Co-stimulation and selection for T-cell help for germinal centres: The role of CD28 and OX40

Immunology Today

Volumn 21, Issue 7, 2000, Pages 333-337

  Walker, Lucy S K ^a   Gulbranson Judge, Adam ^a   Flynn, Sarah ^a   Brocker, Thomas ^b   Lane, Peter J L ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD134 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL SELECTION; GERMINAL CENTER; IMMUNE RESPONSE; INFECTION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD27; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL MOVEMENT; GERMINAL CENTER; HUMANS; RECEPTORS, OX40; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0007970554     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01636-4     Document Type: Note

References (35)

1. MacGregor R.R. Corynebacterium diphtheria. Mandell G.L.et al. Principles and Practice of Infectious Diseases. 1990;1574-1581 Churchill Livingstone.
2. Jerne N.K. A study of avidity: based on rabbit skin responses to diphtheria toxin-antitoxin mixtures. Acta Pathol. Microbiol. Scand. 87:1951;9-183.
3. MacLennan I.C.M. Germinal centers. Annu. Rev. Immunol. 12:1994;117-139.
4. + T cells. J. Exp. Med. 179:1994;819-830.
5. Shahinian A.et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261:1993;609-612.
6. Zimmermann C.et al. Antiviral immune responses in CTLA4 transgenic mice. J. Virol. 71:1997;1802-1807.
7. Ridderstad A.et al. The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection. J. Immunol. 157:1996;3357-3365.
8. Zheng B.et al. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature. 384:1996;263-266.
9. Gulbranson-Judge A., MacLennan I. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome C. Eur. J. Immunol. 26:1996;1830-1837.
10. Garside P.et al. Visualization of specific B and T lymphocyte interactions in the lymph node. Science. 281:1998;96-99.
11. Ansel K.M.et al. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190:1999;1123-1134.
12. Forster R.et al. A putative chemokine receptor, blr1, directs B-cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 87:1996;1037-1047.
13. Gunn M.D.et al. A B-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma type receptor 1. Nature. 391:1998;799-802.
14. de Vinuesa C.G.et al. Germinal centers without T cells. J. Exp. Med. 191:2000;485-494.
15. Walker L.S.K.et al. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXCR-5 positive CD4 cells and germinal centers. J. Exp. Med. 190:1999;1115-1122.
16. Mallett S.et al. Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes - a molecule related to nerve growth factor receptor. EMBO J. 9:1990;1063-1068.
17. Flynn S.et al. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express IL-4 and upregulates expression of the chemokine receptor blr-1. J. Exp. Med. 188:1998;297-304.
18. Kopf M.et al. OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity. 11:1999;699-708.
19. Chen A.I.et al. OX40 ligand has a critical costimulatory role in dendritic cell: T cell interactions. Immunity. 11:1999;689-698.
20. Akiba H.et al. Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J. Exp. Med. 191:2000;375-380.
21. Durkop H.et al. Expression of the human OX40 (hOX40) antigen in normal and neoplastic tissues. Br. J. Haematol. 91:1995;927-931.
22. Brocker T.et al. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40 ligand expressed on dendritic cells leads to the accumulation of CD4 T cells into B follicles. Eur. J. Immunol. 29:1999;1610-1616.
23. Ohshima Y.et al. Expression and function of OX40 ligand on human dendritic cells. J. Immunol. 159:1997;3838-3848.
24. Stüber E., Strober W. The T-cell-B-cell interaction via OX40-OX40L is necessary for the cell-dependent humoral immune response. J. Exp. Med. 183:1996;979-989.
25. McHeyser-Williams L.J.et al. Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J. Exp. Med. 189:1999;1823-1838.
26. Jacob J.et al. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl, III: the kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178:1993;1293-1307.
27. Milstein C., Neuberger M.S. Maturation of the immune response. Adv. Protein Chem. 49:1996;451-485.
28. Jacob J., Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl, II: a common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:1992;679-687.
29. + T cells. J. Exp. Med. 186:1997;757-766.
30. Gramaglia I.et al. OX-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol. 161:1998;6510-6517.
31. Murata K.et al. Impairment of antigen-presenting cell function in mice lacking expression of OX40 ligand. J. Exp. Med. 191:2000;365-374.
32. Lenschow D.J.et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 5:1996;285-293.
33. Secord E.A.et al. Reconstitution of germinal center formation in nude mice with Th1 and Th2 clones. Cell. Immunol. 174:1996;173-179.
34. Randolph D.A.et al. The role of CCR7 in Th1 and Th2 cell localization and delivery of B cell help in vivo. Science. 286:1999;2159-2162.
35. Nilsen E.M.et al. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon γ. Gut. 37:1995;766-776.