Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women

Journal of Nutrition

Volumn 128, Issue 7, 1998, Pages 1204-1212

  Jacob, Robert A ^a   Gretz, Denise M ^a   Taylor, Peter C ^a   James, S Jill ^b   Pogribny, Igor P ^b   Miller, Barbara J ^b   Henning, Susanne M ^c   Swendseid, Marian E ^c  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA; Folic acid; Homocysteine; Humans; Methylation

Indexed keywords

DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA; FOLIC ACID; HOMOCYSTEINE; MITOGENIC AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE; THYMIDINE TRIPHOSPHATE; URACIL;

ADULT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA METHYLATION; DNA REPAIR; FEMALE; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE ACTIVATION; NORMAL HUMAN; POSTMENOPAUSE; VITAMIN INTAKE;

EID: 0031816123     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.7.1204     Document Type: Article

References (48)

1. Araki, A. & Sako, Y. (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 442: 43-52.
2. Ausebel, F. M., Brent, R., Kingston, R. E., Moore, D. D. Seidman, J. G. & Smith, J. A. (1989) 1, 3.5.9(a) and 2.2.3(b). In: Current Protocols in Molecular Biology, Wiley-Interscience, New York, NY.
3. Balaghi, M. & Wagner, C. (1993) DNA methylation in folate deficiency - use of CpG methylase. Biochem. Biophys. Res. Commun. 193: 1184-1190.
4. Basnakian, A. G. & James, S. J. (1996) Quantification of 3' OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay. DNA Cell Biol. 15: 255-262.
5. Blakley, R. L. (1969) The Biochemistry of Folic Acid and Related Pteridines, pp. 92-94. Wiley, New York, NY.
6. Blount, B. C., Mack, M. M., Wehr, C. M., MacGregor, J. T., Hiatt, R. A., Wang, G., Wickramasinghe, S. N., Everson, R. B. & Ames, B. N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl. Acad. Sci. U.S.A. 94: 3290-3295.
7. Boushey, C. J., Beresford, S.A.A., Omen, G. S. & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J. Am. Med. Assoc. 274: 1049-1057.
8. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 97: 77-89.
9. Chirico, S. (1994) High-performance liquid chromatography-based thiobarbituric acid tests. Methods Enzymol. 233: 314-318.
10. Dudman, N.P.B., Wilcken, D.E.L. & Stocker, R. (1993) Circulating lipid hydroperoxide levels in human hyperhomocysteinemia - relevance to development of arteriosclerosis. Arterioscler. Thromb. 13: 512-516.
11. Durand, P., Prost, M. & Blache, D. (1996) Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis 121: 231-243.
12. Fang J. Y., Xiao, S. D., Zhu, S. S., Yuan, J. M., Qiu, D. K. & Jiang, S. J. (1997) Relationship of plasma folic acid and status of DNA methylation in human gastric cancer. J. Gastroenterol. 32: 171-175.
13. Freeman, J. J., Choi, R. L. & Jenden, D. J. (1975) Plasma choline: its turnover and exchange with brain choline. J. Neurochem. 24: 729-734.
14. Glantz, S. A. (1992) Primer of Biostatistics, 3rd ed. McGraw Hill, Inc., New York, NY.
15. Glynn, S. A. & Albanes, D. (1994) Folate and cancer: a review of the literature. Nutr. Cancer 22: 101-119.
16. Halliwell, B. & Chirico, S. (1993) Lipid peroxidation: its mechanism, measurement, and significance, Am. J. Clin. Nutr. 57 (suppl.) :715s-725s.
17. Henning, S. M., Swendseid, M. E. & Coulson, W. F. (1997) Male rats fed methyl-and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly (ADP-ribose) polymerase activity. J. Nutr. 127: 30-36.
18. Herbert, V. (1959) The Megaloblastic Anemias. Grime and Stratton, New York, NY.
19. Herbert, V. & Das, K. (1994) Folic acid and vitamin B-12. In: Modern Nutrition in Health and Disease, 8th ed. (Shils, M. E., Olson, J. A. & Shike, M., eds.), vol. 1, pp. 402-425. Lea and Febiger, Philadelphia, PA.
20. Jacob, R. A., Pianalto, F. S., Henning, S. H., Zhang, J. Z. & Swendseid, M. E. (1995) In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction. J. Nutr. 125: 1495-1502.
21. Jacob, R. A., Wu, M. M., Henning, S. M. & Swendseid, M. E. (1994) Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction. J. Nutr. 124: 1072-1080.
22. James, S. J., Basnakian, A. G., & Miller, B. J. (1994a) In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res. 54: 5075-5080.
23. James, S. J., Cross, D. R. & Miller, B. J., (1992) Alterations in nucleotide pools in rats fed diets deficient in choline, methionine, and/or folic acid. Carcinogenesis 13: 2471-2474.
24. James. S. J., Miller, B. J., Basnakian, A. G., Pogribny, I. P., Pogribna, M. & Muskhelishvili, L. (1997) Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis 18: 287-293.
25. James, S. J., Miller, B. J., Cross, D. R., Mcgarrity, L. J. & Morris, S. M. (1993) The essentiality of folate for the maintenance of deoxynucleotide precursor pools, DNA synthesis, and cell cycle progression in PHA-stimulated lymphocytes. Environ. Health Perspect. 101: 173-178.
26. James, S. J., Miller, B. J., Mcgarrity, L. J. & Morris, S. M. (1994b) The effect of folic acid and/or methionine deficiency on deoxyribonucleotide pools and cell cycle distribution in mitogen-stimulated rat lymphocytes. Cell Prolif. 27: 395-406.
27. James, S. J. & Yin, L. (1989) Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats. Carcinogenesis 10: 1209-1214.
28. Jones, B. G., Rose, F. A. & Tudball, N. (1994) Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis 105: 165-170.
29. Kim, Y.-I. & Christman, J. K. (1995) Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats. Am. J. Clin. Nutr. 61: 1083-1090.
30. Kim, Y.-I., Pogribny, I. P., Basnakian, A. G., Miller, J. W., Selhub, J., James, S. J. & Mason, J. B. (1997) Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. Am. J. Clin. Nutr. 65: 46-52.
31. Kroll, M. H., Chesler, R., Hagengruber, C., Blank, D. W., Kestner, J. & Rawe, M. (1986) Automated determination of urinary creatinine without sample dilution: theory and practice. Clin. Chem. 32: 446-452.
32. MacGregor, J. T., Wehr, C. M., Hiatt, R. A., Peters, B., Tucker, J. D., Langlois, R. G., Jacob, R. A., Jensen, R. H., Yager, J. W., Shigenaga, M. K., Frei, B., Eynon, B. P. & Ames, B. N. (1997) "Spontaneous" genetic damage in man: evaluation of interindividual variability, relationship among markers of damage and influence of nutritional status. Mutat. Res. 377: 125-135.
33. Murphy, J. R. (1973) Influence of temperature and method of centrifugation on the separation of erythrocytes. J. Lab. Clin. Med. 82: 334-341
34. National Research Council (1989) Recommended Dietary Allowances, 10th ed. National Academy Press, Washington, DC.
35. O'Keefe, C. A., Bailey, L. B., Thomas, E. A., Hofler, S. A., Davis, B. A., Cerda, J. J. & Gregory, J. F. III. (1995) Controlled dietary folate affects folate status in nonpregnant women. J. Nutr 125: 2717-2725.
36. Olzewski, A. J. & McCully, K. S. (1993) Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radical Biol. Med. 14: 683-693.
37. Pogribny, I. P., Basnakian, A. G., Miller, B. J., Lopatina, N. G., Poirier, L. A. & James, S. J. (1995) DNA strand breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats. Cancer Res. 55: 1894-1901.
38. Rasmussen, K., Moller, J., Lyngbak, M., Holm Pedersen, A. M. & Dybkjaer, L. (1996) Age-and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin. Chem. 42: 630-636.
39. Sauberlich, H. E., Kretsch, M. J., Skala, J. H., Johnson, H. L. & Taylor, P. C. (1987) Folate requirement and metabolism in nonpregnant women. Am. J. Clin. Nutr. 46: 1016-1028.
40. Selhub, J., Jacques, P. F., Wilson, P.W.F., Rush, D. & Rosenberg, I. H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270: 2693-2698.
41. Selhub, J. & Rosenberg, I. H. (1996) Folic acid. In: Present Knowledge in Nutrition, 7th ed. (Ziegler, E. E. & Filer, L. J., Jr., eds.), pp. 206-219. International Life Sciences Institute Press, Washington, DC.
42. Sparrow, C. P. & Olszewski, A. J. (1993) Cellular oxidation of low density lipo-protein is caused by thiol production in media containing transition metal ions. J. Lipid Res. 34: 1219-1228.
43. Stites, T. E., Bailey, L. B., Scott, K. C., Toth, J. P., Fisher, W. P. & Gregory, J. F. (1997) Kinetic modeling of folate metabolism through use of chronic administration of deuterium-labeled folic acid in men. Am. J. Clin. Nutr. 65: 53-60.
44. Subar, A. F., Block, G. & James, L. D. (1989) Folate intake and food sources in the US population. Am. J. Clin. Nutr. 50: 508-516.
45. Tamura, T., Mizuno, Y., Johnston, K. E. & Jacob, R. A. (1997) Food folate assay with protease, α-amylase, and folate conjugase treatments. J. Agric. Food Chem. 45: 135-139.
46. Tietz, N. W., ed. (1995) Clinical Guide to Laboratory Tests, 3rd ed. W. B. Saunders, Philadelphia, PA.
47. U.S. Department of Agriculture, Human Nutrition Information Service (1991) Composition of Foods, Agriculture Handbook 8, Version 10, Series 1-21. U.S. Government Printing Office, 1976-91, Washington, DC.
48. U.S. Department of Health and Human Services, Food and Drug Administration. (1996) Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed. Register 61: 8781-8787.