The von Hippel-Lindau tumour suppressor protein: New perspectives

Molecular Medicine Today

Volumn 5, Issue 6, 1999, Pages 257-263

  Ohh, M ^a   Kaelin W G , Jr ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; GENE PRODUCT; PROTEIN;

ANGIOGENESIS; CELL CYCLE; COMPLEX FORMATION; EXTRACELLULAR MATRIX; GENE MUTATION; REVIEW; SEQUENCE HOMOLOGY; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

EID: 0033051828     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(99)01481-1     Document Type: Review

References (50)

1. C.E. Stebbins W.G. Kaelin N.P. Pavletich Structure of the VHL-ElonginC-elonginB complex: implications for VHL tumor suppressor function Science 284 1999 455 461
2. T. Kamura Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase Science 284 1999 657 661
3. T. Ohta ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity Mol. Cell 3 1999 535 541
4. P. Tan Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyse the ubiquitination of lkBa Mol. Cell 3 1999 527 533
5. D. Skowyra Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and rbx1 Science 284 1999 662 665
6. E. Maher W.G. Kaelin von Hippel–Lindau disease Medicine 76 1997 381 391
7. F. Latif Identification of the von Hippel–Lindau disease tumor suppressor gene Science 260 1993 1317 1320
8. P. Kessler Expression of the von Hippel–Lindau tumor-suppressor gene, VHL , in human fetal kidney and during mouse embryogenesis Mol. Med. 1 1995 457 466
9. F. Richards P. Schofield S. Fleming E. Maher Expression of the von Hippel–Lindau disease tumour suppressor gene during human embryogenesis Hum. Mol. Genet. 5 1996 639 644
10. J.R. Gnarra Mutations of the VHL tumour suppressor gene in renal carcinoma Nat. Genet. 7 1994 85 90
11. I.A. Lubensky Allelic deletions of the VHL gene detected in multiple microscopic clear cell renal lesions in von Hippel–Lindau disease patients Am. J. Pathol. 149 1996 2089 2094
12. K. Kinzler B. Vogelstein Lessons from hereditary colorectal cancer Cell 87 1996 159 170
13. J. Gnarra Defective placental vasculogenesis causes embryonic lethality in VHL -deficient mice Proc. Natl. Acad. Sci. U. S. A. 94 1997 9102 9107
14. C. Stolle Improved detection of germline mutations in the von Hippel–Lindau disease tumor suppressor gene Hum. Mutat. 12 1998 417 423
15. B. Zbar Germline mutations in the von Hippel–Lindau (VHL) gene in families from North America, Europe, and Japan Hum. Mutat. 8 1996 348 357
16. A. Schoenfeld E. Davidowitz R. Burk A second major native von Hippel–Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor Proc. Natl. Acad. Sci. U. S. A. 95 1998 8817 8822
17. O. Iliopoulos M. Ohh W. Kaelin pVHL19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation Proc. Natl. Acad. Sci. U. S. A. 95 1998 11661 11666
18. M. Kozak At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells J. Mol. Biol. 196 1987 947 950
19. M. Kozak The scanning model for translation: an update J. Cell Biol. 108 1989 229 241
20. O. Iliopoulos A. Kibel S. Gray W.G. Kaelin Tumor suppression by the human von Hippel–Lindau gene product Nat. Med. 1 1995 822 826
21. J.R. Gnarra Post-transcriptional regulation of vascular endothelial growth factor mRNA by the VHL tumor suppressor gene product Proc. Natl. Acad. Sci. U. S. A. 93 1996 10589 10594
22. M. Ohh The von Hippel–Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix Mol. Cell 1 1998 959 968
23. A. Pause The von Hippel–Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins Proc. Natl. Acad. Sci. U. S. A. 94 1997 2156 2161
24. S. Lee Nuclear/cytoplasmic localization of the von Hippel–Lindau tumor suppressor gene product is determined by cell density Proc. Natl. Acad. Sci. U. S. A. 93 1996 1770 1775
25. T. Aso W.S. Lane J.W. Conaway R.C. Conaway Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II Science 269 1995 1439 1443
26. A. Kibel Binding of the von Hippel–Lindau tumor suppressor protein to elongin B and C Science 269 1995 1444 1446
27. T. Aso The inducible elongin A elongation activation domain: structure, function and interaction with elongin BC complex EMBO J. 15 1996 101 110
28. D.R. Duan Inhibition of transcriptional elongation by the VHL tumor suppressor protein Science 269 1995 1402 1406
29. T. Kamura The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families Genes Dev. 12 1998 3872 3881
30. K.M. Lonergan Regulation of hypoxia-inducible mRNAs by the von Hippel–Lindau protein requires binding to complexes containing elongins B/C and Cul2 Mol. Cell Biol. 18 1998 732 741
31. E.T. Kipreos Cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family Cell 85 1996 829 839
32. J-M. Peters SCF and APC: the Yin and Yang of cell cycle regulated proteolysis Curr. Opin. Cell Biol. 10 1998 759 768
33. D. Skowyra F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin–ligase complex Cell 91 1997 209 219
34. J. Lisztwan Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45 (SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34–SCF pathway EMBO J. 17 1998 368 383
35. C. Bai Skp1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box Cell 86 1996 263 274
36. R. King R. Deshaies J-M. Peters M.W. Kirschner How proteolysis drives the cell cycle Science 274 1996 1652 1659
37. M. Gorospe Protective function of pVHL against impaired protein processing in renal carcinoma cells Mol. Cell Biol. 19 1999 1289 1300
38. A. Pause S. Lee K.M. Lonergan R.D. Klausner The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal Proc. Natl. Acad. Sci. U. S. A. 95 1998 993 998
39. R. Hynes Integrins: versatility, modulation, and signalling in cell adhesion Cell 69 1992 11 25
40. R. Pasqualini A polymeric form of fibronectin has antimetastatic effects against multiple tumor types Nat. Med. 2 1996 1197 1203
41. B. Lieubeau-Teillet von Hippel–Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids Cancer Res. 58 1998 4957 4962
42. R.R. Kopito ER quality control: the cytoplasmic connection Cell 88 1997 427 430
43. H. Tsuchiya T. Iseda O. Hino Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product Cancer Res. 56 1996 2881 2885
44. D. Mukhopadhyay The von Hippel–Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity Mol. Cell Biol. 17 1997 5629 5639
45. S. Pal K. Claffey H. Dvorak D. Mukhopadhyay The von Hippel–Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways J. Biol. Chem. 272 1997 27509 27512
46. S. Pal K. Claffey H. Cohen D. Mukhopadhyay Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase Cζ J. Biol. Chem. 273 1998 26277 26280
47. S. Ivanov Down-regulation of transmembrane carbonic anhydrase in renal cell carcinoma cell lines by wild-type von Hippel–Lindau transgenes Proc. Natl. Acad. Sci. U. S. A. 95 1998 12596 12601
48. O. Iliiopoulos Negative regulation of hypoxia-inducible genes by the von Hippel–Lindau protein Proc. Natl. Acad. Sci. U. S. A. 93 1996 10595 10599
49. A.P. Levy N.S. Levy M.A. Goldberg Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel–Lindau protein J. Biol. Chem. 271 1996 25492 25497
50. R. Martinez-Zaguilan Acidic pH enhances the invasive behavior of human melanoma cells Clin. Exp. Metastasis 14 1996 176 186