Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-x(L)

Journal of Experimental Medicine

Volumn 191, Issue 6, 2000, Pages 977-984

  Horita, Machiko ^a   Andreu, Enrique Jose ^b   Benito, Adalberto ^a,c   Arbona, Cristina ^b   Sanz, Cristina ^a   Benet, Isana ^b   Prosper, Felipe ^b   Fernandez Luna, Jose Luis ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Blast crisis; Cell death; CGP 57148; Interleukin 3; Promoter

Indexed keywords

BCR ABL PROTEIN; CD34 ANTIGEN; IMATINIB; INTERLEUKIN 3; PROTEIN BCL X; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; BLAST CELL CRISIS; CELL DEATH; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-X PROTEIN; BLAST CRISIS; DNA-BINDING PROTEINS; DOWN-REGULATION; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, CHRONIC; LEUKEMIA, MYELOID, CHRONIC-PHASE; MILK PROTEINS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFECTION; UP-REGULATION;

EID: 0034689031     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.6.977     Document Type: Article

References (34)

1. Fused transcript of abl and bcr genes in chronic myelogenous leukemia
2. Inhibition of apoptosis by BCR/ABL in chronic myelogenous leukemia
3. Expression of BCR/ABL abrogates factor-dependent growth of human hematopoietic M07E cells by an autocrine mechanism
4. Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia
5. The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: Role in adhesion, invasion and homing
6. Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL
7. Bcr-Abl-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage. A mechanism of resistance to multiple anticancer agents
8. Bcr-Abl maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death
9. Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-x(L)
10. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
11. Erythropoietin can induce the expression of Bcl-x(L) through Stat5 in erythropoietin-dependent progenitor cell lines
12. Fetal anemia and apoptosis of red cell progenitors in Stat5a(-/-)5b(-/-) mice: A direct role for Stat5 in Bcl-x(L) induction
13. IL-3 dependent regulation of Bcl-x(L) gene expression by Stat5 in a bone marrow derived cell line
14. Signals through gpl30 upregulate bcl-x gene expression via Stat1-binding cis-element in cardiac myocytes
15. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
16. Signal transducer and activator of transcription (STAT)5 activation by Bcr-Abl is dependent on intact Src homology (SH)3 and SH2 domains of Bcr-Abl and is required for leukemogenesis
17. Tyrosyl phosphotylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr-Abl
18. Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function
19. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
20. Bcl-25-independent Bcr-Abl-mediated resistance to apoptosis: Protection is correlated with upregulation of Bcl-x(L)
21. Interferon induces up-regulation of Spi-1/PU.1 in human leukemia K562 cells
22. In vivo eradication of human Bcr-Abl-positive leukemia cells with an Abl kinase inliibitor
23. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCD-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
24. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and Erb2/neu tyrosine kinases
25. The function of Bcr-Abl and related proto-oncogenes
26. Euforced expression Of Bcl-xs induces differentiation and sensitizes CML-blast crisis K562 cells to Ara-C mediated differentiation and apoptosis
27. IL-3, GM-CSF, and IL-5 transduce signals through two Stat5 homologs
28. Cytokine receptor signalling
29. Bcl-x(L) is phosphorylated in malignant cells following microtubule disruption
30. Bcr-Abl activates pathways mediating cytokine independence and protection against apoptosis in murine hcmatopoietic cells in a dose-dependent manner
31. Changes in oncogene expression implicated in evolution of chronic granulocytic leukemia from its chronic phase to acceleration
32. Correlation between chromosomal abnormalities and blast phenotype in the blast crisis of Ph-positive CGL
33. Constitutive activation of Jaks and Stats in Bcr-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
34. Acceleration of apoptotic cell death after the cleavage of Bcl-x(L) protein by caspase-3-1ike proteases