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Volumn 23, Issue 10, 1999, Pages 871-880

p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin

Author keywords

Acute lymphoblastic leukemia; Adriamycin; Apoptosis; Drug resistance; p53

Indexed keywords

DOXORUBICIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

EID: 0032824012     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(99)00102-2     Document Type: Article
Times cited : (37)

References (48)
  • 2
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323.
    • (1997) Cell , vol.88 , pp. 323
    • Levine, A.J.1
  • 3
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson W.G., Kastan M.B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1994;1815.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1815
    • Nelson, W.G.1    Kastan, M.B.2
  • 4
    • 0028233868 scopus 로고
    • Increase in p53 protein half-life in mouse keratinocytes following UV-B irradiation
    • Liu M., Dhanwada K.R., Birt D.F., Hecht S., Pelling J.C. Increase in p53 protein half-life in mouse keratinocytes following UV-B irradiation. Carcinogenesis. 15:1994;1089.
    • (1994) Carcinogenesis , vol.15 , pp. 1089
    • Liu, M.1    Dhanwada, K.R.2    Birt, D.F.3    Hecht, S.4    Pelling, J.C.5
  • 6
    • 0029670589 scopus 로고    scopus 로고
    • P53 signaling checkpoint arrest or apoptosis
    • Bates S., Vousden K.H. p53 signaling checkpoint arrest or apoptosis. Curr. Opin. Genet. Dev. 6:1996;12.
    • (1996) Curr. Opin. Genet. Dev. , vol.6 , pp. 12
    • Bates, S.1    Vousden, K.H.2
  • 8
    • 0027451668 scopus 로고
    • P53-dependent apoptosis modulates the cytotoxicity of anticancer agent
    • Lowe S.W., Ruley H.E., Jacks T., Housman D.E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agent. Cell. 74:1993;957.
    • (1993) Cell , vol.74 , pp. 957
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 9
    • 0025880971 scopus 로고
    • Drug-target interactions: Only the first step in the commitment to a programmed cell death?
    • Dive C., Hickman J.A. Drug-target interactions: only the first step in the commitment to a programmed cell death? Br. J. Cancer. 64:1991;192.
    • (1991) Br. J. Cancer , vol.64 , pp. 192
    • Dive, C.1    Hickman, J.A.2
  • 10
    • 0032409781 scopus 로고    scopus 로고
    • Bcl-2 family proteins
    • Reed J.C. Bcl-2 family proteins. Oncogene. 17:1998;3225.
    • (1998) Oncogene , vol.17 , pp. 3225
    • Reed, J.C.1
  • 11
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Liebermann D.A. et al. Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1994;1799.
    • (1994) Oncogene , vol.9 , pp. 1799
    • Miyashita, T.1    Krajewski, S.2    Krajewska, M.3    Wang, H.G.4    Lin, H.K.5    Liebermann, D.A.6
  • 12
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai Z., Milliman C., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:1993;609.
    • (1993) Cell , vol.74 , pp. 609
    • Oltvai, Z.1    Milliman, C.2    Korsmeyer, S.J.3
  • 13
    • 0032568208 scopus 로고    scopus 로고
    • Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents
    • Kobayashi T., Ruan S., Clodi K., Kliche K.O., Shiku H., Andreeff M. et al. Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents. Oncogene. 16:1998;1587.
    • (1998) Oncogene , vol.16 , pp. 1587
    • Kobayashi, T.1    Ruan, S.2    Clodi, K.3    Kliche, K.O.4    Shiku, H.5    Andreeff, M.6
  • 15
    • 0027441217 scopus 로고
    • Wild-type p53-triggered apoptosis is inhibited by Bcl-2 in a v-myc- induced T-cell lymphoma line
    • Wang Y., Szekely L., Okan I., Klein G., Wiman K.G. Wild-type p53-triggered apoptosis is inhibited by Bcl-2 in a v-myc- induced T-cell lymphoma line. Oncogene. 8:1993;3427.
    • (1993) Oncogene , vol.8 , pp. 3427
    • Wang, Y.1    Szekely, L.2    Okan, I.3    Klein, G.4    Wiman, K.G.5
  • 16
    • 0027389763 scopus 로고
    • Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
    • Miyashita T., Reed J.C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood. 81:1993;151.
    • (1993) Blood , vol.81 , pp. 151
    • Miyashita, T.1    Reed, J.C.2
  • 17
    • 0031929376 scopus 로고    scopus 로고
    • Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance
    • Pepper C., Hoy T., Bentley P. Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance. Leuk. Lymphoma. 28:1998;355.
    • (1998) Leuk. Lymphoma , vol.28 , pp. 355
    • Pepper, C.1    Hoy, T.2    Bentley, P.3
  • 18
    • 0027164144 scopus 로고
    • High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
    • Campos L., Rouault J.P., Sabido O., Oriol P., Roubi N., Vasselon C. et al. High expression of Bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. Blood. 81:1993;3091.
    • (1993) Blood , vol.81 , pp. 3091
    • Campos, L.1    Rouault, J.P.2    Sabido, O.3    Oriol, P.4    Roubi, N.5    Vasselon, C.6
  • 19
    • 0028954441 scopus 로고
    • Relationship of DNA topoisomerase IIα and β expression to cytotoxicity of antineoplastic agents in human acute lymphoblastic leukemia cell lines
    • Brown G.A., McPherson J.P., Gu L., Hedley D.W., Toso R., Deuchars K.L. et al. Relationship of DNA topoisomerase IIα and β expression to cytotoxicity of antineoplastic agents in human acute lymphoblastic leukemia cell lines. Cancer Res. 55:1995;78.
    • (1995) Cancer Res. , vol.55 , pp. 78
    • Brown, G.A.1    McPherson, J.P.2    Gu, L.3    Hedley, D.W.4    Toso, R.5    Deuchars, K.L.6
  • 20
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein-mediated multidrug resistance
    • Endicott J.A., Ling V. The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58:1989;137.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 137
    • Endicott, J.A.1    Ling, V.2
  • 21
    • 0023693947 scopus 로고
    • Multifactorial resistance to adriamycin: Relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia
    • Deffie A.M., Alam T., Seneviratne C., Beenken S.W., Batra J.K., Shea T.C. et al. Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia. Cancer Res. 48:1988;3595.
    • (1988) Cancer Res. , vol.48 , pp. 3595
    • Deffie, A.M.1    Alam, T.2    Seneviratne, C.3    Beenken, S.W.4    Batra, J.K.5    Shea, T.C.6
  • 22
    • 0026857985 scopus 로고
    • Multifactorial resistance of antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of topoisomerase II
    • Deffie A.M., McPherson J.P., Gupta R.S., Hedley D.W., Goldenberg G.J. Multifactorial resistance of antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of topoisomerase II. Biochem. Cell. Biol. 70:1992;354.
    • (1992) Biochem. Cell. Biol. , vol.70 , pp. 354
    • Deffie, A.M.1    McPherson, J.P.2    Gupta, R.S.3    Hedley, D.W.4    Goldenberg, G.J.5
  • 26
    • 0032572912 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia
    • Pui C.H., Evans W.E. Acute lymphoblastic leukemia. N. Engl. J. Med. 339:1998;605.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 605
    • Pui, C.H.1    Evans, W.E.2
  • 28
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor DNA complex: Understanding tumorigenic mutations
    • Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P. Crystal structure of a p53 tumor suppressor DNA complex: understanding tumorigenic mutations. Science. 265:1994;346.
    • (1994) Science , vol.265 , pp. 346
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 30
    • 0027459198 scopus 로고
    • Mdm2 expression is induced by wild type p53 activity
    • Barak Y., Juven T., Haffner R., Oren M. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12:1993;461.
    • (1993) EMBO J. , vol.12 , pp. 461
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 31
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T., Reed J.C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:1995;293.
    • (1995) Cell , vol.80 , pp. 293
    • Miyashita, T.1    Reed, J.C.2
  • 32
    • 0030752030 scopus 로고    scopus 로고
    • Database of p53 gene somatic mutations in human tumors and cell lines: Updated compilation and future prospects
    • Hainaut P., Soussi T., Shomer B., Hollstein M., Greenblatt M., Hovig E. et al. Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucl. Acids Res. 25:1997;151.
    • (1997) Nucl. Acids Res. , vol.25 , pp. 151
    • Hainaut, P.1    Soussi, T.2    Shomer, B.3    Hollstein, M.4    Greenblatt, M.5    Hovig, E.6
  • 33
    • 0027969997 scopus 로고
    • Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin
    • Taguchi M., Watanabe S., Yashima K., Murakami Y., Sekiya T., Ikeda S. Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin. J. Invest. Derm. 103:1994;500.
    • (1994) J. Invest. Derm. , vol.103 , pp. 500
    • Taguchi, M.1    Watanabe, S.2    Yashima, K.3    Murakami, Y.4    Sekiya, T.5    Ikeda, S.6
  • 34
    • 0027753935 scopus 로고
    • Mutational spectrum of the p53 gene in human small-cell lung cancer and relationship to clinicopathological data
    • Lohmann D., Putz B., Reich U., Bohm J., Prauer H., Hofler H. Mutational spectrum of the p53 gene in human small-cell lung cancer and relationship to clinicopathological data. Am. J. Path. 142:1993;907.
    • (1993) Am. J. Path. , vol.142 , pp. 907
    • Lohmann, D.1    Putz, B.2    Reich, U.3    Bohm, J.4    Prauer, H.5    Hofler, H.6
  • 35
    • 0026608857 scopus 로고
    • P53 allele losses, mutations and expression in breast cancer and their relationship to clinicopathological parameters
    • Thompson A.M., Anderson T.J., Condie A., Prosser J., Chetty U., Carter D.C. et al. p53 allele losses, mutations and expression in breast cancer and their relationship to clinicopathological parameters. Int. J. Cancer. 50:1992;528.
    • (1992) Int. J. Cancer , vol.50 , pp. 528
    • Thompson, A.M.1    Anderson, T.J.2    Condie, A.3    Prosser, J.4    Chetty, U.5    Carter, D.C.6
  • 36
    • 0027241670 scopus 로고
    • P53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin
    • Campbell C., Quinn A.G., Ro Y.-S., Angus B., Rees J.L. p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin. J. Invest. Derm. 100:1993;746.
    • (1993) J. Invest. Derm. , vol.100 , pp. 746
    • Campbell, C.1    Quinn, A.G.2    Ro, Y.-S.3    Angus, B.4    Rees, J.L.5
  • 38
    • 0031036934 scopus 로고    scopus 로고
    • Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells
    • Ogretmen B., Safa A.R. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene. 14:1997;499.
    • (1997) Oncogene , vol.14 , pp. 499
    • Ogretmen, B.1    Safa, A.R.2
  • 39
  • 40
    • 0030952902 scopus 로고    scopus 로고
    • Expression and regulation of Bcl-2, bcl-xl, and bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia
    • Findley H.W., Gu L., Yeager A.M., Zhou M. Expression and regulation of Bcl-2, bcl-xl, and bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. Blood. 89:1997;2986.
    • (1997) Blood , vol.89 , pp. 2986
    • Findley, H.W.1    Gu, L.2    Yeager, A.M.3    Zhou, M.4
  • 41
    • 0030982224 scopus 로고    scopus 로고
    • The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia
    • Salomons G.S., Brady H.J., Verwijs-Janssen M., Van Den Berg J.D., Hart A.A., Van Den Berg H. et al. The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. Int. J. Cancer. 71:1997;959.
    • (1997) Int. J. Cancer , vol.71 , pp. 959
    • Salomons, G.S.1    Brady, H.J.2    Verwijs-Janssen, M.3    Van Den Berg, J.D.4    Hart, A.A.5    Van Den Berg, H.6
  • 42
    • 0029978058 scopus 로고    scopus 로고
    • Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: Relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance
    • Thomas A., El Rouby S., Reed J.C., Krajewski S., Silber R., Potmesil M. et al. Drug-induced apoptosis in B-cell chronic lymphocytic leukemia: relationship between p53 gene mutation and bcl-2/bax proteins in drug resistance. Oncogene. 12:1996;1055.
    • (1996) Oncogene , vol.12 , pp. 1055
    • Thomas, A.1    El Rouby, S.2    Reed, J.C.3    Krajewski, S.4    Silber, R.5    Potmesil, M.6
  • 44
    • 0031059357 scopus 로고    scopus 로고
    • Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia
    • Marks D.I., Kurz B.W., Link M.P., Ng E., Shuster J.J., Lauer S.J. et al. Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 15:1997;1158.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1158
    • Marks, D.I.1    Kurz, B.W.2    Link, M.P.3    Ng, E.4    Shuster, J.J.5    Lauer, S.J.6
  • 45
    • 0030020462 scopus 로고    scopus 로고
    • High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis
    • Marks D.I., Kurz B.W., Link M.P., Ng E., Shuster J.J., Lauer S.J. et al. High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis. Blood. 87:1996;1155.
    • (1996) Blood , vol.87 , pp. 1155
    • Marks, D.I.1    Kurz, B.W.2    Link, M.P.3    Ng, E.4    Shuster, J.J.5    Lauer, S.J.6
  • 46
    • 0028091651 scopus 로고
    • Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia
    • Diccianni M.B., Hsiao J.Y., Mukherjee S., Shao L.-E., Yu A.L. Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. Blood. 84:1994;3105.
    • (1994) Blood , vol.84 , pp. 3105
    • Diccianni, M.B.1    Hsiao, J.Y.2    Mukherjee, S.3    Shao, L.-E.4    Yu, A.L.5
  • 47
    • 0028295419 scopus 로고
    • Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapsed phase
    • Hsiao M.H., Yu A.L., Yeargin J., Ku D., Haas M. Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapsed phase. Blood. 83:1994;2922.
    • (1994) Blood , vol.83 , pp. 2922
    • Hsiao, M.H.1    Yu, A.L.2    Yeargin, J.3    Ku, D.4    Haas, M.5
  • 48
    • 0030664518 scopus 로고    scopus 로고
    • Exon 5 mutations in the p53 gene in relapse childhood acute lymphoblastic leukemia
    • Blau O., Avigad S., Stark B., Kodman Y., Luria D., Cohen I.J. et al. Exon 5 mutations in the p53 gene in relapse childhood acute lymphoblastic leukemia. Leuk. Res. 21:1997;721.
    • (1997) Leuk. Res. , vol.21 , pp. 721
    • Blau, O.1    Avigad, S.2    Stark, B.3    Kodman, Y.4    Luria, D.5    Cohen, I.J.6


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