Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells

Biochemical Pharmacology

Volumn 51, Issue 10, 1996, Pages 1293-1301

  Aherne, G Wynne ^a   Hardcastle, Anthea ^a   Raynaud, Florence ^a   Jackman, Ann L ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

antimetabolite; cellular pharmacology; drug development

Indexed keywords

DEOXYURIDINE PHOSPHATE; FOLIC ACID ANTAGONIST; N [N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N (2 PROPYNYL)AMINO] 2 FLUOROBENZOYL] GAMMA GLUTAMYL] DEXTRO GLUTAMIC ACID; POLYGLUTAMIC ACID; QUINAZOLINE DERIVATIVE; RALTITREXED; THYMIDINE TRIPHOSPHATE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG TARGETING; ENZYME INHIBITION; LEUKEMIA L 1210; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

EID: 0003267529     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00035-4     Document Type: Article

References (38)

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