Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin

Cancer Research

Volumn 60, Issue 21, 2000, Pages 5988-5994

  Hayakawa, J ^a   Ohmichi, M ^a   Kurachi, H ^a   Kanda, Y ^a   Hisamoto, K ^a   Nishio, Y ^a   Adachi, K ^a   Tasaka, K ^a   Kanzaki, T ^a   Murata, Y ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CISPLATIN; DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; SERINE; TRANSPLATIN; WORTMANNIN;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG SENSITIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOCARCINOMA, PAPILLARY; ANDROSTADIENES; ANTINEOPLASTIC AGENTS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CISPLATIN; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; TUMOR CELLS, CULTURED;

EID: 0034326803     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
2. Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
3. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
4. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity
5. Regulation of neuronal survival by the serine-threonine protein kinase Akt
6. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
7. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
8. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
9. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt
10. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
11. Cellular survival: A play in three Akts
12. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
13. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
14. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-13-3 not BCL-X(L)
15. Bad, a heterodimeric partner for Bcl-X(L) and Bcl-2, displaces Bax and promotes cell death
16. Apoptosis. A Bad kinase makes good
17. Parallel signal processing among mammalian MAPKs
18. Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line
19. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation
20. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
21. Regulation of Bad phosphorylation and association with Bcl-X(L) by the MAPK/Erk kinase
22. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway
23. X-Ray structure of the major adduct of the anticancer drug cisplatin with DNA: Cis-
24. Cisplatin and DNA repair in cancer chemotherapy
25. Augmentation of Adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
26. Adriamycin accumulation and metabolism in Adriamycin-sensitive and -resistant human ovarian cancer cell lines
27. Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line
28. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
31. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation
32. Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I
33. Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
34. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity
35. PI3K signal and DNA repair: A short commentary
36. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
37. Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell linens
38. Mechanisms of drug resistance in ovarian cancer
39. Mechanisms and modulation of resistance to chemotherapy in ovarian cancer
40. Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in untreated human ovarian cancer cell lines
41. Preclinical combination therapy with gemcitabine and mechanisms of resistance
42. The role of erbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: Mechanisms and implications