Methionine Synthase D919G Polymorphism, Folate Metabolism, and Colorectal Adenoma Risk

Cancer Epidemiology Biomarkers and Prevention

Volumn 13, Issue 1, 2004, Pages 157-162

  Goode, Ellen L ^a,b   Potter, John D ^a,b   Bigler, Jeannette ^a   Ulrich, Cornelia M ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; CYANOCOBALAMIN; FOLIC ACID; METHIONINE SYNTHASE; PYRIDOXINE; THYMIDYLATE SYNTHASE;

3' UNTRANSLATED REGION; ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; COLON ADENOMA; COLON CARCINOGENESIS; COLONOSCOPY; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; COLORECTAL TUMOR; CONTROLLED STUDY; DNA POLYMORPHISM; ENHANCER REGION; FEMALE; FOLATE METABOLISM; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADENOMA; ADULT; AGED; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DIET; FEMALE; FOLIC ACID; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MINNESOTA; POLYMORPHISM, GENETIC; RISK FACTORS; SEX DISTRIBUTION;

EID: 1642568671     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-03-0097     Document Type: Article

References (33)

1. Choi, S. W.. and Mason, J. B. Folate and carcinogenesis: an integrated scheme. J. Nutr., 130: 129-132, 2000.
2. Ryan, B. M., and Weir. D. G. Relevance of folate metabolism in the pathogenesis of colorectal cancer. J. Lab. Clin. Med., 138: 164-176. 2001.
3. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Hunter, D. J., Fuchs. C., Rosner. B. A., Speizer. F. E., and Willett. W. C. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann. Intern. Med., 129: 517-524, 1998.
4. Giovannucci, E., Stampfer, M. J., Colditz, G. A., Rimm, E. B., Trichopoulos, D., Rosner. B. A., Speizer, F. E., and Willett, W. C. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J. Natl. Cancer Inst. (Bethesda), 85: 875-884, 1993.
5. Giovannucci, E. Epidemiologic studies of folate and colorectal neoplasia: a review. J. Nutr., 132: 2350S-2355S, 2002.
6. Chen, J., Giovannucci. E., Kelsey, K., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Spiegelman, D., Willett, W. C., and Hunter. D. J. A methylenetetrahydro-folate reductase polymorphism and the risk of colorectal cancer. Cancer Res., 56: 4862-4864, 1996.
7. Ulvik. A., Evensen. E. T., Lien, E. A., Hoff, G., Vollset, S. E., Majak, B. M., and Ueland, P. M. Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum. Am. J. Med. Genet., 101: 246-254, 2001.
8. Ulrich, C. M., Bigler. J., Bostick, R., Fosdick, L., and Potter, J. D. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res., 62: 3361-3364, 2002.
9. Ulrich. C. M., Kampman, E., Bigler. J., Schwartz. S. M., Chen. C., Bostick, R., Fosdick, L., Beresford, S. A., Yasui, Y., and Potter, J. D. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol. Biomark. Prev., 8: 659-668. 1999.
10. Ma. J., Stampfer, M. J., Giovannucci. E., Artigas, C., Hunter, D. J., Fuchs, C., Willett, W. C., Selhub. J., Hennekens, C. H., and Rozen, R. Methylenetetrahy-drofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res., 57: 1098-102, 1997.
11. Duthie, S. J. Folic acid deficiency and cancer: mechanisms of DNA instability. Br. Med. Bull., 55: 578-592. 1999.
12. Leclerc. D., Odievre, M., Wu. Q., Wilson. A., Huizenga, J. J., Rozen, R., Scherer. S. W., and Gravel. R. A. Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene. Gene, 240: 75-88. 1999.
13. Dekou, V., Gudnason. V., Hawe, E., Miller. G. J., Stansbie, D., and Humphries, S. E. Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men. Thromb. Haemost., 85: 67-74, 2001.
14. Chen. J., Stampfer, M. J., Ma. J., Selhub. J., Malinow, M. R., Hennekens, C. H., and Hunter, D. J. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis, 154: 667-672, 2001.
15. Harmon, D. L., Shields, D. C., Woodside, J. V., McMaster, D., Yarnell. J. W., Young, I. S., Peng, K., Shane. B., Evans. A. E., and Whitehead, A. S. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet. Epidemiol., 17: 298-309, 1999.
16. Tsai, M. Y., Bignell. M., Yang. F., Welge, B. G., Graham, K. J., and Hanson, N. Q. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis, 149: 131-137, 2000.
17. Morita, H., Kurihara, H., Sugiyama, T., Hamada, C., Kurihara, Y., Shindo, T., Oh-hashi, Y., and Yazaki, Y. Polymorphism of the methionine synthase gene: association with homocysteine metabolism and late-onset vascular diseases in the Japanese population. Arterioscler. Thromb. Vasc. Biol., 19: 298-302, 1999.
18. van der Put, N. M., van der Molen. E. F., Kluijtmans, L. A., Heil, S. G., Trijbels, J. M., Eskes. T. K., Van Oppenraaij-Emmerzaal. D.. Banerjee, R., and Blom, H. J. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects vascular disease. Q. J. Med., 90: 511-517, 1997.
19. Jacques. P. F.. Bostom, A. G.. Selhub, J., Rich, S., Curtis Ellison. R., Eckfeldt, J. H., Gravel, R. A.. and Rozen, R. Effects of polymorphisms of methionine synthasc and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis. 166: 49-55, 2003.
20. Klerk, M.. Lievers, K. J., Kluijtmans. L. A., Blom, H. J., den Heijer, M., Schouten, E. G., Kok, F. J., and Verhoel, P. The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb. Res., 110: 87-91, 2003.
21. Potter, J. D., Bostick. R. M., Grandits, G. A., Fosdick, L., Elmer, P., Wood, J., Grambsch, P., and Louis. T. A. Hormone replacement therapy is associated with lower risk of adenomatous polyps of the large bowel: the Minnesota Cancer Prevention Research Unit Case-Control Study. Cancer Epidemiol. Biomark. Prev., 5: 779-784, 1996.
22. Willett. W. C.. Sampson, L., Stampfer, M. J., Rosner. B., Bain, C., Witschi, J., Hennekens, C. H., and Speizer. F. E. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am. J. Epidemiol., 122: 51-65, 1985.
23. Le Marchan L., Donlon. T.. Hankin. J. H.. Kolonel, L. N., Wilkens, L. R., and Seifried. A. B-vitamin intake, metabolic genes, and colorectal cancer risk (United States). Cancer Causes Control, 13: 239-248. 2002.
24. Chen, J.. Giovannucci, E., Hankinson, S. E.. Ma, J., Willett, W. C., Spiegelman. D.. Kelsey, K. T.. and Hunter. D. J. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis (Lond.), 19: 2129-2132, 1998.
25. Pufulete, M., Al-Ghnaniem, R., Leather, A. J.. Appleby, P., Gout, S., Terry, C., Emery. P. W.., and Sanders, T. A. Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study. Gastroenterology, 124: 1240-1248, 2003.
26. 12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol. Biomark. Prev., 8: 825-829, 1999.
27. 12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb. Haemost., 83: 563-570, 2000.
28. Wang, X. L., Duarte, N., Cai, H., Adachi, T., Sim, A. S., Cranney, G., and Wilcken. D. E. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population. Atherosclerosis, 146: 133-140, 1999.
29. Finkelstein, J. D. Regulation of homocysteine metabolism. In: R. Carmel and D. W. Jacobsen (eds.), Homocysteine in Health and Disease. pp. 92-99. Cambridge: Cambridge University Press, 2001.
30. Halsted, C. Alcohol and Folate Interactions: Clinical Implications. New York: Marcel Dekker. 1995.
31. Halsted, C. H., Villanueva, J. A.. Devlin. A. M., and Chandler, C. J. Metabolic interactions of alcohol and folate. J. Nutr., 132: 2367S-2372S, 2002.
32. Kenyon, S. H., Nicolaou, A., and Gibbons, W. A. The effect of ethanol and its metabolites upon methionine synthase activity in vitro. Alcohol, 15: 305-309, 1998.
33. Levine, A. J.. Siegmund, K. D., Ervin, C. M., Diep, A., Lee, E. R., Frankl, H. D.. and Haile, R. W. The methylenetetrahydrofolate reductase 677C→T polymorphism and distal colorectal adenoma risk. Cancer Epidemiol. Biomark. Prev., 9: 657-663. 2000.