-
1
-
-
0030594986
-
In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: Evidence that IGF-I increases proliferation of granule cell progenitors
-
P. Ye, Y. Xing, Z. Dai and A.J. D'Ercole, In vivo actions of insulin-like growth factor-I (IGF-I) on cerebellum development in transgenic mice: evidence that IGF-I increases proliferation of granule cell progenitors, Brain Res Dev Brain Res 95 (1996), 44-54.
-
(1996)
Brain Res Dev Brain Res
, vol.95
, pp. 44-54
-
-
Ye, P.1
Xing, Y.2
Dai, Z.3
D'Ercole, A.J.4
-
2
-
-
0036551775
-
Mutant mouse models of insulin-like growth factor actions in the central nervous system
-
A.J. D'Ercole, P. Ye and J.R. O'Kusky, Mutant mouse models of insulin-like growth factor actions in the central nervous system, Neuropeptides 36 (2002), 209-220.
-
(2002)
Neuropeptides
, vol.36
, pp. 209-220
-
-
D'Ercole, A.J.1
Ye, P.2
O'Kusky, J.R.3
-
3
-
-
2342511484
-
In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system
-
G.J. Popken, R.D. Hodge, P. Ye, J. Zhang, W. Ng, J.R. O'Kusky and A.J. D'Ercole, In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system, Eur J Neurosci 19 (2004), 2056-2068.
-
(2004)
Eur J Neurosci
, vol.19
, pp. 2056-2068
-
-
Popken, G.J.1
Hodge, R.D.2
Ye, P.3
Zhang, J.4
Ng, W.5
O'Kusky, J.R.6
D'Ercole, A.J.7
-
4
-
-
0030330547
-
The role of the insulin-like growth factors in the central nervous system
-
A.J. D'Ercole, P. Ye, A.S. Calikoglu and G. Gutierrez-Ospina, The role of the insulin-like growth factors in the central nervous system, Mol Neurobiol 13 (1996), 227-255.
-
(1996)
Mol Neurobiol
, vol.13
, pp. 227-255
-
-
D'Ercole, A.J.1
Ye, P.2
Calikoglu, A.S.3
Gutierrez-Ospina, G.4
-
5
-
-
0034668766
-
Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development
-
J.R. O'Kusky, P. Ye and A.J. D'Ercole, Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development, J Neurosci 20 (2000), 8435-8442.
-
(2000)
J Neurosci
, vol.20
, pp. 8435-8442
-
-
O'Kusky, J.R.1
Ye, P.2
D'Ercole, A.J.3
-
6
-
-
0030006746
-
Use of transgenic mice for understanding the physiology of insulin-like growth factors
-
A.J. D'Ercole, P. Ye and G. Gutierrez-Ospina, Use of transgenic mice for understanding the physiology of insulin-like growth factors, Horm Res 45(Suppl 1) (1996), 5-7.
-
(1996)
Horm Res
, vol.45
, Issue.1 SUPPL.
, pp. 5-7
-
-
D'Ercole, A.J.1
Ye, P.2
Gutierrez-Ospina, G.3
-
7
-
-
0027391758
-
The cellular and physiological actions of insulin in the central nervous system
-
M. Wozniak, B. Rydzewski, S.P. Baker and M.K. Raizada, The cellular and physiological actions of insulin in the central nervous system, Neurochem Int 22 (1993), 1-10.
-
(1993)
Neurochem Int
, vol.22
, pp. 1-10
-
-
Wozniak, M.1
Rydzewski, B.2
Baker, S.P.3
Raizada, M.K.4
-
8
-
-
15444339756
-
Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
-
L. Frolich, D. Blum-Degen, H.G. Bernstein, S. Engelsberger, J. Humrich, S. Laufer, D. Muschner, A. Thalheimer, A. Turk, S. Hoyer, R. Zochling, K.W. Boissl, K. Jellinger and P. Riederer, Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease, J Neural Transm 105 (1998), 423-438.
-
(1998)
J Neural Transm
, vol.105
, pp. 423-438
-
-
Frolich, L.1
Blum-Degen, D.2
Bernstein, H.G.3
Engelsberger, S.4
Humrich, J.5
Laufer, S.6
Muschner, D.7
Thalheimer, A.8
Turk, A.9
Hoyer, S.10
Zochling, R.11
Boissl, K.W.12
Jellinger, K.13
Riederer, P.14
-
9
-
-
0034870813
-
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
-
J.F. Poduslo, G.L. Curran, T.M. Wengenack, B. Malester and K. Duff, Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease, Neurobiol Dis 8 (2001), 555-567.
-
(2001)
Neurobiol Dis
, vol.8
, pp. 555-567
-
-
Poduslo, J.F.1
Curran, G.L.2
Wengenack, T.M.3
Malester, B.4
Duff, K.5
-
10
-
-
0037303635
-
Brain insulin: Regulation, mechanisms of action and functions
-
K. Gerozissis and G. Kyriaki, Brain insulin: regulation, mechanisms of action and functions, Cell Mol Neurobiol 23 (2003), 1-25.
-
(2003)
Cell Mol Neurobiol
, vol.23
, pp. 1-25
-
-
Gerozissis, K.1
Kyriaki, G.2
-
11
-
-
0027519849
-
Expression of insulin-like growth factor-I in transgenic mice
-
A.J. D'Ercole, Expression of insulin-like growth factor-I in transgenic mice, Ann N Y Acad Sci 692 (1993), 149-160.
-
(1993)
Ann N Y Acad Sci
, vol.692
, pp. 149-160
-
-
D'Ercole, A.J.1
-
12
-
-
0030253891
-
The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system
-
F. Folli, S. Ghidella, L. Bonfanti, C.R. Kahn and A. Merighi, The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system, Mol Neurobiol 13 (1996), 155-183.
-
(1996)
Mol Neurobiol
, vol.13
, pp. 155-183
-
-
Folli, F.1
Ghidella, S.2
Bonfanti, L.3
Kahn, C.R.4
Merighi, A.5
-
13
-
-
0030664648
-
Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene
-
P. Ye, Y. Umayahara, D. Ritter, T. Bunting, H. Auman, P. Rotwein and A.J. D'Ercole, Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene, Endocrinology 138 (1997), 5466-5475.
-
(1997)
Endocrinology
, vol.138
, pp. 5466-5475
-
-
Ye, P.1
Umayahara, Y.2
Ritter, D.3
Bunting, T.4
Auman, H.5
Rotwein, P.6
D'Ercole, A.J.7
-
14
-
-
0033548853
-
Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse
-
K.D. Dentremont, P. Ye, A.J. D'Ercole and J.R. O'Kusky, Increased insulin-like growth factor-I (IGF-I) expression during early postnatal development differentially increases neuron number and growth in medullary nuclei of the mouse, Brain Res Dev Brain Res 114 (1999), 135-141.
-
(1999)
Brain Res Dev Brain Res
, vol.114
, pp. 135-141
-
-
Dentremont, K.D.1
Ye, P.2
D'Ercole, A.J.3
O'Kusky, J.R.4
-
15
-
-
0025847968
-
Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects
-
J.W. Unger, J.N. Livingston and A.M. Moss, Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects, Prog Neurobiol 36 (1991), 343-362.
-
(1991)
Prog Neurobiol
, vol.36
, pp. 343-362
-
-
Unger, J.W.1
Livingston, J.N.2
Moss, A.M.3
-
16
-
-
0025808620
-
Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat
-
J.W. Unger, A.M. Moss and J.N. Livingston, Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat, Neuroscience 42 (1991), 853-861.
-
(1991)
Neuroscience
, vol.42
, pp. 853-861
-
-
Unger, J.W.1
Moss, A.M.2
Livingston, J.N.3
-
17
-
-
0036470213
-
Insulin signaling pathways in time and space
-
A.R. Saltiel and J.E. Pessin, Insulin signaling pathways in time and space, Trends Cell Biol 12 (2002), 65-71.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 65-71
-
-
Saltiel, A.R.1
Pessin, J.E.2
-
18
-
-
0034513781
-
Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential
-
B. Giovannone, M.L. Scaldaferri, M. Federici, O. Porzio, D. Lauro, A. Fusco, P. Sbraccia, P. Borboni, R. Lauro and G. Sesti, Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential, Diabetes Metab Res Rev 16 (2000), 434-441.
-
(2000)
Diabetes Metab Res Rev
, vol.16
, pp. 434-441
-
-
Giovannone, B.1
Scaldaferri, M.L.2
Federici, M.3
Porzio, O.4
Lauro, D.5
Fusco, A.6
Sbraccia, P.7
Borboni, P.8
Lauro, R.9
Sesti, G.10
-
19
-
-
0021985413
-
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
-
A. Ullrich, J.R. Bell, E.Y. Chen, R. Herrera, L.M. Petruzzelli, T.J. Dull, A. Gray, L. Coussens, Y.C. Liao and M. Tsubokawa, Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes, Nature 313 (1985), 756-761.
-
(1985)
Nature
, vol.313
, pp. 756-761
-
-
Ullrich, A.1
Bell, J.R.2
Chen, E.Y.3
Herrera, R.4
Petruzzelli, L.M.5
Dull, T.J.6
Gray, A.7
Coussens, L.8
Liao, Y.C.9
Tsubokawa, M.10
-
20
-
-
0033918523
-
Structural and functional characterization of insulin receptor substrate proteins and the molecular mechanisms of their interaction with insulin superfamily tyrosine kinase receptors and effector proteins
-
A.O. Shpakov and M.N. Pertseva, Structural and functional characterization of insulin receptor substrate proteins and the molecular mechanisms of their interaction with insulin superfamily tyrosine kinase receptors and effector proteins, Membr Cell Biol 13 (2000), 455-484.
-
(2000)
Membr Cell Biol
, vol.13
, pp. 455-484
-
-
Shpakov, A.O.1
Pertseva, M.N.2
-
22
-
-
0027437376
-
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
-
X.J. Sun, D.L. Crimmins, M.J. Myers, M. Miralpeix and M.F. White, Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1, Mol Cell Biol 13 (1993), 7418-7428.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 7418-7428
-
-
Sun, X.J.1
Crimmins, D.L.2
Myers, M.J.3
Miralpeix, M.4
White, M.F.5
-
23
-
-
0021188386
-
Insulin-mediated regulation of neuronal maturation
-
D.G. Puro and E. Agardh, Insulin-mediated regulation of neuronal maturation, Science 225 (1984), 1170-1172.
-
(1984)
Science
, vol.225
, pp. 1170-1172
-
-
Puro, D.G.1
Agardh, E.2
-
24
-
-
0022344785
-
Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation
-
J.F. Mill, M.V. Chao and D.N. Ishii, Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation, Proc Natl Acad Sci USA 82 (1985), 7126-7130.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 7126-7130
-
-
Mill, J.F.1
Chao, M.V.2
Ishii, D.N.3
-
25
-
-
0024433715
-
Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis
-
K.A. Heidenreich and S.P. Toledo, Insulin receptors mediate growth effects in cultured fetal neurons. I. Rapid stimulation of protein synthesis, Endocrinology 125 (1989), 1451-1457.
-
(1989)
Endocrinology
, vol.125
, pp. 1451-1457
-
-
Heidenreich, K.A.1
Toledo, S.P.2
-
26
-
-
0028018858
-
The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin
-
K. Lam, C.L. Carpenter, N.B. Ruderman, J.C. Friel and K.L. Kelly, The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin, J Biol Chem 269 (1994), 20648-20652.
-
(1994)
J Biol Chem
, vol.269
, pp. 20648-20652
-
-
Lam, K.1
Carpenter, C.L.2
Ruderman, N.B.3
Friel, J.C.4
Kelly, K.L.5
-
27
-
-
0031034574
-
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
-
G. Kulik, A. Klippel and M.J. Weber, Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt, Mol Cell Biol 17 (1997), 1595-1606.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1595-1606
-
-
Kulik, G.1
Klippel, A.2
Weber, M.J.3
-
28
-
-
0032497842
-
The role of PI 3-kinase in insulin action
-
A.R. Alessi and C.P. Downes, The role of PI 3-kinase in insulin action, Biochim Biophys Acta 1436 (1998), 151-164.
-
(1998)
Biochim Biophys Acta
, vol.1436
, pp. 151-164
-
-
Alessi, A.R.1
Downes, C.P.2
-
29
-
-
0032530482
-
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
-
M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett and S. Dedhar, Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase, Proc Natl Acad Sci USA 95 (1998), 11211-11216.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11211-11216
-
-
Delcommenne, M.1
Tan, C.2
Gray, V.3
Rue, L.4
Woodgett, J.5
Dedhar, S.6
-
30
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
B.M. Burgering and P.J. Coffer, Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction, Nature 376 (1995), 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
31
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
H. Dudek, S.R. Datta, T.F. Franke, M.J. Birnbaum, R. Yao, G.M. Cooper, R.A. Segal, D.R. Kaplan and M.E. Greenberg, Regulation of neuronal survival by the serine-threonine protein kinase Akt, Science 275 (1997), 661-665.
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
32
-
-
0032493729
-
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
-
M. Pap and G.M. Cooper, Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway, J Biol Chem 273 (1998), 19929-19932.
-
(1998)
J Biol Chem
, vol.273
, pp. 19929-19932
-
-
Pap, M.1
Cooper, G.M.2
-
33
-
-
0032557646
-
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB
-
P.C. van Weeren, K.M. de Bruyn, A.M. de Vries-Smits, J. van Lint and B.M. Burgering, Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB, J Biol Chem 273 (1998), 13150-13156.
-
(1998)
J Biol Chem
, vol.273
, pp. 13150-13156
-
-
Van Weeren, P.C.1
De Bruyn, K.M.2
De Vries-Smits, A.M.3
Van Lint, J.4
Burgering, B.M.5
-
34
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
S.R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M.E. Greenberg, Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery, Cell 91 (1997), 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
35
-
-
0034175688
-
Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal
-
M. Hetman, J.E. Cavanaugh, D. Kimelman and Z. Xia, Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal, J Neurosci 20 (2000), 2567-2574.
-
(2000)
J Neurosci
, vol.20
, pp. 2567-2574
-
-
Hetman, M.1
Cavanaugh, J.E.2
Kimelman, D.3
Xia, Z.4
-
36
-
-
0031923788
-
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
-
E.M. Eves, W. Xiong, A. Bellacosa, S.G. Kennedy, P.N. Tsichlis, M.R. Rosner and N. Hay, Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line, Mol Cell Biol 18 (1998), 2143-2152.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2143-2152
-
-
Eves, E.M.1
Xiong, W.2
Bellacosa, A.3
Kennedy, S.G.4
Tsichlis, P.N.5
Rosner, M.R.6
Hay, N.7
-
37
-
-
0035047712
-
Caspase cleavage enhances the apoptosis-inducing effects of BAD
-
F. Condorelli, P. Salomoni, S. Cotteret, V. Cesi, S.M. Srinivasula, E.S. Alnemri and B. Calabretta, Caspase cleavage enhances the apoptosis-inducing effects of BAD, Mol Cell Biol 21 (2001), 3025-3036.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3025-3036
-
-
Condorelli, F.1
Salomoni, P.2
Cotteret, S.3
Cesi, V.4
Srinivasula, S.M.5
Alnemri, E.S.6
Calabretta, B.7
-
38
-
-
0033956949
-
Mitochondria and cell death
-
A.P. Halestrap, E. Doran, J.P. Gillespie and A. O'Toole, Mitochondria and cell death, Biochem Soc Trans 28 (2000), 170-177.
-
(2000)
Biochem Soc Trans
, vol.28
, pp. 170-177
-
-
Halestrap, A.P.1
Doran, E.2
Gillespie, J.P.3
O'Toole, A.4
-
39
-
-
0031892723
-
Mitochondrial permeability transition in apoptosis and necrosis
-
T. Hirsch, S.A. Susin, I. Marzo, P. Marchetti, N. Zamzami and G. Kroemer, Mitochondrial permeability transition in apoptosis and necrosis, Cell Biol Toxicol 14 (1998), 141-145.
-
(1998)
Cell Biol Toxicol
, vol.14
, pp. 141-145
-
-
Hirsch, T.1
Susin, S.A.2
Marzo, I.3
Marchetti, P.4
Zamzami, N.5
Kroemer, G.6
-
40
-
-
0035719947
-
Distinct and overlapping functions of insulin and IGF-I receptors
-
J. Nakae, Y. Kido and D. Accili, Distinct and overlapping functions of insulin and IGF-I receptors, Endocr Rev 22 (2001), 818-835.
-
(2001)
Endocr Rev
, vol.22
, pp. 818-835
-
-
Nakae, J.1
Kido, Y.2
Accili, D.3
-
41
-
-
0027269766
-
Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice
-
M.J. Carson, R.R. Behringer, R.L. Brinster and F.A. Mc-Morris, Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice, Neuron 10 (1993), 729-740.
-
(1993)
Neuron
, vol.10
, pp. 729-740
-
-
Carson, M.J.1
Behringer, R.R.2
Brinster, R.L.3
Mc-Morris, F.A.4
-
42
-
-
0030664841
-
Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1
-
W. Ni, K. Rajkumar, J.I. Nagy and L.J. Murphy, Impaired brain development and reduced astrocyte response to injury in transgenic mice expressing IGF binding protein-1, Brain Res 769 (1997), 97-107.
-
(1997)
Brain Res
, vol.769
, pp. 97-107
-
-
Ni, W.1
Rajkumar, K.2
Nagy, J.I.3
Murphy, L.J.4
-
43
-
-
0033763635
-
Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1
-
S. Doublier, C. Duyckaerts, D. Seurin and M. Binoux, Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1, Growth Horm IGF Res 10 (2000), 267-274.
-
(2000)
Growth Horm IGF Res
, vol.10
, pp. 267-274
-
-
Doublier, S.1
Duyckaerts, C.2
Seurin, D.3
Binoux, M.4
-
44
-
-
0036786241
-
Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: In vitro analysis
-
J. Zhong, J. Deng, B. Ghetti and W.H. Lee, Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis, J Neurosci Res 70 (2002), 36-45.
-
(2002)
J Neurosci Res
, vol.70
, pp. 36-45
-
-
Zhong, J.1
Deng, J.2
Ghetti, B.3
Lee, W.H.4
-
45
-
-
0036066970
-
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
-
F. Mauvais-Jarvis, R.N. Kulkarni and C.R. Kahn, Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance, Clin Endocrinol (Oxf) 57 (2002), 1-9.
-
(2002)
Clin Endocrinol (Oxf)
, vol.57
, pp. 1-9
-
-
Mauvais-Jarvis, F.1
Kulkarni, R.N.2
Kahn, C.R.3
-
46
-
-
0034491351
-
Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: What can we learn from transgenic and knockout mice?
-
F. Mauvais-Jarvis and C.R. Kahn, Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice? Diabetes Metab 26 (2000), 433-448.
-
(2000)
Diabetes Metab
, vol.26
, pp. 433-448
-
-
Mauvais-Jarvis, F.1
Kahn, C.R.2
-
47
-
-
0036999546
-
Tissue-specific targeting of the insulin receptor gene
-
R.N. Kulkarni and T. Okada, Tissue-specific targeting of the insulin receptor gene. Endocrine 19 (2002), 257-266.
-
(2002)
Endocrine
, vol.19
, pp. 257-266
-
-
Kulkarni, R.N.1
Okada, T.2
-
48
-
-
0142029565
-
Insulin resistant states and insulin signaling
-
P. Vollenweider, Insulin resistant states and insulin signaling, Clin Chem Lab Med 41 (2003), 1107-1119.
-
(2003)
Clin Chem Lab Med
, vol.41
, pp. 1107-1119
-
-
Vollenweider, P.1
-
49
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
M. Schubert, D. Gautam, D. Surjo, K. Ueki, S. Baudler, D. Schubert, T. Kondo, J. Alber, N. Galldiks, E. Kustermann, S. Arndt, A.H. Jacobs, W. Krone, C.R. Kahn and J.C. Bruning, Role for neuronal insulin resistance in neurodegenerative diseases, Proc Natl Acad Sci USA 101 (2004), 3100-3105.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
Kondo, T.7
Alber, J.8
Galldiks, N.9
Kustermann, E.10
Arndt, S.11
Jacobs, A.H.12
Krone, W.13
Kahn, C.R.14
Bruning, J.C.15
-
50
-
-
0033305504
-
Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice
-
G. Pete, C.R. Fuller, J.M. Oldham, D.R. Smith, A.J. D'Ercole, C.R. Kahn and P.K. Lund, Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice, Endocrinology 140 (1999), 5478-5487.
-
(1999)
Endocrinology
, vol.140
, pp. 5478-5487
-
-
Pete, G.1
Fuller, C.R.2
Oldham, J.M.3
Smith, D.R.4
D'Ercole, A.J.5
Kahn, C.R.6
Lund, P.K.7
-
51
-
-
0037199092
-
Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination
-
P. Ye, L. Li, P.K. Lund and A.J. D'Ercole, Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination, Brain Res Dev Brain Res 136 (2002), 111-121.
-
(2002)
Brain Res Dev Brain Res
, vol.136
, pp. 111-121
-
-
Ye, P.1
Li, L.2
Lund, P.K.3
D'Ercole, A.J.4
-
52
-
-
0042570843
-
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
-
A. Virkamaki, K. Ueki and C.R. Kahn, Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance, J Clin Invest 103 (1999), 931-943.
-
(1999)
J Clin Invest
, vol.103
, pp. 931-943
-
-
Virkamaki, A.1
Ueki, K.2
Kahn, C.R.3
-
53
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
M. Schubert, D.P. Brazil, D.J. Burks, J.A. Kushner, J. Ye, C.L. Flint, J. Farhang-Fallah, P. Dikkes, X.M. Warot, C. Rio, G. Corfas and M.F. White, Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation, J Neurosci 23 (2003), 7084-7092.
-
(2003)
J Neurosci
, vol.23
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
Kushner, J.A.4
Ye, J.5
Flint, C.L.6
Farhang-Fallah, J.7
Dikkes, P.8
Warot, X.M.9
Rio, C.10
Corfas, G.11
White, M.F.12
-
54
-
-
0020534018
-
Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type
-
G. Bucht, R. Adolfsson, F. Lithner and B. Winblad, Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type, Acta Med Scand 213 (1983), 387-392.
-
(1983)
Acta Med Scand
, vol.213
, pp. 387-392
-
-
Bucht, G.1
Adolfsson, R.2
Lithner, F.3
Winblad, B.4
-
55
-
-
0023936865
-
Metabolic changes in Alzheimer's disease
-
M. Fisman, B. Gordon, V. Feleki, E. Helmes, T. McDonald and J. Dupre, Metabolic changes in Alzheimer's disease, J Am Geriatr Soc 36 (1988), 298-300.
-
(1988)
J Am Geriatr Soc
, vol.36
, pp. 298-300
-
-
Fisman, M.1
Gordon, B.2
Feleki, V.3
Helmes, E.4
McDonald, T.5
Dupre, J.6
-
56
-
-
0032737079
-
Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose
-
S. Craft, S. Asthana, J.W. Newcomer, C.W. Wilkinson, I.T. Matos, L.D. Baker, M. Cherrier, C. Lofgreen, S. Latendresse, A. Petrova, S. Plymate, M. Raskind, K. Grimwood and R.C. Veith, Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose, Arch Gen Psychiatry 56 (1999), 1135-1140.
-
(1999)
Arch Gen Psychiatry
, vol.56
, pp. 1135-1140
-
-
Craft, S.1
Asthana, S.2
Newcomer, J.W.3
Wilkinson, C.W.4
Matos, I.T.5
Baker, L.D.6
Cherrier, M.7
Lofgreen, C.8
Latendresse, S.9
Petrova, A.10
Plymate, S.11
Raskind, M.12
Grimwood, K.13
Veith, R.C.14
-
57
-
-
0038177803
-
Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: Interactions with apolipoprotein E genotype
-
S. Craft, S. Asthana, D.G. Cook, L.D. Baker, M. Cherrier, K. Purganan, C. Wait, A. Petrova, S. Latendresse, G.S. Watson, J.W. Newcomer, G.D. Schellenberg and A.J. Krohn, Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype, Psychoneuroendocrinology 28 (2003), 809-822.
-
(2003)
Psychoneuroendocrinology
, vol.28
, pp. 809-822
-
-
Craft, S.1
Asthana, S.2
Cook, D.G.3
Baker, L.D.4
Cherrier, M.5
Purganan, K.6
Wait, C.7
Petrova, A.8
Latendresse, S.9
Watson, G.S.10
Newcomer, J.W.11
Schellenberg, G.D.12
Krohn, A.J.13
-
58
-
-
0029966901
-
Association of diabetes mellitus and dementia: The Rotterdam Study
-
A. Ott, R.P. Stolk, A. Hofman, F. van Harskamp, D.E. Grobbee and M.M. Breteler, Association of diabetes mellitus and dementia: the Rotterdam Study, Diabetologia 39 (1996), 1392-1397.
-
(1996)
Diabetologia
, vol.39
, pp. 1392-1397
-
-
Ott, A.1
Stolk, R.P.2
Hofman, A.3
Van Harskamp, F.4
Grobbee, D.E.5
Breteler, M.M.6
-
59
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: The Rotterdam Study
-
A. Ott, R.P. Stolk, F. van Harskamp, H.A. Pols, A. Hofman and M.M. Breteler, Diabetes mellitus and the risk of dementia: The Rotterdam Study, Neurology 53 (1999), 1937-1942.
-
(1999)
Neurology
, vol.53
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
Van Harskamp, F.3
Pols, H.A.4
Hofman, A.5
Breteler, M.M.6
-
60
-
-
0030680107
-
Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study
-
J. Heitner and D. Dickson, Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study, Neurology 49 (1997), 1306-1311.
-
(1997)
Neurology
, vol.49
, pp. 1306-1311
-
-
Heitner, J.1
Dickson, D.2
-
61
-
-
0346216156
-
Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
-
T. den Heijer, S.E. Vermeer, E.J. van Dijk, N.D. Prins, P.J. Koudstaal, A. Hofman and M.M. Breteler, Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI, Diabetologia 46 (2003), 1604-1610.
-
(2003)
Diabetologia
, vol.46
, pp. 1604-1610
-
-
Den Heijer, T.1
Vermeer, S.E.2
Van Dijk, E.J.3
Prins, N.D.4
Koudstaal, P.J.5
Hofman, A.6
Breteler, M.M.7
-
62
-
-
9844229370
-
Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: Cross sectional population based study
-
J. Kuusisto, K. Koivisto, L. Mykkanen, E.L. Helkala, M. Vanhanen, T. Hanninen, K. Kervinen, Y.A. Kesaniemi, P.J. Riekkinen and M. Laakso, Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: cross sectional population based study, Bmj 315 (1997), 1045-1049.
-
(1997)
Bmj
, vol.315
, pp. 1045-1049
-
-
Kuusisto, J.1
Koivisto, K.2
Mykkanen, L.3
Helkala, E.L.4
Vanhanen, M.5
Hanninen, T.6
Kervinen, K.7
Kesaniemi, Y.A.8
Riekkinen, P.J.9
Laakso, M.10
-
63
-
-
0032841571
-
Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
-
S. Craft, S. Asthana, G. Schellenberg, M. Cherrier, L.D. Baker, J. Newcomer, S. Plymate, S. Latendresse, A. Petrova, M. Raskind, E. Peskind, C. Lofgreen and K. Grimwood, Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender, Neuroendocrinology 70 (1999), 146-152.
-
(1999)
Neuroendocrinology
, vol.70
, pp. 146-152
-
-
Craft, S.1
Asthana, S.2
Schellenberg, G.3
Cherrier, M.4
Baker, L.D.5
Newcomer, J.6
Plymate, S.7
Latendresse, S.8
Petrova, A.9
Raskind, M.10
Peskind, E.11
Lofgreen, C.12
Grimwood, K.13
-
64
-
-
0034016848
-
Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
-
S. Craft, S. Asthana, G. Schellenberg, L. Baker, M. Cherrier, A.A. Boyt, R.N. Martins, M. Raskind, E. Peskind and S. Plymate, Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype, Ann N Y Acad Sci 903 (2000), 222-228.
-
(2000)
Ann N Y Acad Sci
, vol.903
, pp. 222-228
-
-
Craft, S.1
Asthana, S.2
Schellenberg, G.3
Baker, L.4
Cherrier, M.5
Boyt, A.A.6
Martins, R.N.7
Raskind, M.8
Peskind, E.9
Plymate, S.10
-
65
-
-
0042385094
-
Diabetes, Alzheimer's disease and apolipoprotein genotype
-
C. Messier, Diabetes, Alzheimer's disease and apolipoprotein genotype, Exp Gerontol 38 (2003), 941-946.
-
(2003)
Exp Gerontol
, vol.38
, pp. 941-946
-
-
Messier, C.1
-
66
-
-
0034603552
-
Critically attained threshold of cerebral hypoperfusion: The CATCH hypothesis of Alzheimer's pathogenesis
-
J.C. de la Torre, Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesis, Neurobiol Aging 21 (2000), 331-342.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 331-342
-
-
De La Torre, J.C.1
-
67
-
-
0032229658
-
Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease
-
D. Etiene, J. Kraft, N. Ganju, T. Gomez-Isla, B. Gemelli, B.T. Hyman, E.T. Hedley-Whyte, J.R. Wands and S.M. De La Monte, Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease, J Alzheimers Dis 1 (1998), 119-134.
-
(1998)
J Alzheimers Dis
, vol.1
, pp. 119-134
-
-
Etiene, D.1
Kraft, J.2
Ganju, N.3
Gomez-Isla, T.4
Gemelli, B.5
Hyman, B.T.6
Hedley-Whyte, E.T.7
Wands, J.R.8
De La Monte, S.M.9
-
68
-
-
0033653771
-
Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: An update
-
S. Hoyer, Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update, Exp Gerontol 35 (2000), 1363-1372.
-
(2000)
Exp Gerontol
, vol.35
, pp. 1363-1372
-
-
Hoyer, S.1
-
69
-
-
0036592758
-
The role of the metabolic lesion in Alzheimer's disease
-
J.P. Blass, G.E. Gibson and S. Hoyer, The role of the metabolic lesion in Alzheimer's disease, J Alzheimers Dis 4 (2002), 225-232.
-
(2002)
J Alzheimers Dis
, vol.4
, pp. 225-232
-
-
Blass, J.P.1
Gibson, G.E.2
Hoyer, S.3
-
70
-
-
0347654897
-
Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: Therapeutic implications
-
S. Hoyer, Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications, Adv Exp Med Biol 541 (2004), 135-152.
-
(2004)
Adv Exp Med Biol
, vol.541
, pp. 135-152
-
-
Hoyer, S.1
-
71
-
-
1842785179
-
Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
-
S. Hoyer, Glucose metabolism and insulin receptor signal transduction in Alzheimer disease, Eur J Pharmacol 490 (2004), 115-125.
-
(2004)
Eur J Pharmacol
, vol.490
, pp. 115-125
-
-
Hoyer, S.1
-
72
-
-
0029414741
-
Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders?
-
D. Blum-Degen, L. Frolich, S. Hoyer and P. Riederer, Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders? J Neural Transm Suppl 46 (1995), 139-147.
-
(1995)
J Neural Transm Suppl
, vol.46
, pp. 139-147
-
-
Blum-Degen, D.1
Frolich, L.2
Hoyer, S.3
Riederer, P.4
-
73
-
-
0035577699
-
Glucose and lactate metabolism during brain activation
-
G.A. Dienel and L. Hertz, Glucose and lactate metabolism during brain activation, J Neurosci Res 66 (2001), 824-838.
-
(2001)
J Neurosci Res
, vol.66
, pp. 824-838
-
-
Dienel, G.A.1
Hertz, L.2
-
74
-
-
2942534211
-
Energy transfer from astrocytes to axons: The role of CNS glycogen
-
A.M. Brown, S. Baltan Tekkok and B.R. Ransom, Energy transfer from astrocytes to axons: the role of CNS glycogen, Neurochem Int 45 (2004), 529-536.
-
(2004)
Neurochem Int
, vol.45
, pp. 529-536
-
-
Brown, A.M.1
Baltan Tekkok, S.2
Ransom, B.R.3
-
75
-
-
0242574396
-
Energy substrates for neurons during neural activity: A critical review of the astrocyteneuron lactate shuttle hypothesis
-
C.P. Chih and E.L. Roberts, Jr., Energy substrates for neurons during neural activity: a critical review of the astrocyteneuron lactate shuttle hypothesis, J Cereb Blood Flow Metab 23 (2003), 1263-1281.
-
(2003)
J Cereb Blood Flow Metab
, vol.23
, pp. 1263-1281
-
-
Chih, C.P.1
Roberts Jr., E.L.2
-
76
-
-
0027314683
-
Alterations in glucose metabolism in patients with Alzheimer's disease
-
G.S. Meneilly and A. Hill, Alterations in glucose metabolism in patients with Alzheimer's disease, J Am Geriatr Soc 41 (1993), 710-714.
-
(1993)
J Am Geriatr Soc
, vol.41
, pp. 710-714
-
-
Meneilly, G.S.1
Hill, A.2
-
77
-
-
0033999608
-
Alzheimer disease and vascular dementia: Relationships with fasting glucose and insulin levels
-
M. Carantoni, G. Zuliani, M.R. Munari, K. D'Elia, E. Palmieri and R. Fellin, Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels, Dement Geriatr Cogn Disord 11 (2000), 176-180.
-
(2000)
Dement Geriatr Cogn Disord
, vol.11
, pp. 176-180
-
-
Carantoni, M.1
Zuliani, G.2
Munari, M.R.3
D'Elia, K.4
Palmieri, E.5
Fellin, R.6
-
78
-
-
0029869755
-
Glucose regulation and cognitive functions: Relation to Alzheimer's disease and diabetes
-
C. Messier and M. Gagnon, Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes, Behav Brain Res 75 (1996), 1-11.
-
(1996)
Behav Brain Res
, vol.75
, pp. 1-11
-
-
Messier, C.1
Gagnon, M.2
-
79
-
-
0027742839
-
Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study
-
S. Craft, S.E. Dagogo-Jack, B.V. Wiethop, C. Murphy, R.T. Nevins, S. Fleischman, V. Rice, J.W. Newcomer and P.E. Cryer, Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: a longitudinal study, Behav Neurosci 107 (1993), 926-940.
-
(1993)
Behav Neurosci
, vol.107
, pp. 926-940
-
-
Craft, S.1
Dagogo-Jack, S.E.2
Wiethop, B.V.3
Murphy, C.4
Nevins, R.T.5
Fleischman, S.6
Rice, V.7
Newcomer, J.W.8
Cryer, P.E.9
-
80
-
-
0030053556
-
Memory improvement following induced hyperinsulinemia in Alzheimer's disease
-
S. Craft, J. Newcomer, S. Kanne, S. Dagogo-Jack, P. Cryer, Y. Sheline, J. Luby, A. Dagogo-Jack and A. Alderson, Memory improvement following induced hyperinsulinemia in Alzheimer's disease, Neurobiol Aging 17 (1996), 123-130.
-
(1996)
Neurobiol Aging
, vol.17
, pp. 123-130
-
-
Craft, S.1
Newcomer, J.2
Kanne, S.3
Dagogo-Jack, S.4
Cryer, P.5
Sheline, Y.6
Luby, J.7
Dagogo-Jack, A.8
Alderson, A.9
-
81
-
-
0025856239
-
Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases
-
S. Hoyer, R. Nitsch and K. Oesterreich, Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: a cross-sectional comparison against advanced late-onset and incipient early-onset cases, J Neural Transm Park Dis Dement Sect 3 (1991), 1-14.
-
(1991)
J Neural Transm Park Dis Dement Sect
, vol.3
, pp. 1-14
-
-
Hoyer, S.1
Nitsch, R.2
Oesterreich, K.3
-
82
-
-
0024545260
-
Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type
-
S. Hoyer and R. Nitsch, Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type, J Neural Transm 75 (1989), 227-232.
-
(1989)
J Neural Transm
, vol.75
, pp. 227-232
-
-
Hoyer, S.1
Nitsch, R.2
-
83
-
-
0026332340
-
Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type
-
Y. Fujisawa, K. Sasaki and K. Akiyama, Increased insulin levels after OGTT load in peripheral blood and cerebrospinal fluid of patients with dementia of Alzheimer type, Biol Psychiatry 30 (1991), 1219-1228.
-
(1991)
Biol Psychiatry
, vol.30
, pp. 1219-1228
-
-
Fujisawa, Y.1
Sasaki, K.2
Akiyama, K.3
-
84
-
-
0036917633
-
Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease
-
J.A. Molina, F.J. Jimenez-Jimenez, C. Vargas, P. Gomez, F. de Bustos, C. Gomez-Escalonilla, M. Zurdo, A. Tallon, A. Martinez-Salio, J. Porta-Etessam, C. Villanueva and J. Arenas, Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease, Acta Neurol Scan J 106 (2002), 347-350.
-
(2002)
Acta Neurol Scan J
, vol.106
, pp. 347-350
-
-
Molina, J.A.1
Jimenez-Jimenez, F.J.2
Vargas, C.3
Gomez, P.4
De Bustos, F.5
Gomez-Escalonilla, C.6
Zurdo, M.7
Tallon, A.8
Martinez-Salio, A.9
Porta-Etessam, J.10
Villanueva, C.11
Arenas, J.12
-
85
-
-
0027466571
-
Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease
-
L. Kilander, M. Boberg and H. Lithell, Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease, Acta Neurol Scand 87 (1993), 294-298.
-
(1993)
Acta Neurol Scand
, vol.87
, pp. 294-298
-
-
Kilander, L.1
Boberg, M.2
Lithell, H.3
-
86
-
-
0031907459
-
Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: Relationship to severity of dementia and apolipoprotein E genotype
-
S. Craft, E. Peskind, M.W. Schwartz, G.D. Schellenberg, M. Raskind and D. Porte, Jr., Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype, Neurology 50 (1998), 164-168.
-
(1998)
Neurology
, vol.50
, pp. 164-168
-
-
Craft, S.1
Peskind, E.2
Schwartz, M.W.3
Schellenberg, G.D.4
Raskind, M.5
Porte Jr., D.6
-
87
-
-
0027991714
-
Hyperinsulinaemia and Alzheimer's disease
-
G. Razay and G.K. Wilcock, Hyperinsulinaemia and Alzheimer's disease, Age Ageing 23 (1994), 396-399.
-
(1994)
Age Ageing
, vol.23
, pp. 396-399
-
-
Razay, G.1
Wilcock, G.K.2
-
88
-
-
0030408690
-
Nutritional status of patients with Alzheimer's disease: A 1-year study
-
A.A. Spindler, M.J. Renvall, J.F. Nichols and J.W. Ramsdell, Nutritional status of patients with Alzheimer's disease: a 1-year study, J Am Diet Assoc 96 (1996), 1013-1018.
-
(1996)
J Am Diet Assoc
, vol.96
, pp. 1013-1018
-
-
Spindler, A.A.1
Renvall, M.J.2
Nichols, J.F.3
Ramsdell, J.W.4
-
89
-
-
0022921950
-
Somatostatin and Alzheimer's disease: A hypothesis
-
J.C. Reubi and J. Palacios, Somatostatin and Alzheimer's disease: a hypothesis, J Neurol 233 (1986), 370-372.
-
(1986)
J Neurol
, vol.233
, pp. 370-372
-
-
Reubi, J.C.1
Palacios, J.2
-
90
-
-
0030656250
-
Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus
-
B. Connor, E.J. Beilharz, C. Williams, B. Synek, P.D. Gluckman, R.L. Faull and M. Dragunow, Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus, Brain Res Mol Brain Res 49 (1997), 283-290.
-
(1997)
Brain Res Mol Brain Res
, vol.49
, pp. 283-290
-
-
Connor, B.1
Beilharz, E.J.2
Williams, C.3
Synek, B.4
Gluckman, P.D.5
Faull, R.L.6
Dragunow, M.7
-
91
-
-
0023922851
-
Insulin-like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia of the Alzheimer type
-
A. Tham, K. Sparring, D. Bowen, L. Wetterberg and V.R. Sara, Insulin-like growth factors and somatomedin B in the cerebrospinal fluid of patients with dementia of the Alzheimer type, Acta Psychiatr Scand 77 (1988), 719-723.
-
(1988)
Acta Psychiatr Scand
, vol.77
, pp. 719-723
-
-
Tham, A.1
Sparring, K.2
Bowen, D.3
Wetterberg, L.4
Sara, V.R.5
-
92
-
-
0027170501
-
Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type
-
A. Tham, A. Nordberg, F.E. Grissom, C. Carlsson-Skwirut, M. Viitanen and V.R. Sara, Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type, J Neural Transm Park Dis Dement Sect 5 (1993), 165-176.
-
(1993)
J Neural Transm Park Dis Dement Sect
, vol.5
, pp. 165-176
-
-
Tham, A.1
Nordberg, A.2
Grissom, F.E.3
Carlsson-Skwirut, C.4
Viitanen, M.5
Sara, V.R.6
-
93
-
-
0032712557
-
Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation
-
A. Mustafa, L. Lannfelt, L. Lilius, A. Islam, B. Winblad and A. Adem, Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation, Dement Geriatr Cogn Disord 10 (1999), 446-451.
-
(1999)
Dement Geriatr Cogn Disord
, vol.10
, pp. 446-451
-
-
Mustafa, A.1
Lannfelt, L.2
Lilius, L.3
Islam, A.4
Winblad, B.5
Adem, A.6
-
94
-
-
0025918259
-
Binding of [125I]-insulin-like growth factor-1 (IGF-I) in brains of Alzheimer's and alcoholic patients
-
F.T. Crews, R. McElhaney, G. Freund, W.E. Ballinger, D.W. Walker, B.E. Hunter and M.K. Raizada, Binding of [125I]-insulin-like growth factor-1 (IGF-I) in brains of Alzheimer's and alcoholic patients, Adv Exp Med Biol 293 (1991), 483-492.
-
(1991)
Adv Exp Med Biol
, vol.293
, pp. 483-492
-
-
Crews, F.T.1
McElhaney, R.2
Freund, G.3
Ballinger, W.E.4
Walker, D.W.5
Hunter, B.E.6
Raizada, M.K.7
-
95
-
-
0026572765
-
Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients
-
F.T. Crews, R. McElhaney, G. Freund, W.E. Ballinger, Jr. and M.K. Raizada, Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients, J Neurochem 58 (1992), 1205-1210.
-
(1992)
J Neurochem
, vol.58
, pp. 1205-1210
-
-
Crews, F.T.1
McElhaney, R.2
Freund, G.3
Ballinger Jr., W.E.4
Raizada, M.K.5
-
96
-
-
0034672811
-
Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains
-
S. Jafferali, Y. Dumont, F. Sotty, Y. Robitaille, R. Quirion and S. Kar, Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and alzheimer disease brains, Synapse 38 (2000), 450-459.
-
(2000)
Synapse
, vol.38
, pp. 450-459
-
-
Jafferali, S.1
Dumont, Y.2
Sotty, F.3
Robitaille, Y.4
Quirion, R.5
Kar, S.6
-
97
-
-
0028278398
-
Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease
-
J. De Keyser, N. Wilczak and A. Goossens, Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease, Neurosci Lett 172 (1994), 93-96.
-
(1994)
Neurosci Lett
, vol.172
, pp. 93-96
-
-
De Keyser, J.1
Wilczak, N.2
Goossens, A.3
-
98
-
-
0028344810
-
Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
-
I. Moroo, T. Yamada, H. Makino, I. Tooyama, P.L. McGeer, E.G. McGeer and K. Hirayama, Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease, Acta Neuropathol (Berl) 87 (1994), 343-348.
-
(1994)
Acta Neuropathol (Berl)
, vol.87
, pp. 343-348
-
-
Moroo, I.1
Yamada, T.2
Makino, H.3
Tooyama, I.4
McGeer, P.L.5
McGeer, E.G.6
Hirayama, K.7
-
99
-
-
0033378682
-
A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease
-
L. Frolich, D. Blum-Degen, P. Riederer and S. Hoyer, A disturbance in the neuronal insulin receptor signal transduction in sporadic Alzheimer's disease, Ann N Y Acad Sci 893 (1999), 290-293.
-
(1999)
Ann N Y Acad Sci
, vol.893
, pp. 290-293
-
-
Frolich, L.1
Blum-Degen, D.2
Riederer, P.3
Hoyer, S.4
-
100
-
-
18744438248
-
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
-
L. Xie, E. Helmerhorst, K. Taddei, B. Plewright, W. Van Bronswijk and R. Martins, Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor, J Neurosci 22 (2002), RC221.
-
(2002)
J Neurosci
, vol.22
-
-
Xie, L.1
Helmerhorst, E.2
Taddei, K.3
Plewright, B.4
Van Bronswijk, W.5
Martins, R.6
-
101
-
-
0035574487
-
Effects of age on elements of insulin-signaling pathway in central nervous system of rats
-
M.L. Fernandes, M.J. Saad and L.A. Velloso, Effects of age on elements of insulin-signaling pathway in central nervous system of rats, Endocrine 16 (2001), 227-234.
-
(2001)
Endocrine
, vol.16
, pp. 227-234
-
-
Fernandes, M.L.1
Saad, M.J.2
Velloso, L.A.3
-
102
-
-
0031928535
-
Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
-
S. Hoyer, Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis, J Neural Transm 105 (1998), 415-422.
-
(1998)
J Neural Transm
, vol.105
, pp. 415-422
-
-
Hoyer, S.1
-
103
-
-
0030748390
-
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
-
M. Hong and V.M. Lee, Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons, J Biol Chem 272 (1997), 19547-19553.
-
(1997)
J Biol Chem
, vol.272
, pp. 19547-19553
-
-
Hong, M.1
Lee, V.M.2
-
104
-
-
0028675873
-
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
-
S. Lovestone, C.H. Reynolds, D. Latimer, D.R. Davis, B.H. Anderton, J.M. Gallo, D. Hanger, S. Mulot, B. Marquardt, S. Stabel et al., Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells, Curr Biol 4 (1994), 1077-1086.
-
(1994)
Curr Biol
, vol.4
, pp. 1077-1086
-
-
Lovestone, S.1
Reynolds, C.H.2
Latimer, D.3
Davis, D.R.4
Anderton, B.H.5
Gallo, J.M.6
Hanger, D.7
Mulot, S.8
Marquardt, B.9
Stabel, S.10
-
105
-
-
0032578024
-
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration
-
J.J. Pei, I. Grundke-Iqbal, K. Iqbal, N. Bogdanovic, B. Winblad and R.F. Cowburn, Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration, Brain Res 797 (1998), 267-277.
-
(1998)
Brain Res
, vol.797
, pp. 267-277
-
-
Pei, J.J.1
Grundke-Iqbal, I.2
Iqbal, K.3
Bogdanovic, N.4
Winblad, B.5
Cowburn, R.F.6
-
106
-
-
85062139768
-
Tau phosphorylation in brain slices: Pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase
-
T.D. Garver, G.A. Oyler, K.A. Harris, R. Polavarapu, Z. Damuni, R.A. Lehman and M.L. Billingsley, Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase, Mol Pharmacol 47 (1995), 745-756.
-
(1995)
Mol Pharmacol
, vol.47
, pp. 745-756
-
-
Garver, T.D.1
Oyler, G.A.2
Harris, K.A.3
Polavarapu, R.4
Damuni, Z.5
Lehman, R.A.6
Billingsley, M.L.7
-
107
-
-
0037383322
-
GSK-3: Tricks of the trade for a multi-tasking kinase
-
B.W. Doble and J.R. Woodgett, GSK-3: tricks of the trade for a multi-tasking kinase, J Cell Sci 116 (2003), 1175-1186.
-
(2003)
J Cell Sci
, vol.116
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
108
-
-
0032905727
-
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
-
M. Nishimura, G. Yu, G. Levesque, D.M. Zhang, L. Ruel, F. Chen, P. Milman, E. Holmes, Y. Liang, T. Kawarai, E. Jo, A. Supala, E. Rogaeva, D.M. Xu, C. Janus, L. Levesque, Q. Bi, M. Duthie, R. Rozmahel, K. Mattila, L. Lannfelt, D. Westaway, H.T. Mount, J. Woodgett and P. St George-Hyslop, Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex, Nat Med 5 (1999), 164-169.
-
(1999)
Nat Med
, vol.5
, pp. 164-169
-
-
Nishimura, M.1
Yu, G.2
Levesque, G.3
Zhang, D.M.4
Ruel, L.5
Chen, F.6
Milman, P.7
Holmes, E.8
Liang, Y.9
Kawarai, T.10
Jo, E.11
Supala, A.12
Rogaeva, E.13
Xu, D.M.14
Janus, C.15
Levesque, L.16
Bi, Q.17
Duthie, M.18
Rozmahel, R.19
Mattila, K.20
Lannfelt, L.21
Westaway, D.22
Mount, H.T.23
Woodgett, J.24
St George-Hyslop, P.25
more..
-
110
-
-
0035879075
-
Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase
-
A. Mudher, S. Chapman, J. Richardson, A. Asuni, G. Gibb, C. Pollard, R. Killick, T. Iqbal, L. Raymond, I. Varndell, P. Sheppard, A. Makoff, E. Gower, P.E. Soden, P. Lewis, M. Murphy, T.E. Golde, H.T. Rupniak, B.H. Anderton and S. Lovestone, Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase, J Neurosci 21 (2001), 4987-4995.
-
(2001)
J Neurosci
, vol.21
, pp. 4987-4995
-
-
Mudher, A.1
Chapman, S.2
Richardson, J.3
Asuni, A.4
Gibb, G.5
Pollard, C.6
Killick, R.7
Iqbal, T.8
Raymond, L.9
Varndell, I.10
Sheppard, P.11
Makoff, A.12
Gower, E.13
Soden, P.E.14
Lewis, P.15
Murphy, M.16
Golde, T.E.17
Rupniak, H.T.18
Anderton, B.H.19
Lovestone, S.20
more..
-
111
-
-
0035232145
-
Presenilin function: Connections to Alzheimer's disease and signal transduction
-
P.E. Fraser, G. Yu, L. Levesque, M. Nishimura, D.S. Yang, H.T. Mount, D. Westaway and P.H. St George-Hyslop, Presenilin function: connections to Alzheimer's disease and signal transduction, Biochem Soc Symp (2001), 89-100.
-
(2001)
Biochem Soc Symp
, pp. 89-100
-
-
Fraser, P.E.1
Yu, G.2
Levesque, L.3
Nishimura, M.4
Yang, D.S.5
Mount, H.T.6
Westaway, D.7
St George-Hyslop, P.H.8
-
112
-
-
0348134529
-
Alzheimer's disease linking neurodegeneration with neurodevelopment
-
M. Grilli, G.F. Toninelli, D. Uberti, P. Spano and M. Memo, Alzheimer's disease linking neurodegeneration with neurodevelopment, Fund Neurol 18 (2003), 145-148.
-
(2003)
Fund Neurol
, vol.18
, pp. 145-148
-
-
Grilli, M.1
Toninelli, G.F.2
Uberti, D.3
Spano, P.4
Memo, M.5
-
113
-
-
0142042435
-
Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: Potential strategies for neuroprotection
-
G.J. Chen, J. Xu, S.A. Lahousse, N.L. Caggiano and S.M. de la Monte, Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection, J Alzheimers Dis 5 (2003), 209-228.
-
(2003)
J Alzheimers Dis
, vol.5
, pp. 209-228
-
-
Chen, G.J.1
Xu, J.2
Lahousse, S.A.3
Caggiano, N.L.4
De La Monte, S.M.5
-
114
-
-
0037357190
-
Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures
-
J.T. Egana, C. Zambrano, M.T. Nunez, C. Gonzalez-Billault and R.B. Maccioni, Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures, Biometals 16 (2003), 215-223.
-
(2003)
Biometals
, vol.16
, pp. 215-223
-
-
Egana, J.T.1
Zambrano, C.2
Nunez, M.T.3
Gonzalez-Billault, C.4
Maccioni, R.B.5
-
115
-
-
0345276565
-
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
-
E.M. Mandelkow, K. Stamer, R. Vogel, E. Thies and E. Mandelkow, Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses, Neurobiol Aging 24 (2003), 1079-1085.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1079-1085
-
-
Mandelkow, E.M.1
Stamer, K.2
Vogel, R.3
Thies, E.4
Mandelkow, E.5
-
116
-
-
0036770144
-
The role of mitogen-activated protein kinase pathways in Alzheimer's disease
-
X. Zhu, H.G. Lee, A.K. Raina, G. Perry and M.A. Smith, The role of mitogen-activated protein kinase pathways in Alzheimer's disease, Neurosignals 11 (2002), 270-281.
-
(2002)
Neurosignals
, vol.11
, pp. 270-281
-
-
Zhu, X.1
Lee, H.G.2
Raina, A.K.3
Perry, G.4
Smith, M.A.5
-
117
-
-
0038100358
-
Role of protein kinase B in Alzheimer's neurofibrillary pathology
-
J.J. Pei, S. Khatoon, W.L. An, M. Nordlinder, T. Tanaka, H. Braak, I. Tsujio, M. Takeda, I. Alafuzoff, B. Winblad, R.F. Cowburn, I. Grundke-Iqbal and K. Iqbal, Role of protein kinase B in Alzheimer's neurofibrillary pathology, Acta Neuropathol (Berl) 105 (2003), 381-392.
-
(2003)
Acta Neuropathol (Berl)
, vol.105
, pp. 381-392
-
-
Pei, J.J.1
Khatoon, S.2
An, W.L.3
Nordlinder, M.4
Tanaka, T.5
Braak, H.6
Tsujio, I.7
Takeda, M.8
Alafuzoff, I.9
Winblad, B.10
Cowburn, R.F.11
Grundke-Iqbal, I.12
Iqbal, K.13
-
118
-
-
2342558065
-
Akt activity in Alzheimer's disease and other neurodegenerative disorders
-
A. Rickle, N. Bogdanovic, I. Volkman, B. Winblad, R. Ravid and R.F. Cowburn, Akt activity in Alzheimer's disease and other neurodegenerative disorders, Neuroreport 15 (2004), 955-959.
-
(2004)
Neuroreport
, vol.15
, pp. 955-959
-
-
Rickle, A.1
Bogdanovic, N.2
Volkman, I.3
Winblad, B.4
Ravid, R.5
Cowburn, R.F.6
-
119
-
-
0033540060
-
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
-
G.N. Patrick, L. Zukerberg, M. Nikolic, S. de la Monte, P. Dikkes and L.H. Tsai, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature 402 (1999), 615-622.
-
(1999)
Nature
, vol.402
, pp. 615-622
-
-
Patrick, G.N.1
Zukerberg, L.2
Nikolic, M.3
De La Monte, S.4
Dikkes, P.5
Tsai, L.H.6
-
121
-
-
0036270446
-
Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: Dependence on Ca(2+) and PI3-kinase
-
A.J. Crossthwaite, S. Hasan and R.J. Williams, Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase, J Neurochem 80 (2002), 24-35.
-
(2002)
J Neurochem
, vol.80
, pp. 24-35
-
-
Crossthwaite, A.J.1
Hasan, S.2
Williams, R.J.3
-
122
-
-
0036458808
-
ERK activation and nuclear translocation in amyloid-beta peptide- and iron-stressed neuronal cell cultures
-
F. Kuperstein and E. Yavin, ERK activation and nuclear translocation in amyloid-beta peptide- and iron-stressed neuronal cell cultures, Eur J Neurosci 16 (2002), 44-54.
-
(2002)
Eur J Neurosci
, vol.16
, pp. 44-54
-
-
Kuperstein, F.1
Yavin, E.2
-
123
-
-
0038647463
-
Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity
-
F. Kuperstein and E. Yavin, Pro-apoptotic signaling in neuronal cells following iron and amyloid beta peptide neurotoxicity, J Neurochem 86 (2003), 114-125.
-
(2003)
J Neurochem
, vol.86
, pp. 114-125
-
-
Kuperstein, F.1
Yavin, E.2
-
125
-
-
0035871641
-
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
-
L. Gasparini, G.K. Gouras, R. Wang, R.S. Gross, M.F. Beal, P. Greengard and H. Xu, Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling, J Neurosci 21 (2001), 2561-2570.
-
(2001)
J Neurosci
, vol.21
, pp. 2561-2570
-
-
Gasparini, L.1
Gouras, G.K.2
Wang, R.3
Gross, R.S.4
Beal, M.F.5
Greengard, P.6
Xu, H.7
-
126
-
-
0036591657
-
Does insulin dysfunction play a role in Alzheimer's disease?
-
L. Gasparini, W.J. Netzer, P. Greengard and H. Xu, Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol Sci 23 (2002), 288-293.
-
(2002)
Trends Pharmacol Sci
, vol.23
, pp. 288-293
-
-
Gasparini, L.1
Netzer, W.J.2
Greengard, P.3
Xu, H.4
-
127
-
-
0036813726
-
Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor
-
X. Ling, R.N. Martins, M. Racchi, S. Craft and E. Helmerhorst, Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor, J Alzheimers Dis 4 (2002), 369-374.
-
(2002)
J Alzheimers Dis
, vol.4
, pp. 369-374
-
-
Ling, X.1
Martins, R.N.2
Racchi, M.3
Craft, S.4
Helmerhorst, E.5
-
128
-
-
0035997231
-
Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides
-
G. Evin and A. Weidemann, Biogenesis and metabolism of Alzheimer's disease Abeta amyloid peptides, Peptides 23 (2002), 1285-1297.
-
(2002)
Peptides
, vol.23
, pp. 1285-1297
-
-
Evin, G.1
Weidemann, A.2
-
129
-
-
0030902595
-
Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity
-
S. Dore, S. Kar and R. Quirion, Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity, Proc Natl Acad Sci USA 94 (1997), 4772-4777.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4772-4777
-
-
Dore, S.1
Kar, S.2
Quirion, R.3
-
130
-
-
0033450892
-
Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons
-
S. Dore, S. Bastianetto, S. Kar and R. Quirion, Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons, Ann N Y Acad Sci 890 (1999), 356-364.
-
(1999)
Ann N Y Acad Sci
, vol.890
, pp. 356-364
-
-
Dore, S.1
Bastianetto, S.2
Kar, S.3
Quirion, R.4
-
131
-
-
0034518163
-
Insulin-like growth factor-1 (IGF-1): A neuroprotective trophic factor acting via the Akt kinase pathway
-
W.H. Zheng, S. Kar, S. Dore and R. Quirion, Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway, J Neural Transm Suppl (2000), 261-272.
-
(2000)
J Neural Transm Suppl
, pp. 261-272
-
-
Zheng, W.H.1
Kar, S.2
Dore, S.3
Quirion, R.4
-
132
-
-
0035197347
-
Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons
-
S.M. de la Monte, T.R. Neely, J. Cannon and J.R. Wands, Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons, Cell Mol Life Sci 58 (2001), 1950-1960.
-
(2001)
Cell Mol Life Sci
, vol.58
, pp. 1950-1960
-
-
De La Monte, S.M.1
Neely, T.R.2
Cannon, J.3
Wands, J.R.4
-
133
-
-
0036282840
-
Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons
-
S.M. de laMonte and J.R. Wands, Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons, CMLS, Cell Mol Life Sci 59 (2002), 882-893.
-
(2002)
CMLS, Cell Mol Life Sci
, vol.59
, pp. 882-893
-
-
De Lamonte, S.M.1
Wands, J.R.2
-
134
-
-
0034128363
-
Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase
-
S.M. de la Monte, N. Ganju, K. Banerjee, N.V. Brown, T. Luong and J.R. Wands, Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase, Alcohol Clin Exp Res 24 (2000), 716-726.
-
(2000)
Alcohol Clin Exp Res
, vol.24
, pp. 716-726
-
-
De La Monte, S.M.1
Ganju, N.2
Banerjee, K.3
Brown, N.V.4
Luong, T.5
Wands, J.R.6
-
135
-
-
0021256895
-
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
-
G.G. Glenner and C.W Wong, Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Commun 120 (1984), 885-890.
-
(1984)
Biochem Biophys Res Commun
, vol.120
, pp. 885-890
-
-
Glenner, G.G.1
Wong, C.W.2
-
136
-
-
0042839610
-
Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells
-
E. Tsukamoto, Y. Hashimoto, K. Kanekura, T. Niikura, S. Aiso and I. Nishimoto, Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells, J Neurosci Res 73 (2003), 627-636.
-
(2003)
J Neurosci Res
, vol.73
, pp. 627-636
-
-
Tsukamoto, E.1
Hashimoto, Y.2
Kanekura, K.3
Niikura, T.4
Aiso, S.5
Nishimoto, I.6
-
137
-
-
0031044352
-
Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: Involvement of insulin-degrading enzyme
-
J.R. McDermott and A.M. Gibson, Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme, Neurochem Res 22 (1997), 49-56.
-
(1997)
Neurochem Res
, vol.22
, pp. 49-56
-
-
McDermott, J.R.1
Gibson, A.M.2
-
138
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation
-
W.Q. Qiu, D.M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M.B. Podlisny, M.R. Rosner, A. Safavi, L.B. Hersh and D.J. Selkoe, Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation, J Biol Chem 273 (1998), 32730-32738.
-
(1998)
J Biol Chem
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
139
-
-
0034038036
-
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
-
A. Perez, L. Morelli, J.C. Cresto and E.M. Castano, Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains, Neurochem Res 25 (2000), 247-255.
-
(2000)
Neurochem Res
, vol.25
, pp. 247-255
-
-
Perez, A.1
Morelli, L.2
Cresto, J.C.3
Castano, E.M.4
-
140
-
-
0034161516
-
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
-
K. Vekrellis, Z. Ye, W.Q. Qiu, D. Walsh, D. Hartley, V. Chesneau, M.R. Rosner and D.J. Selkoe, Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme, J Neurosci 20 (2000), 1657-1665.
-
(2000)
J Neurosci
, vol.20
, pp. 1657-1665
-
-
Vekrellis, K.1
Ye, Z.2
Qiu, W.Q.3
Walsh, D.4
Hartley, D.5
Chesneau, V.6
Rosner, M.R.7
Selkoe, D.J.8
-
141
-
-
0034933147
-
Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase
-
A.S. Balasubramanian, Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase, Neumchem Res 26 (2001), 453-456.
-
(2001)
Neumchem Res
, vol.26
, pp. 453-456
-
-
Balasubramanian, A.S.1
-
142
-
-
0033605607
-
Insulin-degrading enzyme in the Alzheimer's disease brain: Prominent localization in neurons and senile plaques
-
H.G. Bernstein, S. Ansorge, P. Riederer, M. Reiser, L. Frolich and B. Bogerts, Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques, Neurosci Lett 263 (1999), 161-164.
-
(1999)
Neurosci Lett
, vol.263
, pp. 161-164
-
-
Bernstein, H.G.1
Ansorge, S.2
Riederer, P.3
Reiser, M.4
Frolich, L.5
Bogerts, B.6
-
143
-
-
0037219221
-
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
-
D.G. Cook, J.B. Leverenz, P.J. McMillan, J.J. Kulstad, S. Ericksen, R.A. Roth, G.D. Schellenberg, L.W. Jin, K.S. Kovacina and S. Craft, Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele, Am J Pathol 162 (2003), 313-319.
-
(2003)
Am J Pathol
, vol.162
, pp. 313-319
-
-
Cook, D.G.1
Leverenz, J.B.2
McMillan, P.J.3
Kulstad, J.J.4
Ericksen, S.5
Roth, R.A.6
Schellenberg, G.D.7
Jin, L.W.8
Kovacina, K.S.9
Craft, S.10
-
144
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
W. Farris, S. Mansourian, M.A. Leissring, E.A. Eckman, L. Bertram, C.B. Eckman, R.E. Tanzi and D.J. Selkoe, Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein, Am J Pathol 164 (2004), 1425-1434.
-
(2004)
Am J Pathol
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
145
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo
-
W. Farris, S. Mansourian, Y. Chang, L. Lindsley, E.A. Eckman, M.P. Frosch, C.B. Eckman, R.E. Tanzi, D.J. Selkoe and S. Guenette, Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo, Proc Natl Acad Sci USA 100 (2003), 4162-4167.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
146
-
-
0346101885
-
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
-
M.A. Leissring, W. Farris, A.Y. Chang, D.M. Walsh, X. Wu, X. Sun, M.P. Frosch and D.J. Selkoe, Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death, Neuron 40 (2003), 1087-1093.
-
(2003)
Neuron
, vol.40
, pp. 1087-1093
-
-
Leissring, M.A.1
Farris, W.2
Chang, A.Y.3
Walsh, D.M.4
Wu, X.5
Sun, X.6
Frosch, M.P.7
Selkoe, D.J.8
-
147
-
-
0034704198
-
Evidence for genetic linkage of Alzheimer's disease to chromosome 1Oq
-
L. Bertram, D. Blacker, K. Mullin, D. Keeney, J. Jones, S. Basu, S. Yhu, M.G. McInnis, R.C. Go, K. Vekrellis, D.J. Selkoe, A.J. Saunders and R.E. Tanzi, Evidence for genetic linkage of Alzheimer's disease to chromosome 1Oq, Science 290 (2000), 2302-2303.
-
(2000)
Science
, vol.290
, pp. 2302-2303
-
-
Bertram, L.1
Blacker, D.2
Mullin, K.3
Keeney, D.4
Jones, J.5
Basu, S.6
Yhu, S.7
McInnis, M.G.8
Go, R.C.9
Vekrellis, K.10
Selkoe, D.J.11
Saunders, A.J.12
Tanzi, R.E.13
-
148
-
-
0035687018
-
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
-
R. Abraham, A. Myers, F. Wavrant-DeVrieze, M.L. Hamshere, H.V. Thomas, H. Marshall, D. Compton, G. Spurlock, D. Turic, B. Hoogendoorn, J.M. Kwon, R.C. Petersen, E. Tangalos, J. Norton, J.C. Morris, R. Bullock, D. Liolitsa, S. Lovestone, J. Hardy, A. Goate, M. O'Donovan, J. Williams, M.J. Owen and L. Jones, Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease, Hum Genet 109 (2001), 646-652.
-
(2001)
Hum Genet
, vol.109
, pp. 646-652
-
-
Abraham, R.1
Myers, A.2
Wavrant-DeVrieze, F.3
Hamshere, M.L.4
Thomas, H.V.5
Marshall, H.6
Compton, D.7
Spurlock, G.8
Turic, D.9
Hoogendoorn, B.10
Kwon, J.M.11
Petersen, R.C.12
Tangalos, E.13
Norton, J.14
Morris, J.C.15
Bullock, R.16
Liolitsa, D.17
Lovestone, S.18
Hardy, J.19
Goate, A.20
O'Donovan, M.21
Williams, J.22
Owen, M.J.23
Jones, L.24
more..
-
149
-
-
0037036168
-
Confirmation of association between D10S583 and Alzheimer's disease in a case - Control sample
-
G. Ait-Ghezala, L. Abdullah, R. Crescentini, F. Crawford, T. Town, S. Singh, D. Richards, R. Duara and M. Mullan, Confirmation of association between D10S583 and Alzheimer's disease in a case - control sample, Neurosci Lett 325 (2002), 87-90,
-
(2002)
Neurosci Lett
, vol.325
, pp. 87-90
-
-
Ait-Ghezala, G.1
Abdullah, L.2
Crescentini, R.3
Crawford, F.4
Town, T.5
Singh, S.6
Richards, D.7
Duara, R.8
Mullan, M.9
-
150
-
-
0037162647
-
Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease
-
M. Boussaha, D. Hannequin, P. Verpillat, A. Brice, T. Frebourg and D. Campion, Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease, Neurosci Lett 329 (2002), 121-123.
-
(2002)
Neurosci Lett
, vol.329
, pp. 121-123
-
-
Boussaha, M.1
Hannequin, D.2
Verpillat, P.3
Brice, A.4
Frebourg, T.5
Campion, D.6
-
151
-
-
0028365004
-
Age as risk factor for sporadic dementia of the Alzheimer type?
-
S. Hoyer, Age as risk factor for sporadic dementia of the Alzheimer type? Ann N Y Acad Sci 719 (1994), 248-256.
-
(1994)
Ann N Y Acad Sci
, vol.719
, pp. 248-256
-
-
Hoyer, S.1
-
152
-
-
0028170864
-
Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism
-
S. Hoyer, D. Muller and K. Plaschke, Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism, J Neural Transm Suppl 44 (1994), 259-268.
-
(1994)
J Neural Transm Suppl
, vol.44
, pp. 259-268
-
-
Hoyer, S.1
Muller, D.2
Plaschke, K.3
-
153
-
-
0027967549
-
Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity
-
S. Hoyer, Neurodegeneration, Alzheimer's disease, and beta-amyloid toxicity, Life Sci 55 (1994), 1977-1983.
-
(1994)
Life Sci
, vol.55
, pp. 1977-1983
-
-
Hoyer, S.1
-
154
-
-
0029689159
-
Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease
-
S. Hoyer, Oxidative metabolism deficiencies in brains of patients with Alzheimer's disease, Acta Neurol Scand Suppl 165 (1996), 18-24.
-
(1996)
Acta Neurol Scand Suppl
, vol.165
, pp. 18-24
-
-
Hoyer, S.1
-
155
-
-
0036205701
-
The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: An update
-
S. Hoyer, The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update, J Neural Transm 109 (2002), 341-360.
-
(2002)
J Neural Transm
, vol.109
, pp. 341-360
-
-
Hoyer, S.1
-
156
-
-
0036311771
-
The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
-
S. Hoyer, The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review, J Neural Transm 109 (2002), 991-1002.
-
(2002)
J Neural Transm
, vol.109
, pp. 991-1002
-
-
Hoyer, S.1
-
157
-
-
0027304893
-
Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus
-
K. Plaschke and S. Hoyer, Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus, Int J Dev Neurosci 11 (1993), 477-483.
-
(1993)
Int J Dev Neurosci
, vol.11
, pp. 477-483
-
-
Plaschke, K.1
Hoyer, S.2
-
158
-
-
0028598190
-
Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats
-
R. Duelli, H. Schrock, W. Kuschinsky and S. Hoyer, Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int J Dev Neurosci 12 (1994), 737-743.
-
(1994)
Int J Dev Neurosci
, vol.12
, pp. 737-743
-
-
Duelli, R.1
Schrock, H.2
Kuschinsky, W.3
Hoyer, S.4
-
159
-
-
0034537362
-
Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
-
S. Hoyer, S.K. Lee, T. Loffler and R. Schliebs, Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease? Ann N Y Acad Sci 920 (2000), 256-258.
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 256-258
-
-
Hoyer, S.1
Lee, S.K.2
Loffler, T.3
Schliebs, R.4
-
160
-
-
0033380660
-
Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats
-
S. Hoyer and H. Lannert, Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats, Ann N Y Acad Sci 893 (1999), 301-303.
-
(1999)
Ann N Y Acad Sci
, vol.893
, pp. 301-303
-
-
Hoyer, S.1
Lannert, H.2
-
161
-
-
0031797937
-
Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
-
H. Lannert and S. Hoyer, Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats, Behav Neurosci 112 (1998), 1199-1208.
-
(1998)
Behav Neurosci
, vol.112
, pp. 1199-1208
-
-
Lannert, H.1
Hoyer, S.2
-
162
-
-
0037883037
-
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
-
Y. Miyazaki, H. He, L.J. Mandarino and R.A. DeFronzo, Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients, Diabetes 52 (2003), 1943-1950.
-
(2003)
Diabetes
, vol.52
, pp. 1943-1950
-
-
Miyazaki, Y.1
He, H.2
Mandarino, L.J.3
Defronzo, R.A.4
-
163
-
-
0042822095
-
Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: Comparison with PPAR-gamma activation
-
E.H. Koh, M.S. Kim, J.Y. Park, H.S. Kim, J.Y. Youn, H.S. Park, J.H. Youn and K.U. Lee, Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation, Diabetes 52 (2003), 2331-2337.
-
(2003)
Diabetes
, vol.52
, pp. 2331-2337
-
-
Koh, E.H.1
Kim, M.S.2
Park, J.Y.3
Kim, H.S.4
Youn, J.Y.5
Park, H.S.6
Youn, J.H.7
Lee, K.U.8
-
164
-
-
3042536908
-
Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling
-
S.M. de la Monte and J.R. Wands, Alzheimer-associated neuronal thread protein mediated cell death is linked to impaired insulin signaling, J Alzheimers Dis 6 (2004), 231-242.
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 231-242
-
-
De La Monte, S.M.1
Wands, J.R.2
-
165
-
-
3042558276
-
Glycogen synthase kinase 3: A drug target for CNS therapies
-
R.V. Bhat, S.L. Budd Haeberlein and J. Avila, Glycogen synthase kinase 3: a drug target for CNS therapies, J Neurochem 89 (2004), 1313-1317.
-
(2004)
J Neurochem
, vol.89
, pp. 1313-1317
-
-
Bhat, R.V.1
Budd Haeberlein, S.L.2
Avila, J.3
|