Role of Costimulators in T Cell Differentiation: Studies Using Antigen-Presenting Cells Lacking Expression of CD80 or CD86

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 2713-2722

  Schweitzer, A Nicola ^a   Borriello, Frank ^a   Wong, Richard C K ^a   Abbas, Abul K ^a   Sharpe, Arlene H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BLOCKING ANTIBODY; CD86 ANTIGEN; CD86 PROTEIN, MOUSE; CYTOKINE; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG ANTAGONISM; GENETICS; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; IMMUNIZATION, SECONDARY; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0031569258     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Green, J. M., P. J. Noel, A. I. Sperling, T. L. Walunas, G. S. Gray, J. A. Bluestone, and C. B. Thompson. 1994. Absence of B7-dependent responses in CD28 deficient mice. Immunity 1:501.
2. Reiser, H., G. J. Freeman, Z. Razi-Wolf, C. D. Gimmi, B. Benacerraf, and L. M. Nadler. 1992. Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex. Proc. Natl. Acad. Sci. USA 89:271.
3. Wu, Y., Y. Guo, and Y. Liu. 1993. A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7. J. Exp. Med. 178:1789.
4. Lenschow, D. J., G. H.-T. Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, and J. A. Bluestone. 1993. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 90:11054.
5. Chen, C., D. A. Faherty, A. Gault, S. E. Connaughton, G. D. Powers, D. I. Godfrey, and N. Nabavi. 1994. Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes. J. Immunol. 152:2105.
6. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
7. June, C. H., J. A. Bluestone, L. M. Nadler, and C. B. Thompson. 1994. The B7 and CD28 receptor families. Immunol. Today 15:321.
8. Thompson, C. B., T. Lindsten, J. A. Ledbetter, S. L. Kunkel, H. A. Young, S. G. Emerson, J. M. Leiden, and C. H. June. 1989. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333.
9. + thymocytes. J. Immunol. 149:3217.
10. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356:607.
11. Boussiotis, V. A., G. J. Freeman, G. Gray, J. Gribben, and L. M. Nadler. 1993. B7 but not ICAM-1 costimulation prevents the induction of human alloantigen specific tolerance. J. Exp. Med. 178:1753.
12. Klaus, S. J., L. M. Pinchuk, H. D. Ochs, C. L. Law, W. C. Fanslow, R. J. Armitage, and E. A. Clark. 1994. Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J. Immunol. 152:5643.
13. De Boer, M., A. Kasran, J. Kwekkeboom, H. Walter, P. Vandenberghe, and J. L. Ceuppens. 1993. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells. Eur. J. Immunol. 23:3120.
14. Boise, L., A. Minn, P. Noel, C. June, M. Accavitti, T. Lindsten, and C. Thompson. 1995. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xl. Immunity 3:87.
15. Lindsten, T., K. P. Lee, E. S. Harris, B. Petryniak, N. Craighead, P. J. Reynolds, D. B. Lombard, G. J. Freeman, L. M. Nadler, G. S. Gray, C. B. Thompson, and C. H. June. 1993 Characterization of CTLA4 structure and expression on human T cells. J. Immunol. 151:3489.
16. Shahinian, A., K. Pfeffer, K. P Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
17. Lucas, P. J., I. Negjshi, K. Nakayama, L. E. Fields, and D. Y. Loh. 1995. Naive CD28-deficiem T cells can initiate but not sustain an in vitro antigen-specific immune response. J. Immunol. 154:5757.
18. Gribben, J. G., G. J. Freeman, V. A. Boussiotis, P. Rennert, C. L. Jellis, E. Greenfield, M. Barber, G. S. Gray, and L. M. Nadler, 1994, CTLA4 mediated costimulation induces apoptosis of activated human T lymphocytes. Proc. Natl. Acad. Sci. USA 92:811.
19. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
20. Krummel, M. F., and J. P. Allison. 1995. CD28 and CTLA4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182:459.
21. + T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. J. Immunol. 155:1032.
22. Freeman, G. J., J. G. Gribben, V. A. Boussiotis, J. W. Ng, V. Restivo, L. Lombard, G. S. Gray, and L. M. Nadler. 1993. Cloning of B7-2: a CTLA4 counter-receptor that costimulates human T cell proliferation. Science 262:909.
23. Freeman, G. J., F. Borriello, R. J. Hodes, H. Reiser, K. S Hathcock, G. Laszlo, A. J. McKnight, J Kim, L. Du, D. B. Lombard, G. S. Gray, L. M. Nadler, and A. H. Sharpe. 1993. Uncovering of functional alternative CTLA4 counter-receptor in B7-dencient mice. Science 262:907.
24. Linsley, P. S., J. L. Greene, W. Brady, I. Bayorath, J. A. Ledbetter, and R. Peach. 1994. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA4 receptors. Immunity 1:793.
25. Hathcock, K. S., G. Laszlo, C. Pucillo, P. Linsley, and R. J. Hodes. 1994. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med. 180:631.
26. Chen, C., and N. Nabavi. 1994. In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2. Immunity 1:147.
27. Lenschow, D. J., A. I. Sperling, M. P. Cooke, G. Freeman, L. Rhee, D. C. Decker, G. Gray, L. M. Nadler, C. C. Goodnow, and J. A. Blue-stone. 1994. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules following immunoglobulin receptor engagement by antigen. J. Immunol. 153:1990.
28. Stack, R. M., D. J. Lenschow, G. S. Gray, J. A. Bluestone, and F. W. Fitch. 1994. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152:5723.
29. Nabavi, N., G. J. Freeman, A. Gault, D. Godfrey, L. M. Nadler, and L. H. Glimcher. 1992. Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression. Nature 360:266.
30. Freedman, A. S., G. J. Freeman, K. Rhynhart, and L. M. Nadler. 1991. Selective induction of B7/BB-1 on interferon-γ stimulated monocytes: a potential mechanism for amplification of T cell activation. Cell. Immunol. 137:429.
31. Larsen, C. P., S. C. Ritchie, R. Hendrix, P. S. Linsley, K. S. Hathcock, R. J. Hodes, R. P. Lowry, and T. C. Pearson. 1994. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152:5208.
32. Lenschow, D. J., S. C. Ho, H. Sattar, L. Rhee, G. Gray, N. Nabavi, K. C. Herold, and J. A. Bluestone. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145.
33. Kuchroo, V., M. Prabhu Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules differentially activate the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
34. Mosmann, T. R., and R. L. Coffman. 1989. ThI and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
35. Freeman, G. J., V. A. Boussiotis, A. Anumanthan, G. M. Bernstein, X.-Y. Ke, P. D. Rennert, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1995. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity 2:523.
36. Lanier, L. L., S. O'Fallon, C. Somoza, J. H. Phillips, P. S. Linsley, K. Okumura, D. Ito, and M. Azuma. 1995. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97.
37. Natesan, M., Z. Razi-Wolf, and H. Reiser. 1996. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules. J. Immunol. 156:2783.
38. Seder, R., R. Germain, P. Linsley, and W. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 179:299.
39. Wallace, P. M., J. N. Rodgers, G. M. Leytze, J. S. Johnson, and P. S. Linsley. 1995. Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment. J. Immunol. 154:5885.
40. Lu, P., X. D. Zhou, S.-J. Chen, M. Moorman, S. C. Morris, F. D. Finkelman, P. Linsley, J. F. Urban, and W. C. Gause. 1994. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 180:693.
41. Corry, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
42. + T lymphocytes from TCR transgenic mice. J. Immunol. 152:5220.
43. Tan, P., C. Anasetti, J. A. Hansen, J. Melrose, M. Brunvard, J. Bradshaw, J. A. Ledbetter, and P. Linsley. 1993. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
44. Sayegh, M. H., E. Akalin, W. W. Hancock, M. E. Russell, C. B. Carpenter, P. S. Linsley, and L. A. Turka. 1995. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cylokines but spares Th2. J. Exp. Med. 181:1869.
45. Perrin, P. J., D. Scott, L. Quigley, P. S. Albert, O. Feder, G. S. Gray, R. Abe, C. H. June, and M. K. Racke. 1995. Role of B7/CD28 CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis. J. Immunol. 154: 1481.
46. Gajewski, T. F., D. W. Lancki, R. Stack, and F. W. Fitch. 1994. "Anergy" of Th0 helper T lymphocytes induces down-regulation of Th1 characteristics and a transition to a Th2-Jike phenotype. J. Exp. Med. 179:481.
47. Sansom, D. M., and N. D. Hall. 1993. B7/BB1. the ligand for CD28, is expressed on repeatedly activated human T cells in vitro. Enr. J. Immunol. 23:295.
48. Prabhu Das, M., S. S. Zamvil, F. Borriello, H. L. Weiner, A. H. Sharpe, and V. K. Kuchroo. 1995. Reciprocal expression of costimulatory molecules, B7-1 and B7-2 on murine T cells. Eur. J. Immunol. 25:207.
49. Azuma, M., H. Yssel, J. H. Phillips, H. Spits, and L. L. Lanier. 1993. Functional expression of B7/BB1 on activated T lymphocytes. J. Exp. Med. 177:845.
50. Wyss-Coray, T., D. Mauri-Hellweg, K. Baumann, F. Bettens, R. Grunow, and W. J. Pichler. 1993. The B7 adhesion molecule is expressed on activated human T cells: functional involvement in T-T cell interactions. Eur. J. Immunnl. 23: 2175.
51. lo thymocytes in vivo. Science 250: 1720.
52. Hsieh, C-S., S. E. Macatonia, A. O'Garra, and K. M. Murphy. 1995. T cell genetic background determines default T helper phenotype in vitro. J. Exp. Med. 181:713.
53. + T helper cell phenotype development in a T cell receplor-αβ-transgenic model. J. Exp. Med. 182:1579.
54. Parish, C., and F. Liew. 1972. Immune response to chemically modified flagellin. III. Enhanced cell-mediated immunity during high and low zone antibody tolerance to flagellin. J. Exp. Med. 135:298.
55. Viola, A., and A. Lanzaveccia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
56. Schmitz, J., A. Thiel, R. Kuhn, K. Rajewsky, W. Muller, M. Assenmacher, and A. Radbruch. 1994. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J. Exp. Med. 179:1349.
57. Trinchieri, G. 1995. Interleukin 12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
58. + T cells to protein antigens in vivo. J. Immunol. 155:3734.
59. Perez, V., J. Lederer, A. Lichtman, and A. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:869.
60. Miller, S., C. Vanderlugt, D. Lenschow, J. Pope. N. Karandikar, M. Dal Canto, and J. Bluestone. 1995. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739.
61. Stephens, L., and T. Kay. 1995. Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Int. Immunol. 7:1885.