Steroid control of longevity in Drosophila melanogaster

Science

Volumn 299, Issue 5611, 2003, Pages 1407-1410

  Simon, Anne F ^a   Shih, Cindy ^a   Mack, Antha ^a   Benzer, Seymour ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; HORMONES; LIFE CYCLE; MUTAGENESIS;

STEROIDS;

GENETIC ENGINEERING;

ECDYSONE; ECDYSONE RECEPTOR; RECEPTOR PROTEIN; STEROID HORMONE; UNCLASSIFIED DRUG;

LONGEVITY; STEROID;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FEMALE; FERTILITY; GENE MUTATION; HETEROZYGOSITY; HORMONAL REGULATION; HORMONE DETERMINATION; LIFESPAN; LONGEVITY; MALE; NONHUMAN; OBSERVATION; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REPRODUCTION; STEROID ANALYSIS; STRESS;

ANIMALS; BODY WEIGHT; CROSSES, GENETIC; DROSOPHILA MELANOGASTER; ECDYSONE; ECDYSTERONE; FEMALE; FERTILITY; GENES, INSECT; LIGANDS; LONGEVITY; MALE; MUTATION; OXIDATIVE STRESS; PHOTOTROPISM; RECEPTORS, STEROID; STARVATION; TEMPERATURE;

ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 0037470439     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080539     Document Type: Article

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24. We thank P. Kazemi-Esfarjani, D. Tracey, D. Walker, P. Kapahi, H.-D. Wang, D. Liang, T. Brummel, M. Dus, M. Tatar, and R. Owen for helpful discussions and comments on the manuscript; G. Lorden and S. Metchev for advice on statistical analysis; and A. Dinh and A. Gomez for technical help. EcR mutants and the parental cn bw line were provided by M. Bender, DTS-3 mutants by P. Maróy, the Samarkand line by the Bloomington Stock center, and 20-OH-ecdysone by R. Laffont. Supported by a California Institute of Technology Surf scholarship to C.S., a postdoctoral fellowship from the John Douglas French Alzheimer's Foundation Research and a postdoctoral research grant from the American Federation for Aging Research (2002 Glenn/AFAR) to A.F.S., and grants to S.B. from NIH (grant AG16630), NSF (grant MCB-9907939), and the Ellison Foundation.