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Volumn 21, Issue 30, 2002, Pages 4595-4600
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Novel gain of function activity of p53 mutants: Activation of the dUTPase gene expression leading to resistance to 5-fluorouracil
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Author keywords
Drug resistance; Gain of function; Mutant p53
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Indexed keywords
AMINO ACID;
DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE;
FLUOROPYRIMIDINE;
FLUOROURACIL;
HISTIDINE;
MUTANT PROTEIN;
PROTEIN P53;
RETROVIRUS VECTOR;
TETRACYCLINE;
TRYPTOPHAN;
AMINO TERMINAL SEQUENCE;
ANIMAL CELL;
ARTICLE;
CANCER THERAPY;
CLONING;
CONTROLLED STUDY;
DRUG WITHDRAWAL;
FIBROBLAST;
GENE EXPRESSION;
GENE INDUCTION;
GENETIC TRANSCRIPTION;
HYBRIDIZATION;
MOUSE;
NONHUMAN;
PREDICTION;
PRIORITY JOURNAL;
PROTEIN DOMAIN;
PROTEIN EXPRESSION;
RECEPTOR UPREGULATION;
REGULATORY MECHANISM;
TIME;
TRANSCRIPTION INITIATION;
TUMOR;
TUMOR CELL;
ANIMALS;
BLOTTING, WESTERN;
CELL DIVISION;
DRUG RESISTANCE, NEOPLASM;
FLUOROURACIL;
HUMANS;
MICE;
MUTATION;
PYROPHOSPHATASES;
REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;
RNA, MESSENGER;
TRANS-ACTIVATION (GENETICS);
TUMOR CELLS, CULTURED;
TUMOR SUPPRESSOR PROTEIN P53;
ANIMALIA;
UNIDENTIFIED RETROVIRUS;
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EID: 0037063173
PISSN: 09509232
EISSN: None
Source Type: Journal
DOI: 10.1038/sj.onc.1205704 Document Type: Article |
Times cited : (89)
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References (41)
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