CARMAI is a critical lipid raft-associated regulator of TCR-induced NF-kB activation

Nature Immunology

Volumn 3, Issue 9, 2002, Pages 836-843

  Gaide, Olivier ^a   Favier, Benoît ^b   Legler, Daniel F ^a   Bonnet, David ^a   Brissoni, Brian ^a   Valitutti, Salvatore ^b   Bron, Claude ^a   Tschopp, Jürg ^a   Thome, Margot ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BCL10 PROTEIN, HUMAN; CARD11 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CD28 ANTIGEN; CHUK PROTEIN, HUMAN; GUANYLATE CYCLASE; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; ISOENZYME; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PRKCQ PROTEIN, HUMAN; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR PROTEIN; GUANYLATE KINASE; LIPID; MUTANT PROTEIN; PROTEIN CARMA1; REGULATOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CELL MEMBRANE; HUMAN; LEUKEMIA CELL LINE; METABOLISM; PHYSIOLOGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DATA ANALYSIS; ENZYME ACTIVATION; GENE ACTIVATION; GENE TRANSLOCATION; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIGENS, CD28; APOPTOSIS REGULATORY PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; GUANYLATE CYCLASE; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-2; ISOENZYMES; JURKAT CELLS; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; NF-KAPPA B; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL;

EID: 0036707522     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni830     Document Type: Article

References (50)

1. Signal transduction by the TCR for antigen
2. The regulation and roles Of Rel/NF-κB transcription factors during lymphocyte activation
3. T cell antigen receptor signal transduction pathways
4. The role of lipid rafts in T cell antigen receptor (TCR) signalling
5. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
6. Fatty acylation of proteins: New insights into membrane targeting of myristoylated and palmitoylated proteins
7. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
8. Membrane compartmentation is required for efficient T cell activation
9. The physical association of protein kinase Cθ with a lipid raft-associated inhibitor of κB factor kinase (IKK) complex plays a role in the activation of the NF-κB cascade by TCR and CD28
10. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
11. Membrane lipid microdomains and the role of PKCθ in T cell activation
12. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
13. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure
14. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types
15. Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)
16. CARMAI, a CARD-containing binding partner of Bcl10, induces Bc110 phosphorylation and NF-κB activation
17. BimpI, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-κB induction
18. CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-κB
19. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-κB
20. Protein modules as organizers of membrane structure
21. Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family
22. PDZ domains: Targeting signalling molecules to sub-membranous sites
23. SH3 domains: Complexity in moderation
24. Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue Bcl10
25. T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates
26. ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain
27. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
28. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
29. Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts
30. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
31. lck adducts in rafts
32. Microdomains in lymphocyte signalling: Beyond GPI-anchored proteins
33. Phase separation of integral membrane proteins in Triton X-114 solution
34. Characterization of two receptors for TRAIL
35. S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
36. Transcriptional regulation of the IL-2 gene
37. JNK is involved in signal integration during costimulation of T lymphocytes
38. Tumor necrosis factor receptor-associated factors (TRAFs)
39. The distinct roles of TRAF2 and RIP in IKK activation by TNF-RI:TRAF2 recruits IKK to TNF-RI while RIP mediates IKK activation
40. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
41. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase
42. Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein
43. Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
44. The apoptosis inhibitor gene AP12 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21)p associated with mucosa-associated lymphoid tissue lymphomas
45. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
46. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18
47. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κB signaling pathway
48. Protein kinase Cθ, a selective upstream regulator of JNK/SAFK and IL-2 promoter activation in Jurkat T cells
49. T-cell regulation by CD28 and CTLA-4
50. Degradation of ZAP-70 after antigenic stimulation in human T lymphocytes: Role of calpain proteolytic pathway