Folate deficiency In vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells

Nutrition and Cancer

Volumn 37, Issue 2, 2000, Pages 245-251

  Duthie, Susan J ^a   Narayanan, Sabrina ^a   Blum, Stephanie ^b   Pirie, Lynn ^a   Brand, Gillian M ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FOLIC ACID; S ADENOSYLMETHIONINE; URACIL;

ARTICLE; CELL IMMORTALIZATION; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; DNA METHYLATION; DNA STRAND BREAKAGE; EXCISION REPAIR; FOLIC ACID DEFICIENCY; HUMAN; HUMAN CELL; MOLECULAR STABILITY; OXIDATIVE STRESS;

AGED; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELLS, CULTURED; COLON; COLORECTAL NEOPLASMS; CULTURE MEDIA; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; EPITHELIAL CELLS; FEMALE; FOLIC ACID DEFICIENCY; HUMANS; RISK FACTORS; URACIL;

EID: 0033635671     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1207/S15327914NC372_18     Document Type: Article

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