The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system

Molecular Neurobiology

Volumn 13, Issue 2, 1996, Pages 155-183

  Folli, Franco ^a,b   Ghidella, Silvana ^c   Bonfanti, Luca ^c   Kahn, C Ronald ^a   Merighi, Adalberto ^c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Department of Medicine ^*  (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

Central nervous system; Glial cells; IGF receptor; IGF I; IGF II; Insulin; IRS 1; IRS 2; Neurons; PI 3 kinase

Indexed keywords

INSULIN; INSULIN RECEPTOR; NERVE PROTEIN; PROTEIN TYROSINE KINASE; SOMATOMEDIN; SOMATOMEDIN RECEPTOR;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL; ATAXIA TELANGIECTASIA; BIOLOGICAL MODEL; BRAIN; BRAIN ISCHEMIA; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MAMMAL; METABOLISM; MOUSE; MOUSE MUTANT; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PRENATAL DEVELOPMENT; PROTEIN PROCESSING; RAT; RETINA; REVIEW; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSGENIC MOUSE;

ADULT; ANIMALS; ATAXIA TELANGIECTASIA; BRAIN; BRAIN ISCHEMIA; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION; HUMANS; INSULIN; MAMMALS; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MODELS, NEUROLOGICAL; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; RATS; RECEPTOR, INSULIN; RECEPTORS, SOMATOMEDIN; RETINA; SIGNAL TRANSDUCTION; SOMATOMEDINS; SPINAL CORD;

EID: 0030253891     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02740639     Document Type: Article

References (207)

1. Adamo M. L., Shemer J., Roberts C. T. Jr., and LeRoith D. (1993) Insulin and insulin-like growth factor-I induced phosphorylation in neurally derived cells. Ann. NY Acad. Sci. 692, 113-125.
2. Al-Khodairy F. and Carr A. M. (1992) DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J. 11, 1343-1350.
3. Alpert S., Hanahan D., and Teitelman G. (1988) Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53, 295-308.
4. Altman J. (1992) Programmed cell death: the paths to suicide. Trends Neurol. Sci. 15, 278-280.
5. Andersson I. K., Edwall D., Norstedt G., Rozell B., Skottner A., and Hansson H.-A. (1988) Differing expression of insulin-like growth factor I in the developing and adult rat cerebellum. Acta Physiol. Scand. 132, 167-173.
6. Ang L. C., Bhaumick B., and Juurlink B. H. J. (1993) Neurite promoting activity of insulin, insulin-like growth factor I and nerve growth factor on spinal motoneurons is astrocyte dependent. Dev. Brain Res. 74, 83-88.
7. Araki E., Sun X., Haag B. L. III, Chuang L., Zhang Y., Yang-Feng T. L., Morris F. W., and Kahn C. R. (1993) Human skeletal muscle insulin receptor substrate-1. Characterization on the cDNA, gene, and chromosomal localization. Diabetes 42, 1041-1054.
8. Araki E., Lipes M. A., Patti M. E., Bruning J. C., Haag B. I., Johnson R. S., and Kahn C. R. (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 7, 43-58.
9. Araujo D. M., Lapchak P. A., Collier B., Chabot J.-G., and Quirion R. (1989) Insulin-like growth factor-I (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system. Brain Res. 484, 130-138.
10. Argetsinger L. S., Hsu G. W., Myers M. G. J., Billestrup N., White M. F., and Carter-Su C. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270, 14,685-14,692.
11. Ayer-le-Lievre A., Stählbom P. A., and Sara V. R. (1991) Expression of IGF-I and II mRNA in the brain and cranio-facial region of the rat fetus. Development 111, 105-111.
12. Bach M. A., Shen-Orr Z., Lowe W. L. Jr., Roberts C. T. Jr., and LeRoith D. (1991) Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain. Mol. Brain Res. 10, 43-48.
13. Backer J. M., Myers M. G., Shoelson S. E., Chin D. J., Jian Sun X., Miralpeix M., Hu P., Margolis B., Skolnik Y., Schlessinger J., and White M. F. (1992) Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479.
14. Backer J., Liu J. P., Robertson E. J., and Efstratiadis A. (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73-82.
15. Ballesteros M., Scott C. D., and Baxter R. C. (1990) Developmental regulation of insulin-like growth factor-II/mannose 6-phosphate receptor mRNA in the rat. Biochem. Biophys. Res. Commun. 172, 775-779.
16. Bare D. J., Lauder J. M., Wilkie M. B., and Maness P. F. (1993) p59fyn in rat brain is localized in developing axon tracts and subpopulations of adult neurons and glia. Oncogene 8, 1429-1436.
17. Barnea A. and Cho G. (1993) Basic fibroblast growth factor selectively amplifies the functional state of neurons producing neuropeptide Y but not somatostatin in cultures of fetal brain cells: evidence for a cooperative interaction with insulin-like growth factor I. Endocrinology 133, 1895-1898.
18. Baron-Van Evercooren A., Olichon-Berthe C., Kowalski A., Visciano G., and Van Obberghen E. (1991) Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional and cellular analysis. J. Neurosci. Res. 28, 244-253.
19. Bartlett W. P., Li X. S., Williams M., and Benkovic S. (1991) Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal development. Dev. Biol. 147, 239-250.
20. Baskin D. G., Sipols A. F., Schwartz M. W., and White M. F. (1993) Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine. Regul. Pept. 48, 257-266.
21. Baskin D. G., Schwartz M. W., Sipols A. J., D'Alessio D. A., Goldstein B. J., and White M. F. (1994) Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology 134, 1952-1955.
22. Batistatou A. and Greene L. A. (1991) Auriinitricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J. Cell Biol. 115, 461-471.
23. Beck K. D. (1994) Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons. Prog. Neurobiol. 44, 497-516.
24. Bohannon N. J., Corp E. S., Wilcox B. J., Figlewicz D. P., Dorsa D. M., and Baskin D. G. (1988) Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography. Brain Res. 444, 205-213.
25. Bondy C. A. (1991) Transient IGF-I gene expression during the maturation of functionally related central projection neurons. J. Neurosci. 11, 3442-3455.
26. Bondy C. A. and Lee W. (1993a) Patterns of insulin-like growth factor and IGF receptor gene expression in the brain. Ann. NY Acad. Sci. 692, 33-43.
27. Bondy C. A. and Lee W. (1993b) Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development. J. Neurosci. 13, 5092-5104.
28. Bondy C. A., Werner H., Roberts C. T. Jr., and LeRoith D. (1992) Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 46, 909-923.
29. Bozyczko-Coyne D., Glicksman M. A., Prantner J. E., McKenna B., Connors T., Friedman C., Dasgupta M., and Neff N. T. (1993) IGF-I supports the survival and/or differentiation of multiple types of central nervous system neurons. Ann. NY Acad. Sci. 692, 311-313.
30. Brown A. L., Graham D. E., Nissley S. P., Hill D. J., Strain A. J., and Rechler M. M. (1986) Developmental regulation of insulin-like growth factor II mRNA in different rat tissues. J. Bio. Chem. 261, 13,144-13,150.
31. Carson M. J., Behringer R. R., Brinster R. L., and McMorris F. A. (1993) Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 10, 729-740.
32. Castro-Alamancos M. A. and Torres-Aleman I. (1993) Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 90, 7386-7390.
33. Castro-Alamancos M. A. and Torres-Aleman I. (1994) Learning of the conditioned eye-blink response is impaired by an antisense insulin-like growth factor I oligonucleotide. Proc. Natl. Acad. Sci. USA 91, 10,203-10,207.
34. Cheatham B. and Kahn C. R. (1995) Insulin action and the insulin signaling network. Endocrine Rev. 16, 117-142.
35. Cheatham B., Vlahos C., Cheatham L., Wang L., Blenis J., and Kahn C. R. (1994) Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation. Mol. Cell. Biol. 14, 4902-4911.
36. Chuang L. M., Hausdorff S. F., Myers M. G. J., White M. F., Birnbaum M. J., and Kahn C. R. (1994) Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. J. Biol. Chem. 269, 27,645-27,649.
37. Cortizo A. M., van Arnaldo J., Burgess S. K., and Espinal J. (1991) Insulin and IGF-I stimulated RNA synthesis in primary cultures of neuronal cells: involvement of cyclic AMP and protein kinase-C. Acta Pysiol. Pharmalcol. Ther. Latinoamericana 41, 295-307.
38. Deltour L., Leduque P., Blume N., Madsen O., Dubois P., Jami J., and Bucchini D. (1993) Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc. Natl. Acad. Sci. USA 90, 527-531.
39. D'Ercole A. J. (1993) Expression of insulin-like growth factor-I in transgenic mice. Ann. NY Acad. Sci. 692, 149-160.
40. D'Ercole A. J., Dai Z., Xing Y., Boney C., Wilkie M. B., Lauder J. M., Han V. K. M., and Clemmons D. R. (1994) Brain growth retardation due to the expression of human insulin-like growth factor binding protein-1 in transgenic mice: an in vivo model for the analysis of igf function in the brain. Dev. Brain Res. 82, 213-222.
41. DeChiara T. M., Efstratiadis A., and Robertson E. J. (1990) A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345, 78-80.
42. DeChiara T. M., Robertson E. J., and Efstratiadis A. (1991) Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64, 849-859.
43. De Pablo F. and De la Rosa E. J. (1995) The developing CNS: a scenario for the action of proinsulin, insulin and insulin-like growth factors. Trends Neurosci. 18, 143-150.
44. Devaskar S. U., Singh B. S., Carnaghi L. R., Rajakumar P. A., and Giddings S. J. (1993) Insulin II gene expression in rat central nervous system. Regul. Pep. 48, 55-63.
45. Devaskar S. U., Giddings S. J., Rajakumar P. A., Carnaghi L. R., Menon R. K., and Zahm D. S. (1994) Insulin gene expression and insulin synthesis in mammalian neuronal cells. J. Biol. Chem. 269, 8445-8454.
46. Devaskar S. U., Holekamp N., Karycki L., and Devaskar U. P. (1995) Ontogenesis of the insulin receptors in the rabbit brain. Horm. Res. 24, 319-327.
47. Doré S., Kar S., and Quirion R. (1995a) Evidence for the presence of two distinct insulin-like growth factor (IGF-I and IGF-II) receptors in cultured rat hippocampal neurons and different process of internalization. Neuroscience, in press.
48. Doré S., Krieger C., Kar S., and Quirion R. (1996b) Distribution and levels of insulin-like growth factors (IGF-I and IGF-II) and insulin receptor binding sites in spinal cords of amyotrophic lateral sclerosis (ALS) patients. Mol. Brain Res. 41, 128-223.
49. Drago J., Murphy M., Carroll S. M., Harvey A. R., and Bartlett P. F. (1991) Fibroblast growth factor-mediated proliferation of central nervous system precursors depends on endogenous production of insulin-like growth factor I. Proc. Natl. Acad. Sci. USA 88, 2199-2203.
50. Drakenberg K., Östenson G.-C., and Sara V. R. (1990) Circulating forms and biological activity of intact and truncated insulin-like growth factor-1 (IGF-1) in adult and neonatal rat. Acta Endocrinol. 123, 43-51.
51. Ebina Y., Ellis L., Jarnagin K., Edery M., Graf L., Clauser E., Ou J., Masiar F., Kan Y. W., Goldfine I. D., Roth R. A., and Rutter W. J. (1985) The human insulin receptor cDNA: the structural basis for hormone activated transmembrane signalling. Cell 40, 747-758.
52. Escobedo J. A., Navankasattusas S., Kavanaugh W. M., Milfay D., Fried V. A., and Williams L. T. (1991) cDNA cloning of a novel 85 kD protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell 65, 75-82.
53. Fantl W. J., Johnson D. E., and Williams L. T. (1993) Signalling by receptor tyrosine kinases. Ann. Rev. Biochem. 62, 453-481.
54. Feener E. P., Backer J. M., King G. L., Wilden P. A., Sun X., Kahn C. R., and White M. F. (1993) Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J. Biol. Chem. 268, 11,256-11,264.
55. Folli F., Saad M. J. A., Backer J. M., and Kahn C. R. (1992) Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat. J. Biol. Chem. 267, 22,171-22,177.
56. Folli F., Bonfanti L., Renard E., Kahn C. R., and Merighi A. (1994) Insulin receptor substrate-1 (IRS-1) distribution in the rat central nervous system. J. Neurosci. 14, 6412-6422.
57. th Ann. Mtg. Endocrine Soc., p. 515 (abstract).
58. Franke T. F., Yang S., Chan T. O., Datta K., Kazlauskas A., Morrison D. K., Kaplan D. R., and Tsichlis P. N. (1995) The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
59. Gage F. H., Ray J., and Fisher L. J. (1995) Isolation, characterization, and use of stem cells from the CNS. Ann. Rev. Neurosci. 18, 159-192.
60. Gammeltoft S., Haselbacher G. K., Humbel R. E., Fehlmann M., and Van Obberghen E. (1985) Two types of receptor for insulin-like growth factors in mammalian brain. EMBO J. 4, 3407-3412.
61. Gammeltoft S., Christiansen J., Nielsen F. C., and Verland S. (1991) Insulin-like growth factor II: complexity of biosynthesis and receptor binding, in Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors (Raizada M. K. and LeRoith D., eds.), Plenum, New York, pp. 31-44.
62. Garcia-Segura L. M., Perez J., Pons S., Rejas M. T., and Torres-Aleman I. (1991) Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain. Brain Res. 560, 167-174.
63. Giacobini M. B., Olson M. J., Hoffer B. J., and Sara V. R. (1990) Truncated IGF-1 exerts trophic effects on fetal brain tissue grafts. Exp. Neurol. 108, 33-39.
64. Girault J. A., Chamak B., Bertuzzi G., Tixier H., Wang J. K., Pang D. T., and Greengard P. (1992) Protein phosphotyrosine in mouse brain: developmental changes and regulation by epidermal growth factor, type I insulin-like growth factor, and insulin. J. Neurochem. 58, 518-528.
65. Gluckman P. D., Guan J., Beilharz E. J., Klempt N. D., Klempt M., Miller O., Sirimanne E., Dragunow M., and Williams C. E. (1993) The role of the insulin-like growth factor system in neuronal rescue. Ann. NY Acad. Sci. 262, 138-148.
66. Gout I., Dhand R., Hiles I. D., Fry M. J., Panayotou G., Das P., Truong O., Totty N. F., Hsuan J., and Booker G. W. (1993) The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 75, 25-36.
67. Grant S. G., O'Dell T. J., Karl K. A., Stein P. L., Soriano P., and Kandel E. R. (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258, 1903-1910.
68. Green B. N., Jones S. B., Streck R. D., Wood T. L., Rotwein P., and Pintar J. E. (1994) Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development. Endocrinology 134, 954-962.
69. Guthrie K. M., Wilson D. A., and Leon M. (1990) Early unilateral deprivation modifies olfactory bulb function. J. Neurosci. 10, 3402-3412.
70. Hansson H.-A., Nilsson A., Isgaard J., Billing H., Isaksson O., Skottner A., Andersson I. K., and Rozell B. (1988) Immunohistochemical localization of insulin-like growth factor I in the adult rat. Histochemistry 89, 403-410.
71. Havrankova J., Roth J., and Brownstein M. (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829.
72. Havrankova J., Brownstein M., and Roth J. (1981) Insulin and insulin receptors in rodent brain. Diabetologia 20, 268-273.
73. Heidenreich K. A., Toledo S. P., and Kenner K. A. (1991) Regulation of protein phosphorylation by insulin and insulin like growth factors in cultured fetal neurons. Adv. Exp. Med. Biol. 293, 379-384.
74. Hues I. D., Otsu M., Volinna S., Fry M. J., Gout I., Dhand R., Panayotou G., Ruiz-Larrea F., Thompson A., Totty N. F., Hsuan J., Courtneidge S. A., Parker P. J., and Waterfield M. D. (1992) Phosphatidylinositol 3-kinase: structure and expression of the 110 kD catalytic subunit. Cell 70, 419-429.
75. Hill J. M., Lesniak M. A., Pert C. B., and Roth J. (1986) Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 17, 1127-1138.
76. Hökfelt T., Johansson O., Ljungdahl Å., Lundberg J. M., and Schultzberg M. (1980) Peptidergic neurones. Nature 284, 515-521.
77. Hubbard S. R., Wei L., Ellis L., and Hendrickson W. A. (1994) Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372, 746-754.
78. Hung J., Granner T. C., Emos K. P., Kazlauskas A., and Blenis J. (1994) PDGF and insulin-dependent pp70S6k activation mediated by phospatidylinositol 3-OH kinase. Nature 370, 71-75.
79. Hunter T. (1995) When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell 83, 1-4.
80. Hynes M. A., Brooks P. J., Van Wyk J. J., and Lund P. K. (1988) Insulin-like growth factor II messenger ribonucleic acids are synthesized in the choroid plexus of the rat brain. Mol. Endocrinol. 2, 47-54.
81. Imamoto A. and Soriano P. (1993) Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 73, 1117-1124.
82. Irminger J., Rosen K. M., Humbel R. E., and Villa-Komaroff L. (1987) Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5′ untranslated regions. Proc. Natl. Acad. Sci. USA 84, 6330-6333.
83. Ito M. (1989) Long-term depression. Ann. Rev. Neurosci. 12, 85-102.
84. Jones J. I. and Clemmons D. R. (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16, 3-34.
85. 125I]insulin receptor binding sites in developing and adult rat brain. J. Comp. Neurol. 333, 375-397.
86. Kasuga M., Hedo J. A., Yamada K. M., and Kahn C. R. (1982a) The structure of the insulin receptor and its subunits: evidence for multiple nonreduced forms and a 210K possible proreceptor. J. Biol. Chem. 257, 10,392-10,399.
87. Kasuga M., Karlsson F. A., and Kahn C. R. (1982b) Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science 215, 185-187.
88. Kasuga M., Zick Y., Blithe D. L., Crettaz M., and Kahn C. R. (1982c) Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature 298, 667-669.
89. Konishi Y., Takahashi K., Chui D. H., Rosenfeld R. G., Himeno M., and Tabira T. (1994) Insulin-like growth factor II promotes in vitro cholinergic development of mouse septal neurons: comparison with the effects of insulin-like growth factor I. Brain Res. 649, 53-61.
90. Kornfeld S. (1987) Trafficking of lysosomal enzymes. FASEB J. 1, 462-468.
91. Kornfeld S. (1992) Structure and function of the mannose 6-phospate/insulin-like growth factor II receptors. Ann. Rev. Biochem. 61, 307-330.
92. Kovacina K. S. and Roth R. A. (1995) Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. J. Biol. Chem. 270, 1881-1887.
93. Kuhne M. R., Pawson T., Lienhard G. E., and Feng G. S. (1993) The insulin receptor substrate-1 associates with the SH2-containing phosphotyrosine phosphatase 5YP. J. Biol. Chem. 268, 11,479-11,481.
94. Lammers R., Gray A., Schlessinger J., and Ullrich A. (1989) Differential signaling potential of insulin and IGF-I receptor cytoplasmic domains. EMBO J. 8, 1369-1375.
95. Lee J. E., Pintar J., and Efstratiadis A. (1990) Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis. Development 110, 151-159.
96. Lee W.-H., Michels K. M., and Bondy C. A. (1993) Localization of insulin-like growth factor binding protein 2 mRNA during postnatal brain development: correlation with IGF-I and II. Neuroscience 53, 251-265.
97. LeRoith D., Werner H., Beitner-Johnson D., and Roberts C. T. Jr. (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr. Rev. 16, 143-163.
98. Lesniak M. A., Hill J. M., Kiess W., Rojeski M., Pert C. B., and Roth J. (1988) Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123, 2089-2099.
99. Liu J., Baker J., Perkins A. S., Robertson E. J., and Efstratiadis A. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75, 59-72.
100. Logan A., Gonzales A. M., Hill D. J., Berry M., Gregson N. A., and Baird A. (1994) Coordinated pattern of expression and localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 in the adult rat brain. Endocrinology 135, 2255-2264.
101. Lowenstein E. J., Daly R. G., Batzer A. G., Li W., Margolis B., Lammers R., Ullrich A., Skolnik E. Y., Bar-Sagi D., and Schlessinger J. (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 70, 431-442.
102. Lund P. K., Moats-Staats B. M., Hynes M. A., Simmons J. G., Jansen M., D'Ercole A. J., and Van Wyk J. J. (1986) Somatomedin-C/insulin-like growth factor I and insulin-like growth factor II mRNAs in rat fetal and adult tissues. J. Biol. Chem. 261, 14,539-14,544.
103. Ma Z. Q., Santagati S., Patrone C., Pollio G., Vegeto E., and Maggi A. (1994) Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3. Mol. Endocrinol. 8, 910-918.
104. Marks J. L., Porte D., Stahl W. L., and Baskin D. G. (1990) Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology 127, 3234-3236.
105. Marks J. L., Porte D., and Baskin D. G. (1991) Localization of type I insulin-like growth factor receptor messenger RNA in the adult rat brain by in situ hybridization. Mol. Endocrinology 5, 1158-1168.
106. Massague J., Pilch P. F., and Czech M. P. (1982) Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries. Proc. Natl. Acad. Sci. USA 77, 7137-7141.
107. Matsuo K., Niwa M., Kurihara M., Shigematsu K., Yamashita S., Ozaki M., and Nagataki S. (1991) Receptor autoradiographic analysis of insulin-like growth factor-I (IGF-I) binding sites in rat forebrain and pituitary gland. Cell. Mol. Neurobiol. 9, 357-367.
108. McMorris F. A., Mozell R. L., Carson M. J., Shinar Y., Meyer R. D., and Marchetti N. (1993) Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors. Ann. NY Acad. Sci. 262, 321-334.
109. McPherson P. S., Czernik A. J., Chilcote T. J., Onofri F., Benfenati F., Greengard P., Schlessinger J., and DeCamilli P. (1994a) Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I. Proc. Natl. Acad. Sci. USA 91, 6486-6490.
110. McPherson P. S., Takei K., Schmid S. L., and DeCamilli P. (1994b) p145, a major grb2-binding protein in brain, is co-localized with dynamin in nerve terminals where it undergoes activity-dependent dephosphorylation. J. Biol. Chem. 269, 30,132-30,139.
111. Mermaridis D. G., Morse D. E., Pansky B., and Budd G. C. (1990) Insulin immunoreactivity in the fetal and neonatal rat retina. Neurosci. Lett. 118, 116-119.
112. Mozell R. L. and McMorris F. A. (1991) Insulin-like growth factor I stimulates oligodendrocyte development and myelination in rat brain aggregate cultures. J. Neurosci. Res. 30, 382-390.
113. S6K signaling during insulin, insulin-like growth factor 1 and interleukin-4 stimulation. J. Biol. Chem. 269, 28,783-28,789.
114. Myers M. G. J., Backer J. M., Sun X., Shoelson S. E., Hu P., Schlessinger J., Yoakim M., Schaffhausen B., and White M. E (1992) IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85. Proc. Natl. Acad. Sci. USA 89, 10,350-10,354.
115. Myers M. G. J., Sun X., Cheatham B., Jachna B. R., Glasheen E. M., Backer J. M., and White M. F. (1993) IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase. Endocrinology 132, 1421-1430.
116. Myers M. G. J., Sun X., and White M. F. (1995) The IRS-1 signaling system. TIBS 19, 289-294.
117. Nada S., Yagi T., Takeda H., Tokunaga T., Nakagawa H., Ikawa Y., Okada M., and Aizawa S. (1993) Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell 73, 1125-1135.
118. Nehlig A., De Vasconcelos A. P., and Boyet S. (1988) Quantitative autoradiographic measurement of local cerebral glucose utilization in freely moving rats during post-natal development. J. Neurosci. 8, 2321-2333.
119. Nielsen F. C. and Gammeltoft S. (1990) Mannose-6-phosphate stimulates proliferation of neuronal precursor cells. FEBS Lett. 262, 142-144.
120. Nielsen F. C., Wang E., and Gammeltoft S. (1991) Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. J. Neurochem. 56, 12-21.
121. Nieto-Bona M. P., Garcia-Segura L. M., and Torres-Aleman I. (1993) Orthograde transport and release of insulin-like growth factor I from the inferior olive to the cerebellum. J. Neurosci. Res. 36, 520-527.
122. Noguchi T., Kurata L. M., and Sugisaki T. (1987) Presence of somatomedin-C immunoreactive substance in the central nervous system: immunohistochemical mapping studies. Neuroendocrinology 46, 277-282.
123. Ocrant I., Valentino K. L., Eng L. F., Hintz R. L., Wilson D. M., and Rosenfeld R. N. (1988) Structural and immunohistochemical characterization of insulin-like growth factor I and II receptors in the murine central nervous system. Endocrinology 123, 1023-1034.
124. Ocrant I. (1993) Insulin-like growth factor binding proteins in nervous-tissue-derived cells. Ann. NY Acad. Sci. 692, 44-50.
125. O'Dell T. J., Kandel E. R., and Grant S. G. N. (1991) Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Letters to Nature 353, 558-560.
126. Okada M., Nada S., Yamanashi Y., Yamamoto T., and Nakagawa H. (1991) CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem. 266, 24,249-24,252.
127. Olson J. A. J., Shiverick K. T., Ogilvie S., Buhi W. C., and Raizada M. K. (1991) Developmental expression of rat insulin-like growth factor binding protein-2 by astrocytic glial cells in culture. Endocrinology 129, 1066-1074.
128. Otsu M., Hues I., Gout I., Fry M. J., Ruis-Larrea F., Panayotou G., Thompson A., Dhand R., Hsuan J., Totty N., Smith A. D., Morgan S. J., Courtneidge S. A., Parker P. J., and Waterfield M. D. (1991) Characterization of two 85 kD proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes and PI3-kinase. Cell 65, 91-104.
129. Park G. H. and Buetow D. E. (1991) Genes for insulin-like growth factors I and II are expressed in senescent rat tissues. Gerontology 37, 310-316.
130. Patti M., Sun X., Bruening J. C., Araki E., Lipes M. A., White M. F., and Kahn C. R. (1995) 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J. Biol. Chem. 270, 24,670-24,673.
131. Pawson T. (1995) Protein modules and signalling networks. Nature 373, 573-580.
132. Perez-Villamil B., De la Rosa E. J., Morales A. V., and De Pablo F. (1994) Developmentally regulated expression of the preproinsulin gene in the chicken embryo during gastrulation and neurulation. Endocrinology 135, 2342-2350.
133. Petruzzelli L. M., Gangaly S., Smith C. R., Cobb M. H., Rubin C. S., and Rosen O. M. (1982) Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc. Natl. Acad. Sci. USA 79, 6792-6796.
134. Pillay T. S., Whittaker J., Lammers R., Ullrich A., and Siddle K. (1991) Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells. FEBS Lett. 288, 206-211.
135. Pomerance M., Gavaret J., Jacquemin C., Matricon C., Toru-Delbauffe D., and Pierre M. (1988) Insulin and insulin-like growth factor I receptors during postnatal development in the rat brain. Dev. Brain Res. 62, 169-175.
136. Pons S. and Torres-Aleman I. (1992) Basic fibroblast growth factor modulates insulin-like growth factor-I, its receptor, and its binding proteins in hypothalamic cell cultures. Endocrinology 131, 2271-2278.
137. Pons S., Asano T., Glasheen E. M., Miralpeix M., Weiland A., Zhang Y., Myers M. G. J., Sun X., and White M. F. (1995) The structure and function of p55pik reveals a new regulatory subunit for the phosphatidyinositol-3 kinase. Mol. Cell. Biol. 15, 4453-4465.
138. Posner B. I., Kelly P. A., Shiu R. P. C., and Friesen H. G. (1974) Studies of insulin, growth hormone and prolactin binding: tissue distribution, species variations and characterization. Endocrinology 95, 521-531.
139. Puro D. G. and Agardh E. (1984) Insulin-mediated regulation of neuronal maturation. Science 225, 1170-1172.
140. Raizada M. K. (1991) Insulin-like growth factor I: a possible modulator of intercellular communication in the brain, in Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors (Raizada M. K. and LeRoith D, eds.), Plenum, New York, pp. 493-505.
141. Reinhardt R. R., Chin E., Zhang B., Roth R. A., and Bondy C. A. (1994) Selective coexpression of insulin receptor-related receptor (IRR) and TRK in NGF-sensitive neurons. J. Neurosci. 14, 4674-4683.
142. Rothenberg P. L., Lane W. S., Karasik A., Backer J., White M., and Kahn C. R. (1991) Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. J. Biol. Chem. 266, 8302-8311.
143. Rothwein P., Burgess S. K., Milbrandt J. D., and Krause J. E. (1988) Differential expression of insulin-like growth factor genes in rat central nervous system. Proc. Natl. Acad. Sci. USA 85, 265-269.
144. Russo V. C. and Werther G. A. (1994) Des (1-3) IGF-I potently enhances differentiated cell growth in olfactory bulb organ culture. Growth Factors 11, 301-311.
145. Saltiel A. R. and Ohmichi M. (1993) Pleiotropic signaling from receptor tyrosine kinases. Curr. Opin. Neurobiol. 3, 352-359.
146. Sara V. R. and Carlsson-Swirut C. (1990) Insulin-like growth factors in the central nervous system: biosynthesis and biological role, in Growth Factors: From Genes to Clinical Application (Sara V. R., Hall K., and Löw H., eds.), Raven, New York, pp. 179-199.
147. Sara V. R. and Hall K. (1990) Insulin-like growth factors and their binding proteins. Physiol. Rev. 70, 591-605.
148. Sara V. R., Hall K., Holtz H. V., Humbel R. E., Sjogren B., and Wetterberg L. (1982) Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain. Neurosci. Lett. 34, 39-44.
149. Sara V. R., Carlsson-Swirut C., Andersson C., Hall E., Sjogren B., Holmgren A., and Jornvall H. (1986) Characterization of somatomedins from human brain: identification of a variant form of IGF-I. Proc. Natl. Acad. Sci. USA 83, 4904-4907.
150. Sara V. R., Carlsson-Swirut C., Bergman T., Jornvall H., Roberts P. J., Crawford M., Hakansson N., Civalero I., and Nordberg A. (1989) Identification of gly-pro-glu (GPE) the aminoterminal tripeptide of IGF-I which is truncated in brain, as a novel neuroactive peptide. Biochem. Biophys. Res. Commun. 165, 766-771.
151. Sara V. R., Sandberg-Nordqvist A., Carlsson-Swirut C., Bergman T., and Ayer-LeLievre C. (1991) Neuroactive products of IGF-I and IGF-2 gene expression in the CNS, in Molecular Biology and Physiology of Insulin and Insulin-like Growth Factors (Raizada M. K. and LeRoith D., eds.), Plenum, New York, pp. 439-448.
152. Savitsky K., Bar-Shira A., Gilad S., Rotman G., Vanagaite L., Tagle D. A., Smith S., Uziel T., Sfez S., Ashkenazi M., Pecker I., Frydman M., Harnik R., Patanjali S. R., Simmons A., Clines G. A., Sartiel A., Gatti R. A., Chessa L., Sanal O., Lavin M. F., Jaspers N. G. J., Taylor A. M. R., Arlett C. F., Miki T., Weissman S. M., Lovett M., Collins F. S., and Shiloh Y. (1995) A single ataxia telangectasia gene with a product similar to PI 3-kinase. Science 268, 1749-1753.
153. Scavo L., Shuldiner A. R., Serrano J., Dashner R., Roth J., and De Pablo F. (1991) Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos. Proc. Natl. Acad. Sci. USA 88, 6214-6218.
154. Schumacher R., Mosthaf L., Schlessinger J., Brandenburg D., and Ullrich A. (1991) Insulin and insulin-like growth factor-1 binding specificity is determined by distinct regions of their cognate receptors. J. Biol. Chem. 266, 19,288-19,295.
155. Shemer J., Adamo M., Wilson G. L., Heffez D., Zick Y., and LeRoith D. (1987a) Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells. J. Biol. Chem. 262, 15,476-15,482.
156. Shemer J., Raizada M. K., Masters B. A., Ota A., and Lerdith D. (1987b) Insulin-like growth factor-I receptors in neuronal and glial cells. J. Biol. Chem. 262, 7693-7699.
157. Shemer J., Adamo M., Raizada M. K., Heffez D., Zick Y., and Le Roith D. (1989) Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture. J. Mol. Neurosci. 1, 3-8.
158. Skolnik E. Y., Margolis B., Mohammadi M., Lowenstein E., Fischer R., Drepps A., Ullrich A., and Schlessinger J. (1991) Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65, 83-90.
159. Smith C. B. (1991) The measurement of regional rates of cerebral protein synthesis. Neurochem. Res. 16, 1037-1045.
160. Sokoloff L. (1981) Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxyglucose. J. Cerebral Blood Flow Metab. 1, 7-36.
161. Soos M. A., Field C. E., and Siddle K. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290, 419-426.
162. Stylianopoulou F., Efstratiadis A., Herbert J., and Pintar J. (1988a) Pattern of the insulin-like growth factor II gene expression during rat embryogenesis. Development 103, 497-506.
163. Stylianopoulou F., Herbert J., Soares M. B., and Efstratiadis A. (1988b) Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system. Proc. Natl. Acad. Sci. 85, 141-144.
164. Sullivan K. A. and Feldman E. L. (1994) Immunohistochemical localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 during development in the rat brain. Endocrinology 135, 540-547.
165. Sun X., Rothenberg P., Kahn C. R., Backer J. M., Araki E., Wilden P. A., Cahill D. A., Goldstein B. J., and White M. F. (1991) The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77.
166. Sun X., Miralpeix M., Myers M. G. J., Glasheen E. M., Backer J. M., Kahn C. R., and White M. F. (1992) The expression and function of IRS-1 in insulin signal transmission. J. Biol. Chem. 267, 22,662-22,672.
167. Sun X., Crimmins D. L., Myers M. G. J., Miralpeix M., and White M. F. (1993) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13, 7418-7428.
168. Sun X. J., Wang L., Zhang Y., Yenush L., Myers M. G., Jr., Giasheen E., Lane W. S., Pierce J. H., and White M. F. (1995) Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.
169. Takei K., McPherson P. S., Schmid S. L., and De Camilli P. (1995) Tubular membrane invaginations coated by dynsmin ring are induced by GTP-ase in nerve terminals. Nature 374, 186-190.
170. Tamemoto H., Kadowaki T., Tobe K., Yagi T., Sakura H., Hayakawa T., Terauchi Y., Ueki K., Kaburagi Y., Satoh S., Sekihara H., Yoshioka S., Horikoshi H., Furuta Y., Ikawa Y., Kasuga M., Yazaki Y., and Aizawa S. (1994) Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372, 182-186.
171. Terlau H. and Seifert W. (1989) Influence of epidermal growth factor on long-term potentiation in hippocampal slice. Brain Res. 484, 352-356.
172. Terlau H. and Seifert W. (1990) Fibroblast growth factor enhances long-term potentiation in the hippocampal slice. Eur. J. Neurosci. 2, 973-977.
173. Tomqvist H. E. and Avruch J. (1988) Relationship of site-specific tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity. J. Biol. Chem. 263, 4593-4601.
174. Tornqvist H. E., Gunsalus J. R., Nemenoff R. A., Frackelton A. R., Pierce M. W., and Avruch J. (1988) Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells. J. Biol. Chem. 263, 350-359.
175. Treadway J. L., Morrison B. D., Soos M. A., Siddle K., Olefsky J., Ullrich A., McClain D. A., and Pessin J. E. (1991) Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors. Proc. Natl. Acad. Sci. USA 88, 214-218.
176. Ullrich A., Bell J. R., Chen E. Y., Herrera R., Petruzzelli L. M., Dull T. J., Gray A., Coussens L., Liao Y., Tsubokawa M., Mason A., Seeburg P. H., Grunfeld C., Rosen O. M., and Ramachandran J. (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313, 756-761.
177. Ullrich A., Gray A., Tam A. W., Yang-Feng T. L., Tsubokawa M., Collins C., Henzel W., Le Bon T., Kathuria S., Chen E., Jacobs S., Franke U., Ramachandran J., and Fujita-Yamaguchi Y. (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5, 2503-2512.
178. Umemori H., Sato S., Yagi T., Aizawa S., and Yamamoto T. (1994) Initial events of myelination involve Fyn tyrosine kinase signalling. Nature 367, 572-576.
179. Unger J., McNeill T. H., Moxley R. T. III, White M., Moss A., and Livingston J. N. (1989) Distribution of insulin receptor-like immunoreactivity in the rat forebrain. Neuroscience 31, 143-157.
180. Unger J. W., Livingston J. N., and Moss A. M. (1991a) Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog. Neurobiol. 36, 343-362.
181. Unger J. W., Moss A. M., and Livingston J. N. (1991b) Immunohistochemical localization of insulin receptors and phosphotyrosine in the brainstem of the adult rat. Neuroscience 42, 853-861.
182. Valentino K. L., Pham H., Ocrant I., and Rosenfeld R. G. (1988) Distribution of insulin-like growth factor II receptor immunoreactivity in rat tissues. Endocrinology 122, 2753-2763.
183. Valentino K. L., Ocrant I., and Rosenfeld R. G. (1990) Developmental expression of insulin-like growth factor II receptor immunoreactivity in the rat central nervous system. Endocrinology 126, 914-920.
184. Varticovski L., Harrison-Findik, D., Keeler M. L., and Susa M. (1994) Role of PI 3-kinase in mitogenesis. Biochem. Biophys. Acta 1226, 1-11.
185. Wang L. M., Keegan A. D., Paul W. E., Heidaran M. A., Gutkind J. S., and Pierce J. H. (1992) IL-4 activates a distinct signal transduction cascade from IL-3 in factor dependent myeloid cells. EMBO J. 11, 4899-4908.
186. Wang L. M., Keegan A. D., Li W., Lienhard G. E., Pacini S., Gutkind J. S., Myers M. G. J., Sun X., White M. F., Aaronson S. A., Paul W. E., and Pierce J. H. (1993a) Common elements in IL4 and insulin signaling pathways in factor dependent hematopoietic cells. Proc. Natl. Acad. Sci. USA 90, 4032-4036.
187. Wang L. M., Myers M. G. J., Sun X., Aaronson S. A., White M. F., and Pierce J. H. (1993b) IRS-1: essential for insulin and IL-4-stimulated mitogenesis in hematopoietic cells. Science 261, 1591-1594.
188. Welham M. J., Learmont L., Bone H., and Schrader J. W. (1995) Interleukine-13 signal transduction in linphohemopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin. J. Biol. Chem. 270, 12,286-12,296.
189. Werner H., Raizada M. K., Mudd L. M., Foyt H. F., Simpson I. A., Roberts C. T., Jr., and Le Roith D. (1989a) Regulation of rat brain/hepG2 glucose transporter gene expression by insulin and IGF-I in primary cultures of neuronal and glial cells. Endocrinology 125, 314-320.
190. Werner H., Woloschak M., Adamo M., Shen-Orr Z., Roberts C. T., Jr., and LeRoith D. (1989b) Developmental regulation of the rat insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. USA 86, 7451-7455.
191. Werner H., Roberts C. T., Jr., Raizada M. K., Bondy C. A., Adamo M., and Le Roith D. (1993) Developmental regulation of the insulin-like growth factor receptors in the central nervous system, in Growth Factors and Hormones (Zagon I. S. and McLaughlin P. J., eds.), Chapman & Hall, New York, 109-127.
192. Werther G. A., Hogg A., Oldfield B. J., McKinley M. J., Figdor R., and Mendelsohn F. A. O. (1989) Localization and characterization of IGF-I receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry: a distinct distribution from insulin receptors. J. Neuroendocrinol. 1, 369-377.
193. White M. F. and Kahn C. R. (1994) The insulin signaling system. J. Biol. Chem. 269, 1-5.
194. r 185,000 protein in intact cells. Nature 318, 183-186.
195. White M. F., Shoelson S. E., Keutmann H., and Kahn C. R. (1988a) A cascade of tyrosine autophosphorylation in the β-subunit activates the insulin receptor. J. Biol. Chem. 263, 2969-2980.
196. White M. F., Livingston J. N., Backer J. M., Lauris V., Dull T. J., Ullrich A., and Kahn C. R. (1988b) Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity. Cell 54, 641-649.
197. Wilden P. A., Kahn C. R., Siddle K., and White M. F. (1992a) Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. J. Biol. Chem. 267, 16,660-16,668.
198. Wilden P. A., Siddle K., Haring E., Backer J. M., White M. F., and Kahn C. R. (1992b) The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. J. Biol. Chem. 267, 13,719-13,727.
199. Wolf G., Trüb T., Ottinger E., Groninga L., Lynch A., White M. F., Miyazaki M., Lee J., and Shoelson S. E. (1995) PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J. Biol. Chem. 370, 27,407-27,410.
200. Wozniak M., Rydzewski B., Baker S. P., and Raizada M. K. (1993) The cellular and physiological actions of insulin in the central nervous system. Neurochem. Int. 22, 1-10.
201. Yagi T., Aizawa S., Tokunaga T., Shigetani Y., Takeda N., and Ikawa Y. (1995) A role for fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature 366, 742-745.
202. Yamaguchi F., Itano T., Mizobuchi M., Miyamoto O., Janjua N. A., Matsui H., Tokuda M., Ohmoto T., Hosokawa K., and Hatase O. (1990) Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain. Brain Res. 533, 344-347.
203. Yao R. and Cooper G. M. (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.
204. Yao D., Liu X., Hudson L. D., and De F. Webster H. (1995) Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis. Proc. Natl. Acad. Sci. USA 92, 6190-6194.
205. Ye P., Carson J., and D'Ercole A. J. (1995) In vivo actions of insulin-like growth-factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic mice. J. Neurosci. 15, 7344-7356.
206. Young W., Kuhar M., Roth J., and Brownstein M. (1980) Radiohistochemical localization of insulin receptors in the adult and developing rat brain. Neuropeptides 1, 15-22.
207. Zachenfels K., Oppenheim R. W., and Roher H. (1995) Evidence for an important role of IGF-I and IGF-II for the early development of chick sympathetic neurons. Neuron 14, 731-741.