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Volumn 24, Issue 1, 2004, Pages 1-13

Von Hippel-Lindau Tumor Suppressor Protein and Hypoxia-Inducible Factor in Kidney Cancer

Author keywords

Angiogenesis; E3 ubiquitin ligase; Hypoxia; Hypoxia inducible factor; Renal clear cell carcinoma; Von Hippel Lindau disease; Von Hippel Lindau tumor suppressor protein

Indexed keywords

DNA; FIBRONECTIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; ISOENZYME; MATRIX METALLOPROTEINASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN SUBUNIT; TISSUE INHIBITOR OF METALLOPROTEINASE; UBIQUITIN PROTEIN LIGASE; VON HIPPEL LINDAU PROTEIN;

EID: 1342301598     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000075346     Document Type: Review
Times cited : (102)

References (152)
  • 2
    • 0028887421 scopus 로고
    • Identification of the von Hippel-Lindau (VHL) gene
    • Linehan WM, Lerman MI, Zbar B: Identification of the von Hippel-Lindau (VHL) gene. JAMA 1995;273:564-570.
    • (1995) JAMA , vol.273 , pp. 564-570
    • Linehan, W.M.1    Lerman, M.I.2    Zbar, B.3
  • 3
    • 0028800884 scopus 로고
    • Prevalence of microscopic lesions in grossly normal renal parenchyma from patients with von Hippel-Lindau disease, sporadic renal cell carcinoma and no renal disease: Clinical implications
    • Walther M, Lubensky I, Venzon D, Zbar B, Linehan W: Prevalence of microscopic lesions in grossly normal renal parenchyma from patients with von Hippel-Lindau disease, sporadic renal cell carcinoma and no renal disease: Clinical implications. J Urol 1995;154:2010-2014.
    • (1995) J Urol , vol.154 , pp. 2010-2014
    • Walther, M.1    Lubensky, I.2    Venzon, D.3    Zbar, B.4    Linehan, W.5
  • 4
    • 0029847090 scopus 로고    scopus 로고
    • Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients
    • Lubensky IA, Gnarra JR, Bertheau P, Walther MM, Linehan WM, Zhuang Z: Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel-Lindau disease patients. Am J Pathol 1996;149:2089-2094.
    • (1996) Am J Pathol , vol.149 , pp. 2089-2094
    • Lubensky, I.A.1    Gnarra, J.R.2    Bertheau, P.3    Walther, M.M.4    Linehan, W.M.5    Zhuang, Z.6
  • 8
    • 0023181644 scopus 로고
    • Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
    • Zbar B, Brauch H, Talmadge C, Linehan M: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 1987;327:721-724.
    • (1987) Nature , vol.327 , pp. 721-724
    • Zbar, B.1    Brauch, H.2    Talmadge, C.3    Linehan, M.4
  • 9
    • 0024517466 scopus 로고
    • Tissue-specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal-cell carcinomas
    • Kovacs G, Brusa P, De Riese W: Tissue-specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal-cell carcinomas. Int J Cancer 1989;43:422-427.
    • (1989) Int J Cancer , vol.43 , pp. 422-427
    • Kovacs, G.1    Brusa, P.2    De Riese, W.3
  • 12
    • 0037683087 scopus 로고    scopus 로고
    • Tumour suppressors hamartin and tuberin: Intracellular signalling
    • Krymskaya VP: Tumour suppressors hamartin and tuberin: Intracellular signalling. Cell Signal 2003;15:729-739.
    • (2003) Cell Signal , vol.15 , pp. 729-739
    • Krymskaya, V.P.1
  • 15
    • 0037364314 scopus 로고    scopus 로고
    • A role for mitochondrial enzymes in inherited neoplasia and beyond
    • Eng C, Kiuru M, Fernandez MJ, Aaltonen LA: A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer 2003;3:193-202.
    • (2003) Nat Rev Cancer , vol.3 , pp. 193-202
    • Eng, C.1    Kiuru, M.2    Fernandez, M.J.3    Aaltonen, L.A.4
  • 18
    • 0036897914 scopus 로고    scopus 로고
    • Renal medullary carcinoma: Clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications
    • Swartz MA, Karth J, Schneider DT, Rodriguez R, Beckwith JB, Perlman EJ: Renal medullary carcinoma: Clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications. Urology 2002;60:1083-1089.
    • (2002) Urology , vol.60 , pp. 1083-1089
    • Swartz, M.A.1    Karth, J.2    Schneider, D.T.3    Rodriguez, R.4    Beckwith, J.B.5    Perlman, E.J.6
  • 19
    • 0029833872 scopus 로고    scopus 로고
    • Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review
    • Lynch HT, Smyrk T: Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review. Cancer 1996;78:1149-1167.
    • (1996) Cancer , vol.78 , pp. 1149-1167
    • Lynch, H.T.1    Smyrk, T.2
  • 20
    • 0034065483 scopus 로고    scopus 로고
    • Hereditary nonpolyposis colorectal cancer
    • Lynch HT, Lynch JF: Hereditary nonpolyposis colorectal cancer. Semin Surg Oncol 2000;18:305-313.
    • (2000) Semin Surg Oncol , vol.18 , pp. 305-313
    • Lynch, H.T.1    Lynch, J.F.2
  • 21
    • 0031445126 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Baltimore
    • Maher E, Kaelin WG: Von Hippel-Lindau disease. Medicine (Baltimore) 1997;76:381-391.
    • (1997) Medicine , vol.76 , pp. 381-391
    • Maher, E.1    Kaelin, W.G.2
  • 22
    • 0002906610 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Fisher DE (ed). Clifton, Humana Press
    • Iliopoulos O, Kaelin WG: Von Hippel-Lindau disease; in Fisher DE (ed): Hereditary Cancer. Clifton, Humana Press, 2000.
    • (2000) Hereditary Cancer
    • Iliopoulos, O.1    Kaelin, W.G.2
  • 24
    • 0028874469 scopus 로고
    • Clinical features and molecular genetics of von Hippel-Lindau disease
    • Maher ER, Webster AR, Moore AT: Clinical features and molecular genetics of von Hippel-Lindau disease. Ophthalmic Genet 1995;16:79-84.
    • (1995) Ophthalmic Genet , vol.16 , pp. 79-84
    • Maher, E.R.1    Webster, A.R.2    Moore, A.T.3
  • 25
    • 0035253381 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein
    • Ivan M, Kaelin WG Jr: The von Hippel-Lindau tumor suppressor protein. Curr Opin Genet Dev 2001;11:27-34.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 27-34
    • Ivan, M.1    Kaelin Jr., W.G.2
  • 28
    • 0344592621 scopus 로고    scopus 로고
    • Playing tag with HIF: The VHL story
    • Leung SK, Ohh M: Playing tag with HIF: The VHL story. J Biomed Biotechnol 2002;2:131-135.
    • (2002) J Biomed Biotechnol , vol.2 , pp. 131-135
    • Leung, S.K.1    Ohh, M.2
  • 29
    • 0035835819 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene
    • Kondo K, Kaelin WG Jr: The von Hippel-Lindau tumor suppressor gene. Exp Cell Res 2001;264:117-125.
    • (2001) Exp Cell Res , vol.264 , pp. 117-125
    • Kondo, K.1    Kaelin Jr., W.G.2
  • 31
    • 0033051828 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: New perspectives
    • Ohh M, Kaelin WG Jr: The von Hippel-Lindau tumour suppressor protein: New perspectives. Mol Med Today 1999;5:257-263.
    • (1999) Mol Med Today , vol.5 , pp. 257-263
    • Ohh, M.1    Kaelin Jr., W.G.2
  • 34
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin WG Jr: Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002;2:673-682.
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin Jr., W.G.1
  • 37
    • 0029859624 scopus 로고    scopus 로고
    • Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene
    • Renbaum P, Duh FM, Latif F, Zbar B, Lerman M, Kuzmin I: Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene. Hum Genet 1996;98:666-671.
    • (1996) Hum Genet , vol.98 , pp. 666-671
    • Renbaum, P.1    Duh, F.M.2    Latif, F.3    Zbar, B.4    Lerman, M.5    Kuzmin, I.6
  • 39
    • 0032555217 scopus 로고    scopus 로고
    • A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
    • Schoenfeld A, Davidowitz EJ, Burk RD: A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci USA 1998;95:8817-8822.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8817-8822
    • Schoenfeld, A.1    Davidowitz, E.J.2    Burk, R.D.3
  • 40
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • Iliopoulos O, Ohh M, Kaelin W: pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 1998;95:11661-11666.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11661-11666
    • Iliopoulos, O.1    Ohh, M.2    Kaelin, W.3
  • 41
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
    • Blankenship C, Naglich J, Whaley J, Seizinger B, Kley N: Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 1999;18:1529-1535.
    • (1999) Oncogene , vol.18 , pp. 1529-1535
    • Blankenship, C.1    Naglich, J.2    Whaley, J.3    Seizinger, B.4    Kley, N.5
  • 42
    • 0029090338 scopus 로고
    • Tumor suppression by the human von Hippel-Lindau gene product
    • Iliopoulos O, Kibel A, Gray S, Kaelin WG: Tumor suppression by the human von Hippel-Lindau gene product. Nat Med 1995;1:822-826.
    • (1995) Nat Med , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin, W.G.4
  • 45
  • 46
    • 0029926989 scopus 로고    scopus 로고
    • Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis
    • Richards F, Schofield P, Fleming S, Maher E: Expression of the von Hippel-Lindau disease tumour suppressor gene during human embryogenesis. Hum Mol Genet 1996;5:639-644.
    • (1996) Hum Mol Genet , vol.5 , pp. 639-644
    • Richards, F.1    Schofield, P.2    Fleming, S.3    Maher, E.4
  • 48
    • 0035852668 scopus 로고    scopus 로고
    • Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
    • Haase VH, Glickman JN, Socolovsky M, Jaenisch R: Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci USA 2001;98:1583-1588.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1583-1588
    • Haase, V.H.1    Glickman, J.N.2    Socolovsky, M.3    Jaenisch, R.4
  • 50
    • 0030958304 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
    • Vortmeyer A, Gnarra J, Emmert-Buck M, Katz D, Linehan W, Oldfield E, Zhuang Z: Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum Pathol 1997;28:540-543.
    • (1997) Hum Pathol , vol.28 , pp. 540-543
    • Vortmeyer, A.1    Gnarra, J.2    Emmert-Buck, M.3    Katz, D.4    Linehan, W.5    Oldfield, E.6    Zhuang, Z.7
  • 51
    • 0032728791 scopus 로고    scopus 로고
    • Angiogenic histogenesis of stromal cells in hemangioblastoma: Ultrastructural and immunohistochemical study
    • Lach B, Gregor A, Rippstein P, Omulecka A: Angiogenic histogenesis of stromal cells in hemangioblastoma: Ultrastructural and immunohistochemical study. Ultrastruct Pathol 1999;23:299-310.
    • (1999) Ultrastruct Pathol , vol.23 , pp. 299-310
    • Lach, B.1    Gregor, A.2    Rippstein, P.3    Omulecka, A.4
  • 52
    • 0030948396 scopus 로고    scopus 로고
    • Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues
    • Corless CL, Kibel A, Iliopoulos O, Kaelin WG Jr: Immunostaining of the von Hippel-Lindau gene product (pVHL) in normal and neoplastic human tissues. Hum Pathol 1997;28:459-464.
    • (1997) Hum Pathol , vol.28 , pp. 459-464
    • Corless, C.L.1    Kibel, A.2    Iliopoulos, O.3    Kaelin Jr., W.G.4
  • 55
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD: The von Hippel-Lindau tumor suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci USA 1997;94:2156-2161.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2156-2161
    • Pause, A.1    Lee, S.2    Worrell, R.A.3    Chen, D.Y.4    Burgess, W.H.5    Linehan, W.M.6    Klausner, R.D.7
  • 58
    • 0029147430 scopus 로고
    • Binding of the von Hippel-Lindau tumor suppressor protein to elongins B and C
    • Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG Jr: Binding of the von Hippel-Lindau tumor suppressor protein to elongins B and C. Science 1995;269:1444-1446.
    • (1995) Science , vol.269 , pp. 1444-1446
    • Kibel, A.1    Iliopoulos, O.2    DeCaprio, J.A.3    Kaelin Jr., W.G.4
  • 60
    • 0031907152 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
    • Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG Jr: Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol 1998;18:732-741.
    • (1998) Mol Cell Biol , vol.18 , pp. 732-741
    • Lonergan, K.M.1    Iliopoulos, O.2    Ohh, M.3    Kamura, T.4    Conaway, R.C.5    Conaway, J.W.6    Kaelin Jr., W.G.7
  • 61
    • 0033279836 scopus 로고    scopus 로고
    • SCF and Cullin/Ring H2-based ubiquitin ligases
    • Deshaies R: SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 1999;15:435-467.
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 435-467
    • Deshaies, R.1
  • 62
    • 0034065822 scopus 로고    scopus 로고
    • Ubiquitin-mediated proteolysis: Biological regulation via destruction
    • Ciechanover A, Orian A, Schwartz AL: Ubiquitin-mediated proteolysis: Biological regulation via destruction. Bioessays 2000;22:442-451.
    • (2000) Bioessays , vol.22 , pp. 442-451
    • Ciechanover, A.1    Orian, A.2    Schwartz, A.L.3
  • 63
    • 0033578405 scopus 로고    scopus 로고
    • Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
    • Pause A, Peterson B, Schaffar G, Stearman R, Klausner R: Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Proc Natl Acad Sci USA 1999;96:9533-9538.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9533-9538
    • Pause, A.1    Peterson, B.2    Schaffar, G.3    Stearman, R.4    Klausner, R.5
  • 65
    • 0028826589 scopus 로고
    • Cellular proteins that bind the von Hippel-Lindau disease gene product: Mapping of binding domains and the effect of missense mutations
    • Kishida T, Stackhouse TM, Chen F, Lerman MI, Zbar B: Cellular proteins that bind the von Hippel-Lindau disease gene product: Mapping of binding domains and the effect of missense mutations. Cancer Res 1995;55:4544-4548.
    • (1995) Cancer Res , vol.55 , pp. 4544-4548
    • Kishida, T.1    Stackhouse, T.M.2    Chen, F.3    Lerman, M.I.4    Zbar, B.5
  • 66
    • 0033120027 scopus 로고    scopus 로고
    • ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    • Ohta T, Michel JJ, Schottelius AJ, Xiaong Y: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 1999;3:535-541.
    • (1999) Mol Cell , vol.3 , pp. 535-541
    • Ohta, T.1    Michel, J.J.2    Schottelius, A.J.3    Xiaong, Y.4
  • 67
    • 0033120593 scopus 로고    scopus 로고
    • Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of 1RBBB
    • Tan P, Fuchs SY, Chen A, Wu K, Gomez C, Ronai Z, Pan ZQ: Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of 1RBBB. Mol Cell 1999;3:527-533.
    • (1999) Mol Cell , vol.3 , pp. 527-533
    • Tan, P.1    Fuchs, S.Y.2    Chen, A.3    Wu, K.4    Gomez, C.5    Ronai, Z.6    Pan, Z.Q.7
  • 69
    • 0030602813 scopus 로고    scopus 로고
    • SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    • Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ: SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 1996;86:263-274.
    • (1996) Cell , vol.86 , pp. 263-274
    • Bai, C.1    Sen, P.2    Hofmann, K.3    Ma, L.4    Goebl, M.5    Harper, J.W.6    Elledge, S.J.7
  • 70
    • 0033574737 scopus 로고    scopus 로고
    • Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function
    • Stebbins CE, Kaelin WG Jr, Pavletich NP: Structure of the VHL-elonginC-elonginB complex: Implications for VHL tumor suppressor function. Science 1999;284:455-461.
    • (1999) Science , vol.284 , pp. 455-461
    • Stebbins, C.E.1    Kaelin Jr., W.G.2    Pavletich, N.P.3
  • 71
    • 0036176874 scopus 로고    scopus 로고
    • Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
    • Hansen WJ, Ohh M, Moslehi J, Kondo K, Kaelin WG Jr, Welch WJ: Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Mol Cell Biol 2002;22:1947-1960.
    • (2002) Mol Cell Biol , vol.22 , pp. 1947-1960
    • Hansen, W.J.1    Ohh, M.2    Moslehi, J.3    Kondo, K.4    Kaelin Jr., W.G.5    Welch, W.J.6
  • 74
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 1999;15:551-578.
    • (1999) Annu Rev Cell Dev Biol , vol.15 , pp. 551-578
    • Semenza, G.1
  • 75
    • 0033529656 scopus 로고    scopus 로고
    • Perspectives on oxygen sensing
    • Semenza G: Perspectives on oxygen sensing. Cell 1999;98:281-284.
    • (1999) Cell , vol.98 , pp. 281-284
    • Semenza, G.1
  • 76
    • 0034107952 scopus 로고    scopus 로고
    • Mammalian oxygen sensing, signalling and gene regulation
    • Wenger R: Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol 2000;203:1253-1263.
    • (2000) J Exp Biol , vol.203 , pp. 1253-1263
    • Wenger, R.1
  • 77
    • 0033007795 scopus 로고    scopus 로고
    • Oxygen sensing and signaling: Impact on the regulation of physiologically important genes
    • Zhu H, Bunn F: Oxygen sensing and signaling: Impact on the regulation of physiologically important genes. Respir Physiol 1999;115:239-247.
    • (1999) Respir Physiol , vol.115 , pp. 239-247
    • Zhu, H.1    Bunn, F.2
  • 78
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener CM, Booth G, Semenza GL: In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun 1996;225:485-488.
    • (1996) Biochem Biophys Res Commun , vol.225 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 79
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA: Characterization of a subset of the basic-helix-loop-helix- PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997;272:8581-8593.
    • (1997) J Biol Chem , vol.272 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 82
    • 0033118983 scopus 로고    scopus 로고
    • Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
    • Ema M, Hirota K, Mimura J, Abe H, Yodoi J, Sogawa K, Poellinger L, Fujii-Kuriyama Y: Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300. EMBO J 1999;18:1905-1914.
    • (1999) EMBO J , vol.18 , pp. 1905-1914
    • Ema, M.1    Hirota, K.2    Mimura, J.3    Abe, H.4    Yodoi, J.5    Sogawa, K.6    Poellinger, L.7    Fujii-Kuriyama, Y.8
  • 83
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997;11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 84
    • 0031000736 scopus 로고    scopus 로고
    • A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development
    • Ema M, Taya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y: A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. Proc Natl Acad Sci USA 1997;94:4273-4278.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4273-4278
    • Ema, M.1    Taya, S.2    Yokotani, N.3    Sogawa, K.4    Matsuda, Y.5    Fujii-Kuriyama, Y.6
  • 85
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling
    • Peng J, Zhang L, Drysdale L, Fong GH: The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci USA 2000;97:8386-8391.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 87
    • 0037031808 scopus 로고    scopus 로고
    • Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
    • Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L: Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem 2002;277:32405-32408.
    • (2002) J Biol Chem , vol.277 , pp. 32405-32408
    • Makino, Y.1    Kanopka, A.2    Wilson, W.J.3    Tanaka, H.4    Poellinger, L.5
  • 88
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL: Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 1995;270:1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 89
    • 0035812789 scopus 로고    scopus 로고
    • Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: Suppression of HIF-mediated gene expression by HIF-3alpha
    • Hara S, Hamada J, Kobayashi C, Kondo Y, Imura N: Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: Suppression of HIF-mediated gene expression by HIF-3alpha. Biochem Biophys Res Commun 2001;287:808-813.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 808-813
    • Hara, S.1    Hamada, J.2    Kobayashi, C.3    Kondo, Y.4    Imura, N.5
  • 90
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
    • Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA: Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 1998;7:205-213.
    • (1998) Gene Expr , vol.7 , pp. 205-213
    • Gu, Y.Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 91
    • 0035812772 scopus 로고    scopus 로고
    • 2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus
    • 2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus [letter; comment]. Cell 2001;107:1-3.
    • (2001) Cell , vol.107 , pp. 1-3
    • Semenza, G.L.1
  • 92
    • 0029928689 scopus 로고    scopus 로고
    • cDNA cloning and tissue-specific expression of a novel basic helix-loophelix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)
    • Hirose K, Morita M, Ema M, Mimura J, Hamada H, Fujii H, Saijo Y, Gotoh O, Sogawa K, Fujii-Kuriyama Y: cDNA cloning and tissue-specific expression of a novel basic helix-loophelix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol 1996;16:1706-1713.
    • (1996) Mol Cell Biol , vol.16 , pp. 1706-1713
    • Hirose, K.1    Morita, M.2    Ema, M.3    Mimura, J.4    Hamada, H.5    Fujii, H.6    Saijo, Y.7    Gotoh, O.8    Sogawa, K.9    Fujii-Kuriyama, Y.10
  • 95
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein
    • Tanimoto K, Makino Y, Pereira T, Poellinger L: Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 2000;19:4298-4309.
    • (2000) EMBO J , vol.19 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 96
    • 0034712939 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    • Sutter C, Laughner E, Semenza G: Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 2000;97:4748-4753.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4748-4753
    • Sutter, C.1    Laughner, E.2    Semenza, G.3
  • 97
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio P, Wilson W, O'Brien S, Makino Y, Poellinger L: Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem 1999;274:6519-6525.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.1    Wilson, W.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 98
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J: Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 1997;272:22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 100
    • 0033526781 scopus 로고    scopus 로고
    • Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins
    • Srinivas V, Zhang L, Zhu X, Caro J: Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins. Biochem Biophys Res Commun 1999;260:557-561.
    • (1999) Biochem Biophys Res Commun , vol.260 , pp. 557-561
    • Srinivas, V.1    Zhang, L.2    Zhu, X.3    Caro, J.4
  • 101
    • 0033593219 scopus 로고    scopus 로고
    • Oxygen-regulated and transactivation domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α
    • O'Rourke J, Tian YM, Ratcliffe PJ, Pugh CW: Oxygen-regulated and transactivation domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1α. J Biol Chem 1999;274:2060-2071.
    • (1999) J Biol Chem , vol.274 , pp. 2060-2071
    • O'Rourke, J.1    Tian, Y.M.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 104
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    • Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ: Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J 2001;20:5197-5206.
    • (2001) EMBO J , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 106
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL: A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 107
    • 0037131159 scopus 로고    scopus 로고
    • Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
    • Huang J, Zhao Q, Mooney SM, Lee FS: Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3. J Biol Chem 2002;277:39792-39800.
    • (2002) J Biol Chem , vol.277 , pp. 39792-39800
    • Huang, J.1    Zhao, Q.2    Mooney, S.M.3    Lee, F.S.4
  • 108
    • 0141643358 scopus 로고    scopus 로고
    • Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation
    • D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C: Hypoxia up-regulates prolyl hydroxylase activity: A feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 2003;278:38183-38187.
    • (2003) J Biol Chem , vol.278 , pp. 38183-38187
    • D'Angelo, G.1    Duplan, E.2    Boyer, N.3    Vigne, P.4    Frelin, C.5
  • 109
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1: Definition of regulatory domains within the alpha subunit
    • Pugh C, O'Rourke J, Nagao M, Gleadle J, Ratcliffe P: Activation of hypoxia-inducible factor-1: Definition of regulatory domains within the alpha subunit. J Biol Chem 1997;272:11205-11214.
    • (1997) J Biol Chem , vol.272 , pp. 11205-11214
    • Pugh, C.1    O'Rourke, J.2    Nagao, M.3    Gleadle, J.4    Ratcliffe, P.5
  • 110
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
    • Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L: Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 1998;17:6573-6586.
    • (1998) EMBO J , vol.17 , pp. 6573-6586
    • Kallio, P.J.1    Okamoto, K.2    O'Brien, S.3    Carrero, P.4    Makino, Y.5    Tanaka, H.6    Poellinger, L.7
  • 111
    • 0033986948 scopus 로고    scopus 로고
    • Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
    • Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L: Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol 2000;20:402-415.
    • (2000) Mol Cell Biol , vol.20 , pp. 402-415
    • Carrero, P.1    Okamoto, K.2    Coumailleau, P.3    O'Brien, S.4    Tanaka, H.5    Poellinger, L.6
  • 113
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML: Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 2002;295:858-861.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 114
    • 0030787469 scopus 로고    scopus 로고
    • Transactivation and inhibitory domains of hypoxia-inducible factor 1α
    • Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL: Transactivation and inhibitory domains of hypoxia-inducible factor 1α. J Biol Chem 1997;272:19253-19260.
    • (1997) J Biol Chem , vol.272 , pp. 19253-19260
    • Jiang, B.H.1    Zheng, J.Z.2    Leung, S.W.3    Roe, R.4    Semenza, G.L.5
  • 115
    • 0035932375 scopus 로고    scopus 로고
    • A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha)
    • Luo JC, Shibuya M: A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene 2001;20:1435-1444.
    • (2001) Oncogene , vol.20 , pp. 1435-1444
    • Luo, J.C.1    Shibuya, M.2
  • 116
    • 0032579265 scopus 로고    scopus 로고
    • Nuclear localization and export signals of the human aryl hydrocarbon receptor
    • Ikuta T, Eguchi H, Tachibana T, Yoneda Y, Kawajiri K: Nuclear localization and export signals of the human aryl hydrocarbon receptor. J Biol Chem 1998;273:2895-2904.
    • (1998) J Biol Chem , vol.273 , pp. 2895-2904
    • Ikuta, T.1    Eguchi, H.2    Tachibana, T.3    Yoneda, Y.4    Kawajiri, K.5
  • 117
    • 0037470245 scopus 로고    scopus 로고
    • Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)
    • Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, et al: Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem 2003;278:7520-7530.
    • (2003) J Biol Chem , vol.278 , pp. 7520-7530
    • Elvert, G.1    Kappel, A.2    Heidenreich, R.3    Englmeier, U.4    Lanz, S.5    Acker, T.6    Rauter, M.7    Plate, K.8    Sieweke, M.9    Breier, G.10
  • 118
    • 0037389490 scopus 로고    scopus 로고
    • Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors
    • Schnell PO, Ignacak ML, Bauer AL, Striet JB, Paulding WR, Czyzyk-Krzeska MF: Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors. J Neurochem 2003;85:483-491.
    • (2003) J Neurochem , vol.85 , pp. 483-491
    • Schnell, P.O.1    Ignacak, M.L.2    Bauer, A.L.3    Striet, J.B.4    Paulding, W.R.5    Czyzyk-Krzeska, M.F.6
  • 121
    • 0033587146 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits
    • Maxwell P, Weisner M, Chang GW, Clifford S, Vaux E, Pugh C, Maher E, Ratcliffe P: The von Hippel-Lindau gene product is necessary for oxgyen-dependent proteolysis of hypoxia-inducible factor α subunits. Nature 1999;399:271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.1    Weisner, M.2    Chang, G.W.3    Clifford, S.4    Vaux, E.5    Pugh, C.6    Maher, E.7    Ratcliffe, P.8
  • 124
    • 0035852630 scopus 로고    scopus 로고
    • Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
    • de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S: Role of transforming growth factor-alpha in von Hippel-Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA 2001;98:1387-1392.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1387-1392
    • De Paulsen, N.1    Brychzy, A.2    Fournier, M.C.3    Klausner, R.D.4    Gnarra, J.R.5    Pause, A.6    Lee, S.7
  • 125
    • 0031964099 scopus 로고    scopus 로고
    • Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor
    • Knebelmann B, Ananth S, Cohen H, Sukhatme V: Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998;58:226-231.
    • (1998) Cancer Res , vol.58 , pp. 226-231
    • Knebelmann, B.1    Ananth, S.2    Cohen, H.3    Sukhatme, V.4
  • 126
    • 0026399678 scopus 로고
    • Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells
    • Humes H, Beals T, Cieslinski D, Sanchez I, Page T: Effects of transforming growth factor-beta, transforming growth factor-alpha, and other growth factors on renal proximal tubule cells. Lab Invest 1991;64:538-545.
    • (1991) Lab Invest , vol.64 , pp. 538-545
    • Humes, H.1    Beals, T.2    Cieslinski, D.3    Sanchez, I.4    Page, T.5
  • 127
  • 128
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-246.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr., W.G.5
  • 130
    • 0037085456 scopus 로고    scopus 로고
    • Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
    • Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G: Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 2002;277:4656-4662.
    • (2002) J Biol Chem , vol.277 , pp. 4656-4662
    • Li, Z.1    Na, X.2    Wang, D.3    Schoen, S.R.4    Messing, E.M.5    Wu, G.6
  • 133
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signalling in cell adhesion
    • Hynes R: Integrins: Versatility, modulation, and signalling in cell adhesion. Cell 1992;69:11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.1
  • 134
    • 0035336706 scopus 로고    scopus 로고
    • Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
    • Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG Jr: Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet 2001;10:1019-1027.
    • (2001) Hum Mol Genet , vol.10 , pp. 1019-1027
    • Hoffman, M.A.1    Ohh, M.2    Yang, H.3    Klco, J.M.4    Ivan, M.5    Kaelin Jr., W.G.6
  • 135
    • 0032211360 scopus 로고    scopus 로고
    • Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids
    • Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel R: Von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res 1998;58:4957-4962.
    • (1998) Cancer Res , vol.58 , pp. 4957-4962
    • Lieubeau-Teillet, B.1    Rak, J.2    Jothy, S.3    Iliopoulos, O.4    Kaelin, W.5    Kerbel, R.6
  • 136
  • 138
    • 0036237781 scopus 로고    scopus 로고
    • Von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter
    • Rafty LA, Khachigian LM: Von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter. J Cell Biochem 2002;85:490-495.
    • (2002) J Cell Biochem , vol.85 , pp. 490-495
    • Rafty, L.A.1    Khachigian, L.M.2
  • 139
    • 0037446951 scopus 로고    scopus 로고
    • The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity
    • Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G: The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity. EMBO J 2003;22:1857-1867.
    • (2003) EMBO J , vol.22 , pp. 1857-1867
    • Li, Z.1    Wang, D.2    Na, X.3    Schoen, S.R.4    Messing, E.M.5    Wu, G.6
  • 140
    • 0030479071 scopus 로고    scopus 로고
    • A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins
    • Kim SS, Chen YM, O'Leary E, Witzgall R, Vidal M, Bonventre JV: A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins. Proc Natl Acad Sci USA 1996;93:15299-15304.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15299-15304
    • Kim, S.S.1    Chen, Y.M.2    O'Leary, E.3    Witzgall, R.4    Vidal, M.5    Bonventre, J.V.6
  • 142
    • 0030459738 scopus 로고    scopus 로고
    • Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1
    • Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W: Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1. Nucleic Acids Res 1996;24:4859-4867.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4859-4867
    • Moosmann, P.1    Georgiev, O.2    Le Douarin, B.3    Bourquin, J.P.4    Schaffner, W.5
  • 143
    • 0034704078 scopus 로고    scopus 로고
    • A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
    • Underhill C, Qutob MS, Yee SP, Torchia J: A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J Biol Chem 2000;275:40463-40470.
    • (2000) J Biol Chem , vol.275 , pp. 40463-40470
    • Underhill, C.1    Qutob, M.S.2    Yee, S.P.3    Torchia, J.4
  • 144
    • 0033838255 scopus 로고    scopus 로고
    • Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
    • Lechner MS, Begg GE, Speicher DW, Rauscher FJ 3rd: Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol Cell Biol 2000;20:6449-6465.
    • (2000) Mol Cell Biol , vol.20 , pp. 6449-6465
    • Lechner, M.S.1    Begg, G.E.2    Speicher, D.W.3    Rauscher III, F.J.4
  • 146
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL: HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 2000;88:1474-1480.
    • (2000) J Appl Physiol , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 148
    • 0036645091 scopus 로고    scopus 로고
    • Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
    • Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER: Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res 2002;62:3803-3811.
    • (2002) Cancer Res , vol.62 , pp. 3803-3811
    • Zatyka, M.1    Da Silva, N.F.2    Clifford, S.C.3    Morris, M.R.4    Wiesener, M.S.5    Eckardt, K.U.6    Houlston, R.S.7    Richards, F.M.8    Latif, F.9    Maher, E.R.10
  • 149
    • 0032477788 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
    • Pause A, Lee S, Lonergan KM, Klausner RD: The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proc Natl Acad Sci USA 1998;95:993-998.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 993-998
    • Pause, A.1    Lee, S.2    Lonergan, K.M.3    Klausner, R.D.4
  • 150
    • 0032583530 scopus 로고    scopus 로고
    • Recombinant adenovirus expressing von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1
    • Kim M, Katayose Y, Li Q, Rakkar A, Li Z, Hwang S, Katayose D, Trepel J, Cowan K, Seth P: Recombinant adenovirus expressing von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1. Biochem Biophys Res Commun 1998;253:672-677.
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 672-677
    • Kim, M.1    Katayose, Y.2    Li, Q.3    Rakkar, A.4    Li, Z.5    Hwang, S.6    Katayose, D.7    Trepel, J.8    Cowan, K.9    Seth, P.10
  • 152
    • 0037223823 scopus 로고    scopus 로고
    • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    • Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W: Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol 2003;5:64-70.
    • (2003) Nat Cell Biol , vol.5 , pp. 64-70
    • Hergovich, A.1    Lisztwan, J.2    Barry, R.3    Ballschmieter, P.4    Krek, W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.