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Volumn 3, Issue 12, 2003, Pages 939-951

CD28-mediated co-stimulation: A quantitative support for TCR signalling

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLYCOLIPID; INTERLEUKIN 2; INTERLEUKIN 2 INDUCIBLE T CELL KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN VAV1; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; TYROSINE; UNCLASSIFIED DRUG;

EID: 0347505003     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1248     Document Type: Review
Times cited : (594)

References (155)
  • 1
    • 0035973343 scopus 로고    scopus 로고
    • Pathways for self-tolerance and the treatment of autoimmune diseases
    • Goodnow, C. C. Pathways for self-tolerance and the treatment of autoimmune diseases. Lancet 357, 2115-2121 (2001).
    • (2001) Lancet , vol.357 , pp. 2115-2121
    • Goodnow, C.C.1
  • 2
    • 0016336419 scopus 로고
    • Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen
    • Lafferty, K. J., Misko, I. S. & Cooley, M. A. Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen. Nature 249, 275-276 (1974).
    • (1974) Nature , vol.249 , pp. 275-276
    • Lafferty, K.J.1    Misko, I.S.2    Cooley, M.A.3
  • 5
    • 0027281691 scopus 로고
    • Differential T cell co-stimulatory requirements in CD28-deficient mice
    • Shahinian, A. et al. Differential T cell co-stimulatory requirements in CD28-deficient mice. Science 261, 609-612 (1993). The first group to describe the CD28 knockout mouse, illustrating that some, but not all, immune responses are affected (see also reference 13).
    • (1993) Science , vol.261 , pp. 609-612
    • Shahinian, A.1
  • 8
    • 0036467547 scopus 로고    scopus 로고
    • CD28 co-stimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major
    • Compton, H. L. & Farrell, J. P. CD28 co-stimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major. J. Immunol. 168, 1302-1308 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1302-1308
    • Compton, H.L.1    Farrell, J.P.2
  • 9
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 co-stimulatory pathways in autoimmunity and transplantation
    • Salomon, B. & Bluestone, J. A. Complexities of CD28/B7: CTLA-4 co-stimulatory pathways in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 10
    • 0030293633 scopus 로고    scopus 로고
    • Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA 4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD
    • Via, C. S., Rus, V., Nguyen, P., Linsley, P. & Gause, W. C. Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD. J. Immunol. 157, 4258-4267 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 4258-4267
    • Via, C.S.1    Rus, V.2    Nguyen, P.3    Linsley, P.4    Gause, W.C.5
  • 12
    • 12644303215 scopus 로고    scopus 로고
    • Inhibition of T cell co-stimulation abrogates airway hyperresponsiveness in a murine model
    • Krinzman, S. J. et al. Inhibition of T cell co-stimulation abrogates airway hyperresponsiveness in a murine model. J. Clin. Invest. 98, 2693-2699 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 2693-2699
    • Krinzman, S.J.1
  • 13
    • 0028500255 scopus 로고
    • Absence of B7-dependent responses in CD28-deficient mice
    • Green, J. M. et al. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1, 501-508 (1994).
    • (1994) Immunity , vol.1 , pp. 501-508
    • Green, J.M.1
  • 14
    • 0029031023 scopus 로고
    • Naive CD28-deficient T cell can initiate but not sustain an in vitro antigen-specific immune response
    • Lucas, P. J., Negishi, I., Nakayama, K., Fields, L. E. & Loh, D. Y. Naive CD28-deficient T cell can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154, 5757-5768 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5757-5768
    • Lucas, P.J.1    Negishi, I.2    Nakayama, K.3    Fields, L.E.4    Loh, D.Y.5
  • 15
    • 0033136945 scopus 로고    scopus 로고
    • A Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity
    • Gudmundsdottir, H., Wells, A. D. & Turka, L. A Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J. Immunol. 162, 5212-5223 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5212-5223
    • Gudmundsdottir, H.1    Wells, A.D.2    Turka, L.3
  • 16
    • 0028153996 scopus 로고
    • + T cells
    • + T cells. J. Exp. Med. 179, 819-830 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 819-830
    • Lane, P.1
  • 17
    • 0029989758 scopus 로고    scopus 로고
    • CD28 is required for germinal center formation
    • Ferguson, S. E., Han, S., Kelsoe, G. & Thompson, C. B. CD28 is required for germinal center formation. J. Immunol. 156, 4576-4581 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 4576-4581
    • Ferguson, S.E.1    Han, S.2    Kelsoe, G.3    Thompson, C.B.4
  • 19
    • 0031569258 scopus 로고    scopus 로고
    • Role of co-stimulators in T cell differentiation: Studies using antigen-presenting cells lacking expression of CD80 or CD86
    • Schweitzer, A. N., Borriello, F., Wong, R. C., Abbas, A. K. & Sharpe, A. H. Role of co-stimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J. Immunol. 158, 2713-2722 (1997).
    • (1997) J. Immunol. , vol.158 , pp. 2713-2722
    • Schweitzer, A.N.1    Borriello, F.2    Wong, R.C.3    Abbas, A.K.4    Sharpe, A.H.5
  • 20
    • 0037108596 scopus 로고    scopus 로고
    • Cutting edge: A crucial role for B7-CD28 in transmitting T help from APC to CTL
    • Prilliman, K. R. et al. Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL. J. Immunol. 169, 4094-4097 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 4094-4097
    • Prilliman, K.R.1
  • 21
    • 0030936275 scopus 로고    scopus 로고
    • B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    • Borriello, F. et al. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6, 303-313 (1997).
    • (1997) Immunity , vol.6 , pp. 303-313
    • Borriello, F.1
  • 23
    • 0036679733 scopus 로고    scopus 로고
    • It's all Rel-ative: NF-κB and CD28 co-stimulation of T-cell activation
    • Kane, L. P., Lin, J. & Weiss, A. It's all Rel-ative: NF-κB and CD28 co-stimulation of T-cell activation. Trends Immunol. 23, 413-420 (2002). A review of co-stimulation on nuclear factor-κB (NF-κB) activation.
    • (2002) Trends Immunol. , vol.23 , pp. 413-420
    • Kane, L.P.1    Lin, J.2    Weiss, A.3
  • 24
    • 0034292369 scopus 로고    scopus 로고
    • CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation
    • Michel, F. et al. CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation J. Immunol. 165, 3820-3829 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 3820-3829
    • Michel, F.1
  • 25
    • 0037015038 scopus 로고    scopus 로고
    • Genomic expression programs and the integration of the CD28 co-stimulatory signal in T cell activation
    • Diehn, M. et al. Genomic expression programs and the integration of the CD28 co-stimulatory signal in T cell activation. Proc. Natl Acad. Sci. USA 99, 11796-11801 (2002). A microarray study showing that CD28 augments the level of expression of genes targeted by T-cell receptor (TCR)-induced activation: a support to a quantitative view of co-stimulation (see also reference 62).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11796-11801
    • Diehn, M.1
  • 26
    • 0027936441 scopus 로고
    • AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes
    • Rincon, M. & Flavell, R. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J. 13, 4370-4381 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4370-4381
    • Rincon, M.1    Flavell, R.2
  • 27
    • 0032055220 scopus 로고    scopus 로고
    • Functional consequences of co-stimulation by ICAM-1 on IL-2 gene expression and T cell activation
    • Zuckerman, L. A., Pullen, L. & Miller, J. Functional consequences of co-stimulation by ICAM-1 on IL-2 gene expression and T cell activation. J. Immunol. 160, 3259-3268 (1998).
    • (1998) J. Immunol. , vol.160 , pp. 3259-3268
    • Zuckerman, L.A.1    Pullen, L.2    Miller, J.3
  • 28
    • 0037090259 scopus 로고    scopus 로고
    • Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 co-stimulatory molecules to IL-2 promoter activation
    • Zhou, X. Y. et al. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 co-stimulatory molecules to IL-2 promoter activation. J. Immunol. 168, 3847-3854 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 3847-3854
    • Zhou, X.Y.1
  • 29
    • 0034177510 scopus 로고    scopus 로고
    • Coordinate regulation of T cell activation by CD2 and CD28
    • Green, J. M., Karpitskiy, V., Kimzey, S. L. & Shaw, A. S. Coordinate regulation of T cell activation by CD2 and CD28. J. Immunol. 164, 3591-3595 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 3591-3595
    • Green, J.M.1    Karpitskiy, V.2    Kimzey, S.L.3    Shaw, A.S.4
  • 30
    • 0042971650 scopus 로고    scopus 로고
    • Molecular interactions mediating T cell antigen recognition
    • Van Der Merwe, P. A. & Davsi, S. J. Molecular interactions mediating T cell antigen recognition. Annu. Rev. Immunol. 21, 659-684 (2003). A review on the biophysical basis of immunoreceptor recognition.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 659-684
    • Van Der Merwe, P.A.1    Davsi, S.J.2
  • 31
    • 0037428080 scopus 로고    scopus 로고
    • Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
    • Shimaoka, M. et al. Structures of the αL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 112, 99-111 (2003).
    • (2003) Cell , vol.112 , pp. 99-111
    • Shimaoka, M.1
  • 32
    • 0031279050 scopus 로고    scopus 로고
    • Regulation of C-C chemokine production by murine T cells by CD28/B7 co-stimulation
    • Herold, K. C. et al. Regulation of C-C chemokine production by murine T cells by CD28/B7 co-stimulation. J. Immunol. 159, 4150-4153 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 4150-4153
    • Herold, K.C.1
  • 33
    • 0034996188 scopus 로고    scopus 로고
    • CD28 co-stimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells
    • Park, W. R. et al. CD28 co-stimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells. Eur. J. Immunol. 31, 1456-1464 (2001),
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1456-1464
    • Park, W.R.1
  • 34
    • 0007970554 scopus 로고    scopus 로고
    • Co-stimulation and selection for T-cell help for germinal centres: The role of CD 28 and OX40
    • Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T. & Lane, P. J. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol. Today 21, 333-337 (2000).
    • (2000) Immunol. Today , vol.21 , pp. 333-337
    • Walker, L.S.1    Gulbranson-Judge, A.2    Flynn, S.3    Brocker, T.4    Lane, P.J.5
  • 35
    • 0035313266 scopus 로고    scopus 로고
    • Cutting edge: In vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells
    • Reichert, P., Reinhardt, R. L., Ingulli, E. & Jankins, M. K. Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. J. Immunol. 166, 4278-4281 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 4278-4281
    • Reichert, P.1    Reinhardt, R.L.2    Ingulli, E.3    Jankins, M.K.4
  • 36
    • 0037114152 scopus 로고    scopus 로고
    • Cutting Edge: B7/CD28 interactions regulate cell cycle progression independent of the strength of TCR signaling
    • Bonnevier, J. L. & Mueller, D. L. Cutting Edge: B7/CD28 interactions regulate cell cycle progression independent of the strength of TCR signaling. J. Immunol. 169, 6659-6663 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6659-6663
    • Bonnevier, J.L.1    Mueller, D.L.2
  • 37
    • 0027688772 scopus 로고
    • Immune responses in interleukin-2-deficient mice
    • Kundig, T. M. et al. Immune responses in interleukin-2-deficient mice. Science 262, 1059-1061 (1993).
    • (1993) Science , vol.262 , pp. 1059-1061
    • Kundig, T.M.1
  • 39
    • 0033976064 scopus 로고    scopus 로고
    • CD28 co-stimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression
    • Appleman, L. J., Berezovskaya, A., Grass, I. & Boussiotis, V. A. CD28 co-stimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression. J. Immunol. 164, 144-151 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 144-151
    • Appleman, L.J.1    Berezovskaya, A.2    Grass, I.3    Boussiotis, V.A.4
  • 40
    • 0036467506 scopus 로고    scopus 로고
    • 1 cell-cycle progression by oncogenes and tumor suppressor genes
    • 1 cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 12, 47-52 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 47-52
    • Ho, A.1    Dowdy, S.F.2
  • 41
    • 0033016465 scopus 로고    scopus 로고
    • CD28 induces cell cycle progression by IL-2-independent downregulation of p27kip1 expression in human peripheral T lymphocytes
    • Boonen, G. J. et al. CD28 induces cell cycle progression by IL-2-independent downregulation of p27kip1 expression in human peripheral T lymphocytes. Eur. J. Immunol. 29, 789-798 (1999).
    • (1999) Eur. J. Immunol. , vol.29 , pp. 789-798
    • Boonen, G.J.1
  • 42
    • 0035884934 scopus 로고    scopus 로고
    • An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation
    • Kovalev, G. I., Franklin, D. S., Coffield, V. M., Xiong, Y. & Su, L. An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation. J. Immunol. 167, 3285-3292 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 3285-3292
    • Kovalev, G.I.1    Franklin, D.S.2    Coffield, V.M.3    Xiong, Y.4    Su, L.5
  • 43
    • 0037374765 scopus 로고    scopus 로고
    • 1 that controls entry into the cell cycle
    • 1 that controls entry into the cell cycle. Mol. Cell Biol. 23, 2351-2361 (2003).
    • (2003) Mol. Cell Biol. , vol.23 , pp. 2351-2361
    • Lea, N.C.1
  • 45
    • 0037087472 scopus 로고    scopus 로고
    • CD28 co-stimulation mediates downregulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells
    • Appleman, L. J., van Puijenbroek, A. A., Shu, K. M., Nadler, L. M. & Boussiotis, V. A. CD28 co-stimulation mediates downregulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J. Immunol. 168, 2729-2736 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 2729-2736
    • Appleman, L.J.1    Van Puijenbroek, A.A.2    Shu, K.M.3    Nadler, L.M.4    Boussiotis, V.A.5
  • 46
    • 0033029809 scopus 로고    scopus 로고
    • Coordination of cell growth with cell division
    • Polymenis, M. & Schmidt, E. V. Coordination of cell growth with cell division. Curr. Opin. Genet. Dev. 9, 76-80 (1999).
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 76-80
    • Polymenis, M.1    Schmidt, E.V.2
  • 47
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T. & Hall, M.N. TOR, a central controller of cell growth. Cell 103, 253-262 (2000).
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 48
    • 0037023755 scopus 로고    scopus 로고
    • Signaling networks that link cell proliferation and cell fate
    • Sears, R. C. & Nevins, J. R. Signaling networks that link cell proliferation and cell fate. J. Biol. Chem. 277, 11617-11620 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 11617-11620
    • Sears, R.C.1    Nevins, J.R.2
  • 49
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
    • (1997) Immunity , vol.6 , pp. 411-417
    • Perez, V.L.1
  • 50
    • 0036234468 scopus 로고    scopus 로고
    • Pathways of apoptosis in lymphocyte development, homeostasis, and disease
    • Rathmell, J. C. & Thompson, C. B. Pathways of apoptosis in lymphocyte development, homeostasis, and disease. Cell 109, S97-S107 (2002).
    • (2002) Cell , vol.109
    • Rathmell, J.C.1    Thompson, C.B.2
  • 52
    • 0030006733 scopus 로고    scopus 로고
    • CD28 co-stimulation prevents cell death during primary T cell activation
    • Noel, P. J., Boise, L. H., Green, J. M. & Thompson, C. B. CD28 co-stimulation prevents cell death during primary T cell activation. J. Immunol. 157, 636-642 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 636-642
    • Noel, P.J.1    Boise, L.H.2    Green, J.M.3    Thompson, C.B.4
  • 55
    • 0034663779 scopus 로고    scopus 로고
    • + lymphocytes
    • + lymphocytes. J. Immunol. 165, 1743-1754 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1743-1754
    • Khoshnan, A.1
  • 56
    • 0037345810 scopus 로고    scopus 로고
    • The survival of antigen-stimulated T cells requires NF-κB-mediated inhibition of p73 expression
    • Wan, Y. Y. & DeGregori, J. The survival of antigen-stimulated T cells requires NF-κB-mediated inhibition of p73 expression. Immunity 18, 331-342 (2003).
    • (2003) Immunity , vol.18 , pp. 331-342
    • Wan, Y.Y.1    DeGregori, J.2
  • 57
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K. M. & Reiner, S. L. The lineage decisions of helper T cells. Nature Rev. Immunol. 2, 933-944 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 58
    • 0036884742 scopus 로고    scopus 로고
    • Progressive differentiation and selection of the fittest in the immune response
    • Lanzavecchia, A. & Sallusto, F. Progressive differentiation and selection of the fittest in the immune response. Nature Rev. Immunol. 2, 982-987 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 982-987
    • Lanzavecchia, A.1    Sallusto, F.2
  • 59
    • 0035070195 scopus 로고    scopus 로고
    • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
    • Grogan, J. L. et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14, 205-215 (2001).
    • (2001) Immunity , vol.14 , pp. 205-215
    • Grogan, J.L.1
  • 60
    • 0035167553 scopus 로고    scopus 로고
    • Cell division is not a 'clock' measunng acquisition of competence to produce IFN-γ or IL-4
    • Ben-Sasson, S. Z., Gerstel, R., Hu-Li, J. & Paul, W. E. Cell division is not a 'clock' measunng acquisition of competence to produce IFN-γ or IL-4. J. Immunol. 166, 112-120 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 112-120
    • Ben-Sasson, S.Z.1    Gerstel, R.2    Hu-Li, J.3    Paul, W.E.4
  • 61
    • 0035222187 scopus 로고    scopus 로고
    • H2 differentiation in allergic airway inflammation
    • H2 differentiation in allergic airway inflammation. Nature Immunol. 2, 45-50 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 45-50
    • Das, J.1
  • 62
    • 0037015055 scopus 로고    scopus 로고
    • Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
    • Riley, J. L. et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc. Natl Acad. Sci. USA 99, 11790-11795 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11790-11795
    • Riley, J.L.1
  • 63
    • 0033198045 scopus 로고    scopus 로고
    • H2 differentiation
    • H2 differentiation. J. Immunol. 163, 2634-2639 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 2634-2639
    • Oosterwegel, M.A.1
  • 65
    • 0032567080 scopus 로고    scopus 로고
    • Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling
    • Zhao, K. et al. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell 95, 625-636 (1998).
    • (1998) Cell , vol.95 , pp. 625-636
    • Zhao, K.1
  • 66
    • 0036721705 scopus 로고    scopus 로고
    • The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation
    • Attema, J. L. et al. The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation. J. Immunol. 169, 2466-2476 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 2466-2476
    • Attema, J.L.1
  • 67
    • 0036604901 scopus 로고    scopus 로고
    • T helper cell differentiation: On again, off again
    • Grogan, J. L. & Locksley, R. M. T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 14, 366-372 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 366-372
    • Grogan, J.L.1    Locksley, R.M.2
  • 68
    • 0346195644 scopus 로고    scopus 로고
    • c-Rel is required for chromatin remodeling across the IL-2 gene promoter
    • Rao, S., Gerondakis, S., Woltring, D. & Shannon, M. F. c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J. Immunol. 170, 3724-3731 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3724-3731
    • Rao, S.1    Gerondakis, S.2    Woltring, D.3    Shannon, M.F.4
  • 69
    • 0037340215 scopus 로고    scopus 로고
    • Selective, stable demethylation of the interleukin-2 gene enhances transcnption by an active process
    • Bruniquel, D. & Schwartz, R. H. Selective, stable demethylation of the interleukin-2 gene enhances transcnption by an active process. Nature Immunol. 4, 236-240 (2003). The authors provided the first evidence of stable demethylation of a TCR/CD28-targeted gene minutes after triggering.
    • (2003) Nature Immunol. , vol.4 , pp. 236-240
    • Bruniquel, D.1    Schwartz, R.H.2
  • 70
    • 0036305450 scopus 로고    scopus 로고
    • H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    • H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nature Immunol. 3, 643-651 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 643-651
    • Avni, O.1
  • 71
    • 0347406609 scopus 로고    scopus 로고
    • Molecular modifiers of T cell antigen receptor triggering threshold: The mechanism of CD28 co-stimulatory receptor
    • Acuto, O., Omata-Mise, S., Mangino, G. & Michel, F. Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 co-stimulatory receptor. Immunol. Rev. 185, 1-11 (2003).
    • (2003) Immunol. Rev. , vol.185 , pp. 1-11
    • Acuto, O.1    Omata-Mise, S.2    Mangino, G.3    Michel, F.4
  • 72
    • 0036221481 scopus 로고    scopus 로고
    • Signal transduction mediated by the T cell antigen receptor: The role of adapter proteins
    • Samelson, L. E. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20, 371-394 (2002).
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 371-394
    • Samelson, L.E.1
  • 73
    • 0029814079 scopus 로고    scopus 로고
    • CD28: A signaling perspective
    • Ward, S. CD28: a signaling perspective. Biochem. J. 318, 361-377 (1996).
    • (1996) Biochem. J. , vol.318 , pp. 361-377
    • Ward, S.1
  • 74
    • 0032530369 scopus 로고    scopus 로고
    • Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
    • Montixi, C. et al. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17, 5334-5348 (1998).
    • (1998) EMBO J. , vol.17 , pp. 5334-5348
    • Montixi, C.1
  • 75
    • 0037318863 scopus 로고    scopus 로고
    • CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
    • Irles, C. et al. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nature Immunol. 4, 189-197 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 189-197
    • Irles, C.1
  • 76
    • 0035693742 scopus 로고    scopus 로고
    • CD28 as a molecular amplifier extending TCR ligation and signaling capabilities
    • Michel, F., Attal-Bonnefoy, G., Mangino, G., Mise-Omata, S. & Acuto, O. CD28 as a molecular amplifier extending TCR ligation and signaling capabilities. Immunity 15, 935-945 (2001). This paper provides evidence that CD28 signalling amplifies a cyclosporin-dependent pathway by activating a TEC protein tyrosine kinase (PTK) with consequent activation of phospholipase C-γ1 (PLC-γ1) and increase in calcium concentration. It supports the view that co-stimulation directly augments TCR-signalling capability (see also reference 125).
    • (2001) Immunity , vol.15 , pp. 935-945
    • Michel, F.1    Attal-Bonnefoy, G.2    Mangino, G.3    Mise-Omata, S.4    Acuto, O.5
  • 77
    • 0034303371 scopus 로고    scopus 로고
    • RasGRP is essential for mouse thymocyte differentiation and TCR signaling
    • Dower, N. A. et al. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nature Immunol. 1, 317-321 (2000).
    • (2000) Nature Immunol. , vol.1 , pp. 317-321
    • Dower, N.A.1
  • 78
    • 0035367805 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinases in T lymphocyte activation
    • Ward, S. G. & Cantrell, D. A. Phosphoinositide 3-kinases in T lymphocyte activation. Curr. Opin. Immunol. 13, 332-338 (2001).
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 332-338
    • Ward, S.G.1    Cantrell, D.A.2
  • 79
    • 0037167816 scopus 로고    scopus 로고
    • Direct observation of ligand recognition by T cells
    • Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Direct observation of ligand recognition by T cells. Nature 419, 845-849 (2002).
    • (2002) Nature , vol.419 , pp. 845-849
    • Irvine, D.J.1    Purbhoo, M.A.2    Krogsgaard, M.3    Davis, M.M.4
  • 80
    • 0030176384 scopus 로고    scopus 로고
    • Upstream-downstream: CD28 cosignal pathways and T cell function
    • Rudd, C. E. Upstream-downstream: CD28 cosignal pathways and T cell function. Immunity 4, 527-534 (1996).
    • (1996) Immunity , vol.4 , pp. 527-534
    • Rudd, C.E.1
  • 81
    • 0033534460 scopus 로고    scopus 로고
    • The role of Tec protein-tyrosine kinase in T cell signaling
    • Yang, W. C., Ghiotto, M., Barbarat, B. & Olive, D. The role of Tec protein-tyrosine kinase in T cell signaling. J. Biol. Chem. 274, 607-617 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 607-617
    • Yang, W.C.1    Ghiotto, M.2    Barbarat, B.3    Olive, D.4
  • 82
    • 0028146530 scopus 로고
    • CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line
    • August, A. et al. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc. Natl Acad. Sci. USA 91, 9347-9351 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9347-9351
    • August, A.1
  • 83
    • 0031896945 scopus 로고    scopus 로고
    • Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein
    • Klasen, D., Pages, F., Peyron, J.-F., Cantrell, D. A. & Olive, D. Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein. Int. Immunol. 10, 481-489 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 481-489
    • Klasen, D.1    Pages, F.2    Peyron, J.-F.3    Cantrell, D.A.4    Olive, D.5
  • 84
    • 0033610868 scopus 로고    scopus 로고
    • Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells
    • Michel, F., Grimaud, L., Tuosto, L. & Acuto, O. Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells. J. Biol. Chem. 273, 31932-31938 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 31932-31938
    • Michel, F.1    Grimaud, L.2    Tuosto, L.3    Acuto, O.4
  • 85
    • 0030686560 scopus 로고    scopus 로고
    • Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
    • Parry, R. V. et al. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur. J. Immunol. 27, 2495-2501 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2495-2501
    • Parry, R.V.1
  • 86
    • 0036200194 scopus 로고    scopus 로고
    • Protein kinase B (Akt) regulation and function in T lymphocytes
    • Cantrell, D. Protein kinase B (Akt) regulation and function in T lymphocytes. Semin. Immunol. 14, 19-26 (2002).
    • (2002) Semin. Immunol. , vol.14 , pp. 19-26
    • Cantrell, D.1
  • 87
    • 0035319244 scopus 로고    scopus 로고
    • A point mutation in CD28 distinguishes proliferative signals from survival signals
    • Okkenhaug, K. et al. A point mutation in CD28 distinguishes proliferative signals from survival signals. Nature Immunol. 2, 325-332 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 325-332
    • Okkenhaug, K.1
  • 89
    • 0035869402 scopus 로고    scopus 로고
    • Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated co-stimulation in vivo
    • Harada, Y. et al. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated co-stimulation in vivo. J. Immunol. 166, 3797-3803 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3797-3803
    • Harada, Y.1
  • 90
    • 0034724201 scopus 로고    scopus 로고
    • NF-κB activation induced by T cell receptor/CD28 co-stimulation is mediated by protein kinase C-θ
    • Coudronniere, N., Villalba, M., Englund, N. & Altman, A. NF-κB activation induced by T cell receptor/CD28 co-stimulation is mediated by protein kinase C-θ. Proc. Natl Acad. Sci. USA 97, 3394-3399 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3394-3399
    • Coudronniere, N.1    Villalba, M.2    Englund, N.3    Altman, A.4
  • 92
    • 0030890234 scopus 로고    scopus 로고
    • Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
    • Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. & Crabtree, G. R. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science 275, 1930-1934 (1997).
    • (1997) Science , vol.275 , pp. 1930-1934
    • Beals, C.R.1    Sheridan, C.M.2    Turck, C.W.3    Gardner, P.4    Crabtree, G.R.5
  • 93
    • 0036069699 scopus 로고    scopus 로고
    • The CD28 signaling pathway regulates glucose metabolism
    • Frauwirth, K. A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002).
    • (2002) Immunity , vol.16 , pp. 769-777
    • Frauwirth, K.A.1
  • 94
    • 0036676540 scopus 로고    scopus 로고
    • Beyond calcium: New signaling pathways for Tec family kinases
    • Takesono, A., Finkelstein, L. D. & Schwartzberg, P. L. Beyond calcium: new signaling pathways for Tec family kinases. J. Cell Sci. 115, 3039-3048 (2002).
    • (2002) J. Cell Sci. , vol.115 , pp. 3039-3048
    • Takesono, A.1    Finkelstein, L.D.2    Schwartzberg, P.L.3
  • 95
    • 0037029653 scopus 로고    scopus 로고
    • Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and-independent pathways
    • Reynolds, L. F. et al. Vav1 transduces T cell receptor signals to the activation of phospholipase C-γ1 via phosphoinositide 3-kinase-dependent and-independent pathways. J. Exp. Med. 195, 1103-1114 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1103-1114
    • Reynolds, L.F.1
  • 96
    • 0032545218 scopus 로고    scopus 로고
    • A receptor/cytoskeletal movement triggered by co-stimulation during T cell activation
    • Wulfing, C. & Davis, M. M. A receptor/cytoskeletal movement triggered by co-stimulation during T cell activation. Science 282, 2266-2269 (1998).
    • (1998) Science , vol.282 , pp. 2266-2269
    • Wulfing, C.1    Davis, M.M.2
  • 97
    • 0028169441 scopus 로고
    • The role of p21ras in CD28 signal transduction: Triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras
    • Nunès, J. A., Collette, Y., Truneh, A., Olive, D. & Cantrell, D. A. The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras. J. Exp. Med. 180, 1067-1076 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 1067-1076
    • Nunès, J.A.1    Collette, Y.2    Truneh, A.3    Olive, D.4    Cantrell, D.A.5
  • 99
    • 0033213484 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Immunity 11, 399-409 (1999).
    • (1999) Immunity , vol.11 , pp. 399-409
    • Fowell, D.J.1
  • 100
    • 0031951071 scopus 로고    scopus 로고
    • H 2 cytokine production
    • H2 cytokine production. Immunity 8, 115-124 (1998).
    • (1998) Immunity , vol.8 , pp. 115-124
    • Yoshida, H.1
  • 101
    • 0036180783 scopus 로고    scopus 로고
    • Vav cooperates with CD28 to induce NF-κB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1
    • Marinari, B. et al. Vav cooperates with CD28 to induce NF-κB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. Eur. J. Immunol. 32, 447-456 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 447-456
    • Marinari, B.1
  • 102
    • 0034674627 scopus 로고    scopus 로고
    • Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription
    • Hehner, S. P., Hofmann, T. G., Dienz, O., Droge, W. & Schmitz, M. L. Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription. J. Biol. Chem. 275, 18160-18171 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 18160-18171
    • Hehner, S.P.1    Hofmann, T.G.2    Dienz, O.3    Droge, W.4    Schmitz, M.L.5
  • 103
    • 0028972712 scopus 로고
    • CD28-mediated co-stimulation in the absence of phosphatidylinositol 3-kinase association and activation
    • Crooks, M. E. et al. CD28-mediated co-stimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol. Cell Biol. 15, 6820-6828 (1995).
    • (1995) Mol. Cell Biol. , vol.15 , pp. 6820-6828
    • Crooks, M.E.1
  • 104
    • 0031962106 scopus 로고    scopus 로고
    • Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
    • Kim, H. H., Tharayil, M. & Rudd, C. E. Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling. J. Biol. Chem. 273, 296-301 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 296-301
    • Kim, H.H.1    Tharayil, M.2    Rudd, C.E.3
  • 105
    • 0034269240 scopus 로고    scopus 로고
    • Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
    • Aghazadeh, B., Lowry, W. E., Huang, X.-Y. & Rosen, M. K. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell 102, 625-633 (2000).
    • (2000) Cell , vol.102 , pp. 625-633
    • Aghazadeh, B.1    Lowry, W.E.2    Huang, X.-Y.3    Rosen, M.K.4
  • 106
    • 0242322243 scopus 로고    scopus 로고
    • CD28 co-stimulation: A source of Vav-1 for TCR signaling with the help of SLP-76?
    • Michel, F. & Acuto, O. CD28 co-stimulation: a source of Vav-1 for TCR signaling with the help of SLP-76? Sci. STKE 2002, PE35 (2002).
    • (2002) Sci. STKE , vol.2002
    • Michel, F.1    Acuto, O.2
  • 107
    • 0036631548 scopus 로고    scopus 로고
    • VAV proteins as signal integrators for multi-subunit immune-recognition receptors
    • Turner, M. & Billadeau, D. D. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nature Rev. Immunol. 2, 476-486 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 476-486
    • Turner, M.1    Billadeau, D.D.2
  • 108
    • 0030060353 scopus 로고    scopus 로고
    • A Signal transduction by CD28 co-stimulatory receptor on T cells
    • Nunès, J. A., Truneh, A., Olive, D. & Cantrell, D. A Signal transduction by CD28 co-stimulatory receptor on T cells. J. Biol. Chem. 271, 1591-1598 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 1591-1598
    • Nunès, J.A.1    Truneh, A.2    Olive, D.3    Cantrell, D.4
  • 109
    • 0029658306 scopus 로고    scopus 로고
    • p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
    • Tuosto, L., Michel, F. & Acuto, O. p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med. 184, 1161-1166 (1996).
    • (1996) J. Exp. Med. , vol.184 , pp. 1161-1166
    • Tuosto, L.1    Michel, F.2    Acuto, O.3
  • 110
    • 18244408051 scopus 로고    scopus 로고
    • Differential requirement for SLP-76 domains in T cell development and function
    • Myung, P. S. et al. Differential requirement for SLP-76 domains in T cell development and function. Immunity 15, 1011-1026 (2001).
    • (2001) Immunity , vol.15 , pp. 1011-1026
    • Myung, P.S.1
  • 111
    • 0033534525 scopus 로고    scopus 로고
    • The actin cytoskeleton and lymphocyte activation
    • Penninger, J. M. & Crabtree, G. R. The actin cytoskeleton and lymphocyte activation. Cell 96, 9-12 (1999).
    • (1999) Cell , vol.96 , pp. 9-12
    • Penninger, J.M.1    Crabtree, G.R.2
  • 112
    • 0034730182 scopus 로고    scopus 로고
    • The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
    • Wulfing, C., Bauch, A., Crabtree, G. R. & Davis, M. M. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc. Natl Acad. Sci. USA 97, 10150-10155 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10150-10155
    • Wulfing, C.1    Bauch, A.2    Crabtree, G.R.3    Davis, M.M.4
  • 113
    • 0036199184 scopus 로고    scopus 로고
    • Vav1 controls integdn clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells
    • Krawczyk, C. et al. Vav1 controls integdn clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16, 331-343 (2002).
    • (2002) Immunity , vol.16 , pp. 331-343
    • Krawczyk, C.1
  • 114
    • 0037351084 scopus 로고    scopus 로고
    • Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse
    • Ardouin, L. et al. Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur. J. Immunol. 33, 790-797 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 790-797
    • Ardouin, L.1
  • 115
    • 0001764561 scopus 로고    scopus 로고
    • Vav1 regulates phospholipase Cγ activation and calcium responses in mast cells
    • Manetz, T. S. et al. Vav1 regulates phospholipase Cγ activation and calcium responses in mast cells. Mol. Cell Biol. 21, 3763-3774 (2001).
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3763-3774
    • Manetz, T.S.1
  • 116
    • 0035020950 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways
    • Cantrell, D. A. Phosphoinositide 3-kinase signalling pathways. J. Cell. Sci. 114, 1439-1445 (2001).
    • (2001) J. Cell. Sci. , vol.114 , pp. 1439-1445
    • Cantrell, D.A.1
  • 117
    • 0035690584 scopus 로고    scopus 로고
    • CD28 signaling via VAV/SLP-76 adaptors: Regulation of cytokine transcription independent of TCR ligation
    • Raab, M., Pfister, S. & Rudd, C. E. CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity 15, 921-933 (2001).
    • (2001) Immunity , vol.15 , pp. 921-933
    • Raab, M.1    Pfister, S.2    Rudd, C.E.3
  • 118
    • 0032498230 scopus 로고    scopus 로고
    • The enhanceosome and transcriptional synergy
    • Carey, M. The enhanceosome and transcriptional synergy. Cell 92, 5-8 (1998).
    • (1998) Cell , vol.92 , pp. 5-8
    • Carey, M.1
  • 119
    • 0023637951 scopus 로고
    • T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
    • June, C. H., Ledbetter, J. A., Gillespie, M. M., Lindsten, T. & Thompson, C. B. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7, 4472-4481 (1987).
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 4472-4481
    • June, C.H.1    Ledbetter, J.A.2    Gillespie, M.M.3    Lindsten, T.4    Thompson, C.B.5
  • 120
    • 0028857929 scopus 로고
    • Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation
    • Rooney, J. W., Sun, Y. L., Glimcher, L. H. & Hoey, T. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15, 6299-6310 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6299-6310
    • Rooney, J.W.1    Sun, Y.L.2    Glimcher, L.H.3    Hoey, T.4
  • 122
    • 0028291525 scopus 로고
    • JNK is involved in signal integration during co-stimulation of T lymphocytes
    • Su, B. et al. JNK is involved in signal integration during co-stimulation of T lymphocytes. Cell 77, 727-736 (1994).
    • (1994) Cell , vol.77 , pp. 727-736
    • Su, B.1
  • 123
    • 0035885004 scopus 로고    scopus 로고
    • CD28 is not required for c-Jun N-terminal kinase activation in T cells
    • Rivas, F. V., O'Herrin, S. & Gajewski, T. F. CD28 is not required for c-Jun N-terminal kinase activation in T cells. J. Immunol. 167, 3123-3128 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 3123-3128
    • Rivas, F.V.1    O'Herrin, S.2    Gajewski, T.F.3
  • 124
    • 0036604985 scopus 로고    scopus 로고
    • New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
    • Miller, A. T. & Berg, L. J. New insights into the regulation and functions of Tec family tyrosine kinases in the immune system. Curr Opin. Immunol. 14, 331-340 (2002).
    • (2002) Curr Opin. Immunol. , vol.14 , pp. 331-340
    • Miller, A.T.1    Berg, L.J.2
  • 125
    • 0031874024 scopus 로고    scopus 로고
    • CD28 affects the earliest signaling events generated by TCR engagement
    • Tuosto, L. & Acuto, O. CD28 affects the earliest signaling events generated by TCR engagement. Eur. J. Immunol. 28, 2131-2142 (1998).
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2131-2142
    • Tuosto, L.1    Acuto, O.2
  • 126
    • 0033613826 scopus 로고    scopus 로고
    • T lymphocyte co-stimulation mediated by reorganization of membrane microdomains
    • Viola, A., Schroeder, S. Sakakibara, Y. & Lanzavecchia, A. T lymphocyte co-stimulation mediated by reorganization of membrane microdomains. Science 283, 680-682 (1999). This paper provides evidence for a role of co-stimulation in facilitating the clustering of glycolipid-enriched membrane microdomains (GEMs).
    • (1999) Science , vol.283 , pp. 680-682
    • Viola, A.1    Schroeder, S.2    Sakakibara, Y.3    Lanzavecchia, A.4
  • 127
    • 0035202768 scopus 로고    scopus 로고
    • The immunological synapse and CD25-CD80 interactions
    • Bromley, S. K. et al. The immunological synapse and CD25-CD80 interactions. Nature Immunol. 2, 1159-1166 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 1159-1166
    • Bromley, S.K.1
  • 128
    • 0033517125 scopus 로고    scopus 로고
    • Proline residues in CD28 and the S1rc homology (SH)3 domain of Lck are required for T cell co-stimulation
    • Holdorf, A. D. et al. Proline residues in CD28 and the S1rc homology (SH)3 domain of Lck are required for T cell co-stimulation. J. Exp. Med. 190, 375-384 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 375-384
    • Holdorf, A.D.1
  • 129
    • 0035339837 scopus 로고    scopus 로고
    • ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κB activation in response to engagement of CD 3 and CD28
    • Herndon, T. M., Shan, X. C., Tsokos, G. C. & Wange, R. L. ZAP-70 and SLP-76 regulate protein kinase C-θ and NF-κB activation in response to engagement of CD3 and CD28. J. Immunol. 166, 5654-5664 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5654-5664
    • Herndon, T.M.1    Shan, X.C.2    Tsokos, G.C.3    Wange, R.L.4
  • 130
    • 0037047136 scopus 로고    scopus 로고
    • CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse
    • Huang, J. et al. CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse. Proc. Natl Acad. Sci. USA 99, 9369-9373 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9369-9373
    • Huang, J.1
  • 131
    • 0036884294 scopus 로고    scopus 로고
    • Live-cell dynamics and the role of co-stimulation in immunological synapse formation
    • Wetzel, S. A., McKeithan, T. W. & Parker, D. C. Live-cell dynamics and the role of co-stimulation in immunological synapse formation. J. Immunol. 169, 6092-6101 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6092-6101
    • Wetzel, S.A.1    McKeithan, T.W.2    Parker, D.C.3
  • 132
    • 0036141994 scopus 로고    scopus 로고
    • Co-stimulation and endogenous MHC ligands contribute to T cell recognition
    • Wulfing, C. et al. Co-stimulation and endogenous MHC ligands contribute to T cell recognition. Nature Immunol. 3, 42-47 (2002). Using live immunofluorescence, this paper shows that CD28 contributes to TCR triggering by facilitating the accumulation of TCRs (including non-ligated TCRs) at the immune synapse (see also reference 131).
    • (2002) Nature Immunol. , vol.3 , pp. 42-47
    • Wulfing, C.1
  • 133
    • 0033033321 scopus 로고    scopus 로고
    • Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
    • Harder, T. & Simons, K. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29, 556-562 (1999).
    • (1999) Eur. J. Immunol. , vol.29 , pp. 556-562
    • Harder, T.1    Simons, K.2
  • 134
    • 0036794399 scopus 로고    scopus 로고
    • Staging and resetting T cell activation in SMACs
    • Freiberg, B. A. et al. Staging and resetting T cell activation in SMACs. Nature Immunol. 3, 911-917 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 911-917
    • Freiberg, B.A.1
  • 135
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigenic stimulation determines the fate of naive and effector T cells
    • Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigenic stimulation determines the fate of naive and effector T cells. Immunity 8, 89-95 (1998). This work illustrates the point that CD28 signalling decreases the duration of TCR stimulation in determining T-cell fate (see also reference 145).
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 136
    • 0036195934 scopus 로고    scopus 로고
    • Regulation of Lck activity by CD4 and CD28 in the immunological synapse
    • Holdorf, A. D., Lee, K. H., Burack, W. R., Allen, P. M. & Shaw, A. S. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nature Immunol. 3, 259-264 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 259-264
    • Holdorf, A.D.1    Lee, K.H.2    Burack, W.R.3    Allen, P.M.4    Shaw, A.S.5
  • 137
    • 0037827638 scopus 로고    scopus 로고
    • Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
    • Jun, J. E. et al. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18, 751-762 (2003). This paper describes a point mutation in CARMA1, which is associated with lipid rafts after immunoreceptor triggering (see reference 138), that affects some but not all of the signalling pathways in which NF-κB is implicated: an example of qualitative differences in biological response with a minimum change in the behaviour of a single signalling component (see also reference 146).
    • (2003) Immunity , vol.18 , pp. 751-762
    • Jun, J.E.1
  • 138
    • 0036707522 scopus 로고    scopus 로고
    • CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation
    • Gaide, O. et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-κB activation. Nature Immunol. 3, 836-843 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 836-843
    • Gaide, O.1
  • 139
    • 0035064074 scopus 로고    scopus 로고
    • Calcium signaling mechanisms in T lymphocytes
    • Lewis, R. S. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 19, 497-521 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 497-521
    • Lewis, R.S.1
  • 140
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A. & Lanzavecchia, A. T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104-106 (1996). The first evidence that ligation of CD28 decreases the threshold number of ligated TCRs that are required for a given biological response.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 141
    • 0032532321 scopus 로고    scopus 로고
    • Qualitative and quantitative effects of CD28/B7-mediated co-stimulation on naive T cells in vitro
    • Manickasingham, S. P., Anderton, S. M., Burkhart, C. & Wraith, D. C. Qualitative and quantitative effects of CD28/B7-mediated co-stimulation on naive T cells in vitro. J. Immunol. 161, 3827-3835 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 3827-3835
    • Manickasingham, S.P.1    Anderton, S.M.2    Burkhart, C.3    Wraith, D.C.4
  • 143
    • 0034654529 scopus 로고    scopus 로고
    • H2 differentiation is directly dependent on the dose of antigen
    • H2 differentiation is directly dependent on the dose of antigen. J. Immunol. 164, 2955-2963 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 2955-2963
    • Rogers, P.R.1    Croft, M.2
  • 144
    • 0037651066 scopus 로고    scopus 로고
    • Stochastic model of T cell proliferation: A calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival
    • Deenick, E. K., Gett, A. V. & Hodgkin, P. D. Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival. J. Immunol. 170, 4963-4972 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 4963-4972
    • Deenick, E.K.1    Gett, A.V.2    Hodgkin, P.D.3
  • 145
    • 1842373718 scopus 로고    scopus 로고
    • Duration of TCR stimulation determines co-stimulatory requirements of T cells
    • Kündig, T. M. et al. Duration of TCR stimulation determines co-stimulatory requirements of T cells. Immunity 5, 41-52 (1996). The first in vivo data that support a quantitative model of co-stimulation.
    • (1996) Immunity , vol.5 , pp. 41-52
    • Kündig, T.M.1
  • 146
    • 0035229933 scopus 로고    scopus 로고
    • Disruption of T cell signaling networks and development by Grb2 haploid insufficiency
    • Gong, Q. et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nature Immunol. 2, 29-36 (2001). An example of how sensitive certain biological responses are to a relatively small variation of a signalling component.
    • (2001) Nature Immunol. , vol.2 , pp. 29-36
    • Gong, Q.1
  • 147
    • 0036604936 scopus 로고    scopus 로고
    • Protein kinase C-θ: Signaling from the center of the T-cell synapse
    • Arendt, C. W., Albrecht, B., Soos, T. J. & Littman, D. R. Protein kinase C-θ: signaling from the center of the T-cell synapse. Curr. Opin. Immunol. 14, 323-330 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 323-330
    • Arendt, C.W.1    Albrecht, B.2    Soos, T.J.3    Littman, D.R.4
  • 148
    • 0037092038 scopus 로고    scopus 로고
    • Translocation of PKCθ in T cells is mediated by a nonconventional, P13-K- and Vav-dependent pathway, but does not absolutely require phospholipase C
    • Villalba, M. et al. Translocation of PKCθ in T cells is mediated by a nonconventional, P13-K- and Vav-dependent pathway, but does not absolutely require phospholipase C. J. Cell. Biol. 157, 253-263 (2002).
    • (2002) J. Cell. Biol. , vol.157 , pp. 253-263
    • Villalba, M.1
  • 149
    • 0035525572 scopus 로고    scopus 로고
    • Positive and negative regulation of T-cell activation by adaptor proteins
    • Koretzky, G. A. & Myung, P. S. Positive and negative regulation of T-cell activation by adaptor proteins. Nature Rev. Immunol. 1, 95-107 (2001).
    • (2001) Nature Rev. Immunol. , vol.1 , pp. 95-107
    • Koretzky, G.A.1    Myung, P.S.2
  • 150
    • 0036604987 scopus 로고    scopus 로고
    • Communication between the TCR and integrins: Role of the molecular adapter ADAP/Fyb/Slap
    • Griffiths, E. K. & Penninger, J. M. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr. Opin. Immunol. 14, 317-322 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 317-322
    • Griffiths, E.K.1    Penninger, J.M.2
  • 151
    • 0037385961 scopus 로고    scopus 로고
    • SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates
    • Wang, H. et al. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nature Immunol. 4, 366-374 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 366-374
    • Wang, H.1
  • 152
    • 0030798980 scopus 로고    scopus 로고
    • Lck phosphoyrlates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity
    • Heyeck, S. D., Wilcox, H. M., Bunnell, S. C. & Berg, L. J. Lck phosphoyrlates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J. Biol. Chem. 272, 25401-25408 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 25401-25408
    • Heyeck, S.D.1    Wilcox, H.M.2    Bunnell, S.C.3    Berg, L.J.4
  • 153
    • 0035167696 scopus 로고    scopus 로고
    • Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain
    • Yang, W. C., Ching, K. A., Tsoukas, C. D. & Berg, L. J. Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain. J. Immunol. 166, 387-395 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 387-395
    • Yang, W.C.1    Ching, K.A.2    Tsoukas, C.D.3    Berg, L.J.4
  • 154
    • 0033680925 scopus 로고    scopus 로고
    • Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
    • Krawczyk, C. et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13, 463-473 (2000).
    • (2000) Immunity , vol.13 , pp. 463-473
    • Krawczyk, C.1
  • 155
    • 0033662376 scopus 로고    scopus 로고
    • The CD28 and CTLA-4 receptors associate with the sedne/threonine phosphatase PP2A
    • Chuang, E. et al. The CD28 and CTLA-4 receptors associate with the sedne/threonine phosphatase PP2A. Immunity 13, 313-322 (2000).
    • (2000) Immunity , vol.13 , pp. 313-322
    • Chuang, E.1


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