Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease

Neuroscience Letters

Volumn 329, Issue 1, 2002, Pages 121-123

  Boussaha, Mekki ^a   Hannequin, Didier ^a   Verpillat, Patrice ^a   Brice, Alexis ^b   Frebourg, Thierry ^a   Campion, Dominique ^a  

^a INSERM   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Alzheimer's disease; Insulin degrading enzyme; Single nucleotide polymorphism

Indexed keywords

INSULINASE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FRANCE; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; MIDDLE AGED;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMAN; INSULYSIN; MALE; MIDDLE AGE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SUPPORT, NON-U.S. GOV'T; HUMANS; MIDDLE AGED;

EID: 0037162647     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(02)00586-4     Document Type: Article

References (21)

1. Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
2. Insulin degrading enzyme
3. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
4. Purified recombinant insulin-degrading enzyme degrades amyloid β-protein but does not promote its oligomerization
5. The extent of linkage disequilibrium in four populations with distinct demographic histories
6. 42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
7. An evolutionary conserved enzyme degrades transforming growth factor-alpha as well as insulin
8. SNPing away at complex disease: Analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
9. Clinical diagnosis of Alzheimer's disease; Report of the NINCDS-ADRDA working group under the auspices of the Department of Health and Human Services task force on Alzheimer's disease
10. Atrial natriuretic peptide (ANP) is a high-affinity substrate for rat insulin-degrading enzyme
11. Rat insulin-degrading enzyme: Cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry
12. Susceptibility locus for Alzheimer's disease on chromosome 10
13. Regulation of APP cleavage by alpha-, beta- and gamma-secretases
14. Identification of novel genes in late-onset Alzheimer's disease
15. Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
16. Degradation of insulin-like growth factors I and II by a human insulin degrading enzyme
17. Identification of γ-endorphin-generating enzyme as insulin-degrading enzyme
18. Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer disease
19. Amyloid B protein in plasma from patients with sporadic Alzheimer's disease
20. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
21. Testing linkage disequilibrium between a disease gene and marker loci