Cell division is not a "clock" measuring acquisition of competence to produce IFN-γ or IL-4

Journal of Immunology

Volumn 166, Issue 1, 2001, Pages 112-120

  Ben Sasson, S Z ^a   Gerstel, R ^a   Hu Li, J ^a   Paul, W E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; BIOLOGICAL RHYTHM; CELL CYCLE S PHASE; CELL DIVISION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNOCOMPETENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 0035167553     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.1.112     Document Type: Article

References (30)

1. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells
2. IL-4 directs the development of Th2-like helper effectors
3. Lack of IL-4-inducing Th2 response and IgE class switching in mice with disrupted Stat6 gene
4. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
5. Essential role of Stat6 in IL-4 signaling
6. + T cells from T cell receptor transgenic mice
7. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones
8. + T cell in vitro is largely dependent on exogenous cytokines
9. + T cells through IL- 12 produced by Listeria-induced macrophages
10. Interleukin-12 signaling in T-helper type-1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription STAT3 and STAT4
11. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system
12. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
13. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
14. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
15. Helper T cell differentiation is controlled by the cell cycle
16. Correlation between DNA methylation and murine IFN-γ and IL-4 expression
17. Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation
18. Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression
19. + T cells
20. Regulation of IL-4 expression by activation of individual alleles
21. Bias in the expression of IL-4 alleles: The use of T cells from a GFP knock-out mouse
22. + Th1 lymphocytes, is ganglioside
23. Cytokine production by mature and immature thymocytes
24. + thymocytes into functionally mature Th2 cells: Exogenous interleukin-12 is required for priming thymocytes to produce both Th 1 cytokines and interleukin-10
25. + T cells
26. Activation events during thymic selection
27. Mouse CD1-specific NK1 T cells: Development, specificity, and function
28. Differentiation of the T-helper phenotypes by analysis of the methylation state of the IFN-γ gene
29. A novel transcription factor, T-bet, directs Th1 lineage commitment
30. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4