Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue

International Journal of Colorectal Disease

Volumn 19, Issue 2, 2004, Pages 95-101

  Suter, Catherine M ^a   Martin, David I ^b   Ward, Robyn I ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

Author keywords

Cytosine methylation; Epigenetic; Retroelement; Transcriptional interference

Indexed keywords

CYTOSINE; DNA;

ADULT; AGED; ARTICLE; CANCER CELL; CARCINOGENESIS; CLINICAL ARTICLE; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DISEASE COURSE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LONG INTERSPERSED REPEAT; LYMPH NODE; METHYLATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; RETROPOSON; SEQUENCE ANALYSIS; SMOOTH MUSCLE; SOUTHERN BLOTTING; TUMOR LOCALIZATION;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COLON; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; HUMANS; INTESTINAL MUCOSA; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MIDDLE AGED; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS);

EID: 1242285594     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-003-0539-3     Document Type: Article

References (36)

1. Kazazian HH Jr (1998) Mobile elements and disease. Curr Opin Genet Dev 8:343-350
2. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W et al (2001) Initial sequencing and analysis of the human genome. Nature 409:860-921
3. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA et al (2001) The sequence of the human genome. Science 291:1304-1351
4. Smit AF (1999) Interspersed repeats and other mementos of transposable elements in mammalian genomes. Curr Opin Genet Dev 9:657-663
5. Sassaman DM, Dombroski BA, Moran JV, Kimberland ML, Naas TP, DeBerardinis RJ, Gabriel A, Swergold GD, Kazazian HH Jr (1997) Many human L1 elements are capable of retrotransposition. Nat Genet 16:37-43
6. Saxton JA, Martin SL (1998) Recombination between subtypes creates a mosaic lineage of LINE-1 that is expressed and actively retrotransposing in the mouse genome. J Mol Biol 280:611-622
7. Morgan HD, Sutherland HG, Martin DI, Whitelaw E (1999) Epigenetic inheritance at the agouti locus in the mouse. Nat Genet 23:314-318
8. Burgers WA, Fuks F, Kouzarides T (2002) DNA methyltransferases get connected to chromatin. Trends Genet 18:275-277
9. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM et al (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700-9704
10. Yoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci USA 92:7416-7419
11. Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, Bussaglia E, Prat J, Harkes IC, Repasky EA et al (2000) Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 92:564-569
12. Herman JG, Baylin SB (2000) Promoter-region hypermethylation and gene silencing in human cancer. Curr Top Microbiol Immunol 249:35-54
13. Roman-Gomez J, Castillejo JA, Jimenez A, Gonzalez MG, Moreno F, Rodriguez Mdel C, Barrios M, Maldonado J, Torres A (2002) 5′ CpG island hypermethylation is associated with transcriptional silencing of the p21 (CIP/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 99:2291-2296
14. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228:187-190
15. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M (1988) Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 48:1159-1161
16. De Smet C, De Backer O, Faraoni I, Lurquin C, Brasseur F, Boon T (1996) The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci USA 93:7149-7153
17. Jones PA, Laird PW (1999) Cancer epigenetics comes of age. Nat Genet 21:163-167
18. Bariol C, Suter CM, Cheong KF, Ku S, Hawkins N, Ward RL (2003) The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol 162:1361-1371
19. Yoder JA, Walsh CP, Bestor TH (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:335-340
20. Crowther PJ, Doherty JP, Linsenmeyer ME, Williamson MR, Woodcock DM (1991) Revised genomic consensus for the hypermethylated CpG island region of the human L1 transposon and integration sites of full length L1 elements from recombinant clones made using methylation-tolerant host strains. Nucleic Acids Res 19:2395-2401
21. Alves G, Tatro A, Fanning T (1996) Differential methylation of human LINE-1 retrotransposons in malignant cells. Gene 176:39-44
22. Thayer RE, Singer MF, Fanning TG (1993) Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1-encoded protein. Gene 133:273-277
23. Jurgens B, Schmitz-Drager BJ, Schulz WA (1996) Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma. Cancer Res 56:5698-5703
24. Florl AR, Lower R, Schmitz-Drager BJ, Schulz WA (1999) DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas. Br J Cancer 80:1312-1321
25. Takai D, Yagi Y, Habib N, Sugimura T, Ushijima T (2000) Hypomethylation of LINE1 retrotransposon in human hepatocellular carcinomas, but not in surrounding liver cirrhosis. Jpn J Clin Oncol 30:306-309
26. McClintock B (1968) The states of a gene locus in maize. Carnegie Institute of Washington Yearbook 66:20-28
27. Fincham JR, Sastry GR (1974) Controlling elements in maize. Annu Rev Genet 8:15-50
28. Martienssen R, Baron A (1994) Coordinate suppression of mutations caused by Robertson's mutator transposons in maize. Genetics 136:1157-1170
29. Kashkush K, Feldman M, Levy AA (2002) Transcriptional activation of retrotransposons alters the expression of adjacent genes in wheat. Nat Genet 16:16
30. Whitelaw E, Martin DI (2001) Retrotransposons as epigenetic mediators of phenotypic variation in mammals. Nat Genet 27:361-365
31. Hata K, Sakaki Y (1997) Identification of critical CpG sites for repression of L1 transcription by DNA methylation. Gene 189:227-234
32. Woodcock DM, Lawler CB, Linsenmeyer ME, Doherty JP, Warren WD (1997) Asymmetric methylation in the hypermethylated CpG promoter region of the human L1 retrotransposon. J Biol Chem 272:7810-7816
33. Cui H, Horon IL, Ohlsson R, Hamilton SR, Feinberg AP (1998) Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nat Med 4:1276-1280
34. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh CL, Feinberg AP (2002) Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res 62:6442-6446
35. Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Powe NR, Feinberg AP (2003) Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299:1753-1755
36. Suter CM, Norrie M, Ku SL, Cheong KF, Tomlinson I, Ward RL (2003) CpG island methylation is a common finding in colorectal cancer cell lines. Br J Cancer 88:413-419