Communication between the TCR and integrins: Role of the molecular adapter ADAP/Fyb/Slap

Current Opinion in Immunology

Volumn 14, Issue 3, 2002, Pages 317-322

  Griffiths, Emily K ^a,b   Penninger, Josef M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTEIN; PROTEIN ENA; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN; WISKOTT ALDRICH SYNDROME PROTEIN;

ANTIGEN PRESENTING CELL; BINDING AFFINITY; CELL ADHESION; CYTOSKELETON; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0036604987     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00334-5     Document Type: Review

References (55)

1. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
2. Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes
3. Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells
4. Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion
5. Integrins in the immune system
6. The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes
7. Avidity regulation of integrins: The driving force in leukocyte adhesion
8. Activation-dependent changes in soluble fibronectin binding and expression of beta 1 integrin activation epitopes in T cells: Relationship to T cell adhesion and migration
9. Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1
10. Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding
11. A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor
12. Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity
13. Regulation of integrin function by T cell activation: Points of convergence and divergence
14. Integrins and inside-out signal transduction: Converging signals from PKC and PIP3
15. Integrin affinity modulation
16. Signaling networks regulating beta 1 integrin-mediated adhesion of T lymphocytes to extracellular matrix
17. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
18. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
19. Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production
20. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells
21. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55
22. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130
23. SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55
24. FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells
25. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton
26. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells
27. Functional association between SLAP-130 and SLP-76 in jurkat T cells
28. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
29. Coupling of the TCR to integrin activation by Slap-130/Fyb
30. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma 1 in an SLP-76-deficient T cell
31. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
32. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
33. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors
34. Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: Differential involvement of the FYB SH3 domain
35. Putting on the brakes: A negative regulatory function for Ena/VASP proteins in cell migration
36. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes
37. Negative regulation of fibroblast motility by Ena/VASP proteins
38. Regulating cellular actin assembly
39. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains
40. Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice
41. Directed actin polymerization is the driving force for epithelial cell-cell adhesion
42. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function
43. Activation of cGMP-dependent protein kinase I beta inhibits interleukin 2 release and proliferation of T cell receptor-stimulated human peripheral T cells
44. A novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration
45. The molecular adapter SLP-76 relays signals from platelet integrin alpha IIb beta3 to the actin cytoskeleton
46. A receptor/cytoskeletal movement triggered by costimulation during T cell activation
47. Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes
48. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
49. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
50. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes
51. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface
52. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
53. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes
54. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen presenting cells
55. Adaptor ADAP (adhesion- and degranulation-promoting adapter protein) regulates beta1 integrin clustering on mast cells