Alzheimer disease and vascular dementia: Relationships with fasting glucose and insulin levels

Dementia and Geriatric Cognitive Disorders

Volumn 11, Issue 3, 2000, Pages 176-180

  Carantoni, M ^a   Zuliani, G ^a   Munari, M R ^b   D'Elia, K ^a   Palmieri, E ^a   Fellin, Renato ^a,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b CA FONCELLO HOSPITAL   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Dementia; Glucose; Insulin; Insulin resistance

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SERUM ALBUMIN; URIC ACID;

AGED; ALBUMIN BLOOD LEVEL; ALZHEIMER DISEASE; ARTICLE; BODY MASS; CEREBROVASCULAR DISEASE; CHOLESTEROL BILE LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; COVARIANCE; DIABETES MELLITUS; DIET RESTRICTION; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; MULTIINFARCT DEMENTIA; NUTRITIONAL STATUS; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; SENILE DEMENTIA; URIC ACID BLOOD LEVEL;

EID: 0033999608     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017232     Document Type: Article

References (42)

1. Jorm AF, Jolley D: The incidence of dementia: A meta-analysis. Neurology 1998;51:728-733.
2. Van Duijn CM: Epidemiology of the dementias: Recent developments and new approaches. J Neurol Neurosurg Psychiatry 1996; 60:478-488.
3. Skoog I: Status of risk factors for vascular dementia. Neuroepidemiology 1998;17:2-9.
4. Stewart R: Cardiovascular factors in Alzheimer's disease. J Neurol Neurosurg Psychiatry 1998;65:143-147.
5. Fisman M, Gordon B, Feleki V, Helmes E, McDonald T: Metabolic changes in Alzheimer's disease. J Am Geriatr Soc 1988;36:298-300.
6. Hoyer S: Oxidative metabolism deficiences in brains of patients with Alzheimer disease. Acta Neurol Scand 1996;165:18-24.
7. Holmes C, Hayford J, Gonzales J, Weydert J: A survey of cognitive functioning at different glucose levels in diabetic persons. Diabetes Care 1983;6:180-185.
8. Gradman TJ, Laws A, Thompson LW, Reaven GM: Verbal learning and/or memory improves with glycemic control in older subjects with non-insulin-dependent diabetes mellitus. J Am Geriatr Soc 1993;41:1305-1312.
9. Leibson CL, Rocca WA, Hanson VA, Cha R, Kokmen E, O'Brien PC, Palumbo PJ: Risk of dementia among persons with diabetes mellitus: A population-based cohort study. Am J Epidemiol 1997;145:301-308.
10. Ott A, Breteler MM, Grobbee DE, van Harskamp F, Hoffman A, Stolk RP: Association of diabetes mellitus and dementia: The Rotterdam Study. Diabetologia 1996;39:1392-1397.
11. Kilander L, Boberg M, Lithell H: Peripheral glucose metabolism and insulin sensitivity in Alzheimer's disease. Acta Neurol Scand 1993; 87:294-298.
12. Razay G, Wilcock GK: Hyperinsulinemia and Alzheimer's disease. Age Ageing 1994;23:396-399.
13. Burchfiel CM, Sharp DS, Curb JD, Rodriguez BL, Abbott RD, Arakaki R, Yano K: Hyperinsulinemia and cardiovascular disease in elderly men - The Honolulu Heart Program. Arterioscler Thromb Vase Biol 1998;18:450-457.
14. Shinozaki K, Naritomi H, Shimizu T, Suzuki M, Ikebuchi M, Sawada T, Harano Y: Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. Stroke 1996;27:37-43.
15. Zunker P, Schick A, Buschmann HC, Georgiadis D, Nabavi DG, Eldemann M, Ringelstein EB: Hyperinsulinism and cerebral microangiopathy. Stroke 1996;27:219-223.
16. 4 phenotype: Cross-sectional population-based study. BMJ 1997;315:1045-1409.
17. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A: Vascular dementia: Diagnostic criteria for research studies. Neurology 1993;43:250-260.
18. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadian EM: Clinical diagnosis of Alzheime's disease: Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984;34:939-944.
19. Folstein M, Folstein S, McHugh PR: Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
20. Zappala G, Measso G, Cavarzeran F, Grigoletto F, Lebowitz B, Pirozzolo F, Amaducci L, Massari D: II Mini-Mental State examination: studio normativo di un campione random della popolazione italiana (in Italian). Dev Neuropsychol 1993;8:1-5.
21. Hachinski VC, Iliff LD, Zilhka E, Bonlay GH, McAllister VL, Marshall J, Russell RW, Symon L: Cerebral blood flow in dementia. Arch Neurol 1975;32:632-637.
22. Katz S, Downs TD, Cash HR, Grotz RC: Progress in the development of the index of ADL. Gerontologist 1970;1:20-30.
23. Lawton MP, Brody EM: Assessment of older people: Self-maintaining and instrumental activities of daily living. Gerontologist 1969;9: 179-186.
24. Kadish AH, Litle RH, Sternberg JC: A new and rapid method for determination of glucose by measurement of rate of oxigen consumption. Clin Chem 1968;14:116-131.
25. Allain CC, Poom LS, Chang CSG, Richmond W, Fu PC: Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475.
26. Walhefeld AW: Triglycerides determination after enzymatic hydrolysis: in Bergmer UU (ed): Methods of Enzymatic Analysis. Weinheim, Verlag Chemie, 1974, vol 2, pp 1831-1835.
27. Gidez LE, Miller GJ, Burstein M, Seagle S, Eder HA: Separation and quantification of subclasses of human plasma high-density lipoprotein by a simple precipitation procedure. J Lipid Res 1982;23:1206-1223.
28. Friedwald WT, Levy RI, Fredrikson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
29. Reaven GM: Role of insulin resistance in human disease. Diabetes 1988;37:1495-1507.
30. Blunt BA, Barrett-Connor E, Wingard DL: Evaluation of fasting plasma glucose as screening test for NIDDM in older adults - Rancho Bernardo Study. Diabetes Care 1991;14:989-993.
31. Kaiser FE, Morley JE: Idiopathic CD4+ T lymphopenia in older persons. J Am Geriatr Soc 1994;42:1291-1294.
32. Mitchell CO, Lipschitz DA: The effect of age and sex on the routinely used measurements to assess the nutritional status of hospitalized patients. Am J Clin Nutr 1982;36:340-344.
33. Corti MC, Guralnik JM, Salive ME, Sorkin JD: Serum albumin level and physical disability as predictors of mortality in older persons. JAMA 1994;272:1036-1042.
34. Reaven GM: Syndrome X: 6 years later. J Intern Med 1994;23:13-22.
35. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S: Hyperinsulinemia as an independent risk factor for ischemic disease. N Engl J Med 1996;334:952-957.
36. Strandberg TE, Tilvis RS, Lindberg O, Valvanne J, Sairanen S, Ehnholm C, Tuomilchto J: High plasma insulin associates with lower LDL-cholesterol in elderly individuals. Atherosclerosis 1996;121:267-273.
37. Calori G, Garancini P, Ruotolo G, Ragogna F, Ruggeri P, Gallus G: Relationship between insulinemia and LDL cholesterol in non-diabetic subjects: The Cremona population study. Diabetologia 1995;38:A248.
38. Mielke R, Herholz K, Grand M, Kessler J, Heiss WD: Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type. Neurobiol Aging 1992;13:93-98.
39. Unger JW, Livingston JN, Moss AM: Insulin receptors in the central nervous system: Localization, signalling mechanisms and functional aspects. Prog Neurobiol 1991;36:343-362.
40. Herzog AG, Kemper TL: Amygdaloid changes in ageing and dementia. Arch Neurol 1980;37: 625-629.
41. Baskin DG, Schwartz MW, Sipols AJ, D'Alessio DA, Goldstein BJ, White MF: Insulin receptors substrate-1 (IRS-1) expression in rat brain. Endocrinology 1994;134:1952-1955.
42. Duelli R, Schröck H, Kuschinsky W, Hoyer S: Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats. Int J Dev Neurosci 1993;11:477-483.