Differential requirement for SLP-76 domains in T cell development and function

Immunity

Volumn 15, Issue 6, 2001, Pages 1011-1026

  Myung, Peggy S ^a,b   Derimanov, Geo S ^b,c   Jordan, Martha S ^b   Punt, Jennifer A ^d   Liu, Qing Hua ^a   Judd, Barbi A ^e   Meyers, Erin E ^b   Sigmund, Curt D ^f   Freedman, Bruce D ^a   Koretzky, Gary A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d HAVERFORD COLLEGE   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; PROTEIN SLP 76; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSGENIC MOUSE;

EID: 18244408051     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00253-9     Document Type: Article

References (61)

1. Allelic exclusion of the T cell receptor β locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein
2. Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT
3. Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin
4. Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development
5. Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76
6. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
7. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals
8. SLP-76 expression is restricted to hemopoietic cells of monocyte, granulocyte, and T lymphocyte lineage and is regulated during T cell maturation and activation
9. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
10. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice
11. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte
12. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production
13. Grid: A novel grb-2-related adapter protein that interacts with the activated t cell costimulatory receptor CD28
14. SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
15. Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity
16. Locus control region function and heterochromatin-induced position effect variegation
17. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
18. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
19. Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes
20. Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice
21. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
22. Evidence that phospholipase C-γ2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor γ-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
23. In vitro maturation of clonal CD4+CD8+ cell lines in response to TCR engagement
24. A new generation of Ca2+ indicators with greatly improved fluorescence properties
25. Induction of antigen-specific hyporesponsiveness by transplantation of hemopoietic cells containing an MHC class I transgene regulated by a lymphocyte-specific promoter
26. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
27. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors
28. Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: Increased synthesis of TCR-α protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
29. Suppression of thymic development by the dominant-negative form of Gads
30. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
31. GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation
32. Identification of the minimal tyrosine residues required for linker for activation of t cell function
33. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
34. Vav1 regulates phospholipase cγ activation and calcium responses in mast cells
35. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
36. Three domains of SLP-76 are required for its optimal function in a T cell line
37. Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4
38. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes
39. LAT is required for tyrosine phosphorylation of phospholipase cγ2 and platelet activation by the collagen receptor GPVI
40. Coupling of the TCR to integrin activation by SLAP-130/Fyb
41. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
42. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells
43. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2
44. LAT is essential for Fc(ε)RI-mediated mast cell activation
45. The kinase HPK1 associates physically and functionally with the adaptor proteins BLNK and SLP-76 in lymphocytes
46. Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity
47. Interaction of SLP adaptors with the SH2 domain of tec family kinases
48. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
49. Activated Ras signals differentiation and expansion of CD4+8+ thymocytes
50. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
51. Pleiotropic changes controlled by the pre-T-cell receptor
52. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
53. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
54. Uncoupling of nonreceptor tyrosine kinases from PLC-γ1 in an SLP-76-deficient T cell
55. Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
56. Requirement for the SLP-76 adaptor GADS in T cell development
57. Lat: The ZAP-70 tyrosine kinase substrate that links t cell receptor to cellular activation
58. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
59. Essential role of LAT in T cell development
60. Association of Grb2, Gads, and phospholipase C-γ 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
61. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice