Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation

American Journal of Pathology

Volumn 160, Issue 1, 2002, Pages 45-50

  Rosty, Christophe ^a   Ueki, Takashi ^a   Argani, Pedram ^a   Jansen, Marnix ^a   Yeo, Charles J ^a   Cameron, John L ^a   Hruban, Ralph H ^a   Goggins, Michael ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; CALCIUM BINDING PROTEIN; CALVASCULIN; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CANCER GRADING; CHRONIC PANCREATITIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EARLY DIAGNOSIS; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRON; INVASIVE CARCINOMA; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036141349     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64347-7     Document Type: Article

References (20)

1. The S100 family of EF-hand calcium-binding proteins: Functions and pathology
2. Growth-related changes in specific mRNAs of cultured mouse cells
3. Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein
4. Cloning of the sequences expressed abundantly in established cell lines: Identification of a cDNA clone highly homologous to S-100, a calcium binding protein
5. Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1
6. Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family
7. Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
8. Transcriptional regulation of the mtsl gene in human lymphoma cells: The role of DNA-methylation
9. Discovery of new markers of cancer through serial analysis of gene expression: Prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
10. A public database for gene expression in human cancers
11. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
12. Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer
13. Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer
14. Increased expression of S100A4, a metastasis-associated gene, in human colorectal adenocarcinomas
15. Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma
16. Hypomethylation distinguishes genes of some human cancers from their normal counterparts
17. Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
18. Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in clichloroacetic and trichloroacetic acid-promoted mouse liver tumors
19. 1) ribozyme
20. Expression of antisense RNA to S100A4 gene encoding an S100-related calcium-binding protein suppresses metastatic potential of high-metastatic Lewis lung carcinoma cells