Inhibition of the neuronal insulin receptor: An in vivo model for sporadic Alzheimer disease?

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 256-258

  Hoyer, Siegfried ^a   Kyung Lee, S A E ^a   Löffler, Thomas ^b   Schliebs, Reinhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; BINDING SITE; CATECHOLAMINE RELEASE; CONFERENCE PAPER; ENERGY METABOLISM; GLUCOSE TRANSPORT; IN VIVO STUDY; NONHUMAN; PATHOGENESIS; PHOSPHOLIPID MEMBRANE; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034537362     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06932.x     Document Type: Conference Paper

References (9)

1. Predominant abnormality in cerebral glucose utilization in late-onset dementia of the Alzheimer type: A cross-sectional comparison against advanced late-onset and incipient early-onset cases
2. Oxidative energy metabolism in Alzheimer brain. Studies in early-onset and late-onset cases
3. Insulin and insulin receptor in the brain in aging and in sporadic Alzheimer's disease
4. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
5. Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism
6. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
7. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
8. Functional alterations in Alzheimer's disease: Decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone
9. Nitric oxide synthase does not mediate neurotoxicity after an i.c.v. injection of streptozotocin in the rat