Insulin receptor substrate (IRS) transduction system: Distinct and overlapping signaling potential

Diabetes/Metabolism Research and Reviews

Volumn 16, Issue 6, 2000, Pages 434-441

  Giovannone, Barbara ^a   Scaldaferri, Maria Lucia ^a   Federici, Massimo ^a   Porzio, Ottavia ^a   Lauro, Davide ^b   Fusco, Angelo ^a   Sbraccia, Paolo ^a   Borboni, Patrizia ^a   Lauro, Renato ^a   Sesti, Giorgio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Insulin receptor substrate; Insulin signaling; IRS 1; IRS 2; IRS 3; IRS 4

Indexed keywords

DOCKING PROTEIN; GROWTH FACTOR RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INSULIN RECEPTOR SUBSTRATE 3; INSULIN RECEPTOR SUBSTRATE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL GROWTH; CELL METABOLISM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; PHOSPHOPROTEINS; RATS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 0034513781     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-7560(2000)9999:9999<::AID-DMRR159>3.0.CO;2-8     Document Type: Review

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4. Role of IRS-2 in insulin and cytokine signalling
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6. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family
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11. Alternative pathways of insulin signalling in mice with targeted disruption of the IRS-1 gene
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13. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin-receptor substrate-1
14. Insulin receptor substrate 1-induced inhibition of endoplasmic reticulum Ca2 + uptake in beta-cells. Autocrine regulation of intracellular Ca2+ homeostasis and insulin secretion
15. 972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic β-cells
16. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured β-cell lines
17. Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signalling molecules
18. Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases
19. Insulin receptor substrate-1 overexpression in human hepatocellular carcinoma cells prevents transforming growth factor beta 1-induced apoptosis
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21. Co-operation of simian virus 40 T antigen and insulin receptor substrate-1 in protection from apoptosis induced by interleukin-3 withdrawal
22. IGF-I receptor protection from apoptosis in cells lacking the IRS proteins
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24. Insulin receptor substrate-1, p70S6K and cell size in transformation and differentiation of hemopoietic cells
25. IGF-I receptor signaling in a prostatic cancer cell line with a PTEN mutation
26. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
27. Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acid 591-786
28. The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action
29. Disruption of IRS-2 causes Type 2 diabetes in mice
30. Insulin receptor substrate-2 is not necessary for insulin- and exercise-stimulated glucose transport in skeletal muscle
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32. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells
33. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
34. The 60-KDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase
35. Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene
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37. Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes
38. Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells
39. Insulin receptor substrate-3 is not essential for growth or glucose homeostasis
40. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells
41. Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells
42. Insulin receptor substrate 4 enhances insulin-like growth factor-I-induced cell proliferation
43. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis
44. Mice lacking insulin receptor substrate 4 exhibit mild defects in growth reproduction, and glucose homeostasis
45. A specific increased expression of insulin receptor substrate 2 in pancreatic β-cell lines is involved in mediating serum-stimulated-cell growth
46. Development of hormone receptors and hormone responsiveness in vitro
47. P19 embryonal carcinoma cells
48. Retention of differentiation potentialities during prolonged cultivation of myogenic cells
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51. Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2