메뉴 건너뛰기




Volumn 63, Issue 6 I, 2005, Pages 183-195

DNA methylation, genomic silencing, and links to nutrition and cancer

Author keywords

Cancer; DNA methylation; Folate; Gene expression

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; DNA METHYLTRANSFERASE; FOLIC ACID; METHIONINE; S ADENOSYLMETHIONINE;

EID: 18344366366     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1301/nr.2005.Jun.183-195     Document Type: Review
Times cited : (65)

References (159)
  • 1
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 2
    • 0842328495 scopus 로고    scopus 로고
    • Evaluation of DNA methylation in the human genome: Why examine it and what method to use
    • Geisler JP, Manahan KJ, Geisler HE. Evaluation of DNA methylation in the human genome: why examine it and what method to use. Eur J Gynaecol Oncol. 2004;25:19-24.
    • (2004) Eur J Gynaecol Oncol , vol.25 , pp. 19-24
    • Geisler, J.P.1    Manahan, K.J.2    Geisler, H.E.3
  • 4
    • 0033135285 scopus 로고    scopus 로고
    • Eukaryotic DNA methylation as an evolutionary device
    • Colot V, Rossignol JL. Eukaryotic DNA methylation as an evolutionary device. Bioessays. 1999;21:402-411.
    • (1999) Bioessays , vol.21 , pp. 402-411
    • Colot, V.1    Rossignol, J.L.2
  • 5
    • 0034305821 scopus 로고    scopus 로고
    • DNA methylation in health and disease
    • Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet. 2000;1:11-19.
    • (2000) Nat Rev Genet , vol.1 , pp. 11-19
    • Robertson, K.D.1    Wolffe, A.P.2
  • 6
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921.
    • (2001) Nature , vol.409 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 7
    • 1842529388 scopus 로고    scopus 로고
    • Reproductive epigenetics
    • Kelly TL, Trasler JM. Reproductive epigenetics. Clin Genet. 2004;65:247-260.
    • (2004) Clin Genet , vol.65 , pp. 247-260
    • Kelly, T.L.1    Trasler, J.M.2
  • 9
    • 0025364861 scopus 로고
    • The mutational spectrum of single base-pair substitutions causing human genetic disease: Patterns and predictions
    • Cooper DN, Krawczak M. The mutational spectrum of single base-pair substitutions causing human genetic disease: patterns and predictions. Hum Genet. 1990;85:55-74.
    • (1990) Hum Genet , vol.85 , pp. 55-74
    • Cooper, D.N.1    Krawczak, M.2
  • 10
    • 0842325730 scopus 로고    scopus 로고
    • Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing
    • Gaudet F, Rideout WM 3rd, Meissner A, Dausman J, Leonhardt H, Jaenisch R. Dnmt1 expression in pre- and postimplantation embryogenesis and the maintenance of IAP silencing. Mol Cell Biol. 2004; 24:1640-1648.
    • (2004) Mol Cell Biol , vol.24 , pp. 1640-1648
    • Gaudet, F.1    Rideout III, W.M.2    Meissner, A.3    Dausman, J.4    Leonhardt, H.5    Jaenisch, R.6
  • 11
    • 0036326659 scopus 로고    scopus 로고
    • The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: An introduction
    • Poirier LA. The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction. J Nutr. 2002;132(suppl 8):2336S-2339S.
    • (2002) J Nutr , vol.132 , Issue.SUPPL. 8
    • Poirier, L.A.1
  • 12
    • 0022309434 scopus 로고
    • The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine
    • Cantoni GL. The role of S-adenosylhomocysteine in the biological utilization of S-adenosylmethionine. Prog Clin Biol Res. 1985;198:47-65.
    • (1985) Prog Clin Biol Res , vol.198 , pp. 47-65
    • Cantoni, G.L.1
  • 13
    • 0037068372 scopus 로고    scopus 로고
    • DNA methylation and chromatin: Unraveling the tangled web
    • Robertson KD. DNA methylation and chromatin: unraveling the tangled web. Oncogene. 2002;21: 5361-5379.
    • (2002) Oncogene , vol.21 , pp. 5361-5379
    • Robertson, K.D.1
  • 14
    • 0032731355 scopus 로고    scopus 로고
    • Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA
    • Bacolla A, Pradhan S, Roberts RJ, Wells RD. Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA. J Biol Chem. 1999; 274:33011-33019.
    • (1999) J Biol Chem , vol.274 , pp. 33011-33019
    • Bacolla, A.1    Pradhan, S.2    Roberts, R.J.3    Wells, R.D.4
  • 15
    • 0031566164 scopus 로고    scopus 로고
    • Purification and characterization of recombinant baculovirus-expressed mouse DNA methyltransferase
    • Glickman JF, Flynn J, Reich NO. Purification and characterization of recombinant baculovirus-expressed mouse DNA methyltransferase. Biochem Biophys Res Commun. 1997;230:280-284.
    • (1997) Biochem Biophys Res Commun , vol.230 , pp. 280-284
    • Glickman, J.F.1    Flynn, J.2    Reich, N.O.3
  • 16
    • 0026439115 scopus 로고
    • A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
    • Leonhardt H, Page AW, Weier H-U, Bestor TH. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell. 1992;71:865-873.
    • (1992) Cell , vol.71 , pp. 865-873
    • Leonhardt, H.1    Page, A.W.2    Weier, H.-U.3    Bestor, T.H.4
  • 17
    • 0032519312 scopus 로고    scopus 로고
    • Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci
    • Liu Y, Oakeley EJ, Sun L, Jost JP. Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci. Nucleic Acids Res. 1998;26:1038-1045.
    • (1998) Nucleic Acids Res , vol.26 , pp. 1038-1045
    • Liu, Y.1    Oakeley, E.J.2    Sun, L.3    Jost, J.P.4
  • 18
    • 0042132027 scopus 로고    scopus 로고
    • Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b
    • Chen T, Ueda Y, Dodge JE, Wang Z, Li E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol. 2003;23: 5594-5605.
    • (2003) Mol Cell Biol , vol.23 , pp. 5594-5605
    • Chen, T.1    Ueda, Y.2    Dodge, J.E.3    Wang, Z.4    Li, E.5
  • 19
    • 0035943709 scopus 로고    scopus 로고
    • Dmnt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    • Bachman KE, Rountree MR, Baylin SB. Dmnt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem. 2001;276:32282-32287.
    • (2001) J Biol Chem , vol.276 , pp. 32282-32287
    • Bachman, K.E.1    Rountree, M.R.2    Baylin, S.B.3
  • 20
    • 20544471128 scopus 로고    scopus 로고
    • S-adenosylmethionine-dependent methyltransferases
    • Carmel R, Jacobsen DW, eds. Cambridge, MA: Cambridge University Press
    • Clarke S, Banfield K. S-adenosylmethionine-dependent methyltransferases. In: Carmel R, Jacobsen DW, eds. Homocysteine in Health and Disease. Cambridge, MA: Cambridge University Press; 200163-200178.
    • Homocysteine in Health and Disease , pp. 200163-200178
    • Clarke, S.1    Banfield, K.2
  • 21
    • 0028940587 scopus 로고
    • Gene number, noise reduction and biological complexity
    • Bird AP. Gene number, noise reduction and biological complexity. Trends Genet. 1995;11:94-100.
    • (1995) Trends Genet , vol.11 , pp. 94-100
    • Bird, A.P.1
  • 22
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder JA, Walsh CP, Bestor TH. Cytosine methylation and the ecology of intragenomic parasites. Trends Genet. 1997;13:335-340.
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 23
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003; 33(suppl);245-254.
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 24
    • 3042701155 scopus 로고    scopus 로고
    • Epigenomics: Beyond CpG islands
    • Fazzari MJ, Greally JM. Epigenomics: beyond CpG islands. Nat Rev Genet. 2004;5:446-455.
    • (2004) Nat Rev Genet , vol.5 , pp. 446-455
    • Fazzari, M.J.1    Greally, J.M.2
  • 25
    • 0036960274 scopus 로고    scopus 로고
    • On the roles of repetitive DNA elements in the context of a unified genomic-epigenetic system
    • von Sternberg RV. On the roles of repetitive DNA elements in the context of a unified genomic-epigenetic system. Ann N Y Acad Sci. 2002;981:154-188.
    • (2002) Ann N Y Acad Sci , vol.981 , pp. 154-188
    • Von Sternberg, R.V.1
  • 26
    • 0031820331 scopus 로고    scopus 로고
    • X-chromosome inactivation: A repeat hypothesis
    • Lyon MF. X-chromosome inactivation: a repeat hypothesis. Cytogenet Cell Genet. 1998;80:133-137.
    • (1998) Cytogenet Cell Genet , vol.80 , pp. 133-137
    • Lyon, M.F.1
  • 27
    • 0033637110 scopus 로고    scopus 로고
    • A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
    • Wutz A, Jaenisch R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell. 2000;5:695-705.
    • (2000) Mol Cell , vol.5 , pp. 695-705
    • Wutz, A.1    Jaenisch, R.2
  • 28
    • 0035228079 scopus 로고    scopus 로고
    • X-chromosome inactivation: Counting, choice and initiation
    • Avner P, Heard E. X-chromosome inactivation: counting, choice and initiation. Nat Rev Genet. 2001;2:59-67.
    • (2001) Nat Rev Genet , vol.2 , pp. 59-67
    • Avner, P.1    Heard, E.2
  • 29
    • 2342481623 scopus 로고    scopus 로고
    • Recent advances in X-chromosome inactivation
    • Heard E. Recent advances in X-chromosome inactivation. Curr Opin Cell Biol. 2004;16:247-255.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 247-255
    • Heard, E.1
  • 30
    • 0037453015 scopus 로고    scopus 로고
    • Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting?
    • Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Curr Biol. 2003;13:R242-R254.
    • (2003) Curr Biol , vol.13
    • Lee, J.T.1
  • 31
    • 1542360090 scopus 로고    scopus 로고
    • CpG islands in human X-inactivation
    • Ke X, Collins A. CpG islands in human X-inactivation. Ann Human Genet. 2003;67(part 3):242-249.
    • (2003) Ann Human Genet , vol.67 , Issue.PART 3 , pp. 242-249
    • Ke, X.1    Collins, A.2
  • 32
    • 0031824010 scopus 로고    scopus 로고
    • Methylation status of CpG sites and methylation CpG binding proteins are involved in the promoter regulation of the mouse Xist gene
    • Allaman-Pillet N, Djemai A, Bonny C, Schorderet D F. Methylation status of CpG sites and methylation CpG binding proteins are involved in the promoter regulation of the mouse Xist gene. Gene Expr. 1998;7:61-73.
    • (1998) Gene Expr , vol.7 , pp. 61-73
    • Allaman-Pillet, N.1    Djemai, A.2    Bonny, C.3    Schorderet, D.F.4
  • 34
    • 0032932528 scopus 로고    scopus 로고
    • Tsix, a gene antisense to Xist at the X-inactivation centre
    • Lee JT, Davidow LS, Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nat Genet. 1999;21:400-404.
    • (1999) Nat Genet , vol.21 , pp. 400-404
    • Lee, J.T.1    Davidow, L.S.2    Warshawsky, D.3
  • 35
    • 0037059554 scopus 로고    scopus 로고
    • CTCF, a candidate trans-acting factor for X-inactivation choice
    • Chao W, Huynh KD, Spencer RJ, Davidow LS, Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002;295:345-347.
    • (2002) Science , vol.295 , pp. 345-347
    • Chao, W.1    Huynh, K.D.2    Spencer, R.J.3    Davidow, L.S.4    Lee, J.T.5
  • 36
    • 0030743612 scopus 로고    scopus 로고
    • DNA methylation and imprinting: Why bother?
    • Jaenisch R. DNA methylation and imprinting: Why bother? Trends Genet. 1997;13:323-329.
    • (1997) Trends Genet , vol.13 , pp. 323-329
    • Jaenisch, R.1
  • 37
    • 0027378582 scopus 로고
    • Role for DNA methylation in genomic imprinting
    • Li E, Beard C, Jaenisch R. Role for DNA methylation in genomic imprinting. Nature. 1993;366: 362-365.
    • (1993) Nature , vol.366 , pp. 362-365
    • Li, E.1    Beard, C.2    Jaenisch, R.3
  • 38
    • 0037168587 scopus 로고    scopus 로고
    • The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a
    • Chedin F, Lieber MR, Hsieh CL. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A. 2002;99:16916-16921.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16916-16921
    • Chedin, F.1    Lieber, M.R.2    Hsieh, C.L.3
  • 39
    • 0035930660 scopus 로고    scopus 로고
    • Dnmt3L and the establishment of maternal genomic imprints
    • Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH. Dnmt3L and the establishment of maternal genomic imprints. Science. 2001;294:2536-2539.
    • (2001) Science , vol.294 , pp. 2536-2539
    • Bourc'His, D.1    Xu, G.L.2    Lin, C.S.3    Bollman, B.4    Bestor, T.H.5
  • 40
    • 1242292420 scopus 로고    scopus 로고
    • Genomic instability and colon cancer
    • Grady WM. Genomic instability and colon cancer. Can Metastasis Rev. 2004;23:11-27.
    • (2004) Can Metastasis Rev , vol.23 , pp. 11-27
    • Grady, W.M.1
  • 41
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 1998;396: 643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 42
    • 0028813895 scopus 로고
    • Microsatellite instability in inherited and sporadic neoplasms
    • Eshleman JR, Markowitz SD. Microsatellite instability in inherited and sporadic neoplasms. Curr Opin Oncol. 1995;7:83-89.
    • (1995) Curr Opin Oncol , vol.7 , pp. 83-89
    • Eshleman, J.R.1    Markowitz, S.D.2
  • 43
    • 13144307115 scopus 로고
    • Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
    • Veigl ML, Kasturi L, Olechnowicz J, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci USA. 1993;95:8698-8702.
    • (1993) Proc Natl Acad Sci USA , vol.95 , pp. 8698-8702
    • Veigl, M.L.1    Kasturi, L.2    Olechnowicz, J.3
  • 44
    • 0035950541 scopus 로고    scopus 로고
    • Methylation in MLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression
    • Deng G, Chen A, Pong E, Kim YS. Methylation in MLH1 promoter interferes with its binding to transcription factor CBF and inhibits gene expression. Oncogene. 2001;20:7120-7127.
    • (2001) Oncogene , vol.20 , pp. 7120-7127
    • Deng, G.1    Chen, A.2    Pong, E.3    Kim, Y.S.4
  • 45
    • 0033816924 scopus 로고    scopus 로고
    • Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
    • Grady WM, Willis J, Guilford PJ, et al. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. Nat Genet. 2000; 26:16-17
    • (2000) Nat Genet , vol.26 , pp. 16-17
    • Grady, W.M.1    Willis, J.2    Guilford, P.J.3
  • 46
    • 1542319832 scopus 로고    scopus 로고
    • Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
    • Etoh T, Kanai Y, Ushijima S, et al. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol. 2004;164:689-699.
    • (2004) Am J Pathol , vol.164 , pp. 689-699
    • Etoh, T.1    Kanai, Y.2    Ushijima, S.3
  • 47
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science. 2003;300:489-492.
    • (2003) Science , vol.300 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Eden, A.3
  • 48
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science. 2003;300:455.
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 49
    • 0032079514 scopus 로고    scopus 로고
    • Suppression of crossing-over by DNA methylation in Ascobolus
    • Maloisel L, Rossignol JL. Suppression of crossing-over by DNA methylation in Ascobolus. Genes Dev. 1998;12:1381-1389.
    • (1998) Genes Dev , vol.12 , pp. 1381-1389
    • Maloisel, L.1    Rossignol, J.L.2
  • 50
    • 0033547330 scopus 로고    scopus 로고
    • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
    • Xu GL, Bestor TH, Bourc'his D, et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999;402:187-191.
    • (1999) Nature , vol.402 , pp. 187-191
    • Xu, G.L.1    Bestor, T.H.2    Bourc'His, D.3
  • 51
    • 0034162852 scopus 로고    scopus 로고
    • Whole-genome methylation scan in ICF syndrome: Hypomethylation of non-satellite DNA repeats D4Z4 and NBL2
    • Kondo T, Bobek MP, Kuick R, et al. Whole-genome methylation scan in ICF syndrome: hypomethylation of non-satellite DNA repeats D4Z4 and NBL2. Hum Mol Genet. 2000;9:597-604.
    • (2000) Hum Mol Genet , vol.9 , pp. 597-604
    • Kondo, T.1    Bobek, M.P.2    Kuick, R.3
  • 52
    • 0036324032 scopus 로고    scopus 로고
    • DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements
    • Ehrlich M. DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements. J Nutr. 2002;132(suppl 8):2424S-2429S.
    • (2002) J Nutr , vol.132 , Issue.SUPPL. 8
    • Ehrlich, M.1
  • 53
    • 0032030675 scopus 로고    scopus 로고
    • Jumping translocations of chromosome 1q in multiple myeloma: Evidence for a mechanism involving decondensation of pericentromeric heterochromatin
    • Sawyer JR, Tricot G, Mattox S, Jagannath S, Barlogie B. Jumping translocations of chromosome 1q in multiple myeloma: evidence for a mechanism involving decondensation of pericentromeric heterochromatin. Blood. 1998;91:1732-1741.
    • (1998) Blood , vol.91 , pp. 1732-1741
    • Sawyer, J.R.1    Tricot, G.2    Mattox, S.3    Jagannath, S.4    Barlogie, B.5
  • 54
    • 0036383067 scopus 로고    scopus 로고
    • Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?
    • Geiman TM, Robertson KD. Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together? J Cell Biochem. 2002; 87:117-125.
    • (2002) J Cell Biochem , vol.87 , pp. 117-125
    • Geiman, T.M.1    Robertson, K.D.2
  • 55
    • 12344296753 scopus 로고    scopus 로고
    • Heterochromatin: Many flavours, common themes
    • Craig JM. Heterochromatin: many flavours, common themes. BioEssays. 2005;27:17-28.
    • (2005) BioEssays , vol.27 , pp. 17-28
    • Craig, J.M.1
  • 56
    • 0036591878 scopus 로고    scopus 로고
    • The many faces of histone lysine methylation
    • Lachner M, Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002;14: 286-298.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 286-298
    • Lachner, M.1    Jenuwein, T.2
  • 57
    • 0035891265 scopus 로고    scopus 로고
    • A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
    • Tamaru H, Selker EU. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature. 2001;414:277-283.
    • (2001) Nature , vol.414 , pp. 277-283
    • Tamaru, H.1    Selker, E.U.2
  • 58
    • 0037041422 scopus 로고    scopus 로고
    • Control of CpNpG DNA methylation by the kryptonite histone H3 methyltransferase
    • Jackson JP, Lindroth AM, Cao X, Jacobsen SE. Control of CpNpG DNA methylation by the kryptonite histone H3 methyltransferase. Nature. 2002; 416:556-560.
    • (2002) Nature , vol.416 , pp. 556-560
    • Jackson, J.P.1    Lindroth, A.M.2    Cao, X.3    Jacobsen, S.E.4
  • 59
    • 0037072666 scopus 로고    scopus 로고
    • Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1
    • Gendrel AV, Lippman Z, Yordan C, Colot V, Martienssen RA. Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1. Science. 2002;297:1871-1873.
    • (2002) Science , vol.297 , pp. 1871-1873
    • Gendrel, A.V.1    Lippman, Z.2    Yordan, C.3    Colot, V.4    Martienssen, R.A.5
  • 60
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074-1080.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 62
    • 0037924433 scopus 로고    scopus 로고
    • Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
    • Bachman KE, Park BH, Rhee I, et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell. 2003;3:89-95.
    • (2003) Cancer Cell , vol.3 , pp. 89-95
    • Bachman, K.E.1    Park, B.H.2    Rhee, I.3
  • 63
    • 2342517250 scopus 로고    scopus 로고
    • Regulation of heterochromatin by histone methylation and small RNAs
    • Grewal SIS, Rice JC. Regulation of heterochromatin by histone methylation and small RNAs. Curr Opin Cell Biol. 2004;16:230-238.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 230-238
    • Grewal, S.I.S.1    Rice, J.C.2
  • 64
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004; 5:522-531.
    • (2004) Nat Rev Genet , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 65
    • 4544242851 scopus 로고    scopus 로고
    • Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
    • Kawasaki H, Taira K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature. 2004;431:211-217.
    • (2004) Nature , vol.431 , pp. 211-217
    • Kawasaki, H.1    Taira, K.2
  • 66
    • 4344705410 scopus 로고    scopus 로고
    • Small interfering RNA-induced transcriptional gene silencing in human cells
    • Morris KV, Chan SW, Jacobsen SE, Looney DJ. Small interfering RNA-induced transcriptional gene silencing in human cells. Science. 2004;305:1289-1292.
    • (2004) Science , vol.305 , pp. 1289-1292
    • Morris, K.V.1    Chan, S.W.2    Jacobsen, S.E.3    Looney, D.J.4
  • 67
    • 0034703084 scopus 로고    scopus 로고
    • Increases in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
    • Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ. Increases in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 2000;275:29318-29323.
    • (2000) J Biol Chem , vol.275 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Hine, R.J.5    James, S.J.6
  • 68
    • 0020528862 scopus 로고
    • Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks
    • Shivapurkar N, Poirier LA. Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks. Carcinogenesis. 1983;4: 1051-1057.
    • (1983) Carcinogenesis , vol.4 , pp. 1051-1057
    • Shivapurkar, N.1    Poirier, L.A.2
  • 69
    • 0026579875 scopus 로고
    • Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression
    • Wainfan E, Poirier LA. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res. 1992;52(suppl 7):2071s-2077s.
    • (1992) Cancer Res , vol.52 , Issue.SUPPL. 7
    • Wainfan, E.1    Poirier, L.A.2
  • 70
    • 0028925741 scopus 로고
    • Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats
    • Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res. 1995;55:1894-1901.
    • (1995) Cancer Res , vol.55 , pp. 1894-1901
    • Pogribny, I.P.1    Basnakian, A.G.2    Miller, B.J.3    Lopatina, N.G.4    Poirier, L.A.5    James, S.J.6
  • 71
    • 1842614152 scopus 로고    scopus 로고
    • Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues
    • Pogribny IP, James SJ, Jernigan S, Pogribna M. Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues. Mutat Res. 2004; 548:53-59.
    • (2004) Mutat Res , vol.548 , pp. 53-59
    • Pogribny, I.P.1    James, S.J.2    Jernigan, S.3    Pogribna, M.4
  • 72
    • 0031719311 scopus 로고    scopus 로고
    • Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets
    • Lopatina NG, Vanyushin BV, Cronin GM, Poirer LA. Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets. Carcinogenesis. 1998;19: 1777-1781.
    • (1998) Carcinogenesis , vol.19 , pp. 1777-1781
    • Lopatina, N.G.1    Vanyushin, B.V.2    Cronin, G.M.3    Poirer, L.A.4
  • 73
    • 0027326933 scopus 로고
    • DNA methylation in folate deficiency: Use of CpG methylase
    • Balaghi M, Wagner C. DNA methylation in folate deficiency: use of CpG methylase. Biochem Biophys Res Commun. 1993;193:1184-1190.
    • (1993) Biochem Biophys Res Commun , vol.193 , pp. 1184-1190
    • Balaghi, M.1    Wagner, C.2
  • 74
    • 0029923325 scopus 로고    scopus 로고
    • Brain folate and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate
    • Alonso-Aperte E, Varela-Moreiras G. Brain folate and DNA methylation in rats fed a choline deficient diet or treated with low doses of methotrexate. Int J Vitam Nutr Res. 1996;66:232-236.
    • (1996) Int J Vitam Nutr Res , vol.66 , pp. 232-236
    • Alonso-Aperte, E.1    Varela-Moreiras, G.2
  • 75
    • 0033933478 scopus 로고    scopus 로고
    • DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats
    • Duthie SJ, Narayanan S, Brand GM, Grant G. DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats. Eur J Nutr. 2000;39:106-111.
    • (2000) Eur J Nutr , vol.39 , pp. 106-111
    • Duthie, S.J.1    Narayanan, S.2    Brand, G.M.3    Grant, G.4
  • 77
    • 0037263628 scopus 로고    scopus 로고
    • Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice
    • Trasler J, Deng L, Melnuk S, et al. Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice. Carcinogenesis. 2003;24:39-45.
    • (2003) Carcinogenesis , vol.24 , pp. 39-45
    • Trasler, J.1    Deng, L.2    Melnuk, S.3
  • 78
    • 0031022797 scopus 로고    scopus 로고
    • Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene
    • Kim YI, Pogribny IP, Basnakian AG, et al. Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am J Clin Nutr. 1997;65:46-52.
    • (1997) Am J Clin Nutr , vol.65 , pp. 46-52
    • Kim, Y.I.1    Pogribny, I.P.2    Basnakian, A.G.3
  • 79
    • 1842425969 scopus 로고    scopus 로고
    • Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    • Choi SW, Friso S, Ghandour G, Bagley PJ, Selhub J, Mason JB. Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. J Nutr. 2004; 134:750-755.
    • (2004) J Nutr , vol.134 , pp. 750-755
    • Choi, S.W.1    Friso, S.2    Ghandour, G.3    Bagley, P.J.4    Selhub, J.5    Mason, J.B.6
  • 80
    • 0028898669 scopus 로고
    • Methyl donors in the diet and responses to chemical carcinogens
    • Rogers AE. Methyl donors in the diet and responses to chemical carcinogens. Am J Clin Nutr. 1995;61(suppl 3):659S-665S.
    • (1995) Am J Clin Nutr , vol.61 , Issue.SUPPL. 3
    • Rogers, A.E.1
  • 81
    • 0036327615 scopus 로고    scopus 로고
    • Diet, methyl donors and DNA methylation: Interactions between dietary folate, methionine and choline
    • Niculescu MD, Zeisel SH. Diet, methyl donors and DNA methylation: Interactions between dietary folate, methionine and choline. J Nutr. 2002; 132(suppl 8):2333S-2335S.
    • (2002) J Nutr , vol.132 , Issue.SUPPL. 8
    • Niculescu, M.D.1    Zeisel, S.H.2
  • 82
    • 0242610894 scopus 로고    scopus 로고
    • Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis
    • James SJ, Pogribny IP, Pogribna M, Miller BJ, Jernigan S, Melnyk S. Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr. 2003;133(11 suppl 1): 3740S-3747S.
    • (2003) J Nutr , vol.133 , Issue.11 SUPPL. 1
    • James, S.J.1    Pogribny, I.P.2    Pogribna, M.3    Miller, B.J.4    Jernigan, S.5    Melnyk, S.6
  • 83
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in post-menopausal women
    • Jacob RA, Gretz DM, Taylor PC, et al. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in post-menopausal women. J Nutr. 1998;128:1204-1212.
    • (1998) J Nutr , vol.128 , pp. 1204-1212
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3
  • 84
    • 0033805888 scopus 로고    scopus 로고
    • Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
    • Rampersaud GC, Kauwell GP, Hutson AD, Cerda JJ, Bailey LB. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. Am J Clin Nutr. 2000;72:998-1003.
    • (2000) Am J Clin Nutr , vol.72 , pp. 998-1003
    • Rampersaud, G.C.1    Kauwell, G.P.2    Hutson, A.D.3    Cerda, J.J.4    Bailey, L.B.5
  • 85
    • 0038523843 scopus 로고    scopus 로고
    • Folate status, genomic DNA hypomethylation, a risk of colorectal adenoma and cancer: A case control study
    • Pufulete M, Al-Ghnaniem R, Leather AJ, et al. Folate status, genomic DNA hypomethylation, a risk of colorectal adenoma and cancer: a case control study. Gastroenterology. 2003;124:1240-1248.
    • (2003) Gastroenterology , vol.124 , pp. 1240-1248
    • Pufulete, M.1    Al-Ghnaniem, R.2    Leather, A.J.3
  • 87
    • 0031005975 scopus 로고    scopus 로고
    • Relationship of plasma folic acid and status of DNA methylation in human gastric cancer
    • Fang JY, Xiao SD, Zhu SS, Yuan JM, Qiu DK, Jiang SJ. Relationship of plasma folic acid and status of DNA methylation in human gastric cancer. J Gastroenterol. 1997;32:171-175.
    • (1997) J Gastroenterol , vol.32 , pp. 171-175
    • Fang, J.Y.1    Xiao, S.D.2    Zhu, S.S.3    Yuan, J.M.4    Qiu, D.K.5    Jiang, S.J.6
  • 88
    • 0037117501 scopus 로고    scopus 로고
    • A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    • Friso S, Choi SW, Girelli D, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A. 2002;99:5606-5611.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 5606-5611
    • Friso, S.1    Choi, S.W.2    Girelli, D.3
  • 89
    • 0027946745 scopus 로고
    • DNA methylation as an intermediate in colorectal cancer: Modulation by folic acid supplementation
    • Cravo M, Fidalgo P, Pereira AD, et al. DNA methylation as an intermediate in colorectal cancer: modulation by folic acid supplementation. Eur J Cancer Prev. 1994;3:473-479.
    • (1994) Eur J Cancer Prev , vol.3 , pp. 473-479
    • Cravo, M.1    Fidalgo, P.2    Pereira, A.D.3
  • 90
    • 0035133904 scopus 로고    scopus 로고
    • Effects of folate supplementation on two provisional molecular makers of colon cancer: A prospective, randomized trial
    • Kim YI, Baik HW, Fawaz K, et al. Effects of folate supplementation on two provisional molecular makers of colon cancer: a prospective, randomized trial. Am J Gastroenterol. 2001;96:184-195.
    • (2001) Am J Gastroenterol , vol.96 , pp. 184-195
    • Kim, Y.I.1    Baik, H.W.2    Fawaz, K.3
  • 91
    • 0038663165 scopus 로고    scopus 로고
    • Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia
    • Ingrosso D, Cimmino A, Perna AF, et al. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet. 2003;361:1693-1699.
    • (2003) Lancet , vol.361 , pp. 1693-1699
    • Ingrosso, D.1    Cimmino, A.2    Perna, A.F.3
  • 92
    • 0033635671 scopus 로고    scopus 로고
    • Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
    • Duthie SJ, Narayanan S, Blum S, Pirie L, Brand GM. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer. 2000;37: 245-251.
    • (2000) Nutr Cancer , vol.37 , pp. 245-251
    • Duthie, S.J.1    Narayanan, S.2    Blum, S.3    Pirie, L.4    Brand, G.M.5
  • 93
    • 0031903189 scopus 로고    scopus 로고
    • Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults
    • Fenech M, Aitken C, Rinaldi J. Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998;19:1163-1171.
    • (1998) Carcinogenesis , vol.19 , pp. 1163-1171
    • Fenech, M.1    Aitken, C.2    Rinaldi, J.3
  • 94
    • 0028915657 scopus 로고
    • Folate status, DNA methylation and colon cancer risk in inflammatory bowel disease
    • Cravo M, Gloria L, Salazar De Sousa L, et al. Folate status, DNA methylation and colon cancer risk in inflammatory bowel disease. Clin Nutr. 1995;14: 50-53.
    • (1995) Clin Nutr , vol.14 , pp. 50-53
    • Cravo, M.1    Gloria, L.2    Salazar De Sousa, L.3
  • 95
    • 0031775688 scopus 로고    scopus 로고
    • Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: Correlation with nutrient intake
    • Cravo ML, Pinto AG, Chaves P, et al. Effect of folate supplementation on DNA methylation of rectal mucosa in patients with colonic adenomas: correlation with nutrient intake. Clin Nutr. 1998;17: 45-49.
    • (1998) Clin Nutr , vol.17 , pp. 45-49
    • Cravo, M.L.1    Pinto, A.G.2    Chaves, P.3
  • 96
    • 2942574352 scopus 로고    scopus 로고
    • Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer?
    • Kim YI. Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer? Cancer Epidimiol Biomarkers Prev. 2004; 13:511-519.
    • (2004) Cancer Epidimiol Biomarkers Prev , vol.13 , pp. 511-519
    • Kim, Y.I.1
  • 97
    • 0038671834 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase 677C→T variant modulates folate status response to controlled folate intakes in young women
    • Guinotte CL, Burns MG, Axume JA, et al. Methylenetetrahydrofolate reductase 677C→T variant modulates folate status response to controlled folate intakes in young women. J Nutr. 2003;133: 1272-1280.
    • (2003) J Nutr , vol.133 , pp. 1272-1280
    • Guinotte, C.L.1    Burns, M.G.2    Axume, J.A.3
  • 98
    • 0034743914 scopus 로고    scopus 로고
    • The 1298 A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine
    • Weisberg IS, Jacques PF, Selhub J, et al. The 1298 A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. 2001; 156:409-415.
    • (2001) Atherosclerosis , vol.156 , pp. 409-415
    • Weisberg, I.S.1    Jacques, P.F.2    Selhub, J.3
  • 99
    • 0032713815 scopus 로고    scopus 로고
    • Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
    • Harmon DL, Shields DC, Woodside JV, et al. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol. 1999;17:298-309.
    • (1999) Genet Epidemiol , vol.17 , pp. 298-309
    • Harmon, D.L.1    Shields, D.C.2    Woodside, J.V.3
  • 100
    • 0033999287 scopus 로고    scopus 로고
    • Polygenic influence on plasma homocysteine: Association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A2756G of methionine synthase, with lowered plasma homocysteine levels
    • Tsai MY, Bignell M, Yang F, Welge BG, Graham KJ, Hanson NQ. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A2756G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis. 2000;149:131-137.
    • (2000) Atherosclerosis , vol.149 , pp. 131-137
    • Tsai, M.Y.1    Bignell, M.2    Yang, F.3    Welge, B.G.4    Graham, K.J.5    Hanson, N.Q.6
  • 101
    • 0038692043 scopus 로고    scopus 로고
    • Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event
    • Yates Z, Lucock M. Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol Genet Metab. 2003;79:201-213.
    • (2003) Mol Genet Metab , vol.79 , pp. 201-213
    • Yates, Z.1    Lucock, M.2
  • 102
    • 1442300286 scopus 로고    scopus 로고
    • Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: A HuGE review
    • Sharp L, Little J. Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: A HuGE review. Am J Epidemiol. 2004;159:423-443.
    • (2004) Am J Epidemiol , vol.159 , pp. 423-443
    • Sharp, L.1    Little, J.2
  • 103
    • 1642568671 scopus 로고    scopus 로고
    • Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk
    • Goode EL, Potter JD, Bigler J, Ulrich CM. Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2004;13:157-162.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 157-162
    • Goode, E.L.1    Potter, J.D.2    Bigler, J.3    Ulrich, C.M.4
  • 104
    • 0345060474 scopus 로고    scopus 로고
    • Esophageal and gastric cardia cancer risk and folate-and vitamin B12-related polymorphisms in Linxian, China
    • Stolzenberg-Solomon R, Qiao YL, Abnet CC, et al. Esophageal and gastric cardia cancer risk and folate-and vitamin B12-related polymorphisms in Linxian, China. Cancer Epidemiol Biomarkers Prev. 2003;12(11 part 1):1222-1226.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , Issue.11 PART 1 , pp. 1222-1226
    • Stolzenberg-Solomon, R.1    Qiao, Y.L.2    Abnet, C.C.3
  • 105
    • 0036278536 scopus 로고    scopus 로고
    • A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability
    • Shannon B, Gnanasampanthan S, Beilby J, Iacopetta B. A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut. 2002;50:520-524.
    • (2002) Gut , vol.50 , pp. 520-524
    • Shannon, B.1    Gnanasampanthan, S.2    Beilby, J.3    Iacopetta, B.4
  • 106
    • 0037308777 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer
    • Tseng TL, Shih YP, Huang YC, et al. Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer. Cancer Res. 2003;63:647-654.
    • (2003) Cancer Res , vol.63 , pp. 647-654
    • Tseng, T.L.1    Shih, Y.P.2    Huang, Y.C.3
  • 107
    • 0035902856 scopus 로고    scopus 로고
    • Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
    • Cho M, Uemura H, Kim SC, et al. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma. Br J Cancer. 2001;85:563-567.
    • (2001) Br J Cancer , vol.85 , pp. 563-567
    • Cho, M.1    Uemura, H.2    Kim, S.C.3
  • 108
    • 0032532092 scopus 로고    scopus 로고
    • Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia
    • Esteller M, Corn PG, Urena JM, et al. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. Cancer Res. 1998;58:4515-4518.
    • (1998) Cancer Res , vol.58 , pp. 4515-4518
    • Esteller, M.1    Corn, P.G.2    Urena, J.M.3
  • 110
    • 0035476868 scopus 로고    scopus 로고
    • Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma
    • Morrissey C, Martinez A, Zatyka M, et al. Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Res. 2001;61:7277-7281.
    • (2001) Cancer Res , vol.61 , pp. 7277-7281
    • Morrissey, C.1    Martinez, A.2    Zatyka, M.3
  • 111
    • 3242725748 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients
    • Cairns P. Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients. Ann N Y Acad Sci. 2004;1022:40-43.
    • (2004) Ann N Y Acad Sci , vol.1022 , pp. 40-43
    • Cairns, P.1
  • 112
    • 3442894720 scopus 로고    scopus 로고
    • Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer
    • Hoque MO, Begum S, Topaloglu O, et al. Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer. Cancer Res. 2004; 64:5511-5517.
    • (2004) Cancer Res , vol.64 , pp. 5511-5517
    • Hoque, M.O.1    Begum, S.2    Topaloglu, O.3
  • 113
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21:5400-5413.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 114
    • 9944233064 scopus 로고    scopus 로고
    • Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis
    • Chalitchagorn K, Shuangshoti S, Hourpai N, et al. Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene. 2004;23:8841-8846.
    • (2004) Oncogene , vol.23 , pp. 8841-8846
    • Chalitchagorn, K.1    Shuangshoti, S.2    Hourpai, N.3
  • 115
    • 20544458020 scopus 로고    scopus 로고
    • DNA hypomethylation is prevalent even in low-grade breast cancers
    • Jackson K, Yu MC, Arakawa K, et al. DNA hypomethylation is prevalent even in low-grade breast cancers. Cancer Biol Ther. 2004;3:1225-1231.
    • (2004) Cancer Biol Ther , vol.3 , pp. 1225-1231
    • Jackson, K.1    Yu, M.C.2    Arakawa, K.3
  • 116
    • 3042822370 scopus 로고    scopus 로고
    • DNA hypomethylation and ovarian cancer biology
    • Widschwendter M, Jiang G, Woods C, et al. DNA hypomethylation and ovarian cancer biology. Cancer Res. 2004;64:4472-4480.
    • (2004) Cancer Res , vol.64 , pp. 4472-4480
    • Widschwendter, M.1    Jiang, G.2    Woods, C.3
  • 117
    • 0035932393 scopus 로고    scopus 로고
    • Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
    • Agathanggelou A, Honorio S, Macartney DP, et al. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene. 2001;20:1509-1518.
    • (2001) Oncogene , vol.20 , pp. 1509-1518
    • Agathanggelou, A.1    Honorio, S.2    Macartney, D.P.3
  • 119
    • 16544378577 scopus 로고    scopus 로고
    • Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas
    • Kobatake T, Yano M, Toyooka S, et al. Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas. Oncol Rep. 2004;12:1087-1092.
    • (2004) Oncol Rep , vol.12 , pp. 1087-1092
    • Kobatake, T.1    Yano, M.2    Toyooka, S.3
  • 120
    • 0028111446 scopus 로고
    • Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma
    • Kim YI, Giuliano A, Hatch KD, et al. Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma. Cancer. 1994;74: 893-899.
    • (1994) Cancer , vol.74 , pp. 893-899
    • Kim, Y.I.1    Giuliano, A.2    Hatch, K.D.3
  • 121
    • 1942508904 scopus 로고    scopus 로고
    • Detection of hypermethylated genes in tumor and plasma of cervical cancer patients
    • Yang HJ, Liu VW, Wang Y, et al. Detection of hypermethylated genes in tumor and plasma of cervical cancer patients. Gynecol Oncol. 2004;93: 435-440.
    • (2004) Gynecol Oncol , vol.93 , pp. 435-440
    • Yang, H.J.1    Liu, V.W.2    Wang, Y.3
  • 122
    • 0026534104 scopus 로고
    • Methylation patterns of long interspersed repeated DNA and alphoid repetitive DNA from human cell lines and tumors
    • Dante R, Dante-Paire J, Rigal D, Roizes G. Methylation patterns of long interspersed repeated DNA and alphoid repetitive DNA from human cell lines and tumors. Anticancer Res. 1992;12:559-563.
    • (1992) Anticancer Res , vol.12 , pp. 559-563
    • Dante, R.1    Dante-Paire, J.2    Rigal, D.3    Roizes, G.4
  • 123
    • 1242285594 scopus 로고    scopus 로고
    • Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
    • Suter CM, Martin DI, Ward RL. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis. 2004;19: 95-101.
    • (2004) Int J Colorectal Dis , vol.19 , pp. 95-101
    • Suter, C.M.1    Martin, D.I.2    Ward, R.L.3
  • 125
    • 3142556380 scopus 로고    scopus 로고
    • Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer
    • Arnold CN, Goel A, Compton C, et al. Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer. Cancer Biol Ther. 2004;3:73-78.
    • (2004) Cancer Biol Ther , vol.3 , pp. 73-78
    • Arnold, C.N.1    Goel, A.2    Compton, C.3
  • 126
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet. 2000;24:132-138.
    • (2000) Nat Genet , vol.24 , pp. 132-138
    • Costello, J.F.1    Fruhwald, M.C.2    Smiraglia, D.J.3
  • 127
    • 4644363411 scopus 로고    scopus 로고
    • Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines
    • Ku JL, Kang SB, Shin YK, et al. Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene. 2004;23:6736-6742.
    • (2004) Oncogene , vol.23 , pp. 6736-6742
    • Ku, J.L.1    Kang, S.B.2    Shin, Y.K.3
  • 128
    • 0033135573 scopus 로고    scopus 로고
    • High frequency of alterations in DNA methylation in adenocarcinoma of the prostate
    • Santourlidis S, Florl A, Ackermann R, Wirtz HC, Schulz WA. High frequency of alterations in DNA methylation in adenocarcinoma of the prostate. Prostate. 1999;39:166-174.
    • (1999) Prostate , vol.39 , pp. 166-174
    • Santourlidis, S.1    Florl, A.2    Ackermann, R.3    Wirtz, H.C.4    Schulz, W.A.5
  • 129
    • 0036022068 scopus 로고    scopus 로고
    • Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
    • Schulz WA, Elo JP, Florl AR, et al. Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma. Genes Chromosomes Cancer. 2002;35:58-65.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 58-65
    • Schulz, W.A.1    Elo, J.P.2    Florl, A.R.3
  • 130
    • 0028152397 scopus 로고
    • Cytidine methylation of regulatory sequences near the π-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
    • Lee W-H, Morton RA, Epstein JI, et al. Cytidine methylation of regulatory sequences near the π-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci U S A. 1994;91:11733-11737.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 11733-11737
    • Lee, W.-H.1    Morton, R.A.2    Epstein, J.I.3
  • 131
    • 0033950894 scopus 로고    scopus 로고
    • Frequent methylation of estrogen receptor in prostate cancer: Correlation with tumor progression
    • Li LC, Chui R, Nakajima K, Oh BR, Au HC, Dahiya R. Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression. Cancer Res. 2000;60:702-706.
    • (2000) Cancer Res , vol.60 , pp. 702-706
    • Li, L.C.1    Chui, R.2    Nakajima, K.3    Oh, B.R.4    Au, H.C.5    Dahiya, R.6
  • 132
    • 7644240707 scopus 로고    scopus 로고
    • Hypermethylation of the CpG islands in the promoter region of the GSTP1 gene in prostate cancer: A useful diagnostic and prognostic marker?
    • Bernardini S, Miano R, Iori R, et al. Hypermethylation of the CpG islands in the promoter region of the GSTP1 gene in prostate cancer: a useful diagnostic and prognostic marker? Clin Chim Acta. 2004;350:181-188.
    • (2004) Clin Chim Acta , vol.350 , pp. 181-188
    • Bernardini, S.1    Miano, R.2    Iori, R.3
  • 133
    • 0033814412 scopus 로고    scopus 로고
    • Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis
    • Takai D, Yagi Y, Habib N, Sugimura T, Ushijima T. Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn J Clin Oncol. 2000;30: 306-309.
    • (2000) Jpn J Clin Oncol , vol.30 , pp. 306-309
    • Takai, D.1    Yagi, Y.2    Habib, N.3    Sugimura, T.4    Ushijima, T.5
  • 134
    • 3042707323 scopus 로고    scopus 로고
    • Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    • Yu J, Ni M, Xu J, et al. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer. 2002;2:29.
    • (2002) BMC Cancer , vol.2 , pp. 29
    • Yu, J.1    Ni, M.2    Xu, J.3
  • 135
    • 0037531563 scopus 로고    scopus 로고
    • Distinct methylation profiles of glioma subtypes
    • Uhlmann K, Rohde K, Zeller C. Distinct methylation profiles of glioma subtypes. Int J Cancer. 2003; 106:52-59.
    • (2003) Int J Cancer , vol.106 , pp. 52-59
    • Uhlmann, K.1    Rohde, K.2    Zeller, C.3
  • 136
    • 0037434432 scopus 로고    scopus 로고
    • CpG island methylation status and mutation analysis of the RBI gene essential promoter region and protein-binding pocket domain in nervous system tumours
    • Gonzalez-Gomez P, Bello MJ, Alonso ME, et al. CpG island methylation status and mutation analysis of the RBI gene essential promoter region and protein-binding pocket domain in nervous system tumours. Br J Cancer. 2003;88:109-114.
    • (2003) Br J Cancer , vol.88 , pp. 109-114
    • Gonzalez-Gomez, P.1    Bello, M.J.2    Alonso, M.E.3
  • 137
    • 0034652596 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
    • Sanchez-Cespedes M, Esteller M, Wu L, et al. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res. 2000;60:892-895.
    • (2000) Cancer Res , vol.60 , pp. 892-895
    • Sanchez-Cespedes, M.1    Esteller, M.2    Wu, L.3
  • 138
    • 0025755712 scopus 로고
    • DNA methylation changes in human testicular cancer
    • Peltomaki P. DNA methylation changes in human testicular cancer. Biochim Biophys Acta. 1991; 1096:187-196.
    • (1991) Biochim Biophys Acta , vol.1096 , pp. 187-196
    • Peltomaki, P.1
  • 139
    • 0037069927 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene in testicular cancer
    • Smith-Sorensen B, Lind GE, Skotheim RI, et al. Frequent promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene in testicular cancer. Oncogene. 2002;21:8878-8884.
    • (2002) Oncogene , vol.21 , pp. 8878-8884
    • Smith-Sorensen, B.1    Lind, G.E.2    Skotheim, R.I.3
  • 140
    • 0029751130 scopus 로고    scopus 로고
    • Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma
    • Jurgens B, Schmitz-Drager BJ, Schulz WA. Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma. Cancer Res. 1996;56: 5698-5703.
    • (1996) Cancer Res , vol.56 , pp. 5698-5703
    • Jurgens, B.1    Schmitz-Drager, B.J.2    Schulz, W.A.3
  • 141
    • 4744370521 scopus 로고    scopus 로고
    • CpG island methylation in Schistosoma and non-Schistosoma-associated bladder cancer
    • Gutierrez MI, Siraj AK, Khaled H, Koon N, El-Rifai W, Bhatia K. CpG island methylation in Schistosoma and non-Schistosoma-associated bladder cancer. Mod Pathol. 2004;17:1268-1274.
    • (2004) Mod Pathol , vol.17 , pp. 1268-1274
    • Gutierrez, M.I.1    Siraj, A.K.2    Khaled, H.3    Koon, N.4    El-Rifai, W.5    Bhatia, K.6
  • 142
    • 0034669126 scopus 로고    scopus 로고
    • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma
    • Kawakami K, Brabender J, Lord RV, et al. Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. J Natl Cancer Inst. 2000;92:1805-1811.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1805-1811
    • Kawakami, K.1    Brabender, J.2    Lord, R.V.3
  • 143
    • 0037390127 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and lymph nodes of stage 1 lung cancer patients
    • Harden SV, Tokumaru Y, Westra WH, et al. Gene promoter hypermethylation in tumors and lymph nodes of stage 1 lung cancer patients. Clin Cancer Res. 2003;9:1370-1375.
    • (2003) Clin Cancer Res , vol.9 , pp. 1370-1375
    • Harden, S.V.1    Tokumaru, Y.2    Westra, W.H.3
  • 144
    • 5044225016 scopus 로고    scopus 로고
    • METH-2 silencing and promoter hypermethylation in NSCLC
    • Dunn JR, Panutsopulos D, Shaw MW, et al. METH-2 silencing and promoter hypermethylation in NSCLC. Br J Cancer. 2004;91:1149-1154.
    • (2004) Br J Cancer , vol.91 , pp. 1149-1154
    • Dunn, J.R.1    Panutsopulos, D.2    Shaw, M.W.3
  • 145
    • 0036141349 scopus 로고    scopus 로고
    • Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    • Rosty C, Ueki T, Argani P, et al. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol. 2002;160:45-50.
    • (2002) Am J Pathol , vol.160 , pp. 45-50
    • Rosty, C.1    Ueki, T.2    Argani, P.3
  • 146
    • 0042674172 scopus 로고    scopus 로고
    • Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
    • Sato N, Maitra A, Fukushima N, et al. Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res. 2003;63:4158-4166.
    • (2003) Cancer Res , vol.63 , pp. 4158-4166
    • Sato, N.1    Maitra, A.2    Fukushima, N.3
  • 147
    • 4143090637 scopus 로고    scopus 로고
    • Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer
    • Sakai M, Hibi K, Koshikawa K, et al. Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer. Cancer Sci. 2004;95: 588-591.
    • (2004) Cancer Sci , vol.95 , pp. 588-591
    • Sakai, M.1    Hibi, K.2    Koshikawa, K.3
  • 148
    • 0642345170 scopus 로고    scopus 로고
    • DNA demethylation is directly related to tumour progression: Evidence in normal, pre-malignant and malignant cells from uterine cervix samples
    • de Capoa A, Musolino A, Della Rosa S, et al. DNA demethylation is directly related to tumour progression: evidence in normal, pre-malignant and malignant cells from uterine cervix samples. Oncol Rep. 2003;10:545-549.
    • (2003) Oncol Rep , vol.10 , pp. 545-549
    • De Capoa, A.1    Musolino, A.2    Della Rosa, S.3
  • 149
    • 0033535612 scopus 로고    scopus 로고
    • A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer
    • Strathdee G, MacKean MJ, Illand M, Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene. 1999;18:2335-2341.
    • (1999) Oncogene , vol.18 , pp. 2335-2341
    • Strathdee, G.1    MacKean, M.J.2    Illand, M.3    Brown, R.4
  • 150
    • 4644271551 scopus 로고    scopus 로고
    • Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients
    • Ibanez de Caceres I, Battagli C, Esteller M, et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res. 2004; 64:6476-6481.
    • (2004) Cancer Res , vol.64 , pp. 6476-6481
    • Ibanez De Caceres, I.1    Battagli, C.2    Esteller, M.3
  • 151
    • 0032403478 scopus 로고    scopus 로고
    • Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
    • Nakayama M, Wada M, Harada T, et al. Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood. 1998;92: 4296-4307.
    • (1998) Blood , vol.92 , pp. 4296-4307
    • Nakayama, M.1    Wada, M.2    Harada, T.3
  • 153
    • 1142275253 scopus 로고    scopus 로고
    • Frequent hypomethylation in multiple promoter CpG islands is associated with frequent promoter hypermethylation
    • Kaneda A, Tsukamoto T, Takamura-Enya T, et al. Frequent hypomethylation in multiple promoter CpG islands is associated with frequent promoter hypermethylation. Cancer Sci. 2004;95:58-64.
    • (2004) Cancer Sci , vol.95 , pp. 58-64
    • Kaneda, A.1    Tsukamoto, T.2    Takamura-Enya, T.3
  • 154
    • 0026008102 scopus 로고
    • Recognition of unusual DNA structures by human DNA (cytosine-5) methyltransferase
    • Smith SS, Kan JL, Baker DJ, Kaplan BE, Dembek P. Recognition of unusual DNA structures by human DNA (cytosine-5) methyltransferase. J Mol Biol. 1991;217:39-51.
    • (1991) J Mol Biol , vol.217 , pp. 39-51
    • Smith, S.S.1    Kan, J.L.2    Baker, D.J.3    Kaplan, B.E.4    Dembek, P.5
  • 155
    • 0032498270 scopus 로고    scopus 로고
    • Stalling of human DNA (cytosine-5) methyltransferase at single-strand conformers from a site of dynamic mutation
    • Kho MR, Baker DJ, Laayoun A, Smith SS. Stalling of human DNA (cytosine-5) methyltransferase at single-strand conformers from a site of dynamic mutation. J Mol Biol. 1998;275:67-79.
    • (1998) J Mol Biol , vol.275 , pp. 67-79
    • Kho, M.R.1    Baker, D.J.2    Laayoun, A.3    Smith, S.S.4
  • 156
    • 0036135014 scopus 로고    scopus 로고
    • Cooper-ativity between DNA methyltransferases in the maintenance methylation of repetitive elements
    • Liang G, Chan MF, Tomigahara Y, et al. Cooper-ativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002;22:480-491.
    • (2002) Mol Cell Biol , vol.22 , pp. 480-491
    • Liang, G.1    Chan, M.F.2    Tomigahara, Y.3
  • 157
    • 18344390653 scopus 로고    scopus 로고
    • DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    • Rhee I, Bachman KE, Park BH, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002;416:552-556.
    • (2002) Nature , vol.416 , pp. 552-556
    • Rhee, I.1    Bachman, K.E.2    Park, B.H.3
  • 158
    • 0033153303 scopus 로고    scopus 로고
    • The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors
    • Robertson KD, Uzvolgyi E, Liang G, et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999;27:2291-2298.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2291-2298
    • Robertson, K.D.1    Uzvolgyi, E.2    Liang, G.3
  • 159
    • 0037162542 scopus 로고    scopus 로고
    • Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis
    • Saito Y, Kanai T, Sakamoto M, Saito H, Ishii H, Hirohashi S. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. Proc Natl Acad Sci U S A. 2002;99: 10060-10065.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10060-10065
    • Saito, Y.1    Kanai, T.2    Sakamoto, M.3    Saito, H.4    Ishii, H.5    Hirohashi, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.