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Volumn 22, Issue 6 A, 2002, Pages 3197-3204

Reduced expression of p53 and p21waf1/cip1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil

Author keywords

5 fluorouracil; Apoptosis; Breast cancer; Mitotic arrest; P21WAF1 CIP1; P53; Paclitaxel

Indexed keywords

COMPLEMENTARY DNA; FLUOROURACIL; PACLITAXEL; PROTEIN P21; PROTEIN P53;

EID: 0036870714     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (22)

References (43)
  • 1
    • 0015211527 scopus 로고
    • Plant antitumor agents: VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
    • Wani MC, Taylor HL, Wall ME et al: Plant antitumor agents: VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93: 23-25, 1971.
    • (1971) J Am Chem Soc , vol.93 , pp. 23-25
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3
  • 4
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J and Horwitz SB: Promotion of microtubule assembly in vitro by taxol. Nature 22: 665-667, 1979.
    • (1979) Nature , vol.22 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 5
    • 0019805521 scopus 로고
    • Taxol induced polymerization of purified tubulin. Mechanism of action
    • Kumar N: Taxol induced polymerization of purified tubulin. Mechanism of action. J Biol Chem 256: 10435-10441, 1981.
    • (1981) J Biol Chem , vol.256 , pp. 10435-10441
    • Kumar, N.1
  • 6
    • 0023809123 scopus 로고
    • Microtubule changes and cyotoxicity in leukemia cell lines treated with taxol
    • Rowinsky EK, Donehower RC, Jones RJ and Tucker RW: Microtubule changes and cyotoxicity in leukemia cell lines treated with taxol. Cancer Res 48: 4093-4100, 1988.
    • (1988) Cancer Res , vol.48 , pp. 4093-4100
    • Rowinsky, E.K.1    Donehower, R.C.2    Jones, R.J.3    Tucker, R.W.4
  • 7
    • 0026516994 scopus 로고
    • Mechanism of action of Taxol
    • Horwitz SB: Mechanism of action of Taxol. Trends Pharmacol Sci 13: 134-136, 1992.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 134-136
    • Horwitz, S.B.1
  • 8
    • 0029328641 scopus 로고
    • Taxol-induced mitotic block triggers rapid onset of a p53-independent pathway
    • Woods CM, Zhu J, McQueney PA, Bollag D and Lazarides E: Taxol-induced mitotic block triggers rapid onset of a p53-independent pathway. Mol Med 1: 506-526, 1995.
    • (1995) Mol Med , vol.1 , pp. 506-526
    • Woods, C.M.1    Zhu, J.2    McQueney, P.A.3    Bollag, D.4    Lazarides, E.5
  • 9
    • 0025224544 scopus 로고
    • Cytotoxic effects of cell cycle specific agents: A result of cell cycle perturbation
    • Kung AL, Zetterberg A, Sherwood AW and Schimke RT: Cytotoxic effects of cell cycle specific agents: a result of cell cycle perturbation. Cancer Res 50: 7307-7314, 1990.
    • (1990) Cancer Res , vol.50 , pp. 7307-7314
    • Kung, A.L.1    Zetterberg, A.2    Sherwood, A.W.3    Schimke, R.T.4
  • 12
    • 0027196777 scopus 로고
    • Paclitaxel induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells
    • Bhalla K, Ibrado AM, Tourkina E, Tang C, Mahoney ME and Huang Y: Paclitaxel induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells, Leukemia 7: 563-568, 1993
    • (1993) Leukemia , vol.7 , pp. 563-568
    • Bhalla, K.1    Ibrado, A.M.2    Tourkina, E.3    Tang, C.4    Mahoney, M.E.5    Huang, Y.6
  • 13
    • 0000881538 scopus 로고
    • Characterizations of paclitaxel-induced apoptosis and altered gene expression in human breast cancer cells
    • Cheng L, Roghunathan K, Priest DG, Willingham MC, Norris JS and Fan W: Characterizations of paclitaxel-induced apoptosis and altered gene expression in human breast cancer cells. Cell Pharmacol 2: 249-257, 1995
    • (1995) Cell Pharmacol , vol.2 , pp. 249-257
    • Cheng, L.1    Roghunathan, K.2    Priest, D.G.3    Willingham, M.C.4    Norris, J.S.5    Fan, W.6
  • 14
    • 0033151262 scopus 로고    scopus 로고
    • Possible mechanisms of paclitaxel-induced apoptosis
    • Fan W: Possible mechanisms of paclitaxel-induced apoptosis. Biochem Pharmacol 57: 1215-1221, 1999.
    • (1999) Biochem Pharmacol , vol.57 , pp. 1215-1221
    • Fan, W.1
  • 15
    • 0027968951 scopus 로고
    • Evidence for invovlement of tyrosine phosphorylation in paclitaxel-induced apoptosis in a human ovarian tumor cell line
    • Liu Y, Bhalla K, Hill C and Priest DG: Evidence for invovlement of tyrosine phosphorylation in paclitaxel-induced apoptosis in a human ovarian tumor cell line. Biochem Pharmacol 48: 1265-1272, 1995.
    • (1995) Biochem Pharmacol , vol.48 , pp. 1265-1272
    • Liu, Y.1    Bhalla, K.2    Hill, C.3    Priest, D.G.4
  • 16
    • 0029618735 scopus 로고
    • Phase I/II study with paclitaxel in combination with weekely high-dose 5-fluorouracil/folinic acid in the treatment of metastatic breast cancer: An interim analysis
    • Klassen U, Wilke H, Pari CP, Strumberg D, Harstrick A, Eberhardt W, Becher R, Diergarten K and Seeber S: Phase I/II study with paclitaxel in combination with weekely high-dose 5-fluorouracil/folinic acid in the treatment of metastatic breast cancer: an interim analysis. Semin Oncol 22(6 Suppl. 14): 7-11, 1995.
    • (1995) Semin Oncol , vol.22 , Issue.6 SUPPL. 14 , pp. 7-11
    • Klassen, U.1    Wilke, H.2    Pari, C.P.3    Strumberg, D.4    Harstrick, A.5    Eberhardt, W.6    Becher, R.7    Diergarten, K.8    Seeber, S.9
  • 17
    • 0029963971 scopus 로고    scopus 로고
    • Paclitaxel and 5-fluorouracil in metastatic breast cancer: The US experience
    • Paul DM, Garrett AM, Meshad M, DeVore RD, Porter LL and Johnson DH: Paclitaxel and 5-fluorouracil in metastatic breast cancer: the US experience. Sem Oncol 23(1 suppl 1): 48-52, 1996.
    • (1996) Sem Oncol , vol.23 , Issue.1 SUPPL. 1 , pp. 48-52
    • Paul, D.M.1    Garrett, A.M.2    Meshad, M.3    DeVore, R.D.4    Porter, L.L.5    Johnson, D.H.6
  • 18
    • 0029039072 scopus 로고
    • Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancer
    • Vokes EE, Stupp R, Haraf D, Moran W, Malone D, Wenig B, Sweeney P and Weichselbaum RR: Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancer. Semin Oncol 22(3 suppl 6): 47-52, 1995.
    • (1995) Semin Oncol , vol.22 , Issue.3 SUPPL. 6 , pp. 47-52
    • Vokes, E.E.1    Stupp, R.2    Haraf, D.3    Moran, W.4    Malone, D.5    Wenig, B.6    Sweeney, P.7    Weichselbaum, R.R.8
  • 19
    • 0028846106 scopus 로고
    • The activity of paclitaxel in gastrointestinal tumors
    • discussion 51-3
    • Ajani JA, Ilson DH and Kelsen DP: The activity of paclitaxel in gastrointestinal tumors. Semin Oncol 22(5 Suppl 12): 46-50; discussion 51-3, 1995.
    • (1995) Semin Oncol , vol.22 , Issue.5 SUPPL. 12 , pp. 46-50
    • Ajani, J.A.1    Ilson, D.H.2    Kelsen, D.P.3
  • 20
    • 0030797889 scopus 로고    scopus 로고
    • 5-Fluorouracil interferes with paclitaxel cytotoxicity against human solid tumor cells
    • Johnson KR, Wang L, Miller MC III, Willingham MC and Fan W: 5-fluorouracil interferes with paclitaxel cytotoxicity against human solid tumor cells. Clin Cancer Res 3: 1739-1745, 1997.
    • (1997) Clin Cancer Res , vol.3 , pp. 1739-1745
    • Johnson, K.R.1    Wang, L.2    Miller M.C. III3    Willingham, M.C.4    Fan, W.5
  • 21
    • 0032882044 scopus 로고    scopus 로고
    • Antagonistic interplay between antimitotic and G1/S arresting agents observed in experimental combination therapy
    • Johnson KR, Young KK and Fan W: Antagonistic interplay between antimitotic and G1/S arresting agents observed in experimental combination therapy. Clin Cancer Res 5: 2559-2565, 1999.
    • (1999) Clin Cancer Res , vol.5 , pp. 2559-2565
    • Johnson, K.R.1    Young, K.K.2    Fan, W.3
  • 22
    • 0031318124 scopus 로고    scopus 로고
    • Cell cycle checkpoints, chromosome stability and the progression of cancer
    • Nojima H: Cell cycle checkpoints, chromosome stability and the progression of cancer. Human Cell 10(4): 221-30, 1997.
    • (1997) Human Cell , vol.10 , Issue.4 , pp. 221-230
    • Nojima, H.1
  • 27
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblast
    • Di Leonardo A, Linke SP, Clarkin K and Wahl GM: DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblast. Genes & Dev 8: 2540-2551, 1994.
    • (1994) Genes & Dev , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 30
    • 0029807822 scopus 로고    scopus 로고
    • Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells
    • Trielli MO, Andreassen PR, Lacroix FB and Margolis RL: Differential taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells. J Biol Chem 135: 689-700, 1996.
    • (1996) J Biol Chem , vol.135 , pp. 689-700
    • Trielli, M.O.1    Andreassen, P.R.2    Lacroix, F.B.3    Margolis, R.L.4
  • 32
    • 0031953822 scopus 로고    scopus 로고
    • Disruption of p53 function in immortalized human cells does not affect cell survival or apoptosis after taxol or vincristine treatment
    • Fan S, Cherney B, Reinhold W, Rucker K and O'Conner PM: Disruption of p53 function in immortalized human cells does not affect cell survival or apoptosis after taxol or vincristine treatment. Clin Cancer Res 4: 1047-1054, 1998.
    • (1998) Clin Cancer Res , vol.4 , pp. 1047-1054
    • Fan, S.1    Cherney, B.2    Reinhold, W.3    Rucker, K.4    O'Conner, P.M.5
  • 33
    • 0001510940 scopus 로고    scopus 로고
    • Glucocorticoids selectively inhibit taxol-induced apoptosis in a human breast cancer cell line
    • Fan W, Cheng L, Norris JS and Willingham MC: Glucocorticoids selectively inhibit taxol-induced apoptosis in a human breast cancer cell line. Cell Pharmacol 3: 435-440, 1996.
    • (1996) Cell Pharmacol , vol.3 , pp. 435-440
    • Fan, W.1    Cheng, L.2    Norris, J.S.3    Willingham, M.C.4
  • 34
    • 0027496935 scopus 로고
    • The p21 protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ: The p21 protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816, 1993.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 35
    • 0031876631 scopus 로고    scopus 로고
    • In vitro evaluation of combination chemotherapy against human tumor cells
    • Fan W, Johnson KR and Miller MC III: In vitro evaluation of combination chemotherapy against human tumor cells (Review). Oncology Reports 5: 1035-1042, 1998.
    • (1998) Oncology Reports , vol.5 , pp. 1035-1042
    • Fan, W.1    Johnson, K.R.2    Miller M.C. III3
  • 36
    • 0033818351 scopus 로고    scopus 로고
    • In vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells
    • Zeng S, Chen YZ, Johnson KR. and Fan W: In vitro evaluation of sequential-dependent combination between docetaxel and doxorubicin in human tumor cells. Clin Cancer Res 6: 3766-3773, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 3766-3773
    • Zeng, S.1    Chen, Y.Z.2    Johnson, K.R.3    Fan, W.4
  • 37
    • 0034662496 scopus 로고    scopus 로고
    • Nuclear factor-κB/I-κB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells
    • Huang Y, Johnson RK, Norris JS and Fan W: Nuclear factor-κB/I-κB signaling pathway may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer Res 60: 4426-4432, 2000.
    • (2000) Cancer Res , vol.60 , pp. 4426-4432
    • Huang, Y.1    Johnson, R.K.2    Norris, J.S.3    Fan, W.4
  • 38
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C: A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139: 271-279, 1991.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 39
    • 0029738931 scopus 로고    scopus 로고
    • Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro
    • Kano Y, Akutsu M, Tsunoda S, Ando J, Matsui J, Suzuki K, Ikeda T, Inoue Y and Adachi K: Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro. Br J Cancer 74: 704-710, 1996.
    • (1996) Br J Cancer , vol.74 , pp. 704-710
    • Kano, Y.1    Akutsu, M.2    Tsunoda, S.3    Ando, J.4    Matsui, J.5    Suzuki, K.6    Ikeda, T.7    Inoue, Y.8    Adachi, K.9
  • 40
    • 0032974159 scopus 로고    scopus 로고
    • Sequence-dependent antagonism between fluorouracil and paclitaxel in human breast cancer cells
    • Grem JL, Nguyen D, Monahan BP, Kao V and Geoffroy FJ: Sequence-dependent antagonism between fluorouracil and paclitaxel in human breast cancer cells. Biochem Pharmacol 58: 477-486, 1999.
    • (1999) Biochem Pharmacol , vol.58 , pp. 477-486
    • Grem, J.L.1    Nguyen, D.2    Monahan, B.P.3    Kao, V.4    Geoffroy, F.J.5
  • 41
    • 0021229643 scopus 로고
    • Paclitaxel: An antimitotic agent with a new mechanism of action
    • Manfredi JJ and Horwitz SB: Paclitaxel: an antimitotic agent with a new mechanism of action. Pharmacol Ther 25: 83-125, 1984.
    • (1984) Pharmacol Ther , vol.25 , pp. 83-125
    • Manfredi, J.J.1    Horwitz, S.B.2
  • 42
    • 0031466503 scopus 로고    scopus 로고
    • Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line
    • Barboule N, Chadebech P, Baldin V, Vidal S and Valette A: Involvement of p21 in mitotic exit after paclitaxel treatment in MCF-7 breast adenocarcinoma cell line. Oncogene 15: 2867-2875, 1997.
    • (1997) Oncogene , vol.15 , pp. 2867-2875
    • Barboule, N.1    Chadebech, P.2    Baldin, V.3    Vidal, S.4    Valette, A.5
  • 43
    • 0033169231 scopus 로고    scopus 로고
    • Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis
    • Stewart ZA, Mays D and Pietenpol JA: Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis. Cancer Res 59: 3831-3837, 1999.
    • (1999) Cancer Res , vol.59 , pp. 3831-3837
    • Stewart, Z.A.1    Mays, D.2    Pietenpol, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.