Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines

European Journal of Cancer

Volumn 36, Issue 15, 2000, Pages 1984-1990

  Holford, J ^a   Beale, P J ^a   Boxall, F E ^a   Sharp, S Y ^a   Kelland, L R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Platinum; Resistance; Thiols; ZD0473

Indexed keywords

AMMINEDICHLORO(2 METHYLPYRIDINE)PLATINUM; ANTINEOPLASTIC AGENT; CADMIUM CHLORIDE; CARBOPLATIN; CISPLATIN; PLATINUM COMPLEX; SATRAPLATIN; TRANS AMMINEDICHLORO(CYCLOHEXYLAMINE)DIHYDROXOPLATINUM;

ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CROSS RESISTANCE; DNA REPAIR; DOSE RESPONSE; DRUG RESISTANCE; DRUG UPTAKE; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL;

EID: 0033806025     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(00)00192-1     Document Type: Article

References (25)

1. L.R. Kelland The development of orally active platinum drugs B. Lippert Cisplatin, Chemistry and Biochemistry of a leading anticancer drug 1999 Wiley-VCH Zurich 497 521
2. S.W. Johnson K.V. Ferry T.C. Hamilton Recent insights into platinum drug resistance in cancer Drug Resistance Updates 1 1998 243 254
3. Judson IR, Kelland LR. Cisplatin and analogues. In Souhami RL, Tannock I, Hohenberger P, Horiot J-C, eds, 2nd edn. Oxford, Oxford Textbook of Oncology, Oxford University Press, 2000, in press.
4. P. Mistry L.R. Kelland G. Abel S. Sidhar K.R. Harrap The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines Br. J. Cancer 64 1991 215 220
5. P. Mistry S.Y. Loh L.R. Kelland K.R. Harrap Effect of buthionine sulfoximine on Pt- (II) and -(IV) accumulation, distribution and the formation of glutathione conjugates in human ovarian carcinoma cell lines Int. J. Cancer 55 1993 848 856
6. C. Meijer N.H. Mulder H. Timmer-Bosscha W.J. Sluiter G.J. Meersma E.G.E. de Vries Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds Cancer Res. 52 1992 6885 6889
7. A.K. Godwin A. Meister P.J. O'Dwyer C.S. Huang T.C. Hamilton M.E. Anderson High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis Proc. Natl. Acad. Sci. USA 89 1992 3070 3074
8. J. Holford S.Y. Sharp B.A. Murrer M. Abrams L.R. Kelland In vitro circumvention of cisplatin-resistance by the novel sterically hindered platinum complex AMD473 Br. J. Cancer 77 1998 366 373
9. J. Holford F. Raynaud B.A. Murrer Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis -[amminedichloro(2-methylpyridine)] platinum (II) (AMD473) Anti-cancer Drug Des. 13 1998 1 18
10. F.I. Raynaud F.E. Boxall P.M. Goddard cis -Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex in vivo activity, toxicology, and pharmacokinetics in mice Clin. Cancer Res. 3 1997 2063 2074
11. L.R. Kelland AMD473 Drugs Fut. 23 1998 1062 1065
12. S.L. Kelley A. Basu B.A. Teicher M.P. Hacker D.H. Hamer J.S. Lazo Overexpression of metallothionein confers resistance to anticancer drugs Science 241 1988 1813 1815
13. K. Kasahara Y. Fujiwara K. Nishio Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin Cancer Res. 51 1991 3237 3242
14. Y. Kondo E.S. Woo A.E. Michalska K.H.A. Choo J.S. Lazo Metallothionein null cells have increased sensitivity to anticancer drugs Cancer Res. 55 1995 2021 2023
15. B.C. Behrens T.C. Hamilton H. Masuda Characterization of a cis -diamminedichloro platinum (II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues Cancer Res. 47 1987 414 418
16. C.A. Hills L.R. Kelland G. Abel J. Siracky A.P. Wilson K.R. Harrap Biological properties of ten human ovarian carcinoma cell lines calibration in vitro against four platinum complexes Br. J. Cancer 59 1989 527 534
17. L.R. Kelland G. Abel M.J. McKeage Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum (IV) an orally active platinum drug Cancer Res. 53 1993 2581 2586
18. L.R. Kelland C.F.J. Barnard K.J. Mellish A novel trans-platinum coordination complex possessing in vitro and in vivo antitumor activity Cancer Res. 54 1994 5618 5622
19. P. Skehan R. Storeng D. Scudiero New colorimetric cytotoxicity assay for anticancer drug screening J. Natl. Cancer Inst. 82 1990 1107 1112
20. S.Y. Sharp V. Smith S. Hobbs L.R. Kelland Lack of a role for MRP1 in platinum drug resistance in human ovarian cancer cell lines Br. J. Cancer 78 1998 175 180
21. J.S. Lazo B.R. Pitt Metallothioneins and cell death by anticancer drugs Ann. Rev. Pharmacol. Toxicol. 35 1995 635 653
22. J.T. Drummond A. Anthoney R. Brown P. Modrich Cisplatin and adriamycin resistance are associated with mutLα; and mismatch repair deficiency in an ovarian tumor cell line J. Biol. Chem. 271 1996 19645 19648
23. L.R. Kelland P. Mistry G. Abel Mechanism-related circumvention of acquired cis-diamminedichloro platinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum (IV) dicarboxylates Cancer Res. 52 1992 3857 3864
24. S. Aebi B. Kurdi-Haider R. Gordon Loss of DNA mismatch repair in acquired resistance to cisplatin Cancer Res. 56 1996 3087 3090
25. P.J. Beale P. Rogers F. Boxall S.Y. Sharp L.R. Kelland BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma Br. J. Cancer 82 2000 436 440