Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias

Blood

Volumn 92, Issue 11, 1998, Pages 4296-4307

  Nakayama, Masaharu ^b   Wada, Morimasa ^a   Harada, Taishi ^b   Nagayama, Jun ^b   Kusaba, Hitoshi ^b   Ohshima, Koichi ^b   Kozuru, Mitsuo ^b   Komatsu, Hirokazu ^b   Ueda, Ryuzo ^b   Kuwano, Michihiko ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CANCER GENETICS; CLINICAL ARTICLE; CORRELATION FUNCTION; DNA METHYLATION; FEMALE; GENE EXPRESSION; HUMAN; MALE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS;

EID: 0032403478     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.11.4296.423k25_4296_4307     Document Type: Article

References (62)

1. Debenham PG, Kartner N, Siminovitch L, Riordan JR, Ling V: DNA mediated transfer of multidrug resistance and plasma membrane glycoprotein expression. Mol Biol Cell 2:881, 1982
2. Kartner N, Riordan JR, Ling V: Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 221:1285, 1983
3. Akiyama S, Fojo AT, Hanover JA, Pastan I, Gottesman MM: Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet 11:117, 1985
4. Pastan I, Gottesman M: Multiple-drug resistance in human cancer. N Engl J Med 316:1388, 1987
5. Gros P, Ben-Neriah Y, Croop JM, Housman D: Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323:728, 1986
6. Dexter DL, Leith JT: Tumor heterogeneity and drug resistance. J Clin Oncol 4:244, 1986
7. Bell DR, Gerlach JH, Kartner N, Buick RN, Ling V: Detection of P-glycoprotein in ovarian cancer: A molecular marker associated with multidrug resistance. J Clin Oncol 3:311, 1985
8. Verrelle P, Meissonnier F, Fonck Y, Feillel V, Dionet C, Kwiatowski F, Plagne R, Chassagne J: Clinical relevance of immunohistochemical detection of multidrug resistance P-glycoprotein in breast carcinoma. J Natl Cancer Inst 83:111, 1991
9. Berman E, Heller G, Santorsa JA, McKenzie S, Gee T, Kempin S, Gulati S, Andreeff M, Kolitz J, Gabrilove J, Reich L, Mayer K, Keefe D, Trainor K, Schluger A, Penenberg D, Raymond V, O'Reilly R, Jhanwar S, Young Ch, Clarkson B: Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 77:1666, 1991
10. Zittoun R, Mandelli F, Willemze R, Witte TD, Labar B, Resegotti L, Leoni F, Damasio E, Visani G, Papa G, caronia F, Hayat M, Strickmans P, Rotoli B, Leoni P, Peetermans M, Dardenne M, Vegna M, Petti M, Solbu G, Suciu S: Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 323:217, 1995
11. Geller RB, Burke PJ, Karp JE, Humphrey RL, Braine HG, Tucker RW, Fox MG, Zahurak M, Morrell L, Hall KL, Piantadosi S: A two step timed sequential treatment for acute myelocytic leukemia. Blood 74:1499, 1989
12. Hiddemann W, Martin WR, Sauerland CM, Heinecke A, Büchner T: Definition of refractoriness against conventional chemotherapy in acute myeloid leukemia: A proposal based on the results of retreatment by thioguanine, cytosine arabinoside, and daunorubicin (TAD 9) in 150 patients with relapse after standardized 1st line therapy. Leukemia 4:184, 1990
13. Estey E: Treatment of acute myelogenous leukemia and myelodysplastic syndromes. Semin Hematol 32:132, 1995
14. Kuwazuru Y, Yoshimura A, Hanada S, Utsunomiya A, Makino T, Ishibashi K, Kodama M, Iwahashi M, Arima T, Akiyama S: Expression of the multidrug transporter, P-glycoprotein, in acute leukemic cells and correlation to clinical drug resistance. Cancer 66:868, 1990
15. Marie JP, Zittoun R, Sikic BI: Multidrug resistance (mdr1) gene expression in adult acute leukemias: Correlation with treatment out-come and in vitro drug sensitivity. Blood 78:586, 1991
16. Campos L, Guyotat D, Archimbaud E, Oriol PC, Tsuruo T, Troncy J, Treille D, Fiere D, Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 79:473, 1992
17. Nüssler V, Fleischer RP, Zwierzina H, Nerl C, Beckert B, Gieseler F, Diem H, Ledderose G, Gullis E, Sauer H, Wilmanns W: P-glycoprotein expression in patients with acute leukemia-clinical relevance. Leukemia 10:S23, 1996 (suppl 3)
18. Fairchild CR, Ivy SP, Kao-Shan CS, Whang-Peng J, Rosen N, Israel MA, Melera PW, Cowan KH Goldsmith ME: Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells. Cancer Res 47:5141, 1987
19. Bates SE, Mickley LA, Chen YN, Richert N, Rudick J, Biedler JL, Fojo AT: Expression of a drug resistance gene in human neuroblastoma cell lines: Modulation by retinoic acid-induced differentiation. Mol Cell Biol 9:4337, 1989
20. Kohno K, Sato S, Takano H, Matsuo K, Kuwano M: The direct activation of human multidrug resistance gene (MDR1) by anticancer agents. Biochem Biophys Res Commun 165:1415, 1989
21. Mickley LA, Bates SE, Richert ND, Currier S, Tanaka S, Foss F, Rosen N, Fojo AT: Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents. J Biol Chem 264:18031, 1989
22. Kohno K, Tanimura H, Sato S, Nakayama Y, Makino Y, Wada M, Fojo AT, Kuwano M: Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells. J Biol Chem 269:20503, 1994
23. Uchiumi T, Kohno K, Tanimura H, Matsuo K, Sato S, Uchida Y, Kuwano M: Enhanced expression of the human multidrug resistance 1 gene in responses to UV light irradiation. Cell Growth Differ 4:147, 1993
24. Asakuno K, Kohno K, Uchiumi T, Kubo T, Sato S, Isono M, Kuwano M: Involvement of a DNA binding protein, MRD-NF1/YB-1, in human MDR1 gene expression by actinomycin D. Biochem Biophys Res Commun 199:1428, 1994
25. Ohga T, Koike K, Ono M, Makino Y, Itagaki Y, Tanimoto M, Kuwano M, Kohno K: Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light. Cancer Res 56:4224, 1996
26. Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD: Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med 3:447, 1997
27. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V: Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 316:817, 1985
28. Van der Bliek AM, Baas F, Van der Velde-Koerts T, Biedler JL, Meyers MB, Ozols RF, Hamilton TC, Joenje H, Borst P: Genes amplified and overexpressed in human multidrug-resistant cell lines. Cancer Res 48:5927, 1988
29. Torigoe K, Sato S, Kusaba H, Kohno K, Kuwano M, Okumura K, Green ED, Tsui LC, Scherer SW, Schlessinger D, Wada M: A YAC-based contig of 1.5 Mb spanning the human multidrug resistance gene region and delineating the amplification unit in three human multidrug-resistant cell lines. Genome Res 5:233, 1995
30. Boyes J, Bird A: DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein. Cell 64:1123, 1991
31. Laird PW, Jaenisch R: DNA methylation and cancer. Hum Mol Genet 3:1487, 1994
32. Stein R, Razin A, Cedar H: In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci USA 79:3418, 1982
33. Vardimon L, Kressmann A, Cedar H, Maechler M, Doerfler W: In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci USA 79:1073, 1982
34. Busslinger M, Hurst J, Flavell RA: DNA methylation and the regulation of globin gene expression. Cell 34:197, 1983
35. Makeh I, Thomas M, Hardelin JP, Briand P, Kahn A, Skala H: Analysis of a brain-specific isozyme. Expression and chromatin structure of the rat aldolase C gene and transgenes. J Biol Chem 269:4194, 1994
36. Kudo S, Fukuda M: Tissue-specific transcriptional regulation of human leukosialin (CD43) gene is achieved by DNA methylation. J Biol Chem 270:13298, 1995
37. Nambu S, Inoue K, Sasaki H: Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma. Jpn J Cancer Res 78:695, 1987
38. Rao PM, Antony A, Rajalakshmi S, Sarma DS: Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver. Carcinogenesis 10:933, 1989
39. Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B: Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 83:155, 1989
40. Kusaba H, Kohno K, Asakuno K, Kuwano M, Okumura K, Green ED, Schlessinger D, Wada M: Functional expression of yeast artificial chromosome-human multidrug resistance genes in mouse cells. Genome Res 5:245, 1995
41. Kusaba H, Nakayama M, Harada T, Torigoe K, Green ED, Scherer SW, Kohno K, Kuwano M, Wada M: Maintenance of hypomethylation status and preferential expression of exogenous human MDR1 / PGY1 gene in mouse L cells by YAC mediated transfer. Somat Cell Mol Genet 23:259, 1997
42. Bennett JM, Catovski D, Daniel MT: Proposed revised criteria for the classification of acute myeloid leukemia. A report of French-American-British Cooperative Group. Ann Intern Med 103:620, 1985
43. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual (ed 2). Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
44. Murphy LD, Herzog CE, Rudick JB, Fojo AT, Bates SE: Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry 29:10351, 1990
45. Kang YK, Zhan Z, Regis J, Robey R, Meadows B, Dickstein B, Lee JS, Otsuki T, Stetler-Stevenson M, Jaffe ES, Solomon D, Wilson WH, Fojo AT, Bates SE: Expression of mdr-1 in refractory lymphoma: Quantitation by polymerase chain reaction and validation of assay. Blood 86:1515, 1995
46. Ueda K, Pastan I, Gottesman M: Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene. J Biol Chem 262:17432, 1987
47. Rothenberg ML, Mickley LA, Cole DE, Balis FM, Tsuruo T, Poplack DG, Fojo AT: Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia. Blood 74:1388, 1989
48. Suzushima J, Ohshima K, Kikuchi M, Takeshita M, Akamatsu M, Tashiro K: Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: A useful method for the diagnosis of lymphoblastic lymphoma. J Pathol 182:86, 1997
49. Nakamura T: BMDP program for piecewise linear regression. Comput Methods Programs Biomed 23:53, 1986
50. Akazawa K, Nakamura T, Palesch Y: Power of logrank test and Cox regression model in clinical trials with heterogeneous samples. Stat Med 16:583, 1997
51. Mickley LA, Spengler BA, Knutsen TA, Biedler JL, Fojo T: Gene rearrangement: A novel mechanism for MDR-1 gene activation. J Clin Invest 99:1947, 1997
52. Antequera F, Boyes J, Bird A: High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62:503, 1990
53. Beck WT, Grogan TM, Willman CL, Cordon-Cardo C, Parham DM, Kuttesch JF, Andreeff M, Bates SE, Berard CW, Boyett JM, Brophy NA, Broxterman HJ, Chan HS, Dalton WS, Dietel M, Fojo AT, Gascoyne RD, Head D, Houghton PJ, Srivastava DK, Lehnert M, Leith CP, Paietta E, Pavelic ZP, Weinstein R: Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations. Cancer Res 56:3010, 1996
54. Geller RB, Zahurak M, Hurwitz GA, Burke PJ, Karp JE, Piantadosi S, Civin CI: Prognostic importance of immunophenotyping in adults with acute myelocytic leukemia: The significance of the stem-cell glycoprotein CD34 (My10). Br J Haematol 76:340, 1990
55. Chaudhary PM, Roninson IB: Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell 66:85, 1991
56. te Boekhorst AW, de Leeuw K, Schoester M, Wittebol S, Nooter K, Hagemeijer A, Löwenberg B, Sonneveld P: Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells. Blood 82:3157, 1993
57. Leith CP, Kopecky KJ, Godwin J, McConnell T, Slovac ML, Chen IM, Ilead DR, Appelbaum FR, Willman CL: Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 89:3323, 1997
58. Gardiner-Garden M, Frommer M: CpG islands in vertebrate genomes. J Mol Biol 196:261, 1987
59. Thompson JP, Simkevich CP, Holness MA, Kang AH, Raghow R: In vitro methylation of the promoter and enhancer of Pro alpha 1(I) collagen gene leads to its transcriptional inactivation. J Biol Chem 266:2549, 1991
60. Komura J, Okada T, Ono T: Repression of transient expression by DNA methylation in transcribed regions of reporter genes introduced into cultured human cells. Biochim Biophys Acta 1260:73, 1995
61. Ohga T, Uchiumi T, Makino Y, Koike K, Wada M, Kuwano M, Kohno K: Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene. J Biol Chem 273:5997, 1998
62. Kantharidis PK, El-Osta A, deSilva M, Wall DMP, Hu XF, Slater A, Nadalin G, Parkin JD, Zalcberg JR: Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance. Clin Cancer Res 3:2025, 1997