-
1
-
-
77957070810
-
Topoisomerase I-targeting drugs: New developments in cancer pharmacology
-
Advances in DNA Sequence-Specific Agents. M. Palumbo et al., Eds. CRC Press, Inc. Boca Raton, FL
-
(1998)
, vol.8
, pp. 39-66
-
-
Gatto, B.1
Liu, L.F.2
-
3
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
(1985)
J Biol. Chem.
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
-
4
-
-
0023924786
-
Identification of mammalian DNA topoisomerase I as an intracellular target of the anticancer drug camptothecin
-
(1988)
Cancer Res.
, vol.48
, pp. 1722-1726
-
-
Hsiang, Y.H.1
Liu, L.F.2
-
5
-
-
0026351183
-
New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site
-
(1991)
J Mol. Biol.
, vol.222
, pp. 669-678
-
-
Svejstrup, J.Q.1
-
6
-
-
0024324205
-
On the mechanism of topoisomerase I inhibition by camptothecin: Evidence for binding to an enzyme-DNA complex
-
(1989)
Biochemistry
, vol.28
, pp. 4629-4638
-
-
Hertzberg, R.P.1
-
7
-
-
0032489634
-
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA
-
see comments
-
(1998)
Science
, vol.279
, pp. 1504-1513
-
-
Redinbo, M.R.1
-
8
-
-
0032489675
-
A model for the mechanism of human topoisomerase I
-
(1998)
Science
, vol.279
, pp. 1534-1541
-
-
Stewart, L.1
-
10
-
-
0027988123
-
Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions
-
(1994)
J Biol. Chem.
, vol.269
, pp. 28702-28707
-
-
Leteurtre, F.1
-
11
-
-
0030002584
-
Characterizing the DNA binding modes of a topoisomerase I-poisoning terbenzimidazole: Evidence for both intercalative and minor groove binding properties
-
(1996)
Drug Des. Discov.
, vol.13
, pp. 115-133
-
-
Pilch, D.S.1
-
12
-
-
0031472259
-
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13565-13570
-
-
Pilch, D.S.1
-
13
-
-
0030753506
-
Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs
-
(1997)
Biochemistry
, vol.36
, pp. 12542-12553
-
-
Pilch, D.S.1
-
14
-
-
0027484629
-
Dual topoisomerase I and II inhibition by intoplicine (RP-60475), a new antitumor agent in early clinical trials
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 767-774
-
-
Poddevin, B.1
-
15
-
-
0027461273
-
Induction of topoisomerase I-mediated DNA cleavage by a new indolocarbazole, ED-110
-
(1993)
Cancer Res.
, vol.53
, pp. 490-494
-
-
Yoshinari, T.1
-
16
-
-
0032502313
-
DNA minor groove binding-directed poisoning of human DNA topoisomerase I by terbenzimidazoles
-
(1998)
Biochemistry
, vol.37
, pp. 3558-3566
-
-
Xu, Z.1
-
17
-
-
0030836293
-
Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar
-
(1997)
Biochemistry
, vol.36
, pp. 13285-13291
-
-
Sim, S.P.1
-
18
-
-
0034090922
-
Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages
-
(2000)
Proc. Nat. Acad. Sci. USA
, vol.97
, pp. 2040-2045
-
-
Pommier, Y.G.1
-
19
-
-
0031003701
-
Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I
-
(1997)
J Biol. Chem.
, vol.272
, pp. 7792-7796
-
-
Pourquier, P.1
-
20
-
-
0030698003
-
Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects
-
(1997)
J Biol. Chem.
, vol.272
, pp. 26441-26447
-
-
Pourquier, P.1
-
21
-
-
0033605675
-
Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine
-
(1999)
J Biol. Chem.
, vol.274
, pp. 8516-8523
-
-
Pourquier, P.1
-
22
-
-
0025133118
-
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons
-
(1990)
Cancer Res.
, vol.50
, pp. 6919-6924
-
-
D'Arpa, P.1
-
23
-
-
0024420685
-
Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin
-
(1989)
Cancer Res.
, vol.49
, pp. 5077-5082
-
-
Hsiang, Y.H.1
-
24
-
-
0026625512
-
The involvement of active DNA synthesis in camptothecin-induced G2 arrest: Altered regulation of p34cdc2/cyclin B
-
(1992)
Cancer Res.
, vol.52
, pp. 1823-1829
-
-
Tsao, Y.P.1
-
25
-
-
0027139317
-
Interaction between replication forks and topoisomerase I-DNA cleavable complexes: Studies in a cell-free SV40 DNA replication system
-
(1993)
Cancer Res.
, vol.53
, pp. 5908-5914
-
-
Tsao, Y.P.1
-
26
-
-
0025276858
-
A model for tumor cell killing by topoisomerase poisons
-
(1990)
Cancer Cells
, vol.2
, pp. 23-27
-
-
Zhang, H.1
-
28
-
-
0034737193
-
NF-kappaB activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9501-9509
-
-
Huang, T.T.1
-
30
-
-
0033104517
-
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes
-
(1999)
EMBO J.
, vol.18
, pp. 1397-1406
-
-
Shao, R.G.1
-
31
-
-
0029029436
-
Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen
-
(1995)
Cancer Res.
, vol.55
, pp. 2116-2121
-
-
Goldwasser, F.1
-
33
-
-
0029738086
-
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: Evidence for cell cycle-independent toxicity
-
(1996)
J. Cell Biol.
, vol.134
, pp. 757-770
-
-
Morris, E.J.1
Geller, H.M.2
-
39
-
-
0027173884
-
Hypersensitivity of Cockayne's syndrome cells to camptothecin is associated with the generation of abnormally high levels of double strand breaks in nascent DNA
-
(1993)
Cancer Res.
, vol.53
, pp. 2012-2019
-
-
Squires, S.1
-
40
-
-
0029072716
-
Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity
-
(1995)
Mol. Pharmacol.
, vol.47
, pp. 907-914
-
-
Beidler, D.R.1
Cheng, Y.C.2
-
41
-
-
0030854371
-
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24159-24164
-
-
Desai, S.D.1
-
42
-
-
0033569666
-
Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes
-
(1999)
Science
, vol.286
, pp. 552-555
-
-
Pouliot, J.J.1
-
43
-
-
0034635958
-
SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4046-4051
-
-
Mao, Y.1
-
44
-
-
0030249870
-
UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteins
-
(1996)
Genomics
, vol.36
, pp. 271-279
-
-
Shen, Z.1
-
45
-
-
0029736651
-
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
-
(1996)
Oncogene
, vol.13
, pp. 971-982
-
-
Boddy, M.N.1
-
46
-
-
0030455748
-
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
-
(1996)
J. Cell Biol.
, vol.135
, pp. 1457-1470
-
-
Matunis, M.J.1
-
47
-
-
0031104910
-
SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family
-
(1997)
Genomics
, vol.40
, pp. 362-366
-
-
Lapenta, V.1
-
48
-
-
0030588674
-
Protection against Fas/APO-1 and tumor necrosis factor-mediated cell death by a novel protein, sentrin
-
(1996)
J. Immunol.
, vol.157
, pp. 4277-4281
-
-
Okura, T.1
-
49
-
-
0030932134
-
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
-
(1997)
Cell
, vol.88
, pp. 97-107
-
-
Mahajan, R.1
-
50
-
-
0033537828
-
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10618-10624
-
-
Desterro, J.M.1
-
51
-
-
0027198563
-
Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha repressor
-
(1993)
Cell
, vol.74
, pp. 357-369
-
-
Chen, P.1
-
52
-
-
0032525130
-
Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae
-
(1998)
EMBO J.
, vol.17
, pp. 2759-2766
-
-
Gilon, T.1
-
54
-
-
0032135131
-
SUMO-1 modification of IkappaB-alpha inhibits NF-kappaB activation
-
(1998)
Mol. Cell.
, vol.2
, pp. 233-239
-
-
Desterro, J.M.1
-
55
-
-
0032567759
-
Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association
-
(1998)
J. Cell. Biol.
, vol.140
, pp. 259-270
-
-
Mahajan, R.1
-
56
-
-
0032498541
-
SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
-
(1998)
J. Cell. Biol
, vol.140
, pp. 499-509
-
-
Matunis, M.J.1
-
57
-
-
0032518581
-
Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2
-
(1998)
Curr. Biol.
, vol.8
, pp. 121-124
-
-
Saitoh, H.1
-
59
-
-
0344299239
-
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption
-
(1999)
J. Virol.
, vol.73
, pp. 5137-5143
-
-
Muller, S.1
Dejean, A.2
-
60
-
-
0033570892
-
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
-
(1999)
EMBO J.
, vol.18
, pp. 6462-6471
-
-
Gostissa, M.1
-
61
-
-
0033571214
-
SUMO-1 modification activates the transcriptional response of p53
-
(1999)
EMBO J.
, vol.18
, pp. 6455-6461
-
-
Rodriguez, M.S.1
-
63
-
-
0006465595
-
The roles of ubiquitin-dependent proteolysis in determining the sensitivity/resistance of tumor cells to topoisomerase inhibitors
-
(1999)
Proc. Am. Assoc. Cancer Res.
, vol.40
, pp. 775
-
-
Leroy, L.F.1
-
65
-
-
0000130128
-
Clinical evaluation of sequential topoisomerase targeting in the treatment of advance maligancy
-
(1998)
Cancer Ther.
, vol.1
, pp. 292-302
-
-
Gupta, E.1
-
66
-
-
0030464036
-
Camptothecin resistance related to drug-induced down-regulation of topoisomerase I and to steps occurring after the formation of protein-linked DNA breaks
-
(1996)
Ann. N.Y. Acad. Sci.
, vol.803
, pp. 74-92
-
-
Murren, J.R.1
|