Does insulin dysfunction play a role in Alzheimer's disease?

Trends in Pharmacological Sciences

Volumn 23, Issue 6, 2002, Pages 288-293

  Gasparini, Laura ^a   Netzer, William J ^b   Greengard, Paul ^b   Xu, Huaxi ^b  

^a Nicox Research Institute   (Italy)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; TAU PROTEIN; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; BRAIN FUNCTION; BRAIN METABOLISM; COGNITION; DIABETES MELLITUS; ELECTRIC POTENTIAL; HORMONE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; BRAIN; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BRAIN; COGNITION; DIABETES MELLITUS; HUMAN; INSULIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS;

EID: 0036591657     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(02)02037-0     Document Type: Review

References (68)

1. The endocrinology of aging
2. Post-menopausal estrogen deprivation and Alzheimer's disease
3. Cognition and synaptic plasticity in diabetes mellitus
4. Cardiovascular risk factors and cognitive decline in middle-aged adults
5. Analysis of familial and individual risk factors among patients with ischemic vascular dementia and Alzheimer's disease
6. Risk of dementia among persons with diabetes mellitus: A population-based cohort study
7. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study
8. Association of diabetes mellitus and dementia: The Rotterdam study
9. Diabetes mellitus and the risk of dementia: The Rotterdam study
10. Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort
11. Association between features of the insulin resistance syndrome and Alzheimer's disease independently of apolipoprotein E4 phenotype: Cross sectional population based study
12. Vascular risk and incident dementia: Results from a cohort study of the very old
13. Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance
14. Low blood pressure and blood glucose levels in Alzheimer's disease. Evidence for a hypometabolic disorder?
15. Diabetics do not have increased Alzheimer-type pathology compared with aged-matched control subjects - A retrospective postmortem immunocytochemical and histofluorescent study
16. Alzheimer's disease: A study of epidemiological aspects
17. Clinical and epidemiological aspects of Alzheimer's disease with presenile onset: A case control study
18. Impact of referral bias on clinical and epidemiological studies of Alzheimer's disease
19. Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease
20. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease
21. Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study
22. Memory improvement following induced hyperinsulinemia in Alzheimer's disease
23. Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
24. Insulin receptors and insulin action in the brain: Review and clinical implications
25. Insulin receptors in the central nervous system: Localizations, signaling mechanisms and functional aspects
26. Role of brain insulin receptors in control of body weight and reproduction
27. IRS-2 pathways integrate female reproduction and energy homeostasis
28. 2+ pool and of neuropeptide secretion
29. A receptors to postsynaptic domains by insulin
30. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
31. Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus
32. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
33. Tracking insulin to the mind
34. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
35. Cognitive effects of insulin in the central nervous system
36. Role of insulin and insulin receptor in learning and memory
37. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats
38. Intracerebroventricular insulin enhances memory in a passive-avoidance task
39. Improving influence of insulin on cognitive functions in humans
40. Is sporadic Alzheimer's disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis
41. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
42. Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors
43. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
44. Insulin transiently increases tau phosphorylation: Involvement of glycogen synthase kinase-3β and Fyn tyrosine kinase
45. Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
46. Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
47. Neurons regulate extracellular levels of amyloid β-protein via proteolysis by insulin-degrading enzyme
48. The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein
49. Stimulation of β-amyloid precursor protein trafficking by insulin reduces intraneuronal β-amyloid and requires mitogen-activated protein kinase signaling
50. Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway
51. Vascular aspects in Alzheimer's disease
52. Dementia and its association in type 2 diabetes mellitus: The Fremantle diabetes study
53. Cerebral microvasculature pathology in aging and Alzheimer's disease
54. Review of alterations in endothelial nitric oxide production in diabetes. Protective role of arginine on endothelial dysfunction
55. Degradation of soluble amyloid β-peptides 1-40, 1-42, and Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
56. Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
57. Metabolic regulation of brain Aβ by neprylisin
58. Intracellular biology of Alzheimer's disease amyloid beta peptide
59. Intracellular APP processing and Aβ production in Alzheimer disease
60. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
61. Intraneuronal Aβ42 accumulation in human brain
62. Aβ42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease
63. Endogenous proteins controlling amyloid β-peptide polymerization. Possible implications for β-amyloid formation in the central nervous system and in peripheral tissues
64. PPAR-γ agonists: Therapeutic role in diabetes, inflammation and cancer
65. Inflammatory mechanisms in Alzheimer's disease: Inhibition of β-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
66. Peroxisome proliferator-activated receptor-β ligands reduce neuronal inducible nitric oxide synthase expression and cell death
67. Genes, models and Alzheimer's disease
68. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP