Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia

Lancet

Volumn 361, Issue 9370, 2003, Pages 1693-1699

  Ingrosso, Diego ^a   Cimmino, Amelia ^a   Perna, Alessandra F ^a   Masella, Lucia ^a   De Santo, Natale G ^a   De Bonis, Maria Luigia ^b   Vacca, Marcella ^b   D'Esposito, Maurizio ^b   D'Urso, Michele ^b   Galletti, Patrizia ^a   Zappia, Vincenzo ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

ADULT; AGED; ALLELISM; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION; HEMODIALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SAMPLING; SOUTHERN BLOTTING; STANDARD; UREMIA;

EID: 0038663165     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)13372-7     Document Type: Article

References (30)

1. Robertson K.D., Wolffe A.P. DNA methylation in health and disease. Nat Rev Genet. 1:2000;11-19.
2. Xu G.L., Bestor T.H., Bourc'his D., et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 402:1999;187-191.
3. Amir R.E., Van den Veyver I.B., Wan M., Tran C.Q., Francke U., Zoghbi H.Y. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet. 2:1999;185-188.
4. McCully K.S. Homocysteine and vascular disease. Nat Med. 2:1996;386-389.
5. Robinson K., Gupta A., Dennis V., et al. Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations. Circulation. 94:1996;2743-2748.
6. Zappia V., Zydek-Cwick R., Schlenk F. The specificity of S-adenosylmethionine derivatives in methyl transfer reactions. J Biol Chem. 244:1969;4499-4509.
7. Perna A.F., Ingrosso D., Zappia V., Galletti P., Capasso G., De Santo N. Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosyl homocysteine. J Clin Invest. 91:1993;2497-2503.
8. Perna A.F., Ingrosso D., Galletti P., Zappia V., De Santo N.G. Membrane protein damage and methylation reactions in chronic renal failure. Kidney Int. 50:1996;358-366.
9. Perna A.F., Castaldo P., De Santo N.G., et al. Plasma proteins containing damaged L-isoaspartyl residues are increased in uremia: implications for mechanism. Kidney Int. 59:2001;2299-2308.
10. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosyl homocysteine and lymphocyte DNA hypomethylation. J Biol Chem. 275:2000;29318-29323.
11. Perna A.F., Ingrosso D., De Santo N.G., Galletti P., Brunone M., Zappia V. Metabolic consequences of folate-induced reduction of hyperhomocysteinemia in uremia. J Am Soc Nephrol. 8:1997;1899-1905.
12. Sutherland E., Coe L., Raleigh E.A. McrBC: a multisubunit GTP-dependent restriction endonuclease. J Mol Biol. 225:1992;327-348.
13. Uejima H., Lee M.P., Cui H., Feinberg A.P. Hot-stop PCR: a simple and general assay for linear quantitation of allele ratios. Nat Genet. 25:2000;375-376.
14. Matarazzo M.R., De Bonis M.L., Gregory R.I., et al. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet. 25:2002;3191-3198.
15. Hansen R.S., Stoger R., Wijmenga C., et al. Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant. Hum Mol Genet. 9:2000;2575-2587.
16. Brown K.W., Villar A.J., Bickmore W., et al. Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway. Hum Mol Genet. 5:1996;2027-2032.
17. Feil R., Charlton J., Bird A.P., Walter J., Reik W. Methylation analysis on individual chromosomes: improved protocol for bisulphite genomic sequencing. Nucleic Acids Res. 22:1994;695-696.
18. Ciccodicola A., D'Esposito M., Esposito T., et al. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. Hum Mol Genet. 12:2000;395-401.
19. Ferguson-Smith A.C., Surani M.A. Imprinting and the epigenetic asymmetry between parental genomes. Science. 293:2001;1086-1089.
20. Hendrich B., Bickmore W. Human diseases with underlying defects in chromatin structure and modification. Hum Mol Genet. 10:2001;2233-2242.
21. Heard E., Clerc P., Avner P. X-chromosome inactivation in mammals. Annu Rev Genet. 31:1997;571-610.
22. Reik W., Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet. 1:2001;21-32.
23. Li E., Beard R., Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell. 69:1992;915-926.
24. Sperandeo M.P., Ungaro P., Vernucci M., et al. Relaxation of insulin-like growth factor 2 imprinting and discordant methylation at KvDMR1 in two first cousins affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber syndromes. Am J Hum Genet. 66:2000;841-847.
25. Pedone P.V., Tirabosco R., Cavazzana A.O., et al. Mono- and bi-allelic expression of insulin-like growth factor II gene in human muscle tumors. Hum Mol Genet. 7:1994;1117-1121.
26. Takai D., Gonzales F.A., Tsai Y.C., Thayer M.J., Jones P.A. Large scale mapping of methylcytosines in CTCF-binding sites in the human H19 promoter and aberrant hypomethylation in human bladder cancer. Hum Mol Genet. 10:2001;2619-2626.
27. D'Esposito M., Ciccodicola A., Gianfrancesco F., et al. A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation. Nat Genet. 13:1996;227-229.
28. Clarke S., Banfield K. S-adenosylmethionine-dependent methyltransferases. Carmel R., Jacobsen D.W. Homocysteine in health and disease. 2001;63-78 Cambridge University Press, Cambridge, UK.
29. James S.J., Melnyk S., Pogribna M., Pogribny I.P., Caudill M.A. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr. 132:(suppl):2002;S2361-S2366.
30. Eikelboom J.W., Loon E., Genest J. Jr, Hankey G., Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiological evidence. Ann Intern Med. 131:1999;363-375.