메뉴 건너뛰기




Volumn 7, Issue 1, 2005, Pages 45-61

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: Relevance to Alzheimer's disease

Author keywords

Alzheimer's disease; Animal models; Diabetes mellitus; Insulin like growth factor; Insulin resistance; Review; Signal transduction

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; GLUCOSE; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN; STREPTOZOCIN; TAU PROTEIN;

EID: 15244350991     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2005-7106     Document Type: Review
Times cited : (485)

References (165)
  • 1
    • 0030594986 scopus 로고    scopus 로고
    • In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: Evidence that IGF-I increases proliferation of granule cell progenitors
    • P. Ye, Y. Xing, Z. Dai and A.J. D'Ercole, In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors, Brain Res Dev Brain Res 95 (1996), 44-54.
    • (1996) Brain Res Dev Brain Res , vol.95 , pp. 44-54
    • Ye, P.1    Xing, Y.2    Dai, Z.3    D'Ercole, A.J.4
  • 2
    • 0036551775 scopus 로고    scopus 로고
    • Mutant mouse models of insulin-like growth factor actions in the central nervous system
    • A.J. D'Ercole, P. Ye and J.R. O'Kusky, Mutant mouse models of insulin-like growth factor actions in the central nervous system, Neuropeptides 36 (2002), 209-220.
    • (2002) Neuropeptides , vol.36 , pp. 209-220
    • D'Ercole, A.J.1    Ye, P.2    O'Kusky, J.R.3
  • 3
    • 2342511484 scopus 로고    scopus 로고
    • In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system
    • G.J. Popken, R.D. Hodge, P. Ye, J. Zhang, W. Ng, J.R. O'Kusky and A.J. D'Ercole, In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system, Eur J Neurosci 19 (2004), 2056-2068.
    • (2004) Eur J Neurosci , vol.19 , pp. 2056-2068
    • Popken, G.J.1    Hodge, R.D.2    Ye, P.3    Zhang, J.4    Ng, W.5    O'Kusky, J.R.6    D'Ercole, A.J.7
  • 4
    • 0030330547 scopus 로고    scopus 로고
    • The role of the insulin-like growth factors in the central nervous system
    • A.J. D'Ercole, P. Ye, A.S. Calikoglu and G. Gutierrez-Ospina, The role of the insulin-like growth factors in the central nervous system, Mol Neurobiol 13 (1996), 227-255.
    • (1996) Mol Neurobiol , vol.13 , pp. 227-255
    • D'Ercole, A.J.1    Ye, P.2    Calikoglu, A.S.3    Gutierrez-Ospina, G.4
  • 5
    • 0034668766 scopus 로고    scopus 로고
    • Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
    • J.R. O'Kusky, P. Ye and A.J. D'Ercole, Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development, J Neurosci 20 (2000), 8435-8442.
    • (2000) J Neurosci , vol.20 , pp. 8435-8442
    • O'Kusky, J.R.1    Ye, P.2    D'Ercole, A.J.3
  • 6
    • 0030006746 scopus 로고    scopus 로고
    • Use of transgenic mice for understanding the physiology of insulin-like growth factors
    • A.J. D'Ercole, P. Ye and G. Gutierrez-Ospina, Use of transgenic mice for understanding the physiology of insulin-like growth factors, Horm Res 45(Suppl 1) (1996), 5-7.
    • (1996) Horm Res , vol.45 , Issue.1 SUPPL. , pp. 5-7
    • D'Ercole, A.J.1    Ye, P.2    Gutierrez-Ospina, G.3
  • 7
    • 0027391758 scopus 로고
    • The cellular and physiological actions of insulin in the central nervous system
    • M. Wozniak, B. Rydzewski, S.P. Baker and M.K. Raizada, The cellular and physiological actions of insulin in the central nervous system, Neurochem Int 22 (1993), 1-10.
    • (1993) Neurochem Int , vol.22 , pp. 1-10
    • Wozniak, M.1    Rydzewski, B.2    Baker, S.P.3    Raizada, M.K.4
  • 9
    • 0034870813 scopus 로고    scopus 로고
    • Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
    • J.F. Poduslo, G.L. Curran, T.M. Wengenack, B. Malester and K. Duff, Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease, Neurobiol Dis 8 (2001), 555-567.
    • (2001) Neurobiol Dis , vol.8 , pp. 555-567
    • Poduslo, J.F.1    Curran, G.L.2    Wengenack, T.M.3    Malester, B.4    Duff, K.5
  • 10
    • 0037303635 scopus 로고    scopus 로고
    • Brain insulin: Regulation, mechanisms of action and functions
    • K. Gerozissis and G. Kyriaki, Brain insulin: regulation, mechanisms of action and functions, Cell Mol Neurobiol 23 (2003), 1-25.
    • (2003) Cell Mol Neurobiol , vol.23 , pp. 1-25
    • Gerozissis, K.1    Kyriaki, G.2
  • 11
    • 0027519849 scopus 로고
    • Expression of insulin-like growth factor-I in transgenic mice
    • A.J. D'Ercole, Expression of insulin-like growth factor-I in transgenic mice, Ann N Y Acad Sci 692 (1993), 149-160.
    • (1993) Ann N Y Acad Sci , vol.692 , pp. 149-160
    • D'Ercole, A.J.1
  • 12
    • 0030253891 scopus 로고    scopus 로고
    • The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system
    • F. Folli, S. Ghidella, L. Bonfanti, C.R. Kahn and A. Merighi, The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system, Mol Neurobiol 13 (1996), 155-183.
    • (1996) Mol Neurobiol , vol.13 , pp. 155-183
    • Folli, F.1    Ghidella, S.2    Bonfanti, L.3    Kahn, C.R.4    Merighi, A.5
  • 13
    • 0030664648 scopus 로고    scopus 로고
    • Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene
    • P. Ye, Y. Umayahara, D. Ritter, T. Bunting, H. Auman, P. Rotwein and A.J. D'Ercole, Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene, Endocrinology 138 (1997), 5466-5475.
    • (1997) Endocrinology , vol.138 , pp. 5466-5475
    • Ye, P.1    Umayahara, Y.2    Ritter, D.3    Bunting, T.4    Auman, H.5    Rotwein, P.6    D'Ercole, A.J.7
  • 14
    • 0033548853 scopus 로고    scopus 로고
    • Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse
    • K.D. Dentremont, P. Ye, A.J. D'Ercole and J.R. O'Kusky, Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse, Brain Res Dev Brain Res 114 (1999), 135-141.
    • (1999) Brain Res Dev Brain Res , vol.114 , pp. 135-141
    • Dentremont, K.D.1    Ye, P.2    D'Ercole, A.J.3    O'Kusky, J.R.4
  • 15
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
    • J.W. Unger, J.N. Livingston and A.M. Moss, Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects, Prog Neurobiol 36 (1991), 343-362.
    • (1991) Prog Neurobiol , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 16
    • 0025808620 scopus 로고
    • Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat
    • J.W. Unger, A.M. Moss and J.N. Livingston, Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat, Neuroscience 42 (1991), 853-861.
    • (1991) Neuroscience , vol.42 , pp. 853-861
    • Unger, J.W.1    Moss, A.M.2    Livingston, J.N.3
  • 17
    • 0036470213 scopus 로고    scopus 로고
    • Insulin signaling pathways in time and space
    • A.R. Saltiel and J.E. Pessin, Insulin signaling pathways in time and space, Trends Cell Biol 12 (2002), 65-71.
    • (2002) Trends Cell Biol , vol.12 , pp. 65-71
    • Saltiel, A.R.1    Pessin, J.E.2
  • 20
    • 0033918523 scopus 로고    scopus 로고
    • Structural and functional characterization of insulin receptor substrate proteins and the molecular mechanisms of their interaction with insulin superfamily tyrosine kinase receptors and effector proteins
    • A.O. Shpakov and M.N. Pertseva, Structural and functional characterization of insulin receptor substrate proteins and the molecular mechanisms of their interaction with insulin superfamily tyrosine kinase receptors and effector proteins, Membr Cell Biol 13 (2000), 455-484.
    • (2000) Membr Cell Biol , vol.13 , pp. 455-484
    • Shpakov, A.O.1    Pertseva, M.N.2
  • 22
    • 0027437376 scopus 로고
    • Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
    • X.J. Sun, D.L. Crimmins, M.J. Myers, M. Miralpeix and M.F. White, Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1, Mol Cell Biol 13 (1993), 7418-7428.
    • (1993) Mol Cell Biol , vol.13 , pp. 7418-7428
    • Sun, X.J.1    Crimmins, D.L.2    Myers, M.J.3    Miralpeix, M.4    White, M.F.5
  • 23
    • 0021188386 scopus 로고
    • Insulin-mediated regulation of neuronal maturation
    • D.G. Puro and E. Agardh, Insulin-mediated regulation of neuronal maturation, Science 225 (1984), 1170-1172.
    • (1984) Science , vol.225 , pp. 1170-1172
    • Puro, D.G.1    Agardh, E.2
  • 24
    • 0022344785 scopus 로고
    • Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation
    • J.F. Mill, M.V. Chao and D.N. Ishii, Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation, Proc Natl Acad Sci USA 82 (1985), 7126-7130.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7126-7130
    • Mill, J.F.1    Chao, M.V.2    Ishii, D.N.3
  • 25
    • 0024433715 scopus 로고
    • Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis
    • K.A. Heidenreich and S.P. Toledo, Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis, Endocrinology 125 (1989), 1451-1457.
    • (1989) Endocrinology , vol.125 , pp. 1451-1457
    • Heidenreich, K.A.1    Toledo, S.P.2
  • 26
    • 0028018858 scopus 로고
    • The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin
    • K. Lam, C.L. Carpenter, N.B. Ruderman, J.C. Friel and K.L. Kelly, The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin, J Biol Chem 269 (1994), 20648-20652.
    • (1994) J Biol Chem , vol.269 , pp. 20648-20652
    • Lam, K.1    Carpenter, C.L.2    Ruderman, N.B.3    Friel, J.C.4    Kelly, K.L.5
  • 27
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
    • G. Kulik, A. Klippel and M.J. Weber, Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt, Mol Cell Biol 17 (1997), 1595-1606.
    • (1997) Mol Cell Biol , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 28
    • 0032497842 scopus 로고    scopus 로고
    • The role of PI 3-kinase in insulin action
    • A.R. Alessi and C.P. Downes, The role of PI 3-kinase in insulin action, Biochim Biophys Acta 1436 (1998), 151-164.
    • (1998) Biochim Biophys Acta , vol.1436 , pp. 151-164
    • Alessi, A.R.1    Downes, C.P.2
  • 29
    • 0032530482 scopus 로고    scopus 로고
    • Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    • M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett and S. Dedhar, Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase, Proc Natl Acad Sci USA 95 (1998), 11211-11216.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11211-11216
    • Delcommenne, M.1    Tan, C.2    Gray, V.3    Rue, L.4    Woodgett, J.5    Dedhar, S.6
  • 30
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • B.M. Burgering and P.J. Coffer, Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction, Nature 376 (1995), 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 32
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • M. Pap and G.M. Cooper, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway, J Biol Chem 273 (1998), 19929-19932.
    • (1998) J Biol Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 33
    • 0032557646 scopus 로고    scopus 로고
    • Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
    • P.C. van Weeren, K.M. de Bruyn, A.M. de Vries-Smits, J. van Lint and B.M. Burgering, Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB, J Biol Chem 273 (1998), 13150-13156.
    • (1998) J Biol Chem , vol.273 , pp. 13150-13156
    • Van Weeren, P.C.1    De Bruyn, K.M.2    De Vries-Smits, A.M.3    Van Lint, J.4    Burgering, B.M.5
  • 34
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M.E. Greenberg, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell 91 (1997), 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 35
    • 0034175688 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
    • M. Hetman, J.E. Cavanaugh, D. Kimelman and Z. Xia, Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal, J Neurosci 20 (2000), 2567-2574.
    • (2000) J Neurosci , vol.20 , pp. 2567-2574
    • Hetman, M.1    Cavanaugh, J.E.2    Kimelman, D.3    Xia, Z.4
  • 36
    • 0031923788 scopus 로고    scopus 로고
    • Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
    • E.M. Eves, W. Xiong, A. Bellacosa, S.G. Kennedy, P.N. Tsichlis, M.R. Rosner and N. Hay, Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line, Mol Cell Biol 18 (1998), 2143-2152.
    • (1998) Mol Cell Biol , vol.18 , pp. 2143-2152
    • Eves, E.M.1    Xiong, W.2    Bellacosa, A.3    Kennedy, S.G.4    Tsichlis, P.N.5    Rosner, M.R.6    Hay, N.7
  • 40
    • 0035719947 scopus 로고    scopus 로고
    • Distinct and overlapping functions of insulin and IGF-I receptors
    • J. Nakae, Y. Kido and D. Accili, Distinct and overlapping functions of insulin and IGF-I receptors, Endocr Rev 22 (2001), 818-835.
    • (2001) Endocr Rev , vol.22 , pp. 818-835
    • Nakae, J.1    Kido, Y.2    Accili, D.3
  • 41
    • 0027269766 scopus 로고
    • Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
    • M.J. Carson, R.R. Behringer, R.L. Brinster and F.A. Mc-Morris, Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice, Neuron 10 (1993), 729-740.
    • (1993) Neuron , vol.10 , pp. 729-740
    • Carson, M.J.1    Behringer, R.R.2    Brinster, R.L.3    Mc-Morris, F.A.4
  • 42
    • 0030664841 scopus 로고    scopus 로고
    • Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1
    • W. Ni, K. Rajkumar, J.I. Nagy and L.J. Murphy, Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1, Brain Res 769 (1997), 97-107.
    • (1997) Brain Res , vol.769 , pp. 97-107
    • Ni, W.1    Rajkumar, K.2    Nagy, J.I.3    Murphy, L.J.4
  • 43
    • 0033763635 scopus 로고    scopus 로고
    • Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1
    • S. Doublier, C. Duyckaerts, D. Seurin and M. Binoux, Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1, Growth Horm IGF Res 10 (2000), 267-274.
    • (2000) Growth Horm IGF Res , vol.10 , pp. 267-274
    • Doublier, S.1    Duyckaerts, C.2    Seurin, D.3    Binoux, M.4
  • 44
    • 0036786241 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: In vitro analysis
    • J. Zhong, J. Deng, B. Ghetti and W.H. Lee, Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis, J Neurosci Res 70 (2002), 36-45.
    • (2002) J Neurosci Res , vol.70 , pp. 36-45
    • Zhong, J.1    Deng, J.2    Ghetti, B.3    Lee, W.H.4
  • 45
    • 0036066970 scopus 로고    scopus 로고
    • Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
    • F. Mauvais-Jarvis, R.N. Kulkarni and C.R. Kahn, Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance, Clin Endocrinol (Oxf) 57 (2002), 1-9.
    • (2002) Clin Endocrinol (Oxf) , vol.57 , pp. 1-9
    • Mauvais-Jarvis, F.1    Kulkarni, R.N.2    Kahn, C.R.3
  • 46
    • 0034491351 scopus 로고    scopus 로고
    • Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: What can we learn from transgenic and knockout mice?
    • F. Mauvais-Jarvis and C.R. Kahn, Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice? Diabetes Metab 26 (2000), 433-448.
    • (2000) Diabetes Metab , vol.26 , pp. 433-448
    • Mauvais-Jarvis, F.1    Kahn, C.R.2
  • 47
    • 0036999546 scopus 로고    scopus 로고
    • Tissue-specific targeting of the insulin receptor gene
    • R.N. Kulkarni and T. Okada, Tissue-specific targeting of the insulin receptor gene. Endocrine 19 (2002), 257-266.
    • (2002) Endocrine , vol.19 , pp. 257-266
    • Kulkarni, R.N.1    Okada, T.2
  • 48
    • 0142029565 scopus 로고    scopus 로고
    • Insulin resistant states and insulin signaling
    • P. Vollenweider, Insulin resistant states and insulin signaling, Clin Chem Lab Med 41 (2003), 1107-1119.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 1107-1119
    • Vollenweider, P.1
  • 50
    • 0033305504 scopus 로고    scopus 로고
    • Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice
    • G. Pete, C.R. Fuller, J.M. Oldham, D.R. Smith, A.J. D'Ercole, C.R. Kahn and P.K. Lund, Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice, Endocrinology 140 (1999), 5478-5487.
    • (1999) Endocrinology , vol.140 , pp. 5478-5487
    • Pete, G.1    Fuller, C.R.2    Oldham, J.M.3    Smith, D.R.4    D'Ercole, A.J.5    Kahn, C.R.6    Lund, P.K.7
  • 51
    • 0037199092 scopus 로고    scopus 로고
    • Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination
    • P. Ye, L. Li, P.K. Lund and A.J. D'Ercole, Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination, Brain Res Dev Brain Res 136 (2002), 111-121.
    • (2002) Brain Res Dev Brain Res , vol.136 , pp. 111-121
    • Ye, P.1    Li, L.2    Lund, P.K.3    D'Ercole, A.J.4
  • 52
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • A. Virkamaki, K. Ueki and C.R. Kahn, Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance, J Clin Invest 103 (1999), 931-943.
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 54
    • 0020534018 scopus 로고
    • Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type
    • G. Bucht, R. Adolfsson, F. Lithner and B. Winblad, Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type, Acta Med Scand 213 (1983), 387-392.
    • (1983) Acta Med Scand , vol.213 , pp. 387-392
    • Bucht, G.1    Adolfsson, R.2    Lithner, F.3    Winblad, B.4
  • 60
    • 0030680107 scopus 로고    scopus 로고
    • Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study
    • J. Heitner and D. Dickson, Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study, Neurology 49 (1997), 1306-1311.
    • (1997) Neurology , vol.49 , pp. 1306-1311
    • Heitner, J.1    Dickson, D.2
  • 62
    • 9844229370 scopus 로고    scopus 로고
    • Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: Cross sectional population based study
    • J. Kuusisto, K. Koivisto, L. Mykkanen, E.L. Helkala, M. Vanhanen, T. Hanninen, K. Kervinen, Y.A. Kesaniemi, P.J. Riekkinen and M. Laakso, Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study, Bmj 315 (1997), 1045-1049.
    • (1997) Bmj , vol.315 , pp. 1045-1049
    • Kuusisto, J.1    Koivisto, K.2    Mykkanen, L.3    Helkala, E.L.4    Vanhanen, M.5    Hanninen, T.6    Kervinen, K.7    Kesaniemi, Y.A.8    Riekkinen, P.J.9    Laakso, M.10
  • 64
    • 0034016848 scopus 로고    scopus 로고
    • Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
    • S. Craft, S. Asthana, G. Schellenberg, L. Baker, M. Cherrier, A.A. Boyt, R.N. Martins, M. Raskind, E. Peskind and S. Plymate, Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype, Ann N Y Acad Sci 903 (2000), 222-228.
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 222-228
    • Craft, S.1    Asthana, S.2    Schellenberg, G.3    Baker, L.4    Cherrier, M.5    Boyt, A.A.6    Martins, R.N.7    Raskind, M.8    Peskind, E.9    Plymate, S.10
  • 65
    • 0042385094 scopus 로고    scopus 로고
    • Diabetes, Alzheimer's disease and apolipoprotein genotype
    • C. Messier, Diabetes, Alzheimer's disease and apolipoprotein genotype, Exp Gerontol 38 (2003), 941-946.
    • (2003) Exp Gerontol , vol.38 , pp. 941-946
    • Messier, C.1
  • 66
    • 0034603552 scopus 로고    scopus 로고
    • Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer's pathogenesis
    • J.C. de la Torre, Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis, Neurobiol Aging 21 (2000), 331-342.
    • (2000) Neurobiol Aging , vol.21 , pp. 331-342
    • De La Torre, J.C.1
  • 68
    • 0033653771 scopus 로고    scopus 로고
    • Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
    • S. Hoyer, Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update, Exp Gerontol 35 (2000), 1363-1372.
    • (2000) Exp Gerontol , vol.35 , pp. 1363-1372
    • Hoyer, S.1
  • 69
    • 0036592758 scopus 로고    scopus 로고
    • The role of the metabolic lesion in Alzheimer's disease
    • J.P. Blass, G.E. Gibson and S. Hoyer, The role of the metabolic lesion in Alzheimer's disease, J Alzheimers Dis 4 (2002), 225-232.
    • (2002) J Alzheimers Dis , vol.4 , pp. 225-232
    • Blass, J.P.1    Gibson, G.E.2    Hoyer, S.3
  • 70
    • 0347654897 scopus 로고    scopus 로고
    • Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: Therapeutic implications
    • S. Hoyer, Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications, Adv Exp Med Biol 541 (2004), 135-152.
    • (2004) Adv Exp Med Biol , vol.541 , pp. 135-152
    • Hoyer, S.1
  • 71
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • S. Hoyer, Glucose metabolism and insulin receptor signal transduction in Alzheimer disease, Eur J Pharmacol 490 (2004), 115-125.
    • (2004) Eur J Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 72
    • 0029414741 scopus 로고
    • Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders?
    • D. Blum-Degen, L. Frolich, S. Hoyer and P. Riederer, Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders? J Neural Transm Suppl 46 (1995), 139-147.
    • (1995) J Neural Transm Suppl , vol.46 , pp. 139-147
    • Blum-Degen, D.1    Frolich, L.2    Hoyer, S.3    Riederer, P.4
  • 73
    • 0035577699 scopus 로고    scopus 로고
    • Glucose and lactate metabolism during brain activation
    • G.A. Dienel and L. Hertz, Glucose and lactate metabolism during brain activation, J Neurosci Res 66 (2001), 824-838.
    • (2001) J Neurosci Res , vol.66 , pp. 824-838
    • Dienel, G.A.1    Hertz, L.2
  • 74
    • 2942534211 scopus 로고    scopus 로고
    • Energy transfer from astrocytes to axons: The role of CNS glycogen
    • A.M. Brown, S. Baltan Tekkok and B.R. Ransom, Energy transfer from astrocytes to axons: the role of CNS glycogen, Neurochem Int 45 (2004), 529-536.
    • (2004) Neurochem Int , vol.45 , pp. 529-536
    • Brown, A.M.1    Baltan Tekkok, S.2    Ransom, B.R.3
  • 75
    • 0242574396 scopus 로고    scopus 로고
    • Energy substrates for neurons during neural activity: A critical review of the astrocyteneuron lactate shuttle hypothesis
    • C.P. Chih and E.L. Roberts, Jr., Energy substrates for neurons during neural activity: a critical review of the astrocyteneuron lactate shuttle hypothesis, J Cereb Blood Flow Metab 23 (2003), 1263-1281.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 1263-1281
    • Chih, C.P.1    Roberts Jr., E.L.2
  • 76
    • 0027314683 scopus 로고
    • Alterations in glucose metabolism in patients with Alzheimer's disease
    • G.S. Meneilly and A. Hill, Alterations in glucose metabolism in patients with Alzheimer's disease, J Am Geriatr Soc 41 (1993), 710-714.
    • (1993) J Am Geriatr Soc , vol.41 , pp. 710-714
    • Meneilly, G.S.1    Hill, A.2
  • 78
    • 0029869755 scopus 로고    scopus 로고
    • Glucose regulation and cognitive functions: Relation to Alzheimer's disease and diabetes
    • C. Messier and M. Gagnon, Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes, Behav Brain Res 75 (1996), 1-11.
    • (1996) Behav Brain Res , vol.75 , pp. 1-11
    • Messier, C.1    Gagnon, M.2
  • 81
    • 0025856239 scopus 로고
    • Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases
    • S. Hoyer, R. Nitsch and K. Oesterreich, Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases, J Neural Transm Park Dis Dement Sect 3 (1991), 1-14.
    • (1991) J Neural Transm Park Dis Dement Sect , vol.3 , pp. 1-14
    • Hoyer, S.1    Nitsch, R.2    Oesterreich, K.3
  • 82
    • 0024545260 scopus 로고
    • Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type
    • S. Hoyer and R. Nitsch, Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type, J Neural Transm 75 (1989), 227-232.
    • (1989) J Neural Transm , vol.75 , pp. 227-232
    • Hoyer, S.1    Nitsch, R.2
  • 83
    • 0026332340 scopus 로고
    • Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type
    • Y. Fujisawa, K. Sasaki and K. Akiyama, Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type, Biol Psychiatry 30 (1991), 1219-1228.
    • (1991) Biol Psychiatry , vol.30 , pp. 1219-1228
    • Fujisawa, Y.1    Sasaki, K.2    Akiyama, K.3
  • 85
    • 0027466571 scopus 로고
    • Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease
    • L. Kilander, M. Boberg and H. Lithell, Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease, Acta Neurol Scand 87 (1993), 294-298.
    • (1993) Acta Neurol Scand , vol.87 , pp. 294-298
    • Kilander, L.1    Boberg, M.2    Lithell, H.3
  • 86
    • 0031907459 scopus 로고    scopus 로고
    • Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
    • S. Craft, E. Peskind, M.W. Schwartz, G.D. Schellenberg, M. Raskind and D. Porte, Jr., Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype, Neurology 50 (1998), 164-168.
    • (1998) Neurology , vol.50 , pp. 164-168
    • Craft, S.1    Peskind, E.2    Schwartz, M.W.3    Schellenberg, G.D.4    Raskind, M.5    Porte Jr., D.6
  • 87
    • 0027991714 scopus 로고
    • Hyperinsulinaemia and Alzheimer's disease
    • G. Razay and G.K. Wilcock, Hyperinsulinaemia and Alzheimer's disease, Age Ageing 23 (1994), 396-399.
    • (1994) Age Ageing , vol.23 , pp. 396-399
    • Razay, G.1    Wilcock, G.K.2
  • 88
    • 0030408690 scopus 로고    scopus 로고
    • Nutritional status of patients with Alzheimer's disease: A 1-year study
    • A.A. Spindler, M.J. Renvall, J.F. Nichols and J.W. Ramsdell, Nutritional status of patients with Alzheimer's disease: a 1-year study, J Am Diet Assoc 96 (1996), 1013-1018.
    • (1996) J Am Diet Assoc , vol.96 , pp. 1013-1018
    • Spindler, A.A.1    Renvall, M.J.2    Nichols, J.F.3    Ramsdell, J.W.4
  • 89
    • 0022921950 scopus 로고
    • Somatostatin and Alzheimer's disease: A hypothesis
    • J.C. Reubi and J. Palacios, Somatostatin and Alzheimer's disease: a hypothesis, J Neurol 233 (1986), 370-372.
    • (1986) J Neurol , vol.233 , pp. 370-372
    • Reubi, J.C.1    Palacios, J.2
  • 91
    • 0023922851 scopus 로고
    • Insulin-like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia of the Alzheimer type
    • A. Tham, K. Sparring, D. Bowen, L. Wetterberg and V.R. Sara, Insulin-like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia of the Alzheimer type, Acta Psychiatr Scand 77 (1988), 719-723.
    • (1988) Acta Psychiatr Scand , vol.77 , pp. 719-723
    • Tham, A.1    Sparring, K.2    Bowen, D.3    Wetterberg, L.4    Sara, V.R.5
  • 92
    • 0027170501 scopus 로고
    • Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type
    • A. Tham, A. Nordberg, F.E. Grissom, C. Carlsson-Skwirut, M. Viitanen and V.R. Sara, Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type, J Neural Transm Park Dis Dement Sect 5 (1993), 165-176.
    • (1993) J Neural Transm Park Dis Dement Sect , vol.5 , pp. 165-176
    • Tham, A.1    Nordberg, A.2    Grissom, F.E.3    Carlsson-Skwirut, C.4    Viitanen, M.5    Sara, V.R.6
  • 93
    • 0032712557 scopus 로고    scopus 로고
    • Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation
    • A. Mustafa, L. Lannfelt, L. Lilius, A. Islam, B. Winblad and A. Adem, Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation, Dement Geriatr Cogn Disord 10 (1999), 446-451.
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 446-451
    • Mustafa, A.1    Lannfelt, L.2    Lilius, L.3    Islam, A.4    Winblad, B.5    Adem, A.6
  • 95
    • 0026572765 scopus 로고
    • Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients
    • F.T. Crews, R. McElhaney, G. Freund, W.E. Ballinger, Jr. and M.K. Raizada, Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients, J Neurochem 58 (1992), 1205-1210.
    • (1992) J Neurochem , vol.58 , pp. 1205-1210
    • Crews, F.T.1    McElhaney, R.2    Freund, G.3    Ballinger Jr., W.E.4    Raizada, M.K.5
  • 96
    • 0034672811 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains
    • S. Jafferali, Y. Dumont, F. Sotty, Y. Robitaille, R. Quirion and S. Kar, Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains, Synapse 38 (2000), 450-459.
    • (2000) Synapse , vol.38 , pp. 450-459
    • Jafferali, S.1    Dumont, Y.2    Sotty, F.3    Robitaille, Y.4    Quirion, R.5    Kar, S.6
  • 97
    • 0028278398 scopus 로고
    • Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease
    • J. De Keyser, N. Wilczak and A. Goossens, Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease, Neurosci Lett 172 (1994), 93-96.
    • (1994) Neurosci Lett , vol.172 , pp. 93-96
    • De Keyser, J.1    Wilczak, N.2    Goossens, A.3
  • 98
    • 0028344810 scopus 로고
    • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    • I. Moroo, T. Yamada, H. Makino, I. Tooyama, P.L. McGeer, E.G. McGeer and K. Hirayama, Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease, Acta Neuropathol (Berl) 87 (1994), 343-348.
    • (1994) Acta Neuropathol (Berl) , vol.87 , pp. 343-348
    • Moroo, I.1    Yamada, T.2    Makino, H.3    Tooyama, I.4    McGeer, P.L.5    McGeer, E.G.6    Hirayama, K.7
  • 99
    • 0033378682 scopus 로고    scopus 로고
    • A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
    • L. Frolich, D. Blum-Degen, P. Riederer and S. Hoyer, A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease, Ann N Y Acad Sci 893 (1999), 290-293.
    • (1999) Ann N Y Acad Sci , vol.893 , pp. 290-293
    • Frolich, L.1    Blum-Degen, D.2    Riederer, P.3    Hoyer, S.4
  • 101
    • 0035574487 scopus 로고    scopus 로고
    • Effects of age on elements of insulin-signaling pathway in central nervous system of rats
    • M.L. Fernandes, M.J. Saad and L.A. Velloso, Effects of age on elements of insulin-signaling pathway in central nervous system of rats, Endocrine 16 (2001), 227-234.
    • (2001) Endocrine , vol.16 , pp. 227-234
    • Fernandes, M.L.1    Saad, M.J.2    Velloso, L.A.3
  • 102
    • 0031928535 scopus 로고    scopus 로고
    • Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
    • S. Hoyer, Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis, J Neural Transm 105 (1998), 415-422.
    • (1998) J Neural Transm , vol.105 , pp. 415-422
    • Hoyer, S.1
  • 103
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • M. Hong and V.M. Lee, Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons, J Biol Chem 272 (1997), 19547-19553.
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.2
  • 104
    • 0028675873 scopus 로고
    • Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
    • S. Lovestone, C.H. Reynolds, D. Latimer, D.R. Davis, B.H. Anderton, J.M. Gallo, D. Hanger, S. Mulot, B. Marquardt, S. Stabel et al., Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells, Curr Biol 4 (1994), 1077-1086.
    • (1994) Curr Biol , vol.4 , pp. 1077-1086
    • Lovestone, S.1    Reynolds, C.H.2    Latimer, D.3    Davis, D.R.4    Anderton, B.H.5    Gallo, J.M.6    Hanger, D.7    Mulot, S.8    Marquardt, B.9    Stabel, S.10
  • 105
    • 0032578024 scopus 로고    scopus 로고
    • Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
    • J.J. Pei, I. Grundke-Iqbal, K. Iqbal, N. Bogdanovic, B. Winblad and R.F. Cowburn, Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration, Brain Res 797 (1998), 267-277.
    • (1998) Brain Res , vol.797 , pp. 267-277
    • Pei, J.J.1    Grundke-Iqbal, I.2    Iqbal, K.3    Bogdanovic, N.4    Winblad, B.5    Cowburn, R.F.6
  • 106
    • 85062139768 scopus 로고
    • Tau phosphorylation in brain slices: Pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase
    • T.D. Garver, G.A. Oyler, K.A. Harris, R. Polavarapu, Z. Damuni, R.A. Lehman and M.L. Billingsley, Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase, Mol Pharmacol 47 (1995), 745-756.
    • (1995) Mol Pharmacol , vol.47 , pp. 745-756
    • Garver, T.D.1    Oyler, G.A.2    Harris, K.A.3    Polavarapu, R.4    Damuni, Z.5    Lehman, R.A.6    Billingsley, M.L.7
  • 107
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • B.W. Doble and J.R. Woodgett, GSK-3: tricks of the trade for a multi-tasking kinase, J Cell Sci 116 (2003), 1175-1186.
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 112
    • 0348134529 scopus 로고    scopus 로고
    • Alzheimer's disease linking neurodegeneration with neurodevelopment
    • M. Grilli, G.F. Toninelli, D. Uberti, P. Spano and M. Memo, Alzheimer's disease linking neurodegeneration with neurodevelopment, Fund Neurol 18 (2003), 145-148.
    • (2003) Fund Neurol , vol.18 , pp. 145-148
    • Grilli, M.1    Toninelli, G.F.2    Uberti, D.3    Spano, P.4    Memo, M.5
  • 113
    • 0142042435 scopus 로고    scopus 로고
    • Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection
    • G.J. Chen, J. Xu, S.A. Lahousse, N.L. Caggiano and S.M. de la Monte, Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection, J Alzheimers Dis 5 (2003), 209-228.
    • (2003) J Alzheimers Dis , vol.5 , pp. 209-228
    • Chen, G.J.1    Xu, J.2    Lahousse, S.A.3    Caggiano, N.L.4    De La Monte, S.M.5
  • 114
    • 0037357190 scopus 로고    scopus 로고
    • Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures
    • J.T. Egana, C. Zambrano, M.T. Nunez, C. Gonzalez-Billault and R.B. Maccioni, Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures, Biometals 16 (2003), 215-223.
    • (2003) Biometals , vol.16 , pp. 215-223
    • Egana, J.T.1    Zambrano, C.2    Nunez, M.T.3    Gonzalez-Billault, C.4    Maccioni, R.B.5
  • 115
    • 0345276565 scopus 로고    scopus 로고
    • Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
    • E.M. Mandelkow, K. Stamer, R. Vogel, E. Thies and E. Mandelkow, Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses, Neurobiol Aging 24 (2003), 1079-1085.
    • (2003) Neurobiol Aging , vol.24 , pp. 1079-1085
    • Mandelkow, E.M.1    Stamer, K.2    Vogel, R.3    Thies, E.4    Mandelkow, E.5
  • 116
    • 0036770144 scopus 로고    scopus 로고
    • The role of mitogen-activated protein kinase pathways in Alzheimer's disease
    • X. Zhu, H.G. Lee, A.K. Raina, G. Perry and M.A. Smith, The role of mitogen-activated protein kinase pathways in Alzheimer's disease, Neurosignals 11 (2002), 270-281.
    • (2002) Neurosignals , vol.11 , pp. 270-281
    • Zhu, X.1    Lee, H.G.2    Raina, A.K.3    Perry, G.4    Smith, M.A.5
  • 119
    • 0033540060 scopus 로고    scopus 로고
    • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    • G.N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes and L.H. Tsai, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature 402 (1999), 615-622.
    • (1999) Nature , vol.402 , pp. 615-622
    • Patrick, G.N.1    Zukerberg, L.2    Nikolic, M.3    De La Monte, S.4    Dikkes, P.5    Tsai, L.H.6
  • 121
    • 0036270446 scopus 로고    scopus 로고
    • Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: Dependence on Ca(2+) and PI3-kinase
    • A.J. Crossthwaite, S. Hasan and R.J. Williams, Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase, J Neurochem 80 (2002), 24-35.
    • (2002) J Neurochem , vol.80 , pp. 24-35
    • Crossthwaite, A.J.1    Hasan, S.2    Williams, R.J.3
  • 122
    • 0036458808 scopus 로고    scopus 로고
    • ERK activation and nuclear translocation in amyloid-beta peptide- and iron-stressed neuronal cell cultures
    • F. Kuperstein and E. Yavin, ERK activation and nuclear translocation in amyloid-beta peptide- and iron-stressed neuronal cell cultures, Eur J Neurosci 16 (2002), 44-54.
    • (2002) Eur J Neurosci , vol.16 , pp. 44-54
    • Kuperstein, F.1    Yavin, E.2
  • 123
    • 0038647463 scopus 로고    scopus 로고
    • Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity
    • F. Kuperstein and E. Yavin, Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity, J Neurochem 86 (2003), 114-125.
    • (2003) J Neurochem , vol.86 , pp. 114-125
    • Kuperstein, F.1    Yavin, E.2
  • 125
    • 0035871641 scopus 로고    scopus 로고
    • Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    • L. Gasparini, G.K. Gouras, R. Wang, R.S. Gross, M.F. Beal, P. Greengard and H. Xu, Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling, J Neurosci 21 (2001), 2561-2570.
    • (2001) J Neurosci , vol.21 , pp. 2561-2570
    • Gasparini, L.1    Gouras, G.K.2    Wang, R.3    Gross, R.S.4    Beal, M.F.5    Greengard, P.6    Xu, H.7
  • 126
    • 0036591657 scopus 로고    scopus 로고
    • Does insulin dysfunction play a role in Alzheimer's disease?
    • L. Gasparini, W.J. Netzer, P. Greengard and H. Xu, Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci 23 (2002), 288-293.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 288-293
    • Gasparini, L.1    Netzer, W.J.2    Greengard, P.3    Xu, H.4
  • 127
    • 0036813726 scopus 로고    scopus 로고
    • Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor
    • X. Ling, R.N. Martins, M. Racchi, S. Craft and E. Helmerhorst, Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor, J Alzheimers Dis 4 (2002), 369-374.
    • (2002) J Alzheimers Dis , vol.4 , pp. 369-374
    • Ling, X.1    Martins, R.N.2    Racchi, M.3    Craft, S.4    Helmerhorst, E.5
  • 128
    • 0035997231 scopus 로고    scopus 로고
    • Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
    • G. Evin and A. Weidemann, Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides, Peptides 23 (2002), 1285-1297.
    • (2002) Peptides , vol.23 , pp. 1285-1297
    • Evin, G.1    Weidemann, A.2
  • 129
    • 0030902595 scopus 로고    scopus 로고
    • Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
    • S. Dore, S. Kar and R. Quirion, Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity, Proc Natl Acad Sci USA 94 (1997), 4772-4777.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4772-4777
    • Dore, S.1    Kar, S.2    Quirion, R.3
  • 130
    • 0033450892 scopus 로고    scopus 로고
    • Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons
    • S. Dore, S. Bastianetto, S. Kar and R. Quirion, Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons, Ann N Y Acad Sci 890 (1999), 356-364.
    • (1999) Ann N Y Acad Sci , vol.890 , pp. 356-364
    • Dore, S.1    Bastianetto, S.2    Kar, S.3    Quirion, R.4
  • 131
    • 0034518163 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 (IGF-1): A neuroprotective trophic factor acting via the Akt kinase pathway
    • W.H. Zheng, S. Kar, S. Dore and R. Quirion, Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway, J Neural Transm Suppl (2000), 261-272.
    • (2000) J Neural Transm Suppl , pp. 261-272
    • Zheng, W.H.1    Kar, S.2    Dore, S.3    Quirion, R.4
  • 132
    • 0035197347 scopus 로고    scopus 로고
    • Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons
    • S.M. de la Monte, T.R. Neely, J. Cannon and J.R. Wands, Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons, Cell Mol Life Sci 58 (2001), 1950-1960.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 1950-1960
    • De La Monte, S.M.1    Neely, T.R.2    Cannon, J.3    Wands, J.R.4
  • 133
    • 0036282840 scopus 로고    scopus 로고
    • Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons
    • S.M. de laMonte and J.R. Wands, Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons, CMLS, Cell Mol Life Sci 59 (2002), 882-893.
    • (2002) CMLS, Cell Mol Life Sci , vol.59 , pp. 882-893
    • De Lamonte, S.M.1    Wands, J.R.2
  • 134
    • 0034128363 scopus 로고    scopus 로고
    • Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase
    • S.M. de la Monte, N. Ganju, K. Banerjee, N.V. Brown, T. Luong and J.R. Wands, Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase, Alcohol Clin Exp Res 24 (2000), 716-726.
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 716-726
    • De La Monte, S.M.1    Ganju, N.2    Banerjee, K.3    Brown, N.V.4    Luong, T.5    Wands, J.R.6
  • 135
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • G.G. Glenner and C.W Wong, Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Commun 120 (1984), 885-890.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 136
    • 0042839610 scopus 로고    scopus 로고
    • Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells
    • E. Tsukamoto, Y. Hashimoto, K. Kanekura, T. Niikura, S. Aiso and I. Nishimoto, Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells, J Neurosci Res 73 (2003), 627-636.
    • (2003) J Neurosci Res , vol.73 , pp. 627-636
    • Tsukamoto, E.1    Hashimoto, Y.2    Kanekura, K.3    Niikura, T.4    Aiso, S.5    Nishimoto, I.6
  • 137
    • 0031044352 scopus 로고    scopus 로고
    • Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
    • J.R. McDermott and A.M. Gibson, Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme, Neurochem Res 22 (1997), 49-56.
    • (1997) Neurochem Res , vol.22 , pp. 49-56
    • McDermott, J.R.1    Gibson, A.M.2
  • 139
    • 0034038036 scopus 로고    scopus 로고
    • Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
    • A. Perez, L. Morelli, J.C. Cresto and E.M. Castano, Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains, Neurochem Res 25 (2000), 247-255.
    • (2000) Neurochem Res , vol.25 , pp. 247-255
    • Perez, A.1    Morelli, L.2    Cresto, J.C.3    Castano, E.M.4
  • 140
    • 0034161516 scopus 로고    scopus 로고
    • Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
    • K. Vekrellis, Z. Ye, W.Q. Qiu, D. Walsh, D. Hartley, V. Chesneau, M.R. Rosner and D.J. Selkoe, Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme, J Neurosci 20 (2000), 1657-1665.
    • (2000) J Neurosci , vol.20 , pp. 1657-1665
    • Vekrellis, K.1    Ye, Z.2    Qiu, W.Q.3    Walsh, D.4    Hartley, D.5    Chesneau, V.6    Rosner, M.R.7    Selkoe, D.J.8
  • 141
    • 0034933147 scopus 로고    scopus 로고
    • Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase
    • A.S. Balasubramanian, Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase, Neumchem Res 26 (2001), 453-456.
    • (2001) Neumchem Res , vol.26 , pp. 453-456
    • Balasubramanian, A.S.1
  • 142
    • 0033605607 scopus 로고    scopus 로고
    • Insulin-degrading enzyme in the Alzheimer's disease brain: Prominent localization in neurons and senile plaques
    • H.G. Bernstein, S. Ansorge, P. Riederer, M. Reiser, L. Frolich and B. Bogerts, Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques, Neurosci Lett 263 (1999), 161-164.
    • (1999) Neurosci Lett , vol.263 , pp. 161-164
    • Bernstein, H.G.1    Ansorge, S.2    Riederer, P.3    Reiser, M.4    Frolich, L.5    Bogerts, B.6
  • 144
    • 1642290835 scopus 로고    scopus 로고
    • Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
    • W. Farris, S. Mansourian, M.A. Leissring, E.A. Eckman, L. Bertram, C.B. Eckman, R.E. Tanzi and D.J. Selkoe, Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein, Am J Pathol 164 (2004), 1425-1434.
    • (2004) Am J Pathol , vol.164 , pp. 1425-1434
    • Farris, W.1    Mansourian, S.2    Leissring, M.A.3    Eckman, E.A.4    Bertram, L.5    Eckman, C.B.6    Tanzi, R.E.7    Selkoe, D.J.8
  • 146
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • M.A. Leissring, W. Farris, A.Y. Chang, D.M. Walsh, X. Wu, X. Sun, M.P. Frosch and D.J. Selkoe, Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death, Neuron 40 (2003), 1087-1093.
    • (2003) Neuron , vol.40 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3    Walsh, D.M.4    Wu, X.5    Sun, X.6    Frosch, M.P.7    Selkoe, D.J.8
  • 150
    • 0037162647 scopus 로고    scopus 로고
    • Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
    • M. Boussaha, D. Hannequin, P. Verpillat, A. Brice, T. Frebourg and D. Campion, Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease, Neurosci Lett 329 (2002), 121-123.
    • (2002) Neurosci Lett , vol.329 , pp. 121-123
    • Boussaha, M.1    Hannequin, D.2    Verpillat, P.3    Brice, A.4    Frebourg, T.5    Campion, D.6
  • 151
    • 0028365004 scopus 로고
    • Age as risk factor for sporadic dementia of the Alzheimer type?
    • S. Hoyer, Age as risk factor for sporadic dementia of the Alzheimer type? Ann N Y Acad Sci 719 (1994), 248-256.
    • (1994) Ann N Y Acad Sci , vol.719 , pp. 248-256
    • Hoyer, S.1
  • 152
    • 0028170864 scopus 로고
    • Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism
    • S. Hoyer, D. Muller and K. Plaschke, Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism, J Neural Transm Suppl 44 (1994), 259-268.
    • (1994) J Neural Transm Suppl , vol.44 , pp. 259-268
    • Hoyer, S.1    Muller, D.2    Plaschke, K.3
  • 153
    • 0027967549 scopus 로고
    • Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity
    • S. Hoyer, Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity, Life Sci 55 (1994), 1977-1983.
    • (1994) Life Sci , vol.55 , pp. 1977-1983
    • Hoyer, S.1
  • 154
    • 0029689159 scopus 로고    scopus 로고
    • Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease
    • S. Hoyer, Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease, Acta Neurol Scand Suppl 165 (1996), 18-24.
    • (1996) Acta Neurol Scand Suppl , vol.165 , pp. 18-24
    • Hoyer, S.1
  • 155
    • 0036205701 scopus 로고    scopus 로고
    • The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: An update
    • S. Hoyer, The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update, J Neural Transm 109 (2002), 341-360.
    • (2002) J Neural Transm , vol.109 , pp. 341-360
    • Hoyer, S.1
  • 156
    • 0036311771 scopus 로고    scopus 로고
    • The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
    • S. Hoyer, The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review, J Neural Transm 109 (2002), 991-1002.
    • (2002) J Neural Transm , vol.109 , pp. 991-1002
    • Hoyer, S.1
  • 157
    • 0027304893 scopus 로고
    • Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus
    • K. Plaschke and S. Hoyer, Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus, Int J Dev Neurosci 11 (1993), 477-483.
    • (1993) Int J Dev Neurosci , vol.11 , pp. 477-483
    • Plaschke, K.1    Hoyer, S.2
  • 158
    • 0028598190 scopus 로고
    • Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
    • R. Duelli, H. Schrock, W. Kuschinsky and S. Hoyer, Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int J Dev Neurosci 12 (1994), 737-743.
    • (1994) Int J Dev Neurosci , vol.12 , pp. 737-743
    • Duelli, R.1    Schrock, H.2    Kuschinsky, W.3    Hoyer, S.4
  • 159
    • 0034537362 scopus 로고    scopus 로고
    • Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
    • S. Hoyer, S.K. Lee, T. Loffler and R. Schliebs, Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease? Ann N Y Acad Sci 920 (2000), 256-258.
    • (2000) Ann N Y Acad Sci , vol.920 , pp. 256-258
    • Hoyer, S.1    Lee, S.K.2    Loffler, T.3    Schliebs, R.4
  • 160
    • 0033380660 scopus 로고    scopus 로고
    • Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats
    • S. Hoyer and H. Lannert, Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats, Ann N Y Acad Sci 893 (1999), 301-303.
    • (1999) Ann N Y Acad Sci , vol.893 , pp. 301-303
    • Hoyer, S.1    Lannert, H.2
  • 161
    • 0031797937 scopus 로고    scopus 로고
    • Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
    • H. Lannert and S. Hoyer, Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats, Behav Neurosci 112 (1998), 1199-1208.
    • (1998) Behav Neurosci , vol.112 , pp. 1199-1208
    • Lannert, H.1    Hoyer, S.2
  • 162
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Y. Miyazaki, H. He, L.J. Mandarino and R.A. DeFronzo, Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients, Diabetes 52 (2003), 1943-1950.
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    Defronzo, R.A.4
  • 163
    • 0042822095 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: Comparison with PPAR-gamma activation
    • E.H. Koh, M.S. Kim, J.Y. Park, H.S. Kim, J.Y. Youn, H.S. Park, J.H. Youn and K.U. Lee, Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation, Diabetes 52 (2003), 2331-2337.
    • (2003) Diabetes , vol.52 , pp. 2331-2337
    • Koh, E.H.1    Kim, M.S.2    Park, J.Y.3    Kim, H.S.4    Youn, J.Y.5    Park, H.S.6    Youn, J.H.7    Lee, K.U.8
  • 164
    • 3042536908 scopus 로고    scopus 로고
    • Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling
    • S.M. de la Monte and J.R. Wands, Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling, J Alzheimers Dis 6 (2004), 231-242.
    • (2004) J Alzheimers Dis , vol.6 , pp. 231-242
    • De La Monte, S.M.1    Wands, J.R.2
  • 165
    • 3042558276 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A drug target for CNS therapies
    • R.V. Bhat, S.L. Budd Haeberlein and J. Avila, Glycogen synthase kinase 3: a drug target for CNS therapies, J Neurochem 89 (2004), 1313-1317.
    • (2004) J Neurochem , vol.89 , pp. 1313-1317
    • Bhat, R.V.1    Budd Haeberlein, S.L.2    Avila, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.