CD28 signaling via VAV/SLP-76 adaptors: Regulation of cytokine transcription independent of TCR ligation

Immunity

Volumn 15, Issue 6, 2001, Pages 921-933

  Raab, Monika ^a,b   Pfister, Stefan ^a,c   Rudd, Christopher E ^a,b,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Department of Pathology ^*  (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CD28 ANTIGEN; CYTOKINE; F ACTIN; INTERLEUKIN 2; INTERLEUKIN 4; PROTEIN SLP 76; RAC1 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; VAV PROTEIN;

ARTICLE; CELL MEMBRANE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOID CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

EID: 0035690584     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00248-5     Document Type: Article

References (61)

1. Negative regulation of lymphocyte activation and autoimmunity by the adaptor Cbl-b
2. Distinct roles for LFA-1 and CD28 during the activation of naive T cells: Adhesion versus costimulation
3. New perspectives of CD28-B7-mediated T cell costimulation
4. Distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL
5. Regulatory and signaling properties of the Vav family
6. Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation
7. CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: Common co-signals induced by CD80 and CD86
8. CD28 endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation
9. Cbl-b regulates the CD28 dependence of T-cell activation
10. Requirement for the leucocyte-specific adpater protein SLP-76 for normal T cell development
11. The protection: The unit of humoral immunity selected by evolution
12. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production
13. SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
14. Tyrosine 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity
15. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
16. Phosphoinositide binding domains: Embracing 3-phosphate
17. Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo
18. Tryosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38 and interlukin-2 transcription
19. Proline residues in CD28 and the Src homology (SH)3 domains in Lck are required for T cell costimulation
20. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signaling transduction
21. Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor
22. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells
23. The ups and downs of T cell costimulation
24. The B7 and CD28 receptor families
25. Stimulation of CD28 with B7-2 promotes focal adhesion-like cell contacts where Rho family small G proteins accumulate in T-cells
26. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines
27. Growth factor receptor-bound 2 SH2/SH3 domain binding to CD28 and its role in co-signaling
28. The origin and mechanism of allograft reaction
29. CD28 ligation in T-cell activation: Evidence for two signal transduction pathways
30. The hematopoietic-specific adaptor protein, Gads functions in T-cell receptor signaling through interactions with SLP-76 and LAT adaptors
31. CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT avtivation
32. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases
33. A point mutation in CD28 distinguishes proliferate signals from survival signal
34. Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase
35. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signaling
36. Adaptor proteins in lymphocyte antigen-receptor signaling
37. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
38. Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TcRz/CD3 induction of interleukin 2
39. Transcription factors of the NFAT family: Regulation and function
40. Upstream-downstream: CD28 co-signaling pathways and T cell function
41. Adaptors and molecular scaffolds in immune cell signaling
42. Adaptor proteins and T-cell antigen receptor signaling
43. ras
44. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
45. CTLA-4 Interacts with the trans-Golgi clathrin adaptor complex AP-1: Mechanism to regulate homeostatic levels of intracellular receptor
46. A cell culture model for T lymphocyte clonal anergy
47. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation
48. A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement
49. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3-kinase
50. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
51. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
52. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol-3-kinase
53. CD28 affects the earliest signaling events generated by TCR engagement
54. Uncoupling IL-2 signals that regulate T cell proliferation, survival and Fas-mediated activation-induced cell death
55. A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation
56. T lymphocyte costimulation mediated by reorganization of membrane microdomains
57. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
58. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
59. Uncoupling of nonreceptor tyrosine kinases from PLC-g1 in a SLP-76-deficient T cell
60. CD28-mediated up-regulation of beta 1 integrin adhesion involves phosphatidylinositol 3-kinase
61. Defective signaling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene