Gene promoter hypermethylation in tumors and lymph nodes of stage I lung cancer patients

Clinical Cancer Research

Volumn 9, Issue 4, 2003, Pages 1370-1375

  Harden, Susan V ^a   Tokumaru, Yutaka ^a   Westra, William H ^a   Goodman, Steven ^a   Ahrendt, Steven A ^b   Yang, Stephen C ^a   Sidransky, David ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN KINASE; PROTEIN P16; UNCLASSIFIED DRUG;

ADENOMATOUS POLYPOSIS COLI GENE; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; DNA METHYLATION; FEMALE; GENE; GENE REPRESSION; GENETIC TRANSCRIPTION; HISTOLOGY; HUMAN; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ADULT; AGED; AGED, 80 AND OVER; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA; DNA METHYLATION; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFITES; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037390127     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Greenlee, R. T., Hill-Harmon, M. B., Murray, T., and Thun, M. Cancer statistics, 2001. CA Cancer J. Clin., 51: 15-36, 2001.
2. Martini, N., Bains, M. S., Burt, M. E., Zakowski, M. F., McCormack, P., Rusch, V. W., and Ginsberg. R. J. Incidence of local recurrence and second primary tumors in resected stage I lung cancer. J. Thorac. Cardiovasc. Surg., 109: 120-129, 1995.
3. Van Trappen, P. O., Gyselman, V. G., Lowe, D. G., Ryan, A., Oram, D. H., Bosze, P., Weekes, A. R., Shepherd, J. H., Dorudi, S., Bustin, S. A., and Jacobs, I. J. Molecular quantification and mapping of lymphnode micrometastases in cervical cancer. Lancet, 357: 15-20, 2001.
4. Sanchez-Cespedes, M., Esteller, M., Hibi, K., Cope, F. O., Westra, W. H., Piantadosi, S., Herman, J. G., Jen, J., and Sidransky, D. Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. Clin. Cancer Res., 5: 2450-2454, 1999.
5. Kassis, E. S., Nguyen, N., Shriver, S. P., Siegfried, J. M., Schauer, P. R., and Luketich, J. D. Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques. JSLS, 2: 331-336, 1998.
6. Bostick, P. J., Morton, D. L., Turner, R. R., Huynh, K. T., Wang, H. J., Elashoff, R., Essner, R., and Hoon, D. S. Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase-polymerase chain reaction in early-stage melanoma patients. J. Clin. Oncol., 17: 3238-3244, 1999.
7. Ahrendt, S. A., Yang, S. C., Wu, L., Roig, C. M., Russell, P., Westra, W. H., Jen, J., Brock, M. V., Heitmiller, R. F., and Sidransky, D. Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study. J. Thorac. Cardiovasc. Surg., 123: 466-474, 2002.
8. Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., and Sidransky, D. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med., 1: 686-692, 1995.
9. Herman, J. G., Merlo, A., Mao, L., Lapidus, R. G., Issa, J. P., Davidson, N. E., Sidransky, D., and Baylin, S. B. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55: 4525-4530, 1995.
10. Esteller, M., Corn, P. G., Baylin, S. B., and Herman, J. G. A gene hypermethylation profile of human cancer. Cancer Res., 61: 3225-3229, 2001.
11. Dong, S. M., Kim, H. S., Rha, S. H., and Sidransky, D. Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res., 7: 1982-1986, 2001.
12. Esteller, M., Sanchez-Cespedes, M., Rosell, R., Sidransky, D., Baylin, S. B., and Herman, J. G. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients [published erratum appears in Cancer Res., 59: 3853, 19991. Cancer Res., 59: 67-70, 1999.
13. Zochbauer-Muller, S., Fong, K. M., Virmani, A. K., Geradts, J., Gazdar, A. F., and Minna, J. D. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res., 61: 249-255, 2001.
14. Usadel, H., Brabender, J., Danenberg, K. D., Jeronimo, C., Harden, S., Engles, J., Danenberg, P. V., Yang, S., and Sidransky, D. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. Cancer Res., 62: 371-375, 2002.
15. Ahrendt, S. A., Chow, J. T., Xu, L. H., Yang, S. C., Eisenberger, C. F., Esteller, M., Herman, J. G., Wu, L., Decker, P. A., Jen, J., and Sidransky, D. Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J. Natl. Cancer Inst. (Bethesda), 91: 332-339, 1999.
16. Eads, C. A., Danenberg, K. D., Kawakami, K., Saltz, L. B., Blake, C., Shibata, D., Danenberg, P. V., and Laird, P. W. MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res., 28: E32, 2000.
17. Lo, Y. M., Wong, I. H., Zhang, J., Tein, M. S., Ng, M. H., and Hjelm, N. M. Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation-specific polymerase chain reaction. Cancer Res., 59: 3899-3903, 1999.
18. Sobin, L. UICC: TNM Classification of Malignant Tumours. New York: John Wiley, 1997.
19. Nawroz, H., Koch, W., Anker, P., Stroun, M., and Sidransky, D. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat. Med., 2: 1035-1037, 1996.
20. Jeronimo, C., Usadel, H., Henrique, R., Oliveira, J., Lopes, C., Nelson, W. G., and Sidransky, D. Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ-confined prostate adenocarcinoma. J. Natl. Cancer Inst. (Bethesda), 93: 1747-1752, 2001.
21. Brabender, J., Usadel, H., Danenberg, K. D., Metzger, R., Schneider, P. M., Lord, R. V., Wickramasinghe, K., Lum, C. E., Park, J., Salonga, D., Singer, J., Sidransky, D., Holscher, A. H., Meltzer, S. J., and Danenberg, P. V. Adenomatous polyposis coli gene promoter hypermethylation in non-small cell lung cancer is associated with survival. Oncogene, 20: 3528-3532, 2001.
22. Tang, X., Khuri, F. R., Lee, J. J., Kemp, B. L., Liu, D., Hong, W. K., and Mao, L. Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small-cell lung cancer. J. Natl. Cancer Inst. (Bethesda), 92: 1511-1516, 2000.