Phosphoinositide 3-kinases in T lymphocyte activation

Current Opinion in Immunology

Volumn 13, Issue 3, 2001, Pages 332-338

  Ward, Stephen G ^a   Cantrell, Doreen A ^b  

^a UNIVERSITY OF BATH   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL LIPID PHOSPHATASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CELL POLARITY; CHEMOTAXIS; ENZYME ACTIVATION; LIPID METABOLISM; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; NONHUMAN; PHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BINDING; REVIEW; T LYMPHOCYTE;

EID: 0035367805     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00223-5     Document Type: Review

References (69)

1. Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase
2. The role of phosphoinositide 3-kinase lipid products in cell function
3. Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens
4. PI 3-kinase: A pivotal pathway in T cell activation
5. Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
6. Phosphatidylinositol 3-kinase controls E2F transcriptional activity in response to interleukin-2
7. Polarization of chemoattractant receptor signalling during neutrophil chemotaxis
8. Phosphoinositide 3-kinase: A key biochemical signal for cell migration in response to chemokines
9. Phosphoinositides 3-kinases: A conserved family of signal transducers
10. Phosphoinositide kinases
11. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
12. Protein modules and signalling networks
13. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
14. The docking molecule Gab2 is induced by lymphocyte activation and is involved in signalling by interleukin-2 and interleukin-15 but not other common γ chain-using cytokines
15. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
16. T-cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3ζ complex, recruits intracellular signalling proteins to the plasma-membrane
17. BCAP: The tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
18. p110δ, a novel phosphoinositide 3-kinase in leukocytes
19. Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages
20. The PI 3-kinase isoforms p110 (alpha) and p110 (beta) have differential roles in PDGF- and insulin-mediated signalling
21. Autophosphorylation of p110 delta phosphoinositide 3-kinase: A new paradigm for the regulation of lipid kinases in vitro and in vivo
22. Divergent regulation of phosphatidylinositol 3-kinase p85α and p85β isoforms upon T cell activation
23. Tec family kinases in lymphocyte signalling and function
24. Tec kinase signalling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain
25. Networking Rho family GTPases in lymphocytes
26. Involvement of phosphoinositide 3-kinase and Rac in membrane ruffling induced by IL-2 in T cells
27. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
28. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
29. 3-phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
30. The PI3K-PDK1 connection: More than just a road to PKB
31. Cellular signalling: Pivoting around PDK-1
32. s6k by PDK1
33. Do growth and cell division rates determine cell size in multicellular organisms?
34. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
35. Role of phosphatidylinositol 3,4,5 triphosphate in regulating the activity and localisation of 3′ phosphoinositide-dependent protein kinase 1
36. Multiple pathways control protein kinase C phosphorylation
37. Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
38. The dynamics of protein kinase B regulation during B cell antigen receptor engagement
39. The T cell antigen receptor activates phosphatidylinositol 3-kinase regulated serine kinases protein kinase B (PKB) and ribosomal S6 kinase 1
40. p70S6 kinase integrates PI 3-kinase and rapamycin regulated signals for E2F regulation in T lymphocytes
41. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFNγ but not TH2 cytokines
42. PKCθ is required for TCR-induced NFκB activation in mature but not immature T lymphocytes
43. Nuclear export of NFATc enhanced by glycogen synthase kinase-3
44. AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
45. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
46. Xid-like immunodeficiency in mice with disruption of the p85 subunit of phosphoinositide 3-kinase
47. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of PI3K
48. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
49. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
50. Central role for G protein-coupled phosphoinositide 3-kinase-γ in inflammation
51. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
52. PTEN: A tumour suppressor that functions as a phospholipid phosphatase
53. Structure, function, and biology of SHIP proteins
54. PTEN is essential for embryonic development and tumor suppression
55. Mutation of the PTEN/MMAC1 in mice causes neoplasia in multiple organ systems
56. Negative regulation of PKB/Akt-dependent cell-survival by the tumor-suppressor PTEN
57. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
58. Genetic deletion of the PTEN tumor suppressor gene promotes cell motility by activation of Rac and Cdc42 GTPases
59. Targeted disruption of SHIP leads to hematopoietic perturbations, lung pathology, and a shortened life-span
60. Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signalling
61. CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP
62. The inositol polyphosphate 5-phosphatase SHIP is a crucial negative regulator of B-cell antigen receptor signalling
63. Phosphatidylinositol-3,4,5-trisphosphate-Tec kinase-dependent calcium signalling pathway - A target for SHIP-mediated inhibitory signals
64. SHIP modulates immune receptor responses by regulating membrane association of Btk
65. The inositol polyphosphate 5-phosphatase SHIP is a crucial negative regulator of B cell antigen receptor signalling
66. 2+ oscillatory response
67. Identification of PH domain containing proteins with novel phosphoinositide-binding specificities
68. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
69. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo