메뉴 건너뛰기




Volumn 82, Issue 3, 2000, Pages 560-567

Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients

Author keywords

Colorectal cancer; p53; Predictive factor; Prognosis; TS

Indexed keywords

FLUOROURACIL; FOLINIC ACID; METHOTREXATE; PROTEIN P53; THYMIDYLATE SYNTHASE;

EID: 0033975032     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.0964     Document Type: Article
Times cited : (155)

References (42)
  • 1
    • 0003452668 scopus 로고
    • Lippincott: Philadelphia
    • American Joint Committee on Cancer (1988) Manual for Staging of Cancer 3rd edn, p.7. Lippincott: Philadelphia
    • (1988) Manual for Staging of Cancer 3rd Edn , pp. 7
  • 2
    • 0030741462 scopus 로고    scopus 로고
    • Coexpression of Bcl-2, c-myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma
    • Bathasdekar JM, Patel DD, Ghosh N, Chikhlikar PR, Trivedi TI, Suthar TP, et al (1997) Coexpression of Bcl-2, c-myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma. Dis Colon Rectum 40: 785-790
    • (1997) Dis Colon Rectum , vol.40 , pp. 785-790
    • Bathasdekar, J.M.1    Patel, D.D.2    Ghosh, N.3    Chikhlikar, P.R.4    Trivedi, T.I.5    Suthar, T.P.6
  • 3
    • 0028286988 scopus 로고
    • Cytoplasmic accumulation of p53 protein: An independent prognostic indicator in colorectal adenocarcinomas
    • Bosari S and Viale G (1994) Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. J Natl Cancer Inst 86: 681-687
    • (1994) J Natl Cancer Inst , vol.86 , pp. 681-687
    • Bosari, S.1    Viale, G.2
  • 4
    • 0030956045 scopus 로고    scopus 로고
    • Global burden of cancer
    • Boyle P (1997) Global burden of cancer. Lancet 349: 23-26
    • (1997) Lancet , vol.349 , pp. 23-26
    • Boyle, P.1
  • 5
    • 0029738119 scopus 로고    scopus 로고
    • p53 nuclear protein overexpression in colorectal cancer: A dominant predictor of survival in patients with advanced hepatic metastases
    • Bulleco C, Guillem JG, Kemeney N, Huang Y, Klimistra D, Berger MF, et al (1996) p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 14: 2696-2701
    • (1996) J Clin Oncol , vol.14 , pp. 2696-2701
    • Bulleco, C.1    Guillem, J.G.2    Kemeney, N.3    Huang, Y.4    Klimistra, D.5    Berger, M.F.6
  • 6
    • 0026555717 scopus 로고
    • Modulation of activity of the promoter of the human MDR1 gene by RAS and p53
    • Chin KV, Ueda K, Pastran I and Gottesman MM (1992) Modulation of activity of the promoter of the human MDR1 gene by RAS and p53. Science 255: 459-462
    • (1992) Science , vol.255 , pp. 459-462
    • Chin, K.V.1    Ueda, K.2    Pastran, I.3    Gottesman, M.M.4
  • 7
    • 0026030052 scopus 로고
    • Induction of thymidilate synthase associated with multidrug resistance in human breast and colon cancer cell lines
    • Chu E, Drake JC, Koeller DM, Zinn S, Jamis-Dow CA, Yeh GC, et al (1990) Induction of thymidilate synthase associated with multidrug resistance in human breast and colon cancer cell lines. Mol Pharmacol 39: 136-143
    • (1990) Mol Pharmacol , vol.39 , pp. 136-143
    • Chu, E.1    Drake, J.C.2    Koeller, D.M.3    Zinn, S.4    Jamis-Dow, C.A.5    Yeh, G.C.6
  • 9
    • 0025214277 scopus 로고
    • Evidence of allosteric variants for wild type p53, a tumour suppressor protein
    • Cook A and Milner J (1990) Evidence of allosteric variants for wild type p53, a tumour suppressor protein. Br J Cancer 61: 548-562
    • (1990) Br J Cancer , vol.61 , pp. 548-562
    • Cook, A.1    Milner, J.2
  • 11
    • 0031053520 scopus 로고    scopus 로고
    • Lack of correlation between thymidylate synthase levels in primary colorectal tumors and subsequent response to chemotherapy
    • Findlay MPN, Cunningham D, Morgan G and Clinton S (1997) Lack of correlation between thymidylate synthase levels in primary colorectal tumors and subsequent response to chemotherapy. Br J Cancer 75: 903-909
    • (1997) Br J Cancer , vol.75 , pp. 903-909
    • Findlay, M.P.N.1    Cunningham, D.2    Morgan, G.3    Clinton, S.4
  • 12
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M and Harris CC (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855-4878
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 13
    • 0028171968 scopus 로고
    • Mediation of c-myc-induced apoptosis by p53
    • Hermeking H and Heick D (1994) Mediation of c-myc-induced apoptosis by p53. Science 265: 2091-2093
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Heick, D.2
  • 14
    • 0030847561 scopus 로고    scopus 로고
    • Chemotherapy for the treatment of patients with metastatic colorectal cancer: An overview
    • Isacoff WH and Borud K (1997) Chemotherapy for the treatment of patients with metastatic colorectal cancer: an overview. World J Surg 21: 748-762
    • (1997) World J Surg , vol.21 , pp. 748-762
    • Isacoff, W.H.1    Borud, K.2
  • 15
    • 0026335113 scopus 로고
    • Production and characterization of monoclonal antibodies that localise human thymidilate synthase in the cytoplasm of human cells and tissue
    • Johnston PG, Liang CM, Henry S, Chabner BA and Allegra C (1991) Production and characterization of monoclonal antibodies that localise human thymidilate synthase in the cytoplasm of human cells and tissue. Cancer Res 51: 6668-6676
    • (1991) Cancer Res , vol.51 , pp. 6668-6676
    • Johnston, P.G.1    Liang, C.M.2    Henry, S.3    Chabner, B.A.4    Allegra, C.5
  • 16
    • 0028151449 scopus 로고
    • The role of thymidilate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
    • Johnston PG, Fisher ER, Rockette HE, Fisher B, Wolmark N, Drake JC, et al (1994) The role of thymidilate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 12: 2640-2647
    • (1994) J Clin Oncol , vol.12 , pp. 2640-2647
    • Johnston, P.G.1    Fisher, E.R.2    Rockette, H.E.3    Fisher, B.4    Wolmark, N.5    Drake, J.C.6
  • 17
    • 0028940399 scopus 로고
    • Thymidilate synthase gene and protein expression correlate and are associated with response to 5-Fluorouracil in human colorectal and gastric cancer
    • Johnston PG, Lenz HJ, Leichman CG, Danenberg K, Allegra C, Danenberg PV, et al (1995) Thymidilate synthase gene and protein expression correlate and are associated with response to 5-Fluorouracil in human colorectal and gastric cancer. Cancer Res 55: 1407-1412
    • (1995) Cancer Res , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.4    Allegra, C.5    Danenberg, P.V.6
  • 18
    • 0031019404 scopus 로고    scopus 로고
    • Thymidilate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer
    • Johnston PG, Mick R, Recant W, Behan KA, Dolan ME, Ratain MJ, et al (1997) Thymidilate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. J Natl Cancer Inst 89: 308-313
    • (1997) J Natl Cancer Inst , vol.89 , pp. 308-313
    • Johnston, P.G.1    Mick, R.2    Recant, W.3    Behan, K.A.4    Dolan, M.E.5    Ratain, M.J.6
  • 19
    • 0345973521 scopus 로고    scopus 로고
    • Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion
    • Kornmann M, Link KH, Lenz HJ, Pillasch J, Metzger R, Butzer U, et al (1997) Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion. Cancer Letter 118: 29-35
    • (1997) Cancer Letter , vol.118 , pp. 29-35
    • Kornmann, M.1    Link, K.H.2    Lenz, H.J.3    Pillasch, J.4    Metzger, R.5    Butzer, U.6
  • 21
    • 0031213588 scopus 로고    scopus 로고
    • Inhibition of mouse thymidilate synthase promoter activity by the wild-type p53 tumor suppressor protein
    • Lee Y, Chen Y, Chang LS and Johnson LF (1997) Inhibition of mouse thymidilate synthase promoter activity by the wild-type p53 tumor suppressor protein. Exp Cell Res 234: 270-276
    • (1997) Exp Cell Res , vol.234 , pp. 270-276
    • Lee, Y.1    Chen, Y.2    Chang, L.S.3    Johnson, L.F.4
  • 22
    • 0030883708 scopus 로고    scopus 로고
    • Quantitation of intratumoral thymidilate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
    • Leichman CG, Lenz HJ, Leichman L, Danenberg K, Baranda J, Groshen S, et al (1997) Quantitation of intratumoral thymidilate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 15: 3223-3229
    • (1997) J Clin Oncol , vol.15 , pp. 3223-3229
    • Leichman, C.G.1    Lenz, H.J.2    Leichman, L.3    Danenberg, K.4    Baranda, J.5    Groshen, S.6
  • 26
    • 0030931974 scopus 로고    scopus 로고
    • A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma
    • Machover D (1997) A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma. Cancer 80: 1179-1187
    • (1997) Cancer , vol.80 , pp. 1179-1187
    • Machover, D.1
  • 27
    • 0030791861 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma
    • Manne U, Myers RB, Moron C, Poczatek RB, Dillard S, Weiss H, et al (1997) Prognostic significance of Bcl-2 expression and p53 nuclear accumulation in colorectal adenocarcinoma. Int J Cancer 74: 346-358
    • (1997) Int J Cancer , vol.74 , pp. 346-358
    • Manne, U.1    Myers, R.B.2    Moron, C.3    Poczatek, R.B.4    Dillard, S.5    Weiss, H.6
  • 28
    • 0030474552 scopus 로고    scopus 로고
    • Expression of wild-type p53 stimulates an increase in both Bax and Bcl-x(L) protein content in HT29 cells
    • Merchant AK, Loney TL and Maybaum J (1996) Expression of wild-type p53 stimulates an increase in both Bax and Bcl-x(L) protein content in HT29 cells. Oncogene 13: 2631-2637
    • (1996) Oncogene , vol.13 , pp. 2631-2637
    • Merchant, A.K.1    Loney, T.L.2    Maybaum, J.3
  • 29
    • 0030485536 scopus 로고    scopus 로고
    • The dual role of mutant p53 protein in chemosensitivity of human cancer
    • Mueller H and Eppenberger U (1996) The dual role of mutant p53 protein in chemosensitivity of human cancer. Anticancer Res 16: 3845-3848
    • (1996) Anticancer Res , vol.16 , pp. 3845-3848
    • Mueller, H.1    Eppenberger, U.2
  • 30
    • 0019321438 scopus 로고
    • Cell cycle regulation of thymidilate synthase gene expression in culture mouse fibroblasts
    • Navalgund LG, Rossann C, Muench AJ and Johnson LF (1980) Cell cycle regulation of thymidilate synthase gene expression in culture mouse fibroblasts. J Biol Chem 255: 7386-7390
    • (1980) J Biol Chem , vol.255 , pp. 7386-7390
    • Navalgund, L.G.1    Rossann, C.2    Muench, A.J.3    Johnson, L.F.4
  • 31
    • 0030453230 scopus 로고    scopus 로고
    • p53 and PCNA expression in advanced colorectal cancer. Response to chemotherapy and long-term prognosis
    • Paradiso A, Rabinovich M, Vallejo C, Machiavelli M, Romero A, Perez J, et al (1996) p53 and PCNA expression in advanced colorectal cancer. Response to chemotherapy and long-term prognosis. Int J Cancer 69: 437-441
    • (1996) Int J Cancer , vol.69 , pp. 437-441
    • Paradiso, A.1    Rabinovich, M.2    Vallejo, C.3    Machiavelli, M.4    Romero, A.5    Perez, J.6
  • 32
    • 0029021602 scopus 로고
    • Increased thymidilate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells
    • Pestalozzi BC, McGinn CJ, Kinsella TJ, Drake JC, Glennon MC, Allegra CJ, et al (1995) Increased thymidilate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. Br J Cancer 71: 1151-1157
    • (1995) Br J Cancer , vol.71 , pp. 1151-1157
    • Pestalozzi, B.C.1    McGinn, C.J.2    Kinsella, T.J.3    Drake, J.C.4    Glennon, M.C.5    Allegra, C.J.6
  • 34
    • 0028019880 scopus 로고
    • Thymidilate synthase inhibition after administration of 5-fluorouracil with or without leucovorin; implications for treatment with 5-fluorouracil
    • Peters GJ, Van Der Wilt CL, Van Groeningen CJ, Meijer S, Smid K and Pinedo HM (1994) Thymidilate synthase inhibition after administration of 5-fluorouracil with or without leucovorin; implications for treatment with 5-fluorouracil. J Clin Oncol 12: 2035-2042
    • (1994) J Clin Oncol , vol.12 , pp. 2035-2042
    • Peters, G.J.1    Van Der Wilt, C.L.2    Van Groeningen, C.J.3    Meijer, S.4    Smid, K.5    Pinedo, H.M.6
  • 36
    • 0008915955 scopus 로고    scopus 로고
    • Colorectal cancer incidence
    • SEER Cancer Statistics Review, 1973-1993, preliminary edition (1997) Colorectal cancer incidence. J Natl. Cancer Inst 89: 416
    • (1997) J Natl. Cancer Inst , vol.89 , pp. 416
  • 37
    • 0022004617 scopus 로고
    • Exploratory data analysis and the use of the hazard function for interpreting survival data: An investigator's prime
    • Simes RJ and Zelen M (1985) Exploratory data analysis and the use of the hazard function for interpreting survival data: an investigator's prime. J Clin Oncol 3: 1418-1431
    • (1985) J Clin Oncol , vol.3 , pp. 1418-1431
    • Simes, R.J.1    Zelen, M.2
  • 38
    • 0030037868 scopus 로고    scopus 로고
    • Clinical and pathological associations with p53 tumor-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma
    • Slebos RJC, Baas IO, Clement M, Polak M, Mulder JW, Van Den Berg FM, et al (1996) Clinical and pathological associations with p53 tumor-suppressor gene mutations and expression of p21WAF1/Cip1 in colorectal carcinoma. Br J Cancer 74: 165-171
    • (1996) Br J Cancer , vol.74 , pp. 165-171
    • Slebos, R.J.C.1    Baas, I.O.2    Clement, M.3    Polak, M.4    Mulder, J.W.5    Van Den Berg, F.M.6
  • 39
    • 0030035991 scopus 로고    scopus 로고
    • Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas
    • Smith DR, Ji CY and Goh HS (1996) Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas. Br J Cancer 74: 216-223
    • (1996) Br J Cancer , vol.74 , pp. 216-223
    • Smith, D.R.1    Ji, C.Y.2    Goh, H.S.3
  • 40
    • 0028937496 scopus 로고
    • Clinical resistance to antimetabolites
    • Spears C (1995) Clinical resistance to antimetabolites. Haematol Oncol Clin North Am 9: 397-413
    • (1995) Haematol Oncol Clin North Am , vol.9 , pp. 397-413
    • Spears, C.1
  • 41
    • 0020056302 scopus 로고
    • In vivo kinetics of thymidilate synthase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocacarcinomas
    • Spears CP, Shahanian AH and Moran RG (1982) In vivo kinetics of thymidilate synthase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocacarcinomas. Cancer Res 42: 450-456
    • (1982) Cancer Res , vol.42 , pp. 450-456
    • Spears, C.P.1    Shahanian, A.H.2    Moran, R.G.3
  • 42
    • 0029962567 scopus 로고    scopus 로고
    • Wild-type p53 potentiates cytotoxicity of therapeutic agents in human colon cancer cells
    • Yang B, Eshleman JR, Berger NA and Markowitz SD (1996) Wild-type p53 potentiates cytotoxicity of therapeutic agents in human colon cancer cells. Clin Cancer Res 2: 1649-1657
    • (1996) Clin Cancer Res , vol.2 , pp. 1649-1657
    • Yang, B.1    Eshleman, J.R.2    Berger, N.A.3    Markowitz, S.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.