Degradation of soluble amyloid β-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains

Neurochemical Research

Volumn 25, Issue 2, 2000, Pages 247-255

  Pérez, Adriana ^a   Morelli, Laura ^c   Cresto, Juan Carlos ^a   Castaño, Eduardo M ^b  

^a HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c NONE

Author keywords

Alzheimer's disease; Amyloid peptide; Dutch variant; Insulin degrading enzyme

Indexed keywords

AMYLOID BETA PROTEIN; INSULINASE;

ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BLOTTING, WESTERN; BRAIN; CASE-CONTROL STUDIES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROLYSIS; INSULYSIN; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; SUBSTRATE SPECIFICITY;

LEUCISCUS IDUS;

EID: 0034038036     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007527721160     Document Type: Article

References (49)

1. Selkoe, D. J. 1994. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell. Biol. 10:373-403.
2. Selkoe, D. J. 1996. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271:18295-18298.
3. Levy, E., Carman M. D., Fernandez Madrid I., Power M. D., Lieberburg I., van Duinen S. G., Gererd T., Bots G. T. A. M., Luvendijk W., and Frangione B. 1990. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage. Science 248:1124-1126.
4. Mann, D. M. A. 1989. Cerebral amyloidosis, aging and Alzheimer's disease; a contribution from studies on Down's syndrome. Neurobiol. Aging 10:397-399.
5. Seubert, P., Vigo Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Sclossmacher, G., Whaley, J., Swindlehurst, C., Mc Cormack, R., Wolfert, R., Selkoe, D. J., Lieberburg, I., and Schenk, D. 1992. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature 359:325-327.
6. Miller, D. L., Papayannopoulos, I. A., Styles, J., Bobin, S. A., Lin, Y. Y., Biemann, K., and Iqbal K. 1993. Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease. Arch. Biochem. Biophys. 301:41-52.
7. Roher, A. E., Kasunic, T. C., Woods, A. S., Cotter, R. J., Ball, M. J., and Fridman, R. 1994. Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem. Biophys. Res. Commun. 205:1755-1761.
8. Naidu, A., Quon, D., and Cordell, B. 1995. β-amyloid peptide produced in vitro is degraded by proteinases released by cultured cells. J. Biol. Chem. 270:1369-1374.
9. Backstrom, J. R., Lim, G. P., Cullen, M. J., and Tokes, Z. A. 1996. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40). J. Neurosci. 16:7910-7919.
10. Howell, S., Nalantoglu, J., and Crine, P. 1995. Neutral endopeptidase can hydrolyze β-amyloid (1-40) but shows no effect on β-amyloid precursor protein metabolism. Peptides 16:647-652.
11. Ladror, U. S., Snyder, S. W., Wang, G. T., Holzman, T. F., and Krafft, G. A. 1994. Cleavage at the amino and carboxyl termini of Alzheimer's amyloid-β by cathepsin D. J. Biol. Chem. 269:18422-18428.
12. 2-macroglobulin complex. J. Biol. Chem. 271:8443-8451.
13. Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., and Selkoe, D. J. 1998. Insulin-degrading enzyme regulates extracellular levels of amyloid beta protein by degradation. J. Biol. Chem. 273:32730-3278.
14. Kurochkin, I. V. and Goto, S. 1994. Alzheimer's β-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett. 345:33-37.
15. Mc Dermott, J. R. and Gibson, A. M. 1997. Degradation of Alzheimer's β-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem. Res. 22:49-56.
16. Bernstein, H.-G., Ansorge, S., Riederer, P., Reiser, M., Frolich, L., and Bogerts, B. 1999. Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques. Neurosci. Lett. 263:161-164.
17. Duckworth, W. C. 1988. Insulin degradation: mechanisms, products and significance. Endocrine Rev. 9:319-345.
18. Affholter, J. A., Fried, V. A., and Roth, R. A. 1988. Human insulin-degrading enzyme shares structural and functional homologies with E. coli protease III. Science 242:1415-1418.
19. Kuo, W.-L., Montag, A. G., and Rosner, M. R. 1993. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues. Endocrinology 132:604-611.
20. Akiyama, H., Yokono, K., Shii, K., Ogawa, W., Taniguchi, H., and Baba, S. 1990. Natural regulatory mechanisms of insulin degradation enzyme. Biochem. Biophys. Res. Commun. 170: 1325-1330.
21. Misbin, R. I., Almira, E. C., Duckworth, W. C., and Mehl, T. D. 1983. Inhibition of insulin degradation by insulin-like growth factors. Endocrinology 113:1525.
22. Garcia, J. V., Gehm, B. D., and Rosner, M. R. 1989. An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin. J. Cell. Biol. 109:1301-1307.
23. Müller, D., Baumeister, H., Buck, F., and Richter, D. 1991. Atrial natriuretic peptide is a high-affinity substrate for rat insulin-degrading enzyme. Eur. J. Biochem. 202:285-292.
24. Safavi, A., Miller, B. C., Cottam, L., and Hersh, L. B. 1996. Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme. Biochemistry 35:14318-14325.
25. Baumeister, H., Müller, D., Rehbein, M., and Richter, D. 1993. The rat insulin-degrading enzyme: Molecular cloning and characterization of tissue-specific transcripts. FEBS Lett. 317:250-254.
26. Soto, C., Sigurdsson, E. M., Morelli, L., Kumar, R. A., Castaño, E. M., and Frangione, B. 1998. β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer disease. Nature Med. 4:822-825.
27. Schägger, H. and von Jagow, G. 1987. Tricine-sodium dodecyl sulfate-polyacrilamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166: 368-379.
28. 125I-insulin to a cytosolic insulin-degrading enzyme. J. Biol. Chem. 260:6503-6506.
29. Morelli, L., Giambartolomei, G. H., Prat, M. I., Castaño, E. M. 1999. Internalization and resistance to degradation of Alzheimer's Aβ 1-42 at nanomolar concentrations in THP-1 human monocytic cell line. Neurosci. Lett. 262:5-8.
30. Shii, K., Yokono, K., Baba, S., and Roth, R. A. 1986. Purification and characterization of insulin-degrading enzyme from human erythrocytes. Diabetes 35:675-683.
31. Kurochkin, I. V. 1998. Amyloidogenic determinant as a sustrate recognition motif of insulin-degrading enzyme. FEBS Lett. 427:153-156.
32. Soto, C., Castaño, E. M., Frangione, B., and Inestrosa, N. C. 1995. The alfa-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation. J. Biol. Chem. 270:3063-3067.
33. Castaño, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, R. A., Soto, C., and Frangione, B. 1995. Fibrillogenesis of Alzheimer's amyloid β peptides and apolipoprotein E. Biochem. J. 306:599-604.
34. 125I-insulin with a cytosolic insulin-degrading enzyme: detection by covalent cross-linking and immunoprecipitation with a monoclonal antibody. Endocrinology 120:829-831.
35. Gehm, B. D. and Rosner, M. R. 1991. Regulation of insulin, epidermal growth factor, and transforming growth factor-α levels by growth factor-degrading enzymes. Endocrinology 128:1603-1610.
36. Matsas, R., Kenny, J. and Turner, A. J. 1984. The metabolism of neuropeptides. Biochem. J. 223:433-440.
37. Jarrett, J., Berger, E. P., and Lansbury, P. T. Jr. 1993. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697.
38. Kuo, Y.-M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J., and Roher, A. E. 1996. Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains. J. Biol. Chem. 271: 4077-4081.
39. Qiu, W. Q., Ye, Z., Kholodenko, D., Seubert, P., and Selkoe, D. J. 1997. Degradation of amyloid β-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. J. Biol. Chem. 272:6641-6646.
40. Nordsted, C., Näslund, J., Tjemberg, L. O., Karlström, A. R., Thyberg, J., and Terenius, L. 1994. The Alzheimer Aβ peptide develops protease resistance in association with its polymerization into fibrils. J. Biol. Chem. 269:30773-30776.
41. Runyan, K., Duckworth, W. C., Kitabchi, A. E., and Huff, G. 1979. The effect on age on insulin-degrading activity in rat tissue. Diabetes 28:324-325.
42. Fergusson, J., Landon, M., Lowe, J., Dawson, S. P., Layfield, R., Hanger, D. P., and Mayer, R. J. 1996. Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome. Neurosci. Lett. 219:167-170.
43. Saido, T. C. 1998. Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. Neurobiol. Aging 19:869-75.
44. Cataldo, A., Barnett, J. L., Berman, S. A., Li, J., Quarless, S., Bursztajn, S., Lippa, C., and Nixon, R. A. 1995. Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14:671-680.
45. Mc Dermott, J. R., Biggins, J. A., and Gibson, A. M. 1992. Human brain peptidase activity with the specificity to generate the N-terminus of the Alzheimer β-amyloid protein from its precursor. Biochem. Biophys. Res. Commun. 185:746-752.
46. 6 myoblasts inhibit insulin degradation by the endogenous insulin-degrading enzyme. J. Biol. Chem. 264:8928-8934.
47. Duckworth, W. C., Bennett, R. G., and Hamel, F. G. 1998. Insulin degradation: progress and potential. Endocrine Rev. 19: 608-624.
48. Hamel, F. G., Bennett, R. G., and Duckworth, W. C. 1998. Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme. Endocrinology 139:4061-4066.
49. Kupfer, S. R., Wilson, E. M., and French F. S. 1994 Androgen and glucocorticoid receptors interact with insulin degrading enzyme. J. Biol. Chem. 269:20622-20628.