Direct observation of ligand recognition by T cells

Nature

Volumn 419, Issue 6909, 2002, Pages 845-849

  Irvine, Darrell J ^a   Purbhoo, Marco A ^a   Krogsgaard, Michelle ^a   Davis, Mark M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; IMMUNIZATION; IMMUNOLOGY; MICROSCOPIC EXAMINATION;

LIGAND RECOGNITION;

CELLS;

CD4 ANTIGEN; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PHYCOBILIPROTEIN; PHYCOERYTHRIN; T LYMPHOCYTE RECEPTOR;

IMMUNITY;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THREE DIMENSIONAL IMAGING;

ANIMALIA;

EID: 0037167816     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01076     Document Type: Article

References (30)

1. Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
2. Grakoui, A. et al. The immunogical synapse: A molecular machine controlling T cell activation. Science 285, 221-227 (1999).
3. Krummel, M. E. Sjaastad, M. D., Wulfing, C. & Davis, M. M. Differential clustering of CD4 and CD3ζ during T cell recognition. Science 289, 1349-1352 (2000).
4. Harding, C. V. & Unanue, E. R. Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature 346, 574-576 (1990).
5. Demotz, S., Grey, H. M. & Sette, A. The minimal number of class-I MHC antigen complexes needed for T-cell activation. Science 249, 1028-1030 (1990).
6. Kimachi, K., Croft, M. & Grey, H. M. The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells. Eur. J. Immunol. 27, 3310-3317 (1997).
7. Reay, P. A. et al. Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies. J. Immunol. 164, 5626-5634 (2000).
8. Christinck, E. R., Luscher, M. A., Barber, B. H. & Williams, D. B. Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature 352, 67-70 (1991).
9. + CTL. Mol. Immunol. 31, 1285-1293 (1994).
10. Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. J. & Eisen, H. N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571 (1996).
11. Triantafilou, K., Triantafilou, M. & Wilson, K. M. Phycobiliprotein-Fab conjugates as probes for single particle fluorescence imaging. Cytometry 41, 226-234 (2000).
12. Sako, Y., Minoghchi, S. & Yanagida, T. Single-molecule imaging of EGFR signalling on the surface of living cells. Nature Cell Biol. 2, 168-172 (2000).
13. Tsien, R. Y. Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253 (1989).
14. Negulescu, P. A., Krasieva, T. B., Khan, A., Kerschbaum, H. H. & Cahalan, M. D. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 4, 421-430 (1996).
15. Wülfing, C. et al. Costimulation and endogenous MHC ligands contribute to T cell recognition. Nature Immunol. 3, 42-47 (2002).
16. Marrack, P. et al. The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product. J. Exp. Med. 158, 1077-1091 (1983).
17. Hampl, J., Chien, Y. H. & Davis, M. M. CD4 augments the response of a T cell to agonist but not to antagonist ligands. Immunity 7, 379-385 (1997).
18. Vidal, K., Daniel, C., Hill, M., Littman, D. R. & Allen, P. M. Differential requirements for CD4 in TCR-ligand interactions. J. Immunol. 163, 4811-4818 (1999).
19. Baylor, D. A., Lamb, T. D. & Yau, K. W. Responses of retinal rods to single photons. J. Physiol. (Lond.) 288, 613-634 (1979).
20. Boniface, J. J. et al. Initiation of signal transduction through the T cell receptor requires the peptide multivalent engagement of MHC ligands. Immunity 9, 459-466 (1998).
21. Cochran, J. R., Cameron, T. O. & Stern, L. J. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12, 241-250 (2000).
22. Heldin, C. H. Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223 (1995).
23. Wang, J. H. et al. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl. Acad. Sci. USA 98, 10799-10804 (2001).
24. Anderson, P., Blue, M. L. & Schlossman; S. F. Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes. J. Immunol. 140, 1732-1737 (1988).
25. Beyers, A. D., Spruyt, L. L. & Williams, A. F. Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5. Proc. Natl. Acad. Sci. USA 89, 2945-2949 (1992).
26. Xiong, Y., Kern, P., Chang, H.-C. & Reinherz, E. L. T cell receptor binding to a pMHCII ligand is kinetically distinct from and independent of CD4. J. Biol. Chem. 276, 5659-5667 (2001).
27. Crawford, F., Kozono, H., White, J., Marrack, P. & Kappler, J. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 8, 675-682 (1998).
28. Wülfing, C., Sjaastad, M. D. & Davis, M. M. Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc. Natl. Acad. Sci. USA 95, 6302-6307 (1998).
29. Pear, W. S., Nolan, G. P., Scott, M. L. & Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90, 8392-8396 (1993).
30. Wülfing, C. & Davis, M. M. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 282, 2266-2269 (1998).