SCF and cullin/RING H2-based ubiquitin ligases

Annual Review of Cell and Developmental Biology

Volumn 15, Issue , 1999, Pages 435-467

  Deshaies, R J ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cdc34; F box; Skpl; Ubiquitin; Ubiquitination

Indexed keywords

CULLIN; LIGASE; PROTEIN; STEM CELL FACTOR; UBIQUITIN; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; REVIEW; TRANSCRIPTION REGULATION;

EUKARYOTA;

EID: 0033279836     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.15.1.435     Document Type: Review

References (120)

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15. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis
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38. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swel
39. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
40. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
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54. Cdc4 complex
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59. A novel protein modification pathway related to the ubiquitin system
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63. A novel human WD protein, hβTrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif
64. β-TrCP is a negative regulator of Wnt/β-catenin signaling pathway and dorsal axis formation in Xenopus embryos
65. SCFSKP2 ubiquitin ligase/E2F-1 transcription factor complex formation underlies regulation of E2F-1 protein stability and S phase promoting function
66. The abundance of cell cycle regulatory protein Cdc4p is controlled by interactions between its F box and Skplp
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68. An essential domain within Cdc34p is required for binding to a complex containing Cdc4p and Cdc53p in Saccharomyces cerevisiae
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70. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A
71. The Aspergillus nidulans sulphur regulatory gene sconB encodes a protein with WD40 repeats and an F-box
72. Characterization of the cullin and F-box protein partner Skpl
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81. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast
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98. IκBα ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1 and two F-box/WD4-repeat proteins, β-TrCP1 and β-TrCP2
99. Characterization of elongin C functional domains required for interaction with elongin B and activation of elongin A
100. Identification of elongin C sequences required for interaction with the Von Hippel-Lindau tumor suppressor protein
101. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skpl and HOS to catalyze the ubiquitination of IκBα
102. The cytoplasmic F-box binding protein SKP1 contains a novel pentasaccharide linked to hydroxyproline in Dictyostelium
103. Slimb coordinates wg and dpp expression in the dorsal-ventral and anteriorposterior axes during limb development
104. Phosphorylation of Siclp by G1 Cdk required for its degradation and entry into S phase
105. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities
106. Identification of NEDD8-conjugation site in human cullin-2
107. 1γ2Cell
108. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway
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110. COI1: An Arabidopsis gene required for jasmonate-regulated defense and fertility
111. Cdc28-mediated control of CLN3 cyclin degradation
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113. Identification of the receptor component of the IκBα-ubiquitin ligase
114. Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle
115. Identification of a cullin homology region in a subunit of the anaphase-promoting complex
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118. p19(SKP1) and p45(SKP2) are essential elements of the cyclin A-CDK2 S phase kinase
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120. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases