol Chem
, vol.271
, pp. 27225-27228
-
-
Teramoto, H.1
Coso, O.A.2
Miyata, H.3
Igishi, T.4
Miki, T.5
Gutkind, J.S.6
-
61
-
-
0029911520
-
The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway
-
Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, Gutkind JS. The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J Biol Chem. 271:1996;25731-25734.
-
(1996)
J Biol Chem
, vol.271
, pp. 25731-25734
-
-
Teramoto, H.1
Crespo, P.2
Coso, O.A.3
Igishi, T.4
Xu, N.5
Gutkind, J.S.6
-
62
-
-
0030875602
-
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
-
Fanger GR, Johnson NL, Johnson GL. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J. 16:1997;4961-4972.
-
(1997)
EMBO J
, vol.16
, pp. 4961-4972
-
-
Fanger, G.R.1
Johnson, N.L.2
Johnson, G.L.3
-
63
-
-
0030606319
-
C-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
-
Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 87:1996;929-939.
-
(1996)
Cell
, vol.87
, pp. 929-939
-
-
Kallunki, T.1
Deng, T.2
Hibi, M.3
Karin, M.4
-
64
-
-
0029908198
-
Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase sub-groups
-
Strahl T, Gille H, Shaw PE. Selective response of ternary complex factor Sap1a to different mitogen-activated protein kinase sub-groups. Proc Natl Acad Sci USA. 93:1996;11563-11568.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11563-11568
-
-
Strahl, T.1
Gille, H.2
Shaw, P.E.3
-
65
-
-
0030901584
-
Convergence of MAP kinase pathways on the ternary complex factor Sap1a
-
Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap1a. EMBO J. 16:1997;1620-1627.
-
(1997)
EMBO J
, vol.16
, pp. 1620-1627
-
-
Janknecht, R.1
Hunter, T.2
-
66
-
-
0031052087
-
Activation of the Sap1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase
-
Janknecht R, Hunter T. Activation of the Sap1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem. 272:1997;4219-4224.
-
(1997)
J Biol Chem
, vol.272
, pp. 4219-4224
-
-
Janknecht, R.1
Hunter, T.2
-
68
-
-
0030931125
-
Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
-
Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, Wakeham A, Shahinian A, Takimoto H, Bernstein A, et al. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med. 186:1997;941-953.
-
(1997)
J Exp Med
, vol.186
, pp. 941-953
-
-
Nishina, H.1
Bachmann, M.2
Oliveira-Dos-Santos, A.J.3
Kozieradzki, I.4
Fischer, K.D.5
Odermatt, B.6
Wakeham, A.7
Shahinian, A.8
Takimoto, H.9
Bernstein, A.10
-
69
-
-
0030027538
-
Developmental expression in the mouse nervous system of the p49F12 SAP kinase
-
Martin JH, Mohit AA, Miller CA. Developmental expression in the mouse nervous system of the p49F12 SAP kinase. Brain Res Mol Brain Res. 35:1996;45-57.
-
(1996)
Brain Res Mol Brain Res
, vol.35
, pp. 45-57
-
-
Martin, J.H.1
Mohit, A.A.2
Miller, C.A.3
-
70
-
-
0030625679
-
The multifunctional role of the co-activator CBP in transcriptional regulation
-
Goldman PS, Tran VK, Goodman RH. The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog Horm Res. 52:1997;103-120.
-
(1997)
Recent Prog Horm Res
, vol.52
, pp. 103-120
-
-
Goldman, P.S.1
Tran, V.K.2
Goodman, R.H.3
-
71
-
-
0029829562
-
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
-
of special interest. See annotation to [73].
-
Fuchs SY, Dolan L, Davis RJ, Ronai Z. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. of special interest Oncogene. 13:1996;1531-1535 See annotation to [73].
-
(1996)
Oncogene
, vol.13
, pp. 1531-1535
-
-
Fuchs, S.Y.1
Dolan, L.2
Davis, R.J.3
Ronai, Z.4
-
73
-
-
0031023756
-
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
-
of special interest. These two papers [71,73] establish that Jun phosphorylation by JNK regulates protein stability by inhibiting ubiquitination. The c-Jun protein has a short half-life because it is rapidly degraded by proteasomes. Phosphorylation by JNK increases the half-life of the c-Jun protein by inhibiting ubiquitination, and therefore degradation by the proteasome pathway.
-
Musti AM, Treier M, Bohmann D. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. of special interest Science. 275:1997;400-402 These two papers [71,73] establish that Jun phosphorylation by JNK regulates protein stability by inhibiting ubiquitination. The c-Jun protein has a short half-life because it is rapidly degraded by proteasomes. Phosphorylation by JNK increases the half-life of the c-Jun protein by inhibiting ubiquitination, and therefore degradation by the proteasome pathway.
-
(1997)
Science
, vol.275
, pp. 400-402
-
-
Musti, A.M.1
Treier, M.2
Bohmann, D.3
-
74
-
-
0030706186
-
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway
-
of special interest. This study demonstrates that JNK regulates the nuclear accumulation of a transcription factor.
-
Chow C-W, Rincon M, Cavanagh J, Dickens M, Davis RJ. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. of special interest Science. 278:1997;1638-1641 This study demonstrates that JNK regulates the nuclear accumulation of a transcription factor.
-
(1997)
Science
, vol.278
, pp. 1638-1641
-
-
Chow C-W1
Rincon, M.2
Cavanagh, J.3
Dickens, M.4
Davis, R.J.5
-
75
-
-
0030927326
-
Activation of the JNK pathway is essential for transformation by the Met oncogene
-
Rodrigues GA, Park M, Schlessinger J. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16:1997;2634-2645.
-
(1997)
EMBO J
, vol.16
, pp. 2634-2645
-
-
Rodrigues, G.A.1
Park, M.2
Schlessinger, J.3
-
76
-
-
0029887278
-
Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis
-
Xu X, Heidenreich O, Kitajima I, McGuire K, Li Q, Su B, Nerenberg M. Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis. Oncogene. 13:1996;135-142.
-
(1996)
Oncogene
, vol.13
, pp. 135-142
-
-
Xu, X.1
Heidenreich, O.2
Kitajima, I.3
McGuire, K.4
Li, Q.5
Su, B.6
Nerenberg, M.7
-
77
-
-
0031004266
-
Downstream of Crk adaptor signaling pathway: Activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G
-
Tanaka S, Ouchi T, Hanafusa H. Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. Proc Natl Acad Sci USA. 94:1997;2356-2361.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2356-2361
-
-
Tanaka, S.1
Ouchi, T.2
Hanafusa, H.3
-
78
-
-
0029589929
-
The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation
-
Raitano AB, Halpern JR, Hambuch TM, Sawyers CL. The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation. Proc Natl Acad Sci USA. 92:1995;11746-11750.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11746-11750
-
-
Raitano, A.B.1
Halpern, J.R.2
Hambuch, T.M.3
Sawyers, C.L.4
-
79
-
-
0030757691
-
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor
-
of special interest. This study demonstrates that the MKK4 gene is mutated in some human tumor cells. Whether these mutations contribute to the tumor phenotype remains to be established.
-
Teng DH, Perry WL, Hogan JK, Baumgard M, Bell R, Berry S, Davis T, Frank D, Frye C, Hattier T, et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. of special interest Cancer Res. 57:1997;4177-4182 This study demonstrates that the MKK4 gene is mutated in some human tumor cells. Whether these mutations contribute to the tumor phenotype remains to be established.
-
(1997)
Cancer Res
, vol.57
, pp. 4177-4182
-
-
Teng, D.H.1
Perry, W.L.2
Hogan, J.K.3
Baumgard, M.4
Bell, R.5
Berry, S.6
Davis, T.7
Frank, D.8
Frye, C.9
Hattier, T.10
-
80
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
-
Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J Biol Chem. 271:1996;17920-17926.
-
(1996)
J Biol Chem
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen, C.2
Li, Z.3
Guo, W.4
Gegner, J.A.5
Lin, S.6
Han, J.7
-
81
-
-
0031061712
-
Reprogramming the signaling requirement for AP-1 activation during differentiation of precursor CD4+ T cells to effector Th1 and Th2 cells
-
Rincon M, Dérijard B, Chow CW, Davis RJ, Flavell RA. Reprogramming the signaling requirement for AP-1 activation during differentiation of precursor CD4+ T cells to effector Th1 and Th2 cells. Genes Function. 1:1997;51-68.
-
(1997)
Genes Function
, vol.1
, pp. 51-68
-
-
Rincon, M.1
Dérijard, B.2
Chow, C.W.3
Davis, R.J.4
Flavell, R.A.5
-
82
-
-
0031008005
-
Mast cell tumor necrosis factor α production is regulated by MEK kinases
-
Ishizuka T, Terada N, Gerwins P, Hamelmann E, Oshiba A, Fanger GR, Johnson GL, Gelfand EW. Mast cell tumor necrosis factor α production is regulated by MEK kinases. Proc Natl Acad Sci USA. 94:1997;6358-6363.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6358-6363
-
-
Ishizuka, T.1
Terada, N.2
Gerwins, P.3
Hamelmann, E.4
Oshiba, A.5
Fanger, G.R.6
Johnson, G.L.7
Gelfand, E.W.8
-
83
-
-
0030999872
-
Role of endothelial selectins in wound repair
-
Subramaniam M, Saffaripour S, Van De Water L, Frenette PS, Mayadas TN, Hynes RO, Wagner DD. Role of endothelial selectins in wound repair. Am J Pathol. 150:1997;1701-1709.
-
(1997)
Am J Pathol
, vol.150
, pp. 1701-1709
-
-
Subramaniam, M.1
Saffaripour, S.2
Van De Water, L.3
Frenette, P.S.4
Mayadas, T.N.5
Hynes, R.O.6
Wagner, D.D.7
-
84
-
-
13344278032
-
Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice
-
Reimold AM, Grusby MJ, Kosaras B, Fries JW, Mori R, Maniwa S, Clauss IM, Collins T, Sidman RL, Glimcher MJ, et al. Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 379:1996;262-265.
-
(1996)
Nature
, vol.379
, pp. 262-265
-
-
Reimold, A.M.1
Grusby, M.J.2
Kosaras, B.3
Fries, J.W.4
Mori, R.5
Maniwa, S.6
Clauss, I.M.7
Collins, T.8
Sidman, R.L.9
Glimcher, M.J.10
-
85
-
-
0031252641
-
TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappaB and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways
-
Min W, Pober JS. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappaB and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways. J Immunol. 159:1997;3508-3518.
-
(1997)
J Immunol
, vol.159
, pp. 3508-3518
-
-
Min, W.1
Pober, J.S.2
-
86
-
-
0031018424
-
TNFα induced E-selectin expression is activated by the NF-κB and JNK/p38 MAP kinase pathways
-
Read MA, Whitely MZ, Gupta S, Pierce JW, Best J, Davis RJ, Collins T. TNFα induced E-selectin expression is activated by the NF-κB and JNK/p38 MAP kinase pathways. J Biol Chem. 272:1997;2753-2761.
-
(1997)
J Biol Chem
, vol.272
, pp. 2753-2761
-
-
Read, M.A.1
Whitely, M.Z.2
Gupta, S.3
Pierce, J.W.4
Best, J.5
Davis, R.J.6
Collins, T.7
-
87
-
-
0029821787
-
CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases
-
Cahill MA, Peter ME, Kischkel FC, Chinnaiyan AM, Dixit VM, Krammer PH, Nordheim A. CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases. Oncogene. 13:1996;2087-2096.
-
(1996)
Oncogene
, vol.13
, pp. 2087-2096
-
-
Cahill, M.A.1
Peter, M.E.2
Kischkel, F.C.3
Chinnaiyan, A.M.4
Dixit, V.M.5
Krammer, P.H.6
Nordheim, A.7
-
88
-
-
0029753773
-
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
-
Chen YR, Wang X, Templeton D, Davis RJ, Tan TH. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem. 271:1996;31929-31936.
-
(1996)
J Biol Chem
, vol.271
, pp. 31929-31936
-
-
Chen, Y.R.1
Wang, X.2
Templeton, D.3
Davis, R.J.4
Tan, T.H.5
-
89
-
-
0031015043
-
Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases
-
Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP, Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases. Mol Cell Biol. 17:1997;24-35.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 24-35
-
-
Juo, P.1
Kuo, C.J.2
Reynolds, S.E.3
Konz, R.F.4
Raingeaud, J.5
Davis, R.J.6
Biemann, H.P.7
Blenis, J.8
-
90
-
-
0031016440
-
Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis
-
Lenczowski JM, Dominguez L, Eder AM, King LB, Zacharchuk CM, Ashwell JD. Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis. Mol Cell Biol. 17:1997;170-181.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 170-181
-
-
Lenczowski, J.M.1
Dominguez, L.2
Eder, A.M.3
King, L.B.4
Zacharchuk, C.M.5
Ashwell, J.D.6
-
91
-
-
0030755579
-
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
-
Cardone MH, Salvesen GS, Widmann C, Johnson G, Frisch SM. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell. 90:1997;315-323.
-
(1997)
Cell
, vol.90
, pp. 315-323
-
-
Cardone, M.H.1
Salvesen, G.S.2
Widmann, C.3
Johnson, G.4
Frisch, S.M.5
-
92
-
-
0030918572
-
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
-
Rudel T, Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science. 276:1997;1571-1574.
-
(1997)
Science
, vol.276
, pp. 1571-1574
-
-
Rudel, T.1
Bokoch, G.M.2
-
93
-
-
0000154443
-
Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death
-
Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI, Johnson GL. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 271:1996;3229-3237.
-
(1996)
J Biol Chem
, vol.271
, pp. 3229-3237
-
-
Johnson, N.L.1
Gardner, A.M.2
Diener, K.M.3
Lange-Carter, C.A.4
Gleavy, J.5
Jarpe, M.B.6
Minden, A.7
Karin, M.8
Zon, L.I.9
Johnson, G.L.10
-
94
-
-
0030920914
-
The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
-
Potapova O, Haghighi A, Bost F, Liu C, Birrer MJ, Gjerset R, Mercola D. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J Biol Chem. 272:1997;14041-14044.
-
(1997)
J Biol Chem
, vol.272
, pp. 14041-14044
-
-
Potapova, O.1
Haghighi, A.2
Bost, F.3
Liu, C.4
Birrer, M.J.5
Gjerset, R.6
Mercola, D.7
-
95
-
-
0028880006
-
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
-
Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
-
(1995)
Science
, vol.270
, pp. 1326-1331
-
-
Xia, Z.1
Dickens, M.2
Raingeaud, J.3
Davis, R.J.4
Greenberg, M.E.5
-
96
-
-
0030041536
-
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ radiation-induced apoptosis
-
Chen Y-R, Meyer CF, Tan T-H. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in γ radiation-induced apoptosis. J Biol Chem. 271:1996;631-634.
-
(1996)
J Biol Chem
, vol.271
, pp. 631-634
-
-
Chen Y-R1
Meyer, C.F.2
Tan T-H3
-
97
-
-
0030458602
-
A role for Jun-N-terminal kinase in anoikis; Suppression by bcl-2 and crmA
-
Frisch SM, Vuori K, Kelaita D, Sicks S. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J Cell Biol. 135:1996;1377-1382.
-
(1996)
J Cell Biol
, vol.135
, pp. 1377-1382
-
-
Frisch, S.M.1
Vuori, K.2
Kelaita, D.3
Sicks, S.4
-
98
-
-
0347537940
-
Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis
-
Verheij M, Bose R, Lin XH, Yao B, Jarvis D, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, et al. Requirement for ceramide-initiated SAPK/JNK signaling in stress-induced apoptosis. Nature. 380:1996;75-79.
-
(1996)
Nature
, vol.380
, pp. 75-79
-
-
Verheij, M.1
Bose, R.2
Lin, X.H.3
Yao, B.4
Jarvis, D.5
Grant, S.6
Birrer, M.J.7
Szabo, E.8
Zon, L.I.9
Kyriakis, J.M.10
-
99
-
-
0030134173
-
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
-
Zanke BW, Boudreau K, Rubie E, Winnett E, Tibbles LA, Zon L, Kyriakis J, Liu F-F, Woodgett JR. The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat. Curr Biol. 6:1996;606-613.
-
(1996)
Curr Biol
, vol.6
, pp. 606-613
-
-
Zanke, B.W.1
Boudreau, K.2
Rubie, E.3
Winnett, E.4
Tibbles, L.A.5
Zon, L.6
Kyriakis, J.7
Liu F-F8
Woodgett, J.R.9
-
100
-
-
0030868250
-
Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-β through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway
-
Atfi A, Buisine M, Mazars A, Gespach C. Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-β through stress-activated protein Kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J Biol Chem. 272:1997;24731-24734.
-
(1997)
J Biol Chem
, vol.272
, pp. 24731-24734
-
-
Atfi, A.1
Buisine, M.2
Mazars, A.3
Gespach, C.4
-
101
-
-
0030803278
-
Fas- Or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
-
Brenner B, Koppenhoefer U, Weinstock C, Linderkamp O, Lang F, Gulbins E. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153. J Biol Chem. 272:1997;22173-22181.
-
(1997)
J Biol Chem
, vol.272
, pp. 22173-22181
-
-
Brenner, B.1
Koppenhoefer, U.2
Weinstock, C.3
Linderkamp, O.4
Lang, F.5
Gulbins, E.6
-
102
-
-
0030611189
-
2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation
-
2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation. J Biol Chem. 272:1997;10110-10116.
-
(1997)
J Biol Chem
, vol.272
, pp. 10110-10116
-
-
Butterfield, L.1
Storey, B.2
Maas, L.3
Heasley, L.E.4
-
103
-
-
0030798405
-
The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes
-
Chuang TH, Hahn KM, Lee JD, Danley DE, Bokoch GM. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Mol Biol Cell. 8:1997;1687-1698.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 1687-1698
-
-
Chuang, T.H.1
Hahn, K.M.2
Lee, J.D.3
Danley, D.E.4
Bokoch, G.M.5
-
105
-
-
0030914282
-
Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway
-
Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sanchez I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci USA. 94:1997;3302-3307.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3302-3307
-
-
Goillot, E.1
Raingeaud, J.2
Ranger, A.3
Tepper, R.I.4
Davis, R.J.5
Harlow, E.6
Sanchez, I.7
-
106
-
-
0030614914
-
2-terminal kinase-mediated activation of interleukin-1 β converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis
-
2-terminal kinase-mediated activation of interleukin-1 β converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis. J Biol Chem. 272:1997;4631-4636.
-
(1997)
J Biol Chem
, vol.272
, pp. 4631-4636
-
-
Seimiya, H.1
Mashima, T.2
Toho, M.3
Tsuruo, T.4
-
107
-
-
0030670626
-
Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
-
Herr I, Wilhelm D, Bohler T, Angel P, Debatin K-M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16:1997;6200-6208.
-
(1997)
EMBO J
, vol.16
, pp. 6200-6208
-
-
Herr, I.1
Wilhelm, D.2
Bohler, T.3
Angel, P.4
Debatin K-M5
-
108
-
-
0029838165
-
Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells
-
Park DS, Stefanis L, Yan CYI, Farinelli SE, Greene LA. Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells. J Biol Chem. 271:1996;21898-21905.
-
(1996)
J Biol Chem
, vol.271
, pp. 21898-21905
-
-
Park, D.S.1
Stefanis, L.2
Yan, C.Y.I.3
Farinelli, S.E.4
Greene, L.A.5
-
109
-
-
0030751556
-
Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones
-
Virdee K, Bannister AJ, Hunt SP, Tolkovsky AM. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J Neurochem. 69:1997;550-561.
-
(1997)
J Neurochem
, vol.69
, pp. 550-561
-
-
Virdee, K.1
Bannister, A.J.2
Hunt, S.P.3
Tolkovsky, A.M.4
-
110
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 91:1997;231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
111
-
-
0030899235
-
Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways
-
Furukawa K, Estus S, Fu W, Mark RJ, Mattson MP. Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways. J Cell Biol. 136:1997;1137-1149.
-
(1997)
J Cell Biol
, vol.136
, pp. 1137-1149
-
-
Furukawa, K.1
Estus, S.2
Fu, W.3
Mark, R.J.4
Mattson, M.P.5
-
112
-
-
0031149046
-
The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration
-
Herdegen T, Skene P, Bahr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20:1997;227-231.
-
(1997)
Trends Neurosci
, vol.20
, pp. 227-231
-
-
Herdegen, T.1
Skene, P.2
Bahr, M.3
-
113
-
-
0030067803
-
Programmed cell death in the absence of c-Fos and c-Jun
-
Roffler-Tarlov S, Brown JJ, Tarlov E, Stolarov J, Chapman DL, Alexiou M, Papaioannou VE. Programmed cell death in the absence of c-Fos and c-Jun. Development. 122:1996;1-9.
-
(1996)
Development
, vol.122
, pp. 1-9
-
-
Roffler-Tarlov, S.1
Brown, J.J.2
Tarlov, E.3
Stolarov, J.4
Chapman, D.L.5
Alexiou, M.6
Papaioannou, V.E.7
-
114
-
-
0030741894
-
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells
-
Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, Gotoh Y, Nishida E. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem. 272:1997;18518-18521.
-
(1997)
J Biol Chem
, vol.272
, pp. 18518-18521
-
-
Kawasaki, H.1
Morooka, T.2
Shimohama, S.3
Kimura, J.4
Hirano, T.5
Gotoh, Y.6
Nishida, E.7
-
115
-
-
0030957325
-
Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons
-
Schwarzschild MA, Cole RL, Hyman SE. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J Neurosci. 17:1997;3455-3466.
-
(1997)
J Neurosci
, vol.17
, pp. 3455-3466
-
-
Schwarzschild, M.A.1
Cole, R.L.2
Hyman, S.E.3
-
116
-
-
0030808984
-
Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
-
Kummer JL, Rao PK, Heidenreich KA. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem. 272:1997;20490-20494.
-
(1997)
J Biol Chem
, vol.272
, pp. 20490-20494
-
-
Kummer, J.L.1
Rao, P.K.2
Heidenreich, K.A.3
-
117
-
-
0030220456
-
P38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF2 phosphorylation are insufficient
-
Hazzalin CA, Cano E, Cuenda A, Barratt MJ, Cohen P, Mahadevan LC. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF2 phosphorylation are insufficient. Curr Biol. 6:1996;1028-1031.
-
(1996)
Curr Biol
, vol.6
, pp. 1028-1031
-
-
Hazzalin, C.A.1
Cano, E.2
Cuenda, A.3
Barratt, M.J.4
Cohen, P.5
Mahadevan, L.C.6
-
118
-
-
0029827366
-
The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light
-
Price MA, Cruzalegui FH, Treisman R. The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. EMBO J. 15:1996;6552-6563.
-
(1996)
EMBO J
, vol.15
, pp. 6552-6563
-
-
Price, M.A.1
Cruzalegui, F.H.2
Treisman, R.3
-
119
-
-
0030894683
-
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
-
Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 386:1997;296-299.
-
(1997)
Nature
, vol.386
, pp. 296-299
-
-
Han, J.1
Jiang, Y.2
Li, Z.3
Kravchenko, V.V.4
Ulevitch, R.J.5
-
120
-
-
15644381250
-
Bcl-2 undergoes phosphorylation by c-Jun N-terminal Kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein rac1
-
Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C, Gillieron C, Boschert U, Vial-Knecht E, Martinou JC, Arkinstall S. Bcl-2 undergoes phosphorylation by c-Jun N-terminal Kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein rac1. J Biol Chem. 272:1997;25238-25242.
-
(1997)
J Biol Chem
, vol.272
, pp. 25238-25242
-
-
Maundrell, K.1
Antonsson, B.2
Magnenat, E.3
Camps, M.4
Muda, M.5
Chabert, C.6
Gillieron, C.7
Boschert, U.8
Vial-Knecht, E.9
Martinou, J.C.10
Arkinstall, S.11
-
121
-
-
0029088484
-
Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator
-
Tsirka SE, Gualandris A, Amaral DG, Strickland S. Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature. 377:1995;340-344.
-
(1995)
Nature
, vol.377
, pp. 340-344
-
-
Tsirka, S.E.1
Gualandris, A.2
Amaral, D.G.3
Strickland, S.4
-
122
-
-
0030031514
-
Cyclin D1 is an essential mediator of apoptotic neuronal cell death
-
Kranenburg O, van der Eb AJ, Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15:1996;46-54.
-
(1996)
EMBO J
, vol.15
, pp. 46-54
-
-
Kranenburg, O.1
Van Der Eb, A.J.2
Zantema, A.3
-
123
-
-
0030797727
-
Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death
-
Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson EM. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J Cell Biol. 139:1997;205-217.
-
(1997)
J Cell Biol
, vol.139
, pp. 205-217
-
-
Miller, T.M.1
Moulder, K.L.2
Knudson, C.M.3
Creedon, D.J.4
Deshmukh, M.5
Korsmeyer, S.J.6
Johnson, E.M.7
-
124
-
-
0031001244
-
Bax promotes neuronal cell death and is downregulated during the development of the nervous system
-
Vekrellis K, McCarthy MJ, Watson A, Whitfield J, Rubin LL, Ham J. Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development. 124:1997;1239-1249.
-
(1997)
Development
, vol.124
, pp. 1239-1249
-
-
Vekrellis, K.1
McCarthy, M.J.2
Watson, A.3
Whitfield, J.4
Rubin, L.L.5
Ham, J.6
-
125
-
-
0030742943
-
Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement
-
of special interest. See annotation to [128].
-
Hou XS, Goldstein ES, Perrimon N. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. of special interest Genes Dev. 11:1997;1728-1737 See annotation to [128].
-
(1997)
Genes Dev
, vol.11
, pp. 1728-1737
-
-
Hou, X.S.1
Goldstein, E.S.2
Perrimon, N.3
-
126
-
-
0030857388
-
Jun in Drosophila development: Redundant and nonredundant functions and regulation by two MAPK signal transduction pathways
-
of special interest. See annotation to [128].
-
Kockel L, Zeitlinger J, Staszewski LM, Mlodzik M, Bohmann D. Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. of special interest Genes Dev. 11:1997;1748-1758 See annotation to [128].
-
(1997)
Genes Dev
, vol.11
, pp. 1748-1758
-
-
Kockel, L.1
Zeitlinger, J.2
Staszewski, L.M.3
Mlodzik, M.4
Bohmann, D.5
-
127
-
-
0030708573
-
Common and distinct roles of DFos and DJun during Drosophila development
-
of outstanding interest. This manuscript presents an elegant study of the AP-1 proteins DFos and DJun. Genetic analysis of the DFos and DJun genes demonstrates non-redundant and cooperative functions during dorsal closure. Also see annotation to [128].
-
Riesgo-Escovar JR, Hafen E. Common and distinct roles of DFos and DJun during Drosophila development. of outstanding interest Science. 278:1997;669-672
-
(1997)
Science
, vol.278
, pp. 669-672
-
-
Riesgo-Escovar, J.R.1
Hafen, E.2
-
128
-
-
0030797351
-
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
-
of outstanding interest. of special interest. These six papers[8,18,125,126,127,128] describe detailed molecular genetic analyses of the dorsal closure pathway. DJNK initiates elongation of the leading edge cells of the dorsal epidermis. This signal is relayed to the other cells in the epidermis by the TGF-β homolog Dpp. This signaling requires the DJNK substrates DJun and Aop/Yan.
-
of outstanding interest Riesgo-Escovar JR, Hafen E. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure. of special interest Genes Dev. 11:1997;1717-1727 These six papers[8,18,125,126,127,128] describe detailed molecular genetic analyses of the dorsal closure pathway. DJNK initiates elongation of the leading edge cells of the dorsal epidermis. This signal is relayed to the other cells in the epidermis by the TGF-β homolog Dpp. This signaling requires the DJNK substrates DJun and Aop/Yan.
-
(1997)
Genes Dev
, vol.11
, pp. 1717-1727
-
-
Riesgo-Escovar, J.R.1
Hafen, E.2
-
129
-
-
0030917227
-
The role of RhoA in tissue polarity and Frizzled signalling
-
of special interest. This paper presents evidence that DJNK genetically interacts with the frizzled signaling pathway.
-
Strutt DI, Weber U, Mlodzik M. The role of RhoA in tissue polarity and Frizzled signalling. of special interest Nature. 387:1997;292-295 This paper presents evidence that DJNK genetically interacts with the frizzled signaling pathway.
-
(1997)
Nature
, vol.387
, pp. 292-295
-
-
Strutt, D.I.1
Weber, U.2
Mlodzik, M.3
-
130
-
-
0000480639
-
Development and patterning of the larval epidermis of Drosophila
-
New York: Cold Spring Harbor Laboratory Press
-
Martinez-Arias A. Development and patterning of the larval epidermis of Drosophila. The Development of Drosophila melanogaster. 1993;517-607 Cold Spring Harbor Laboratory Press, New York.
-
(1993)
The Development of Drosophila Melanogaster
, pp. 517-607
-
-
Martinez-Arias, A.1
-
131
-
-
0029963547
-
A Drosophila homology of the Rac- And Cdc42-activated serine/theonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures
-
Harden N, Lee J, Loh H-Y, Ong Y-M, Tan I, Leung T, Manser E, Lim L. A Drosophila homology of the Rac- and Cdc42-activated serine/theonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol Cell Biol. 16:1996;1896-1980.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1896-1980
-
-
Harden, N.1
Lee, J.2
Loh H-Y3
Ong Y-M4
Tan, I.5
Leung, T.6
Manser, E.7
Lim, L.8
-
132
-
-
0028266628
-
Embryonic expression patterns of the Drosophila melanogaster decapentaplegic gene: Separate elements control blastoderm expression and lateral ectoderm expression
-
Jackson PD, Hoffmann FM. Embryonic expression patterns of the Drosophila melanogaster decapentaplegic gene: separate elements control blastoderm expression and lateral ectoderm expression. Dev Dynamics. 199:1994;28-44.
-
(1994)
Dev Dynamics
, vol.199
, pp. 28-44
-
-
Jackson, P.D.1
Hoffmann, F.M.2
-
133
-
-
0028072133
-
Molecular genetics of Drosophila immunity
-
Ip YT, Levine M. Molecular genetics of Drosophila immunity. Curr Opin Genet Dev. 4:1994;672-677.
-
(1994)
Curr Opin Genet Dev
, vol.4
, pp. 672-677
-
-
Ip, Y.T.1
Levine, M.2
-
134
-
-
0030595339
-
The dorsoventral regulatory gene cassette spStzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spStzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:1996;973-983.
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
135
-
-
0028353694
-
Determination of neuronal cell fate: Lessons from the R7 neuron of Drosophila
-
Zipursky SL, Rubin GM. Determination of neuronal cell fate: lessons from the R7 neuron of Drosophila. Annu Rev Neurosci. 17:1994;373-397.
-
(1994)
Annu Rev Neurosci
, vol.17
, pp. 373-397
-
-
Zipursky, S.L.1
Rubin, G.M.2
|