Use of transgenic mice for understanding the physiology of insulin-like growth factors

Hormone Research in Paediatrics

Volumn 45, Issue , 1996, Pages 5-7

  D'ercole, A J ^a   Ye, P ^a   Gutierrez Ospina, G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Development; Growth; Insulin like growth factors; Transgenic mice

Indexed keywords

SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; BODY GROWTH; BRAIN DEVELOPMENT; CONFERENCE PAPER; FETUS GROWTH; FETUS MATURITY; MOUSE; MYELINATION; NONHUMAN; PLACENTA DEVELOPMENT; POSTNATAL GROWTH; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; BRAIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MICE; MICE, TRANSGENIC; SOMATOMEDINS;

EID: 0030006746     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000184816     Document Type: Article

References (11)

1. Malhews LS, Hammer RE, Behringer HR, D'ErcoIe AJ, Bell GI, Brinster RL, Palmiter RD: Growth enhancement of transgenic mice expressing human insulin-like growth factor I. Endocrinology 1988; 123:2827-2833.
2. Behringer RR, Lewin TM, Quaile CJ, Palmiter RD, Brinster RL, D’Ercole AJ: Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice. Endocrinology 1990:127: 1033-1040.
3. DeChiara TM, Efstratiadis A, Robertson EJ: A growth-dcficicncy phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 1990:345: 78-80.
4. DeChiara TM, Robertson EJ, Efstratiadis A: Parental imprinting of the mouse insulin-like growth factor II gene. Cell 1991:64:849-859.
5. Baker J, Liu J, Robertson EJ, Efstratiadis A: Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993:75: 73-82.
6. Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart TA: 1GF-I is required for normal embryonic growth in mice. Genes Dev 1993:7: 2609-2617.
7. Liu J, Baker J, Perkins AS, Robertson EJ, Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-I)and type 1 IGF receptor. Cell 1993:75: 59-72.
8. Carson MJ, Behringer RR, Brinster RL, McMorris FA: Insulin-like growth factor I increases brain growth and central nervous system mvelination in transgenic mice. Neuron 1993;10:729-740.
9. Dai Z, Xing Y, Boney C, Clemmons DR, D'Er-cole AJ: Human insulin-like growth factor binding protcin-l (IGFBP-I) transgenic mice: Characterization and insights into the regulation of IGFBP-1 expression. Endocrinology 1994;135:1316-1327.
10. D'ErcoIe AJ, Dai Z, Xing Y, Boney C, Wilkie MB, Lauder JM, Han VK, Clemmons DR: Brain growth retardation due to the expression of human insulin-like growth factor binding protein-1 (IGFBP-I) in transgenic mice: An in vivo model for analysis of IGF function in the brain. Dev Brain Res 1994;82:213-222.
11. Ye P, Carson J, D'ErcoIe AJ: In vivo actions of insulin-like growth factor-I (1GF-I) on brain myelination: Studies of IGF-I and IGF binding proten-1 (IGFBP-I) transgenic mice. J Neu-rosci 1995;15:7344-7356.