Von Hippel-Lindau tumor suppressor protein represses platelet-derived growth factor B-chain gene expression via the Sp1 binding element in the proximal PDGF-B promoter

Journal of Cellular Biochemistry

Volumn 85, Issue 3, 2002, Pages 490-495

  Rafty, Louise A ^a   Khachigian, Levon M ^b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Gene expression; Platelet derived growth factor B chain; Transcription; Von Hippel Lindau protein

Indexed keywords

GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; TRANSCRIPTION FACTOR SP1; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CLEAR CELL CARCINOMA; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; KIDNEY CANCER; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; CELLS, CULTURED; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DOWN-REGULATION; GENE EXPRESSION REGULATION; LIGASES; MUSCLE, SMOOTH, VASCULAR; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, INBRED WKY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

FELIS CATUS;

EID: 0036237781     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10152     Document Type: Article

References (18)

1. An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
2. Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype
3. Characterization of the VHL tumor suppressor gene product: Localization, complex formation, and the effect of natural inactivating mutations
4. Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma
5. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
6. The von Hippel-Lindau tumor suppressor protein
7. Novel cis-acting elements in the human platelet-derived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells
8. Identification of the von Hippel-Lindau disease tumor suppressor gene
9. Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density
10. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
11. Transcriptional regulation of the SIS/PDGF-B gene in human osteosarcoma cells by the Sp family of transcription factors
12. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vacular endothelial growth factor promoter activity
13. Activation of Sp1-mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase C zeta
14. Identification of a thrombin response element in the human platelet-derived growth factor B-chain (c-sis) promoter
15. Eversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
16. Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3
17. Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
18. c-sis/PDGF-B promoter transactivation by the Yax protein of human T-cell leukemia virus type 1