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Volumn 16, Issue 3, 2004, Pages 247-255

Recent advances in X-chromosome inactivation

(1)  Heard, Edith a  

a CNRS   (France)

Author keywords

Eed; embryonic ectoderm development; embryonic stem; Enhancer of zeste (EZ) mouse homolog; Enx1; ES; ESC; extra sex combs; histone methyltransferase; HMTase; ICM; inactive X chromosome; inner cell mass; male meiotic sex chromosome inactivation; MMSI; Xi; Xic

Indexed keywords

BRCA1 PROTEIN; HISTONE; POLYCOMB COMPLEX; PROTEIN; UNCLASSIFIED DRUG;

EID: 2342481623     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2004.03.005     Document Type: Review
Times cited : (228)

References (53)
  • 1
    • 0035839097 scopus 로고    scopus 로고
    • Epigenetic aspects of X-chromosome dosage compensation
    • Park Y., Kuroda M.I. Epigenetic aspects of X-chromosome dosage compensation. Science. 293:2001;1083-1085
    • (2001) Science , vol.293 , pp. 1083-1085
    • Park, Y.1    Kuroda, M.I.2
  • 2
    • 0034195219 scopus 로고    scopus 로고
    • Sex in the worm: Counting and compensating X-chromosome dose
    • Meyer B.J. Sex in the worm: counting and compensating X-chromosome dose. Trends Genet. 16:2000;247-251
    • (2000) Trends Genet , vol.16 , pp. 247-251
    • Meyer, B.J.1
  • 3
    • 0035839058 scopus 로고    scopus 로고
    • Genes, genetics and epigenetics: A correspondence
    • Wu C.-t., Morris J.R. Genes, genetics and epigenetics: a correspondence. Science. 293:2001;1103-1105
    • (2001) Science , vol.293 , pp. 1103-1105
    • Wu, C.-T.1    Morris, J.R.2
  • 4
    • 0035228079 scopus 로고    scopus 로고
    • X-chromosome inactivation: Counting, choice and initiation
    • Avner P., Heard E. X-chromosome inactivation: counting, choice and initiation. Nat Rev Genet. 2:2001;59-67
    • (2001) Nat Rev Genet , vol.2 , pp. 59-67
    • Avner, P.1    Heard, E.2
  • 5
    • 0035473989 scopus 로고    scopus 로고
    • Forty years of decoding the silence in X-chromosome inactivation
    • Boumil R.M., Lee J. Forty years of decoding the silence in X-chromosome inactivation. Hum Mol Gen. 10:2001;2225-2232
    • (2001) Hum Mol Gen , vol.10 , pp. 2225-2232
    • Boumil, R.M.1    Lee, J.2
  • 7
    • 0842287648 scopus 로고    scopus 로고
    • Controlling X-inactivation in mammals: What does the centre hold?
    • Rougeulle C., Avner P. Controlling X-inactivation in mammals: what does the centre hold? Semin Cell Dev Biol. 14:2003;331-340
    • (2003) Semin Cell Dev Biol , vol.14 , pp. 331-340
    • Rougeulle, C.1    Avner, P.2
  • 8
    • 0037324676 scopus 로고    scopus 로고
    • Multiple elements within the Xic regulate random X inactivation in mice
    • Clerc P., Avner P. Multiple elements within the Xic regulate random X inactivation in mice. Semin Cell Dev Biol. 14:2003;85-92
    • (2003) Semin Cell Dev Biol , vol.14 , pp. 85-92
    • Clerc, P.1    Avner, P.2
  • 9
    • 0842346470 scopus 로고    scopus 로고
    • Beyond sense: The role of antisense RNA in controlling Xist expression
    • Brown C.J., Chow J.C. Beyond sense: the role of antisense RNA in controlling Xist expression. Semin Cell Dev Biol. 14:2003;341-347
    • (2003) Semin Cell Dev Biol , vol.14 , pp. 341-347
    • Brown, C.J.1    Chow, J.C.2
  • 10
    • 1442338339 scopus 로고    scopus 로고
    • The region 3′ to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene
    • Using a targeted deletion and transgenic add-back approach, this study refines the 65-kb candidate region responsible for counting to a 20-kb bipartite domain within a 37-kb region lying 3′ to Xist. Counting elements are functionally separable from the Tsix promoter and Xite, both of which are involved in choice. Furthermore, the 65-kb deletion leads to aberrant X inactivation in XY cells, thus excluding the involvement of sex-specific mechanisms in the initiation of X inactivation. Deletion of the counting region also affects H3 Lys-4 methylation within the Xist gene.
    • Morey C., Navarro P., Debrand E., Avner P., Rougeulle C., Clerc P. The region 3′ to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J. 23:2004;594-604 Using a targeted deletion and transgenic add-back approach, this study refines the 65-kb candidate region responsible for counting to a 20-kb bipartite domain within a 37-kb region lying 3′ to Xist. Counting elements are functionally separable from the Tsix promoter and Xite, both of which are involved in choice. Furthermore, the 65-kb deletion leads to aberrant X inactivation in XY cells, thus excluding the involvement of sex-specific mechanisms in the initiation of X inactivation. Deletion of the counting region also affects H3 Lys-4 methylation within the Xist gene.
    • (2004) EMBO J , vol.23 , pp. 594-604
    • Morey, C.1    Navarro, P.2    Debrand, E.3    Avner, P.4    Rougeulle, C.5    Clerc, P.6
  • 12
    • 0035964420 scopus 로고    scopus 로고
    • A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice
    • Stavropoulos N., Lu N., Lee J.T. A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc Natl Acad Sci USA. 98:2001;10232-103237
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10232-103237
    • Stavropoulos, N.1    Lu, N.2    Lee, J.T.3
  • 13
    • 0037349309 scopus 로고    scopus 로고
    • Xite, X-inactivation intergenic transcription elements that regulate the probability of choice
    • This study identifies a cis element in the mouse Xic that regulates Tsix. Xite harbours intergenic transcription start sites and DNaseI hypersensitive sites with allelic differences. Deletion of Xite down-regulates Tsix in cis and skews X inactivation ratios, suggesting that Xite promotes Tsix persistence on the active X. Truncating Xite RNA has no affect on Xite action, demonstrating that it does not require intact transcripts.
    • Ogawa Y., Lee J.T. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 11:2003;731-743 This study identifies a cis element in the mouse Xic that regulates Tsix. Xite harbours intergenic transcription start sites and DNaseI hypersensitive sites with allelic differences. Deletion of Xite down-regulates Tsix in cis and skews X inactivation ratios, suggesting that Xite promotes Tsix persistence on the active X. Truncating Xite RNA has no affect on Xite action, demonstrating that it does not require intact transcripts.
    • (2003) Mol Cell , vol.11 , pp. 731-743
    • Ogawa, Y.1    Lee, J.T.2
  • 15
    • 0036993322 scopus 로고    scopus 로고
    • Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivation
    • Johnston C.M., Newall A.E., Brockdorff N., Nesterova T.B. Enox, a novel gene that maps 10 kb upstream of Xist and partially escapes X inactivation. Genomics. 80:2002;236-244
    • (2002) Genomics , vol.80 , pp. 236-244
    • Johnston, C.M.1    Newall, A.E.2    Brockdorff, N.3    Nesterova, T.B.4
  • 16
    • 0035861875 scopus 로고    scopus 로고
    • Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X-inactivation
    • Heard E., Rougeulle C., Arnaud D., Avner P., Allis C.D., Spector D.L. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X-inactivation. Cell. 107:2001;727-738
    • (2001) Cell , vol.107 , pp. 727-738
    • Heard, E.1    Rougeulle, C.2    Arnaud, D.3    Avner, P.4    Allis, C.D.5    Spector, D.L.6
  • 18
    • 0037059554 scopus 로고    scopus 로고
    • CTCF, a candidate trans-acting factor for X-inactivation choice
    • Chao W., Huynh K.D., Spencer R.J., Davidow L.S., Lee J.T. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 295:2002;345-347
    • (2002) Science , vol.295 , pp. 345-347
    • Chao, W.1    Huynh, K.D.2    Spencer, R.J.3    Davidow, L.S.4    Lee, J.T.5
  • 19
    • 0037052541 scopus 로고    scopus 로고
    • Autosomal dominant mutations affecting X inactivation choice in the mouse
    • In this study, chemical mutagenesis is performed in a genetic screen to identify specific factors involved in X inactivation. The screen takes advantage of allelism at the Xce locus, which is a classic mouse model of choice, enabling quantitation of effects of new mutants on non-random X inactivation. Two genetically distinct autosomal mutations with dominant effects on X-inactivation choice during early embryogenesis are identified: X-inactivation autosomal factors (Xiaf)1 and 2. This work presents the first direct genetic evidence that autosomal factors are involved in the initiation of X inactivation.
    • Percec I., Plenge R.M., Nadeau J.H., Bartolomei M.S., Willard H. Autosomal dominant mutations affecting X inactivation choice in the mouse. Science. 296:2002;1136-1139 In this study, chemical mutagenesis is performed in a genetic screen to identify specific factors involved in X inactivation. The screen takes advantage of allelism at the Xce locus, which is a classic mouse model of choice, enabling quantitation of effects of new mutants on non-random X inactivation. Two genetically distinct autosomal mutations with dominant effects on X-inactivation choice during early embryogenesis are identified: X-inactivation autosomal factors (Xiaf)1 and 2. This work presents the first direct genetic evidence that autosomal factors are involved in the initiation of X inactivation.
    • (2002) Science , vol.296 , pp. 1136-1139
    • Percec, I.1    Plenge, R.M.2    Nadeau, J.H.3    Bartolomei, M.S.4    Willard, H.5
  • 20
    • 0033637110 scopus 로고    scopus 로고
    • A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation
    • Wutz A., Jaenisch R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell. 5:2000;695-705
    • (2000) Mol Cell , vol.5 , pp. 695-705
    • Wutz, A.1    Jaenisch, R.2
  • 21
    • 0036479009 scopus 로고    scopus 로고
    • Chromosomal silencing and localization are mediated by different domains of Xist RNA
    • An important study that characterizes the functional domains of the Xist transcript. The strategy involves the use of 48 inducible Xist cDNA transgenes carrying different deletions, all targeted into the same site on the X chromosome to avoid variation due to position effects. Xist RNA chromosome coating and silencing activities are found to be distinct. The silencing domain corresponds to a conserved region at the 5′ end of the Xist transcript and consists of 7.5 repeated units, each predicted to contain two RNA stem loops. Domains involved in chromosome coating are dispersed throughout the Xist transcript, are functionally redundant and show no common sequence homology. Some of these localisation regions are also found to be important for macroH2A.
    • Wutz A., Rasmussen T.P., Jaenisch R. Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet. 30:2002;1-8 An important study that characterizes the functional domains of the Xist transcript. The strategy involves the use of 48 inducible Xist cDNA transgenes carrying different deletions, all targeted into the same site on the X chromosome to avoid variation due to position effects. Xist RNA chromosome coating and silencing activities are found to be distinct. The silencing domain corresponds to a conserved region at the 5′ end of the Xist transcript and consists of 7.5 repeated units, each predicted to contain two RNA stem loops. Domains involved in chromosome coating are dispersed throughout the Xist transcript, are functionally redundant and show no common sequence homology. Some of these localisation regions are also found to be important for macroH2A.
    • (2002) Nat Genet , vol.30 , pp. 1-8
    • Wutz, A.1    Rasmussen, T.P.2    Jaenisch, R.3
  • 22
    • 18744372123 scopus 로고    scopus 로고
    • BRCA1 supports XIST RNA concentration on the inactive X chromosome
    • This study describes the exciting finding that BRCA1, a breast and ovarian tumor suppressor, is important for XIST RNA chromosome localization. Breast and ovarian carcinoma cells lacking BRCA1 show a lack of XIST RNA coating; re-expression of the BRCA1 protein leads to relocalization of XIST RNA to the X chromosome. Cells lacking BRCA1 also show some evidence of defects in Xi chromatin structure, suggesting that this protein may be involved in maintenance of the inactive state.
    • Ganesan S., Silver D.P., Greenberg R.A., Avni D., Drapkin R., Miron A., Mok S.C., Randrianarison V., Brodie S., Salstrom J., et al. BRCA1 supports XIST RNA concentration on the inactive X chromosome. Cell. 111:2002;393-405 This study describes the exciting finding that BRCA1, a breast and ovarian tumor suppressor, is important for XIST RNA chromosome localization. Breast and ovarian carcinoma cells lacking BRCA1 show a lack of XIST RNA coating; re-expression of the BRCA1 protein leads to relocalization of XIST RNA to the X chromosome. Cells lacking BRCA1 also show some evidence of defects in Xi chromatin structure, suggesting that this protein may be involved in maintenance of the inactive state.
    • (2002) Cell , vol.111 , pp. 393-405
    • Ganesan, S.1    Silver, D.P.2    Greenberg, R.A.3    Avni, D.4    Drapkin, R.5    Miron, A.6    Mok, S.C.7    Randrianarison, V.8    Brodie, S.9    Salstrom, J.10
  • 23
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., Allis C.D. Translating the histone code. Science. 293:2001;1074-1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 24
    • 0036850325 scopus 로고    scopus 로고
    • Cellular memory and the histone code
    • Turner B.M. Cellular memory and the histone code. Cell. 111:2002;285-291
    • (2002) Cell , vol.111 , pp. 285-291
    • Turner, B.M.1
  • 25
    • 0036337759 scopus 로고    scopus 로고
    • Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
    • Boggs B.A., Cheung P., Heard E., Spector D.L., Chinault A.C., Allis C.D. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet. 30:2002;73-76
    • (2002) Nat Genet , vol.30 , pp. 73-76
    • Boggs, B.A.1    Cheung, P.2    Heard, E.3    Spector, D.L.4    Chinault, A.C.5    Allis, C.D.6
  • 26
    • 0344530944 scopus 로고    scopus 로고
    • Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells
    • Chaumeil J., Okamoto I., Guggiari M., Heard E. Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells. Cytogenet Genome Res. 99:2002;75-84
    • (2002) Cytogenet Genome Res , vol.99 , pp. 75-84
    • Chaumeil, J.1    Okamoto, I.2    Guggiari, M.3    Heard, E.4
  • 27
    • 0037387711 scopus 로고    scopus 로고
    • Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes
    • This study demonstrates that recruitment of Eed-Enx1(Ezh2) to the Xi occurs during random X inactivation in the embryo proper. Localization of Eed-Enx1 complexes to Xi occurs very early, at the onset of Xist expression, but then disappears as differentiation and development progress. In Eed mutant mice, Enx1 can no longer be recruited to the Xi and Eed-Enx1 is found to be required to establish methylation of histone H3 at lysine 27 on Xi. This, in turn, appears to be required to stabilize the Xi chromatin structure, as histone re-acetylation and sporadic X-linked gene reactivation on the Xi is observed in some cells.
    • Silva J., Mak W., Zvetkova I., Appanah R., Nesterova T.B., Webster Z., Peters A.H., Jenuwein T., Otte A.P., Brockdorff N. Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell. 4:2003;481-495 This study demonstrates that recruitment of Eed-Enx1(Ezh2) to the Xi occurs during random X inactivation in the embryo proper. Localization of Eed-Enx1 complexes to Xi occurs very early, at the onset of Xist expression, but then disappears as differentiation and development progress. In Eed mutant mice, Enx1 can no longer be recruited to the Xi and Eed-Enx1 is found to be required to establish methylation of histone H3 at lysine 27 on Xi. This, in turn, appears to be required to stabilize the Xi chromatin structure, as histone re-acetylation and sporadic X-linked gene reactivation on the Xi is observed in some cells.
    • (2003) Dev Cell , vol.4 , pp. 481-495
    • Silva, J.1    Mak, W.2    Zvetkova, I.3    Appanah, R.4    Nesterova, T.B.5    Webster, Z.6    Peters, A.H.7    Jenuwein, T.8    Otte, A.P.9    Brockdorff, N.10
  • 28
    • 0242668706 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in X inactivation
    • ••], this study demonstrates the transient recruitment of the Eed-Enx1(Ezh2) complex to the Xi during initiation of X inactivation in both extra-embryonic and embryonic cells, accompanied by H3-K27 methylation. Evidence is also provided that recruitment of the complex and methylation on the Xi depend on Xist RNA coating, but are independent of Xist's silencing function. Together, these studies demonstrate a role for Eed-Enx1(Ezh2)-mediated H3-K27 methylation during the early stages of both imprinted and random X inactivation and show that although H3-K27 methylation is not sufficient for silencing of the Xi, it may be involved in the early maintenance of the inactive state.
    • ••], this study demonstrates the transient recruitment of the Eed-Enx1(Ezh2) complex to the Xi during initiation of X inactivation in both extra-embryonic and embryonic cells, accompanied by H3-K27 methylation. Evidence is also provided that recruitment of the complex and methylation on the Xi depend on Xist RNA coating, but are independent of Xist's silencing function. Together, these studies demonstrate a role for Eed-Enx1(Ezh2)-mediated H3-K27 methylation during the early stages of both imprinted and random X inactivation and show that although H3-K27 methylation is not sufficient for silencing of the Xi, it may be involved in the early maintenance of the inactive state.
    • (2003) Science , vol.300 , pp. 131-135
    • Plath, K.1    Fang, J.2    Mlynarczyk-Evans, S.K.3    Cao, R.4    Worringer, K.A.5    Wang, H.6    De La Cruz, C.C.7    Otte, A.P.8    Panning, B.9    Zhang, Y.10
  • 29
    • 0042379770 scopus 로고    scopus 로고
    • Chromatin of the Barr body: Histone and non-histone proteins associated with or excluded from the inactive X chromosome
    • An up-to-date evaluation of the various histone variants, histone modifications and non-histone proteins on the human inactive X chromosome.
    • Chadwick B.P., Willard H.F. Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome. Hum Mol Genet. 12:2003;2167-2178 An up-to-date evaluation of the various histone variants, histone modifications and non-histone proteins on the human inactive X chromosome.
    • (2003) Hum Mol Genet , vol.12 , pp. 2167-2178
    • Chadwick, B.P.1    Willard, H.F.2
  • 30
    • 0042131581 scopus 로고    scopus 로고
    • X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation
    • Chromatin immunoprecipitation is used to follow changes in histone modifications on the X chromosome before and after X inactivation. Evidence is presented for X-chromosome-specific hyperacetylation of all core histones, hyper(di)methylation of H3 lysine 4 and hypo(di)methylation of H3 lysine 9, compared with autosomal genes or genes on the single active X in XY male cells in undifferentiated XX ES cells. After the onset of X inactivation, hypoacetylation of all four core histones, hypo(di)methylation of H3K4 and hyper(di)methylation of H3K9 are found. It is proposed that X-linked genes are selectively marked in female ES cells in a way that distinguishes them from the equivalent genes in males.
    • O'Neill L.P., Randall T.E., Lavender J., Spotswood H.T., Lee J.T., Turner B.M. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 12:2003;1783-1790 Chromatin immunoprecipitation is used to follow changes in histone modifications on the X chromosome before and after X inactivation. Evidence is presented for X-chromosome-specific hyperacetylation of all core histones, hyper(di)methylation of H3 lysine 4 and hypo(di)methylation of H3 lysine 9, compared with autosomal genes or genes on the single active X in XY male cells in undifferentiated XX ES cells. After the onset of X inactivation, hypoacetylation of all four core histones, hypo(di)methylation of H3K4 and hyper(di)methylation of H3K9 are found. It is proposed that X-linked genes are selectively marked in female ES cells in a way that distinguishes them from the equivalent genes in males.
    • (2003) Hum Mol Genet , vol.12 , pp. 1783-1790
    • O'Neill, L.P.1    Randall, T.E.2    Lavender, J.3    Spotswood, H.T.4    Lee, J.T.5    Turner, B.M.6
  • 31
    • 0348013083 scopus 로고    scopus 로고
    • Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression
    • A profile of H3K4 di-methylation that is specific for monoallelically expressed genes is described in this study. X-linked genes subject to X-inactivation as well as autosomal imprinted genes have di-methylated H3K4 restricted to their promoter regions. In contrast, high levels of H3K4 di-methylation are found in both promoters and exonic parts of autosomal genes and of X-linked genes that escape X-inactivation. This pattern of promoter-restricted H3 Lys 4 di-methylation could thus represent an epigenetic mark for monoallelically expressed genes.
    • Rougeulle C., Navarro P., Avner P. Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression. Hum Mol Genet. 12:2003;3343-3348 A profile of H3K4 di-methylation that is specific for monoallelically expressed genes is described in this study. X-linked genes subject to X-inactivation as well as autosomal imprinted genes have di-methylated H3K4 restricted to their promoter regions. In contrast, high levels of H3K4 di-methylation are found in both promoters and exonic parts of autosomal genes and of X-linked genes that escape X-inactivation. This pattern of promoter-restricted H3 Lys 4 di-methylation could thus represent an epigenetic mark for monoallelically expressed genes.
    • (2003) Hum Mol Genet , vol.12 , pp. 3343-3348
    • Rougeulle, C.1    Navarro, P.2    Avner, P.3
  • 32
    • 0037172659 scopus 로고    scopus 로고
    • Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells
    • Mak W., Baxter J., Silva J., Newall A.E., Otte A.P., Brockdorff N. Mitotically stable association of polycomb group proteins Eed and Enx1 with the inactive X chromosome in trophoblast stem cells. Curr Biol. 12:2002;1016-1020
    • (2002) Curr Biol , vol.12 , pp. 1016-1020
    • Mak, W.1    Baxter, J.2    Silva, J.3    Newall, A.E.4    Otte, A.P.5    Brockdorff, N.6
  • 33
    • 0042310137 scopus 로고    scopus 로고
    • Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
    • Using a conditional allele of Ezh2 to deplete the oocyte of maternal inheritance, this study shows that Ezh2 has important and diverse roles during early development. It appears to be involved in establishing a unique epigenetic state and plasticity in the embryonic lineage, explaining why loss of Ezh2 is early-embryonic-lethal, and it is also involved in the establishment of the first differentiated cells, the trophectoderm, and of the pluripotent epiblast cells.
    • Erhardt S., Su I.H., Schneider R., Barton S., Bannister A.J., Perez-Burgos L., Jenuwein T., Kouzarides T., Tarakhovsky A., Surani M.A. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development. 130:2003;4235-4348 Using a conditional allele of Ezh2 to deplete the oocyte of maternal inheritance, this study shows that Ezh2 has important and diverse roles during early development. It appears to be involved in establishing a unique epigenetic state and plasticity in the embryonic lineage, explaining why loss of Ezh2 is early-embryonic-lethal, and it is also involved in the establishment of the first differentiated cells, the trophectoderm, and of the pluripotent epiblast cells.
    • (2003) Development , vol.130 , pp. 4235-4348
    • Erhardt, S.1    Su, I.H.2    Schneider, R.3    Barton, S.4    Bannister, A.J.5    Perez-Burgos, L.6    Jenuwein, T.7    Kouzarides, T.8    Tarakhovsky, A.9    Surani, M.A.10
  • 34
    • 0036532114 scopus 로고    scopus 로고
    • Programming off and on states in chromatin: Mechanisms of Polycomb and trithorax group complexes
    • Simon J.A., Tamkun J.W. Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Curr Opin Genet Dev. 12:2002;210-218
    • (2002) Curr Opin Genet Dev , vol.12 , pp. 210-218
    • Simon, J.A.1    Tamkun, J.W.2
  • 35
    • 0141785202 scopus 로고    scopus 로고
    • Gene repression by Polycomb group protein complexes: A distinct complex for every occasion?
    • Otte A.P., Kwaks T.H. Gene repression by Polycomb group protein complexes: a distinct complex for every occasion? Curr Opin Genet Dev. 13:2003;448-454
    • (2003) Curr Opin Genet Dev , vol.13 , pp. 448-454
    • Otte, A.P.1    Kwaks, T.H.2
  • 37
    • 0035858882 scopus 로고    scopus 로고
    • Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation
    • Csankovszki G., Nagy A., Jaenisch R. Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol. 153:2001;773-784
    • (2001) J Cell Biol , vol.153 , pp. 773-784
    • Csankovszki, G.1    Nagy, A.2    Jaenisch, R.3
  • 38
    • 0842281679 scopus 로고    scopus 로고
    • Imprinted X-chromosome inactivation: Enlightenment from embryos in vivo
    • Takagi N. Imprinted X-chromosome inactivation: enlightenment from embryos in vivo. Semin Cell Dev Biol. 14:2003;319-329
    • (2003) Semin Cell Dev Biol , vol.14 , pp. 319-329
    • Takagi, N.1
  • 39
    • 0031044166 scopus 로고    scopus 로고
    • Xist-deficient mice are defective in dosage compensation but not spermatogenesis
    • Marahrens Y., Panning B., Dausman J., Strauss W., Jaenisch R. Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev. 11:1997;156-166
    • (1997) Genes Dev , vol.11 , pp. 156-166
    • Marahrens, Y.1    Panning, B.2    Dausman, J.3    Strauss, W.4    Jaenisch, R.5
  • 40
    • 0034730332 scopus 로고    scopus 로고
    • Disruption of imprinted X inactivation by parent-of-origin effects at Tsix
    • Lee J.T. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Cell. 103:2001;17-27
    • (2001) Cell , vol.103 , pp. 17-27
    • Lee, J.T.1
  • 41
    • 0024153031 scopus 로고
    • Mechanism of X-chromosome regulation
    • Grant S.G., Chapman V.M. Mechanism of X-chromosome regulation. Annu Rev Genet. 22:1988;199-233
    • (1988) Annu Rev Genet , vol.22 , pp. 199-233
    • Grant, S.G.1    Chapman, V.M.2
  • 42
    • 0030464831 scopus 로고    scopus 로고
    • X-chromosome activity impact of imprinting and chromatin structure
    • Jamieson R.V., Gardiner-Garden M. X-chromosome activity impact of imprinting and chromatin structure. Int J Dev Biol. 40:1996;1065-1080
    • (1996) Int J Dev Biol , vol.40 , pp. 1065-1080
    • Jamieson, R.V.1    Gardiner-Garden, M.2
  • 43
    • 0035546002 scopus 로고    scopus 로고
    • Imprinted X inactivation in eutherians: A model of gametic execution and zygotic relaxation
    • Huynh K.D., Lee J.T. Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr Opin Cell Biol. 13:2000;690-697
    • (2000) Curr Opin Cell Biol , vol.13 , pp. 690-697
    • Huynh, K.D.1    Lee, J.T.2
  • 44
    • 0347357614 scopus 로고    scopus 로고
    • Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos
    • ••].
    • ••].
    • (2003) Nature , vol.426 , pp. 857-862
    • Huynh, K.D.1    Lee, J.T.2
  • 47
    • 6444245240 scopus 로고    scopus 로고
    • X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse
    • McCarrey J.R., Watson C., Atencio J., Ostermeier G.C., Marahrens Y., Jaenisch R., Krawetz S.A. X-chromosome inactivation during spermatogenesis is regulated by an Xist/Tsix-independent mechanism in the mouse. Genesis. 34:2002;257-266
    • (2002) Genesis , vol.34 , pp. 257-266
    • McCarrey, J.R.1    Watson, C.2    Atencio, J.3    Ostermeier, G.C.4    Marahrens, Y.5    Jaenisch, R.6    Krawetz, S.A.7
  • 48
    • 0346634937 scopus 로고    scopus 로고
    • H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis
    • During meiotic prophase in male mammals, the X and Y chromosomes condense to form a macrochromatin body, termed the sex, or XY, body, within which X- and Y-linked genes are transcriptionally repressed. A phosphorylated form of H2AX, a histone H2A variant implicated in DNA repair, accumulates in the sex body. This paper shows that the X and Y chromosomes of histone-H2AX-deficient spermatocytes fail to condense to form a sex body, do not initiate male meiotic sex chromosome inactivation, and exhibit severe defects in meiotic pairing. H2AX is thus required for the chromatin remodelling and associated silencing in male meiosis.
    • Fernandez-Capetillo O., Mahadevaiah S.K., Celeste A., Romanienko P.J., Camerini-Otero R.D., Bonner W.M., Manova K., Burgoyne P., Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell. 4:2003;497-508 During meiotic prophase in male mammals, the X and Y chromosomes condense to form a macrochromatin body, termed the sex, or XY, body, within which X- and Y-linked genes are transcriptionally repressed. A phosphorylated form of H2AX, a histone H2A variant implicated in DNA repair, accumulates in the sex body. This paper shows that the X and Y chromosomes of histone-H2AX-deficient spermatocytes fail to condense to form a sex body, do not initiate male meiotic sex chromosome inactivation, and exhibit severe defects in meiotic pairing. H2AX is thus required for the chromatin remodelling and associated silencing in male meiosis.
    • (2003) Dev Cell , vol.4 , pp. 497-508
    • Fernandez-Capetillo, O.1    Mahadevaiah, S.K.2    Celeste, A.3    Romanienko, P.J.4    Camerini-Otero, R.D.5    Bonner, W.M.6    Manova, K.7    Burgoyne, P.8    Nussenzweig, A.9
  • 49
    • 0942268864 scopus 로고    scopus 로고
    • Epigenetic dynamics of imprinted X inactivation during early mouse development
    • Using single-cell analysis, this study assesses Xist expression and Xp activity during pre-implantation development, using RNA polymerase II, Polycomb group proteins and nascent transcript detection as assays. They show that imprinted Xp inactivation in the mouse initiates much earlier than was previously thought. The Xp appears to be active at the two-cell stage, but becomes rapidly inactivated following Xist RNA coating from the four-cell stage onwards. Furthermore, by the early blastocyst stage, Xp inactivation is observed in all cells. The inactive state of the Xp, including its association with several histone modifications and Polycomb group proteins, is shown to be reversed in cells of the ICM, which gives rise to the embryonic lineage where random X inactivation is known to occur.
    • Okamoto I., Otte A.P., Allis C.D., Reinberg D., Heard E. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science. 303:2004;644-649 Using single-cell analysis, this study assesses Xist expression and Xp activity during pre-implantation development, using RNA polymerase II, Polycomb group proteins and nascent transcript detection as assays. They show that imprinted Xp inactivation in the mouse initiates much earlier than was previously thought. The Xp appears to be active at the two-cell stage, but becomes rapidly inactivated following Xist RNA coating from the four-cell stage onwards. Furthermore, by the early blastocyst stage, Xp inactivation is observed in all cells. The inactive state of the Xp, including its association with several histone modifications and Polycomb group proteins, is shown to be reversed in cells of the ICM, which gives rise to the embryonic lineage where random X inactivation is known to occur.
    • (2004) Science , vol.303 , pp. 644-649
    • Okamoto, I.1    Otte, A.P.2    Allis, C.D.3    Reinberg, D.4    Heard, E.5
  • 50
    • 0035093826 scopus 로고    scopus 로고
    • Evolution of imprinting mechanisms: The battle of the sexes begins in the zygote
    • Reik W., Walter J. Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote. Nat Genet. 3:2001;255-256
    • (2001) Nat Genet , vol.3 , pp. 255-256
    • Reik, W.1    Walter, J.2
  • 51
    • 0942268867 scopus 로고    scopus 로고
    • Reactivation of the paternal X chromosome in early mouse embryos
    • ••] to examine preimplantation mouse embryos from the morula stage onwards. They show that the paternal X chromosome is inactivated in all cells by the blastocyst stage, but becomes reactivated in cells allocated to the ICM.
    • ••] to examine preimplantation mouse embryos from the morula stage onwards. They show that the paternal X chromosome is inactivated in all cells by the blastocyst stage, but becomes reactivated in cells allocated to the ICM.
    • (2004) Science , vol.303 , pp. 666-669
    • Mak, W.1    Nesterova, T.B.2    De Napoles, M.3    Appanah, R.4    Yamanaka, S.5    Otte, A.P.6    Brockdorff, N.7
  • 53
    • 0035797898 scopus 로고    scopus 로고
    • Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    • Tada M., Takahama Y., Abe K., Nakatsuji N., Tada T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol. 11:2001;1553-1558
    • (2001) Curr Biol , vol.11 , pp. 1553-1558
    • Tada, M.1    Takahama, Y.2    Abe, K.3    Nakatsuji, N.4    Tada, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.