Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus, and cerebellum of normal human and Alzheimer disease brains

Synapse

Volumn 38, Issue 4, 2000, Pages 450-459

  Jafferali, S ^a   Dumont, Y ^a   Sotty, F ^a   Robitaille, Y ^b   Quirion, R ^a   Kar, S ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Amyloid peptide; Autoradiography; Growth factors; Immunocytochemistry; Receptor binding assays

Indexed keywords

AMYLOID BETA PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; BINDING KINETICS; CELL LOSS; CELL SUBPOPULATION; CEREBELLUM; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IC 50; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PURKINJE CELL; RECEPTOR BINDING;

AGED; ALZHEIMER DISEASE; BINDING SITES; CEREBELLUM; FRONTAL LOBE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; RECEPTOR, IGF TYPE 1; REFERENCE VALUES; TISSUE DISTRIBUTION;

EID: 0034672811     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2396(20001215)38:4<450::AID-SYN10>3.0.CO;2-J     Document Type: Article

References (50)

1. Insulin-like growth factor-I (IGF-I) receptors in the human brain: Quantitative autoradiographic localization
2. Insulin-like growth factor I-immunoreactive peptide in adult human cerebellar Purkinje cells: Co-localization with lowaffinity nerve growth factor receptor
3. Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus
4. Insulin-like growth factor-I receptor signal transduction: At the interface between physiology and cell biology
5. IGF-I and IGF-II protect cultured hippocampal and septal neurones against calcium-mediated hypoglycemic damage
6. The role of neuronal growth factors in neurodegenerative disorders of the human brain
7. Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus
8. β-Amyloid and its contributions to neurodegeneration in Alzheimer's disease
9. Insulin-like growth factor I receptor binding in brains of Alzheimer's and alcoholic patients
10. Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, Alzheimer's disease, and in Huntington's disease
11. The developing CNS: A scenario for the action of proinsulin, insulin and insulin-like growth factors
12. The pathogenesis of senile plaques
13. Rediscovering an old friend. IGF-I: Potential use in the treatment of neurodegenerative diseases
14. IGF-I protects and rescues hippocampal neurones against β-amyloid- and human amylin-induced toxicity
15. Molecular profile of reactive astrocytes - Implications for their role in neurologic disease
16. Astroglia in Alzheimer's disease
17. Expression of insulin-like growth factor I by astrocytes in response to injury
18. Localization of insulin-like growth factor I (IGF-I)-like immunoreactivity in the developing and adult rat brain
19. A beta42 is the predominant form of amyloid beta-protein in the brains of short-term survivors of head injury
20. The role of insulin-like growth factor system in neuronal rescue
21. The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats
22. Amyloid, the presenilins and Alzheimer's disease
23. Neurotrophic factor therapy for nervous system degenerative diseases
24. Insulin and insulin-like growth factor-I regulate tau phosphorylation in cultured human neurons
25. Role of insulin-like growth factors in peripheral nerve regeneration
26. Insulin-like growth factors and their binding proteins: Biological actions
27. Origin and projection of peptideimmunoreactive nerves in the male rat genitofemoral nerve
28. 125I]insulin receptor binding sites in the rat hippocampal formation
29. 125I]insulin receptor binding sites in developing and adult rat brain
30. Insulin-like growth factor-I and -II differentially regulate endogenous acetylcholine release from the hippocampal formation
31. Aging-related changes in IGF-II and c-fos gene expression in the rat brain
32. Molecular and cellular aspects of the insulin-like growth factor I receptor
33. Neurotrophic factors: From molecule to man
34. Displacement of insulin-like growth factors from their binding proteins as a potential treatment or stroke
35. Insulin-like growth factors: Putative muscle-derived trophic agents that promote motoneuron survival
36. Presence of a somatomedin-C-immunoreactive substance in the central nervous system: Immunohistochemical mapping studies
37. Genes for insulin-like growth factors I and II are expressed in senescent rat tissues
38. β-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease
39. Alzheimer's disease: Genetic studies and transgenic models
40. Cholinergic markers in Alzheimer's disease and the autoregulation of acetylcholine release
41. Translating cell biology into therapeutic advances in Alzheimer's disease
42. Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture
43. Nerve growth factor, ageing and Alzheimer's disease
44. Increased expression of type I insulin-like growth factor receptor messenger RNA in rat hippocampal formation is associated with aging and behavioral impairment
45. Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer's type
46. Neurotrophic factors and neuronal loss: Potential relevance to Alzheimer's disease
47. Localization and characterization of IGF-I receptors in rat brain and pituitary gland using in vitro autoradiography and computerised densitometry: A distinct distribution from insulin receptors
48. Biology of Aβ amyloid in Alzheimer's disease
49. Deafferentation-induced increases in hippocampal insulin-like growth factor-1 messenger RNA expression are severely attenuated in middle aged and aged rats
50. Therapeutic potential of neurotrophic factors for neurological disorders